{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:47:05Z","timestamp":1788479225101,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.dld.2023.10.025","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T12:15:20Z","timestamp":1699877720000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Flow cytometry for the assessment and monitoring of aberrant intraepithelial lymphocytes in non-responsive celiac disease and non-celiac enteropathies"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-7698","authenticated-orcid":false,"given":"Annalisa","family":"Schiepatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-8179","authenticated-orcid":false,"given":"Stiliano","family":"Maimaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-0930","authenticated-orcid":false,"given":"Chiara","family":"Scarcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5283-3897","authenticated-orcid":false,"given":"Patrizia","family":"Pignatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Betti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiftach","family":"Shoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Arpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Ciccocioppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-4622","authenticated-orcid":false,"given":"Federico","family":"Biagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2023.10.025_bib0001","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease","volume":"357","author":"Green","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2023.10.025_bib0002","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"BSG Coeliac Disease Guidelines Development Group; British Society of Gastroenterology. Diagnosis and management of adult celiac disease: guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0003","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.3390\/nu14132776","article-title":"Non-responsive and refractory coeliac disease: experience from the NHS England National Centre","volume":"14","author":"Penny","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2023.10.025_bib0004","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cgh.2006.12.006","article-title":"Etiologies and predictors of diagnosis in nonresponsive celiac disease","volume":"5","author":"Leffler","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.10.025_bib0005","article-title":"High prevalence of functional gastrointestinal disorders in celiac patients with persistent symptoms on a gluten-free diet: a 20-year follow-up study","author":"Schiepatti","year":"2022","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2023.10.025_bib0006","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/gut.30.3.333","article-title":"Malignancy in coeliac disease \u2014 effect of a gluten free diet","volume":"30","author":"Holmes","year":"1989","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0007","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1053\/j.gastro.2008.11.026","article-title":"Celiac disease and its complications: a time traveller's perspective","volume":"136","author":"West","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2023.10.025_bib0008","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1471-230X-14-139","article-title":"A case control study on complicated coeliac disease: two different patterns of natural history, two different prognoses","volume":"14","author":"Biagi","year":"2014","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.dld.2023.10.025_bib0009","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.dld.2017.12.001","article-title":"Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation","volume":"50","author":"Biagi","year":"2018","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2023.10.025_bib0010","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/gut.2009.195131","article-title":"Classification and management of refractory coeliac disease","volume":"59","author":"Rubio-Tapia","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0011","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(00)02481-8","article-title":"Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group","volume":"356","author":"Cellier","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2023.10.025_bib0012","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.gastro.2008.09.069","article-title":"Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II","volume":"136","author":"Malamut","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2023.10.025_bib0013","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/MEG.0b013e328307c20c","article-title":"High rates of complications and substantial mortality in both types of refractory sprue","volume":"21","author":"Daum","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.10.025_bib0014","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/gut.2006.114512","article-title":"Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience","volume":"56","author":"Al-Toma","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2008.10.013","article-title":"Clinical staging and survival in refractory celiac disease: a single center experience","volume":"136","author":"Rubio-Tapia","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2023.10.025_bib0016","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/apt.13755","article-title":"Creation of a model to predict survival in patients with refractory coeliac disease using a multinational registry","volume":"44","author":"Rubio-Tapia","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2023.10.025_bib0017","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0016-5085(98)70530-X","article-title":"Abnormal intestinal intraepithelial lymphocytes in refractory sprue","volume":"114","author":"Cellier","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2023.10.025_bib0018","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clim.2007.09.002","article-title":"Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in Refractory Celiac Disease","volume":"126","author":"Verbeek","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.dld.2023.10.025_bib0019","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gut.2009.186007","article-title":"Continual monitoring of intraepithelial lymphocyte immunophenotype and clonality is more important than snapshot analysis in the surveillance of refractory coeliac disease","volume":"59","author":"Liu","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0020","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s10875-014-0075-7","article-title":"Optimal strategies to identify aberrant intra-epithelial lymphocytes in refractory coeliac disease","volume":"34","author":"van Wanrooij","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.dld.2023.10.025_bib0021","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MEG.0b013e3282f16a4b","article-title":"Flow