{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:39:11Z","timestamp":1792276751826,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell&apos;Istruzione dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.dld.2024.03.007","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:01:07Z","timestamp":1711645267000},"page":"1327-1334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Reticulated platelets are increased and hyper-activated in patients with cirrhosis, especially those with poor outcome"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-7178","authenticated-orcid":false,"given":"Alberto","family":"Zanetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Toffanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Maria","family":"Radu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Gavasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-191X","authenticated-orcid":false,"given":"Patrizia","family":"Burra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Senzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.dld.2024.03.007_bib0001","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1515\/cclm-2014-0165","article-title":"Reticulated platelets: analytical aspects and clinical utility","volume":"52","author":"Hoffmann","year":"2014","journal-title":"Clin Chem Lab Med"},{"issue":"5","key":"10.1016\/j.dld.2024.03.007_bib0002","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/ATVBAHA.121.316244","article-title":"Role of reticulated platelets in cardiovascular disease","volume":"42","author":"Bongiovanni","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.dld.2024.03.007_bib0003","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/ijlh.13177","article-title":"Reticulated platelets and immature platelet fraction: clinical applications and method limitations","volume":"42","author":"Buttarello","year":"2020","journal-title":"Int J Lab Hematol"},{"issue":"5","key":"10.1016\/j.dld.2024.03.007_bib0004","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0039-1681101","article-title":"Evaluation of an alternative staining method using syto 13 to determine reticulated platelets","volume":"119","author":"Hille","year":"2019","journal-title":"Thromb Haemost."},{"key":"10.1016\/j.dld.2024.03.007_bib0005","article-title":"The evolving knowledge on primary hemostasis in patients with cirrhosis: a comprehensive review","author":"Zanetto","year":"2023","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.dld.2024.03.007_bib0006","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/apt.14522","article-title":"Von willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity","volume":"47","author":"Mandorfer","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.dld.2024.03.007_bib0007","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jhep.2022.09.005","article-title":"Severity of systemic inflammation is the main predictor of ACLF and bleeding in individuals with acutely decompensated cirrhosis","volume":"78","author":"Zanetto","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2024.03.007_bib0008","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cca.2014.10.024","article-title":"Clinical applicability of reticulated platelets","volume":"439","author":"Dusse","year":"2015","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.dld.2024.03.007_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192271","article-title":"Immature platelet fraction and thrombopoietin in patients with liver cirrhosis: a cohort study","volume":"13","author":"Rauber","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dld.2024.03.007_bib0010","article-title":"Reticulated platelets predict cardiovascular death and adverse events in coronary artery disease: a systematic review and meta-analysis","author":"Bongiovanni","year":"2023","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.dld.2024.03.007_bib0011","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1440-1746.2006.04359.x","article-title":"Evaluation of platelet kinetics in patients with liver cirrhosis: similarity to idiopathic thrombocytopenic purpura","volume":"22","author":"Kajihara","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.dld.2024.03.007_bib0012","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jhep.2010.08.018","article-title":"Platelet production and destruction in liver cirrhosis","volume":"54","author":"Pradella","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2024.03.007_bib0013","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.thromres.2022.12.004","article-title":"Platelet ageing: a review","volume":"231","author":"Allan","year":"2023","journal-title":"Thromb Res"},{"issue":"11","key":"10.1016\/j.dld.2024.03.007_bib0014","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1111\/j.1538-7836.2009.03586.x","article-title":"Platelet functions beyond hemostasis","volume":"7","author":"Smyth","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"7","key":"10.1016\/j.dld.2024.03.007_bib0015","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/jth.13327","article-title":"Role of hemostatic factors in hepatic injury and disease: animal models