{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:17:54Z","timestamp":1788520674368,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060385"],"award-info":[{"award-number":["82060385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060385,81760383"],"award-info":[{"award-number":["82060385,81760383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760383"],"award-info":[{"award-number":["81760383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.dld.2024.05.012","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T07:14:23Z","timestamp":1717226063000},"page":"1897-1905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["ELMO1 regulates macrophage directed migration and attenuates inflammation via NF-\u03baB signaling pathway in primary biliary cholangitis"],"prefix":"10.1016","volume":"56","author":[{"given":"Di","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-929X","authenticated-orcid":false,"given":"Wenlin","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10266","key":"10.1016\/j.dld.2024.05.012_bib0001","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(20)31607-X","article-title":"Primary biliary cholangitis","volume":"396","author":"Lleo","year":"2020","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.dld.2024.05.012_bib0002","first-page":"949","article-title":"Emerging therapeutic strategies in the fight against primary biliary cholangitis","volume":"11","author":"Medford","year":"2023","journal-title":"J Clin Transl Hepatol"},{"issue":"6","key":"10.1016\/j.dld.2024.05.012_bib0003","doi-asserted-by":"crossref","first-page":"e0179","DOI":"10.1097\/HC9.0000000000000179","article-title":"Primary biliary cholangitis: epidemiology, prognosis, and treatment","volume":"7","author":"Trivella","year":"2023","journal-title":"Hepatol Commun"},{"issue":"5","key":"10.1016\/j.dld.2024.05.012_bib0004","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/JLB.2A0622-586RRRR","article-title":"IL-17A produced by invariant natural killer T cells and CD3+ CD56+ \u03b1Galcer-CD1d tetramer- T cells promote liver fibrosis in patients with primary biliary cholangitis","volume":"112","author":"Jia","year":"2022","journal-title":"J Leukoc Biol"},{"issue":"17","key":"10.1016\/j.dld.2024.05.012_bib0005","doi-asserted-by":"crossref","first-page":"9814","DOI":"10.3390\/ijms23179814","article-title":"Macrophage activation markers predict liver-related complications in primary biliary cholangitis","volume":"23","author":"Fujinaga","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dld.2024.05.012_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111754","article-title":"The pathogenesis, models and therapeutic advances of primary biliary cholangitis","volume":"140","author":"Li","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/j.dld.2024.05.012_bib0007","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3390\/biomedicines10061288","article-title":"Primary biliary cholangitis and primary sclerosing cholangitis: current knowledge of pathogenesis and therapeutics","volume":"10","author":"Park","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.dld.2024.05.012_bib0008","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.23783","article-title":"Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis","volume":"52","author":"Lleo","year":"2010","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.dld.2024.05.012_bib0009","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cld.2022.06.003","article-title":"Immunologic responses and the pathophysiology of primary biliary cholangitis","volume":"26","author":"Chen","year":"2022","journal-title":"Clin Liver Dis"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/HEP.0000000000000317","article-title":"P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases","volume":"78","author":"Zhang","year":"2023","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.dld.2024.05.012_bib0011","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.3390\/ijms24065301","article-title":"DHEA and its metabolites reduce the cytokines involved in the inflammatory response and fibrosis in primary biliary cholangitis","volume":"24","author":"Blatkiewicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dld.2024.05.012_bib0012","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bpg.2018.05.012","article-title":"Pathophysiology of primary biliary cholangitis","volume":"34-35","author":"Gulamhusein","year":"2018","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0013","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41467-022-34606-w","article-title":"Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.dld.2024.05.012_bib0014","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00281-022-00909-9","article-title":"Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target","volume":"44","author":"Trussoni","year":"2022","journal-title":"Semin Immunopathol"},{"issue":"2","key":"10.1016\/j.dld.2024.05.012_bib0015","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/JLB.5MR0320-200R","article-title":"Immune system and cholangiocytes: a puzzling affair in primary biliary cholangitis","volume":"108","author":"Ronca","year":"2020","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.dld.2024.05.012_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102328","article-title":"The challenges of primary biliary cholangitis: what is new and what needs to be done","volume":"105","author":"Terziroli Beretta-Piccoli","year":"2019","journal-title":"J Autoimmun"},{"issue":"2","key":"10.1016\/j.dld.2024.05.012_bib0017","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/cas.15628","article-title":"Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer","volume":"114","author":"Wen","year":"2023","journal-title":"Cancer Sci"},{"issue":"9","key":"10.1016\/j.dld.2024.05.012_bib0018","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.3390\/ijms24098103","article-title":"ELMO1 deficiency reduces neutrophil chemotaxis in murine peritonitis","volume":"24","author":"Yu","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.dld.2024.05.012_bib0019","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s13402-022-00680-x","article-title":"Role of ELMO1 in inflammation and cancer-clinical implications","volume":"45","author":"Tocci","year":"2022","journal-title":"Cell Oncol (Dordr)"},{"issue":"11","key":"10.1016\/j.dld.2024.05.012_bib0020","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.21873\/anticanres.16058","article-title":"Engulfment and cell motility 1 (ELMO1) regulates tumor cell behavior and predicts prognosis in colorectal cancer","volume":"42","author":"Park","year":"2022","journal-title":"Anticancer Res"},{"issue":"26","key":"10.1016\/j.dld.2024.05.012_bib0021","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1016\/j.cell.2022.11.029","article-title":"Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation","volume":"185","author":"Morioka","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0022","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1991776","article-title":"The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses","volume":"13","author":"Sayed","year":"2021","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0023","article-title":"Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis","volume":"18","author":"Yang","year":"2023","journal-title":"Open Med (Wars)"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0024","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1038\/s41467-021-25710-4","article-title":"TNF-\u03b1-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis","volume":"12","author":"Xie","year":"2021","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.dld.2024.05.012_bib0025","doi-asserted-by":"crossref","first-page":"16397","DOI":"10.1096\/fj.202001703R","article-title":"ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1","volume":"34","author":"Chan","year":"2020","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0026","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1038\/s41467-020-17271-9","article-title":"Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state","volume":"11","author":"Chang","year":"2020","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.dld.2024.05.012_bib0027","first-page":"7797","article-title":"Engulfment and cell motility 1 promotes tumor progression via the modulation of tumor cell survival in gastric cancer","volume":"12","author":"Park","year":"2020","journal-title":"Am J Transl Res"},{"issue":"5","key":"10.1016\/j.dld.2024.05.012_bib0028","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jhep.2022.06.014","article-title":"NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis","volume":"77","author":"Huang","year":"2022","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0029","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s12876-023-03031-8","article-title":"High neutrophil-lymphocyte ratio indicates a worse response to ursodeoxycholic acid in primary biliary cholangitis: a retrospective cohort study","volume":"23","author":"Zhu","year":"2023","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cld.2023.06.006","article-title":"Primary Biliary Cholangitis: pathophysiology","volume":"28","author":"Houri","year":"2024","journal-title":"Clin Liver Dis"},{"issue":"7","key":"10.1016\/j.dld.2024.05.012_bib0031","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41419-021-03931-1","article-title":"Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19","volume":"12","author":"Tian","year":"2021","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.dld.2024.05.012_bib0032","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/MOG.0000000000000814","article-title":"Macrophages in cholangiopathies","volume":"38","author":"Bruneau","year":"2022","journal-title":"Curr Opin Gastroenterol"},{"issue":"7","key":"10.1016\/j.dld.2024.05.012_bib0033","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/1751-2980.12790","article-title":"Autoantibodies in patients with interleukin 12 receptor beta 1 deficiency","volume":"20","author":"Ronca","year":"2019","journal-title":"J Dig Dis"},{"issue":"2","key":"10.1016\/j.dld.2024.05.012_bib0034","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hep.32405","article-title":"Mechanisms and molecules: what are the treatment targets for primary biliary cholangitis?","volume":"76","author":"Mayo","year":"2022","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/cells9010190","article-title":"Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions","volume":"9","author":"Li","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.dld.2024.05.012_bib0036","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jhep.2021.12.036","article-title":"Liver stromal cells restrict macrophage maturation and stromal IL-6 limits the differentiation of cirrhosis-linked macrophages","volume":"76","author":"Buonomo","year":"2022","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0037","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/HEP.0000000000000270","article-title":"Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression","volume":"78","author":"Guillot","year":"2023","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0038","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41420-023-01326-z","article-title":"Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NF\u03baB\/Caspase-1\/GSDMD signaling in cholestasis","volume":"9","author":"Liao","year":"2023","journal-title":"Cell Death Discov"},{"issue":"6","key":"10.1016\/j.dld.2024.05.012_bib0039","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/CS20181123","article-title":"Immunological abnormalities in patients with primary biliary cholangitis","volume":"133","author":"Ma","year":"2019","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1016\/j.dld.2024.05.012_bib0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41590-018-0293-x","article-title":"A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis","volume":"20","author":"Arandjelovic","year":"2019","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.dld.2024.05.012_bib0041","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2171690","article-title":"The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses","volume":"14","author":"Sharma","year":"2023","journal-title":"Virulence"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824007692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824007692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:34:18Z","timestamp":1778621658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865824007692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1590865824007692"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2024.05.012","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ELMO1 regulates macrophage directed migration and attenuates inflammation via NF-\u03baB signaling pathway in primary biliary cholangitis","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2024.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}