{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:16:31Z","timestamp":1788041791753,"version":"build-2784847793"},"reference-count":15,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.dld.2024.02.015","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T09:11:47Z","timestamp":1710148307000},"page":"1021-1022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting inflammation to prevent severe acute pancreatitis: NSAIDs are not the holy grail"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-8753","authenticated-orcid":false,"given":"Gabriele","family":"Capurso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Malesci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2024.02.015_bib0001","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.dld.2023.12.010","article-title":"Peri-onset non-steroidal anti-inflammatory drugs use and organ failure in acute pancreatitis: a multicenter retrospective analysis","volume":"56","author":"Wu","year":"2024","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2024.02.015_bib0002","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/MPA.0000000000000344","article-title":"The effect of lornoxicam on TLR2 and TLR4 messenger RNA expression and tumor necrosis factor-\u03b1, interleukin-6, and interleukin-8 secretion in patients with systemic complications of acute pancreatitis","volume":"44","author":"Gorsky","year":"2015","journal-title":"Pancreas"},{"key":"10.1016\/j.dld.2024.02.015_bib0003","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3121\/cmr.2021.1663","article-title":"Ketorolac and predicted severe acute pancreatitis: a randomized, controlled clinical trial","volume":"20","author":"Shariatpanahi","year":"2022","journal-title":"Clin Med Res"},{"key":"10.1016\/j.dld.2024.02.015_bib0004","doi-asserted-by":"crossref","first-page":"473","DOI":"10.14309\/ajg.0000000000000529","article-title":"Prevention of severe acute pancreatitis with cyclooxygenase-2 inhibitors: a randomized controlled clinical trial","volume":"115","author":"Huang","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2024.02.015_bib0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pan.2023.12.006","article-title":"Remission of organ failure in patients with predicted severe acute pancreatitis treated by somatostatin, octreotide and cyclo-oxygenase-2 inhibitors","volume":"24","author":"Huang","year":"2024","journal-title":"Pancreatology"},{"key":"10.1016\/j.dld.2024.02.015_bib0006","article-title":"A systematic review of NSAIDs treatment for acute pancreatitis in animal studies and clinical trials","volume":"44S","author":"Wu","year":"2020","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"4","key":"10.1016\/j.dld.2024.02.015_bib0007","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.amjmed.2021.10.020","article-title":"Prior exposure to nonsteroidal anti-inflammatory drugs reduces the rate of organ failure and in-hospital mortality in acute pancreatitis","volume":"135","author":"Ladd","year":"2022","journal-title":"Am J Med"},{"key":"10.1016\/j.dld.2024.02.015_bib0008","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/MEG.0000000000002578","article-title":"Does use of long-term aspirin impact outcomes in patients with acute pancreatitis?","volume":"35","author":"Chaudhry","year":"2023","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.dld.2024.02.015_bib0009","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.gie.2022.10.005","article-title":"American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: summary and recommendations","volume":"97","author":"Buxbaum","year":"2023","journal-title":"Gastrointest Endosc"},{"issue":"7","key":"10.1016\/j.dld.2024.02.015_bib0010","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","article-title":"Organ failure due to systemic injury in acute pancreatitis","volume":"156","author":"Garg","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2024.02.015_bib0011","article-title":"Buprenorphine versus diclofenac for pain relief in acute pancreatitis: a double-blinded randomized controlled trial","volume":"3","author":"Saini","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2024.02.015_sbref0012","doi-asserted-by":"crossref","DOI":"10.1002\/ueg2.12542","article-title":"Opioid analgesia and severity of acute pancreatitis:an international multicentre cohort study on pain management in acute pancreatitis","author":"Pandanaboyana","year":"2024","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.dld.2024.02.015_bib0013","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.pan.2013.03.008","article-title":"Prior statin therapy is associated with milder course and better outcome in acute pancreatitis - a cohort study","volume":"13","author":"Gornik","year":"2013","journal-title":"Pancreatology"},{"key":"10.1016\/j.dld.2024.02.015_bib0014","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/den.13801","article-title":"Chronic use of statins and acetylsalicylic acid and incidence of post-endoscopic retrograde cholangiopancreatography acute pancreatitis: a multicenter, prospective, cohort study","volume":"33","author":"C\u00e1rdenas-Ja\u00e9n","year":"2021","journal-title":"Dig Endosc"},{"key":"10.1016\/j.dld.2024.02.015_bib0015","doi-asserted-by":"crossref","first-page":"G428","DOI":"10.1152\/ajpgi.00100.2022","article-title":"Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study","volume":"323","author":"Greer","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824002767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824002767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T06:05:50Z","timestamp":1716617150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865824002767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1590865824002767"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2024.02.015","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting inflammation to prevent severe acute pancreatitis: NSAIDs are not the holy grail","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2024.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.12.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}