de-liver","volume":"14","author":"Kopec","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.dld.2024.03.007_bib0016","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-0037-1604091","article-title":"Platelets as modulators of liver diseases","volume":"44","author":"Lisman","year":"2018","journal-title":"Semin Thromb Hemost"},{"issue":"11","key":"10.1016\/j.dld.2024.03.007_bib0017","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa1912035","article-title":"Association of aspirin with hepatocellular carcinoma and liver-related mortality","volume":"382","author":"Simon","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2024.03.007_bib0018","article-title":"Whole blood thrombin generation shows a significant hypocoagulable state in patients with decompensated cirrhosis","author":"Zanetto","year":"2023","journal-title":"J Thromb Haemost"},{"issue":"5","key":"10.1016\/j.dld.2024.03.007_bib0019","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2023.01.010","article-title":"Haemostasis in cirrhosis: understanding destabilising factors during acute decompensation","volume":"78","author":"Zanetto","year":"2023","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2024.03.007_bib0020","article-title":"PFA-100 in advanced chronic liver disease: end of the story?","volume":"6","author":"Zanetto","year":"2024","journal-title":"JHEP Rep"},{"issue":"4","key":"10.1016\/j.dld.2024.03.007_bib0021","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno vii - Renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J Hepatol"},{"issue":"17","key":"10.1016\/j.dld.2024.03.007_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10173867","article-title":"New indications for liver transplantation","volume":"10","author":"Zanetto","year":"2021","journal-title":"J Clin Med"},{"issue":"10","key":"10.1016\/j.dld.2024.03.007_bib0023","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/liv.15001","article-title":"Coagulopathy is not predictive of bleeding in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure","volume":"41","author":"Campello","year":"2021","journal-title":"Liver Int"},{"issue":"1","key":"10.1016\/j.dld.2024.03.007_bib0024","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/jth.15112","article-title":"Global hemostatic status in patients with acute-on-chronic liver failure and septics without underlying liver disease","volume":"19","author":"Lisman","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.dld.2024.03.007_bib0025","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/hep.31443","article-title":"Acute kidney injury in decompensated cirrhosis is associated with both hypo-coagulable and hyper-coagulable features","volume":"72","author":"Zanetto","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2024.03.007_bib0026","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-1-4939-7196-1_25","article-title":"Platelet function analyzed by light transmission aggregometry","volume":"1646","author":"Hvas","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.dld.2024.03.007_bib0027","first-page":"7","article-title":"[Comparison of an immature platelet fraction and reticulated platelet in liver cirrhosis]","volume":"27","author":"Kim","year":"2007","journal-title":"Korean J Lab Med"},{"issue":"Suppl 1","key":"10.1016\/j.dld.2024.03.007_bib0028","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1134\/S0006297923140031","article-title":"Laboratory markers of platelet production and turnover","volume":"88","author":"Bodrova","year":"2023","journal-title":"Biochemistry (Mosc)"},{"issue":"6","key":"10.1016\/j.dld.2024.03.007_bib0029","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/09537109777050","article-title":"Reticulated platelets","volume":"8","author":"Harrison","year":"1997","journal-title":"Platelets"},{"issue":"3","key":"10.1016\/j.dld.2024.03.007_bib0030","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11239-017-1533-x","article-title":"Characterization of surface antigens of reticulated immature platelets","volume":"44","author":"Lador","year":"2017","journal-title":"J Thromb Thrombolysis"},{"issue":"6","key":"10.1016\/j.dld.2024.03.007_bib0031","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1055\/s-0040-1715451","article-title":"Thrombopoietin receptor agonists in patients with chronic liver disease","volume":"46","author":"Khemichian","year":"2020","journal-title":"Semin Thromb Hemost"},{"issue":"9","key":"10.1016\/j.dld.2024.03.007_bib0032","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/ueg2.12472","article-title":"Toward a more precise prognostic stratification in acute decompensation of cirrhosis: the padua model 2.0. united","volume":"11","author":"Zanetto","year":"2023","journal-title":"European Gastroenterol J"},{"issue":"5","key":"10.1016\/j.dld.2024.03.007_bib0033","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jhep.2021.09.003","article-title":"EASL clinical practice guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis","volume":"76","year":"2022","journal-title":"J Hepatol"},{"issue":"7","key":"10.1016\/j.dld.2024.03.007_bib0034","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.dld.2020.12.118","article-title":"Acute