{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:13:03Z","timestamp":1788307983361,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK118190"],"award-info":[{"award-number":["K23DK118190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 DK131156"],"award-info":[{"award-number":["R03 DK131156"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007727"],"award-info":[{"award-number":["T32 DK007727"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.dld.2023.10.011","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T09:04:28Z","timestamp":1699088668000},"page":"444-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute pancreatitis is associated with gut dysbiosis in children"],"prefix":"10.1016","volume":"56","author":[{"given":"Chinenye R.","family":"Dike","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-7368","authenticated-orcid":false,"given":"Nicholas J.","family":"Ollberding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kotha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Minar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom K.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-1364","authenticated-orcid":false,"given":"Alexander","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee A.","family":"Denson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Haslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu-El-Haija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0001","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/MPA.0b013e3181baac47","article-title":"Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible?","volume":"39","author":"Morinville","year":"2010","journal-title":"Pancreas"},{"issue":"4","key":"10.1016\/j.dld.2023.10.011_bib0002","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.pan.2019.05.001","article-title":"Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children","volume":"19","author":"Abu-El-Haija","year":"2019","journal-title":"Pancreatology"},{"issue":"2","key":"10.1016\/j.dld.2023.10.011_bib0003","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/MPG.0000000000002405","article-title":"Risk factors for rapid progression from acute recurrent to chronic pancreatitis in children: report from INSPPIRE","volume":"69","author":"Liu","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0004","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/MPG.0000000000002145","article-title":"Rapid progression of acute pancreatitis to acute recurrent pancreatitis in children","volume":"68","author":"Sweeny","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"10.1016\/j.dld.2023.10.011_bib0005","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1097\/MPA.0000000000000918","article-title":"Increased burden of pediatric acute pancreatitis on the health care system","volume":"46","author":"Hornung","year":"2017","journal-title":"Pancreas"},{"issue":"2","key":"10.1016\/j.dld.2023.10.011_bib0006","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1053\/j.gastro.2020.09.056","article-title":"Inflammatory Bowel Diseases (IBD) and the microbiome-searching the crime scene for clues","volume":"160","author":"Lee","year":"2021","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.dld.2023.10.011_bib0007","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s10620-020-06109-5","article-title":"Microbiome, and its role in irritable bowel syndrome","volume":"65","author":"Pimentel","year":"2020","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2023.10.011_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.11.051","article-title":"Role of gut microbiota in type 2 diabetes pathophysiology","volume":"51","author":"Gurung","year":"2020","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.dld.2023.10.011_bib0009","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.chom.2017.10.005","article-title":"The human microbiome and obesity: moving beyond associations","volume":"22","author":"Maruvada","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"30","key":"10.1016\/j.dld.2023.10.011_bib0010","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.3748\/wjg.v27.i30.5019","article-title":"Gut microbiome in acute pancreatitis: a review based on current literature","volume":"27","author":"Patel","year":"2021","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0011","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41575-019-0242-7","article-title":"Microbiota in pancreatic health and disease: the next frontier in microbiome research","volume":"17","author":"Thomas","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"18","key":"10.1016\/j.dld.2023.10.011_bib0012","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.3748\/wjg.v26.i18.2187","article-title":"Role of gut microbiota on intestinal barrier function in acute pancreatitis","volume":"26","author":"Li","year":"2020","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.dld.2023.10.011_bib0013","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.surg.2008.09.011","article-title":"Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis","volume":"145","author":"Rychter","year":"2009","journal-title":"Surgery"},{"issue":"7","key":"10.1016\/j.dld.2023.10.011_bib0014","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.3748\/wjg.v22.i7.2219","article-title":"Gut microbiota role in irritable bowel syndrome: new therapeutic strategies","volume":"22","author":"Distrutti","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.dld.2023.10.011_bib0015","first-page":"483","article-title":"Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extra-gastrointestinal diseases","volume":"66","author":"Konturek","year":"2015","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin J Gastroenterol"},{"issue":"15","key":"10.1016\/j.dld.2023.10.011_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155389","article-title":"Gut microbiota manipulation as a tool for colorectal cancer management: recent advances in its use for therapeutic purposes","volume":"21","author":"Perillo","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dld.2023.10.011_bib0018","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coph.2016.01.002","article-title":"Gut microbiome as a novel cardiovascular therapeutic target","volume":"27","author":"Singh","year":"2016","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0019","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MPG.0000000000001715","article-title":"Management of acute pancreatitis in the pediatric population: a clinical report from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee","volume":"66","author":"Abu-El-Haija","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.dld.2023.10.011_bib0020","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/MPG.0000000000001583","article-title":"Classification of acute pancreatitis in the pediatric population: clinical report from the NASPGHAN pancreas committee","volume":"64","author":"Abu-El-Haija","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2023.10.011_bib0021","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65088","article-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini","year":"2021","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.dld.2023.10.011_bib0022","doi-asserted-by":"crossref","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dld.2023.10.011_bib0023","unstructured":"Ernst F.G., Shetty S., Borman T., et al. miaverse: r\/Biocondunctor ecosystem for microbiome bioinformatics based on (Tree) Summarized Experiment 2021 [Available from: http:\/\/microbiome.github.io\/."},{"key":"10.1016\/j.dld.2023.10.011_bib0024","series-title":"H In Stevens and Eduard Szoecs and Helene Wagner joafgbamfarkapladmaprmarbohag","author":"Simpson","year":"2019"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13059-022-02655-5","article-title":"LinDA: linear models for differential abundance analysis of microbiome compositional data","volume":"23","author":"Zhou","year":"2022","journal-title":"Genome Biol"},{"key":"10.1016\/j.dld.2023.10.011_bib0026","series-title":"The R project for statistical computing","author":"Bates","year":"2021"},{"issue":"6","key":"10.1016\/j.dld.2023.10.011_bib0027","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1080\/19490976.2020.1770042","article-title":"The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice","volume":"11","author":"Li","year":"2020","journal-title":"Gut Microbes"},{"issue":"5","key":"10.1016\/j.dld.2023.10.011_bib0028","doi-asserted-by":"crossref","DOI":"10.1093\/bjsopen\/zrab061","article-title":"Spatioregional assessment of the gut microbiota in experimental necrotizing pancreatitis","volume":"5","author":"van den Berg","year":"2021","journal-title":"BJS Open"},{"key":"10.1016\/j.dld.2023.10.011_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.813735","article-title":"Sodium butyrate attenuates taurocholate-induced acute pancreatitis by maintaining colonic barrier and regulating gut microorganisms in mice","volume":"13","author":"Xiong","year":"2022","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.dld.2023.10.011_bib0030","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/MPA.0000000000000355","article-title":"Dysbiosis of intestinal microbiota associated with inflammation involved in the progression of acute pancreatitis","volume":"44","author":"Tan","year":"2015","journal-title":"Pancreas"},{"issue":"4","key":"10.1016\/j.dld.2023.10.011_bib0031","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00535-018-1529-0","article-title":"Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice","volume":"54","author":"Zhu","year":"2019","journal-title":"J Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0032","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1725220","article-title":"Microbiota insights in clostridium difficile infection and inflammatory bowel disease","volume":"12","author":"Rodr\u00edguez","year":"2020","journal-title":"Gut microbes"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0033","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13073-017-0490-5","article-title":"A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients","volume":"9","author":"Hall","year":"2017","journal-title":"Genome Med"},{"key":"10.1016\/j.dld.2023.10.011_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02993","article-title":"New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages","volume":"10","author":"Batista-Gonzalez","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-065X.2012.01149.x","article-title":"Amino acid catabolism: a pivotal regulator of innate and adaptive immunity","volume":"249","author":"McGaha","year":"2012","journal-title":"Immunol Rev"},{"issue":"4","key":"10.1016\/j.dld.2023.10.011_bib0036","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00006676-200305000-00009","article-title":"The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis","volume":"26","author":"Akyol","year":"2003","journal-title":"Pancreas"},{"issue":"4","key":"10.1016\/j.dld.2023.10.011_bib0037","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.ejcn.1602338","article-title":"Effects of probiotics on the severity of experimental acute pancreatitis","volume":"60","author":"Muftuoglu","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.dld.2023.10.011_bib0038","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2482-4-12","article-title":"Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicenter trial [ISRCTN38327949]","volume":"4","author":"Besselink","year":"2004","journal-title":"BMC Surg"},{"issue":"9613","key":"10.1016\/j.dld.2023.10.011_bib0039","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(08)60207-X","article-title":"Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo- controlled trial","volume":"371","author":"Besselink","year":"2008","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.dld.2023.10.011_bib0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nbt.3436","article-title":"A reassessment of the PROPATRIA study and its implications for probiotic therapy","volume":"34","author":"Bongaerts","year":"2016","journal-title":"Nat Biotechnol"},{"issue":"9","key":"10.1016\/j.dld.2023.10.011_bib0041","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1046\/j.1365-2168.2002.02189.x","article-title":"Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis","volume":"89","author":"Ol\u00e1h","year":"2002","journal-title":"Br J Surg"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823010009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823010009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:24:58Z","timestamp":1761625498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865823010009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1590865823010009"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2023.10.011","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute pancreatitis is associated with gut dysbiosis in children","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}