cytometric analysis of intestinal intraepithelial lymphocytes in the diagnosis of refractory celiac sprue","volume":"20","author":"Sanchez-Mu\u00f1oz","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.10.025_bib0022","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1136\/gut.2010.223438","article-title":"Accurate classification of RCD requires flow cytometry","volume":"59","author":"van Wanrooij","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0023","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.49.6.804","article-title":"Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue","volume":"49","author":"Daum","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0024","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.mcg.0000212616.66713.61","article-title":"Is TCRgamma clonality assay useful to detect early celiac disease?","volume":"41","author":"Ubiali","year":"2007","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2023.10.025_bib0025","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/MCG.0b013e31823eff20","article-title":"TCR\u03b2 clonality improves diagnostic yield of TCR\u03b3 clonality in refractory celiac disease","volume":"46","author":"Perfetti","year":"2012","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2023.10.025_bib0026","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/jclinpath-2018-205023","article-title":"Clonal T cell receptor gene rearrangements in coeliac disease: implications for diagnosing refractory coeliac disease","volume":"71","author":"Hussein","year":"2018","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.dld.2023.10.025_bib0027","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/PAS.0000000000001172","article-title":"Clinical insignficance of monoclonal T-cell populations and duodenal intraepithelial T-cell phenotypes in celiac and nonceliac patients","volume":"43","author":"Celli","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.dld.2023.10.025_bib0028","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.dld.2022.06.024","article-title":"The combination of clinical parameters and immunophenotyping of intraepithelial lymphocytes allows to assess disease severity in refractory celiac disease","volume":"54","author":"Branchi","year":"2022","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2023.10.025_bib0029","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1136\/gutjnl-2021-326645","article-title":"Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus","volume":"71","author":"Schiepatti","year":"2022","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.dld.2023.10.025_bib0030","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/gutjnl-2016-312271","article-title":"The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015)","volume":"66","author":"Aziz","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.dld.2023.10.025_bib0031","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/MEG.0000000000000836","article-title":"Short article: mortality and differential diagnoses of villous atrophy without coeliac antibodies","volume":"29","author":"Schiepatti","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.10.025_bib0032","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/apt.15663","article-title":"Gamma delta+ intraepithelial lymphocytes and coeliac lymphogram in a diagnostic approach to coeliac disease in patients with seronegative villous atrophy","volume":"51","author":"Fern\u00e1ndez-Ba\u00f1ares","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2023.10.025_bib0033","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1017\/S0007114509301579","article-title":"A gluten-free diet score to evaluate dietary compliance in patients with coeliac disease","volume":"102","author":"Biagi","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.dld.2023.10.025_bib0034","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0140-6736(97)01042-8","article-title":"Autoimmune enteropathy and villous atrophy in adults","volume":"350","author":"Corazza","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2023.10.025_bib0035","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1038\/ajg.2010.214","article-title":"The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease","volume":"105","author":"Malamut","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2023.10.025_bib0036","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/MEG.0000000000001726","article-title":"Clinical phenotype and mortality in patients with idiopathic small bowel villous atrophy: a dual-centre international study","volume":"32","author":"Schiepatti","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.10.025_bib0037","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hon.2494","article-title":"Intestinal T-cell lymphoma with enteropathy-associated T-cell lymphoma-like features arising in the setting of adult autoimmune enteropathy","volume":"36","author":"Ciccocioppo","year":"2018","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.dld.2023.10.025_bib0038","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1159\/000506305","article-title":"the intracellular intensity of CD3 on aberrant intraepithelial lymphocytes is a prognostic factor of the progression to overt lymphoma in refractory celiac disease type II (pre-enteropathy-associated T cell lymphoma)","volume":"38","author":"Garc\u00eda-Hoz","year":"2020","journal-title":"Dig Dis"},{"issue":"11","key":"10.1016\/j.dld.2023.10.025_bib0039","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3390\/nu11091992","article-title":"Systematic review and meta-analysis: accuracy of both gamma delta+ intraepithelial lymphocytes and coeliac lymphogram evaluated by flow cytometry for coeliac disease diagnosis","volume":"23","author":"Fern\u00e1ndez-Ba\u00f1ares","year":"2019","journal-title":"Nutrients"},{"issue":"13","key":"10.1016\/j.dld.2023.10.025_bib0040","article-title":"Intestinal and blood lymphograms as new diagnostic tests for celiac disease","volume":"10","author":"Roy","year":"2023","journal-title":"Front Immunol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823010174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823010174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T14:15:17Z","timestamp":1714054517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865823010174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1590865823010174"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2023.10.025","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flow cytometry for the assessment and monitoring of aberrant intraepithelial lymphocytes in non-responsive celiac disease and non-celiac enteropathies","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}