kidney injury is associated with increased levels of circulating microvesicles in patients with decompensated cirrhosis","volume":"53","author":"Campello","year":"2021","journal-title":"Dig Liver Dis"},{"issue":"12","key":"10.1016\/j.dld.2024.03.007_bib0035","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep4.1781","article-title":"More pronounced hypercoagulable state and hypofibrinolysis in patients with cirrhosis with versus without hcc","volume":"5","author":"Zanetto","year":"2021","journal-title":"Hepatol Commun"},{"issue":"5","key":"10.1016\/j.dld.2024.03.007_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13051150","article-title":"Influence of hepatocellular carcinoma on platelet aggregation in cirrhosis","volume":"13","author":"Zanetto","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.dld.2024.03.007_bib0037","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.28853","article-title":"Low-grade endotoxemia and platelet activation in cirrhosis","volume":"65","author":"Raparelli","year":"2017","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.dld.2024.03.007_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113737","article-title":"Reticulated platelets in medicine: current evidence and further perspectives","volume":"9","author":"Corpataux","year":"2020","journal-title":"J Clin Med."},{"issue":"6","key":"10.1016\/j.dld.2024.03.007_bib0039","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jhep.2021.11.004","article-title":"Haemostatic alterations and management of haemostasis in patients with cirrhosis","volume":"76","author":"Lisman","year":"2022","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2024.03.007_bib0040","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/hep.31462","article-title":"Noninvasive risk stratification after hcv eradication in patients with advanced chronic liver disease","volume":"73","author":"Semmler","year":"2021","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.dld.2024.03.007_bib0041","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jhep.2022.03.009","article-title":"Increased platelet aggregation in patients with decompensated cirrhosis indicates higher risk of further decompensation and death","volume":"77","author":"Zanetto","year":"2022","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2024.03.007_bib0042","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/liv.15435","article-title":"Increased platelet ratio in patients with decompensated cirrhosis indicates a higher risk of portal vein thrombosis","volume":"43","author":"Zanetto","year":"2023","journal-title":"Liver Int"},{"issue":"1","key":"10.1016\/j.dld.2024.03.007_bib0043","article-title":"Platelet adhesion assessed by PFA-100 is not linked to progression of acld","volume":"6","author":"Balcar","year":"2024","journal-title":"JHEP Rep"},{"key":"10.1016\/j.dld.2024.03.007_bib0044","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000740","article-title":"Decreased platelet activation predicts hepatic decompensation and mortality in patients with cirrhosis","author":"Hofer","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2024.03.007_bib0045","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000799","article-title":"Letter to the editor: are we comparing apples with oranges?","author":"Zanetto","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2024.03.007_bib0046","article-title":"Immature platelet dynamics are associated with clinical outcomes after major trauma","author":"Schofield","year":"2023","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10.1016\/j.dld.2024.03.007_bib0047","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/hep.32596","article-title":"The role of transjugular intrahepatic portosystemic shunt in patients with cirrhosis and ascites: recent evolution and open questions","volume":"77","author":"Deltenre","year":"2023","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.dld.2024.03.007_bib0048","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.dld.2015.10.018","article-title":"Prognostic role of mean platelet volume in patients with cirrhosis","volume":"48","author":"Giannini","year":"2016","journal-title":"Dig Liver Dis"},{"issue":"6","key":"10.1016\/j.dld.2024.03.007_bib0049","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/cyto.990070603","article-title":"Thiazole orange: a new dye for reticulocyte analysis","volume":"7","author":"Lee","year":"1986","journal-title":"Cytometry"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824003086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824003086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T11:28:48Z","timestamp":1722079728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865824003086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1590865824003086"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2024.03.007","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reticulated platelets are increased and hyper-activated in patients with cirrhosis, especially those with poor outcome","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2024.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}