{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:59:03Z","timestamp":1781078343002,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.dld.2024.09.011","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T17:10:05Z","timestamp":1728407405000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early life exposures and risk of inflammatory bowel disease: A nested case-control study in Quebec, Canada"],"prefix":"10.1016","volume":"57","author":[{"given":"Canisius","family":"Fantodji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5215-8086","authenticated-orcid":false,"given":"Marie-Claude","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Nicolau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenath","family":"Madathil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-5687","authenticated-orcid":false,"given":"Pr\u00e9vost","family":"Jantchou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2024.09.011_bib0001","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the global burden of disease study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.dld.2024.09.011_bib0002","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","article-title":"Inflammatory bowel disease: cause and immunobiology","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2024.09.011_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00551","article-title":"Inflammatory bowel disease: genetics, epigenetics, and pathogenesis","volume":"6","author":"Loddo","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.dld.2024.09.011_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020423","article-title":"Priming for life: early life nutrition and the microbiota-gut-brain axis","volume":"13","author":"Ratsika","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2024.09.011_bib0005","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1824564","article-title":"The early life education of the immune system: Moms, microbes and (missed) opportunities","volume":"12","author":"Jain","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.dld.2024.09.011_bib0006","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/gut.2004.054353","article-title":"Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study","volume":"54","author":"Baron","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.dld.2024.09.011_bib0007","first-page":"143","article-title":"Oral tolerance: therapeutic implications for autoimmune diseases","volume":"13","author":"Faria","year":"2006","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.dld.2024.09.011_bib0008","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamapediatrics.2017.0378","article-title":"Association between breast milk bacterial communities and establishment and development of the infant gut microbiome","volume":"171","author":"Pannaraj","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.dld.2024.09.011_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082639","article-title":"Infants' first solid foods: impact on gut microbiota development in two intercontinental cohorts","volume":"13","author":"Homann","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2024.09.011_bib0010","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1097\/MIB.0000000000000852","article-title":"Environmental hygiene and risk of inflammatory bowel diseases: a systematic review and meta-analysis","volume":"22","author":"Cholapranee","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2024.09.011_bib0011","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.cgh.2024.01.020","article-title":"Early life and childhood environmental exposures, more than genetic predisposition, influence age of diagnosis in a diverse cohort of 2952 patients with IBD","volume":"22","author":"Khakoo","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2024.09.011_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.100884","article-title":"Early life exposures and the risk of inflammatory bowel disease: systematic review and meta-analyses","volume":"36","author":"Agrawal","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.dld.2024.09.011_bib0013","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2019.04.016","article-title":"Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses","volume":"157","author":"Piovani","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2024.09.011_bib0014","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1111\/j.1572-0241.2008.01999.x","article-title":"Passive smoking and inflammatory bowel disease: a meta-analysis","volume":"103","author":"Jones","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2024.09.011_bib0015","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/apt.14291","article-title":"Systematic review with meta-analysis: breastfeeding and the risk of Crohn's disease and ulcerative colitis","volume":"46","author":"Xu","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2024.09.011_bib0016","unstructured":"Yu J, Jantchou P, Gong R, et al. Use of a self-completed life history calendar: impact on data completeness and accuracy. Submitted. 2024."},{"key":"10.1016\/j.dld.2024.09.011_bib0017","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2022-000925","article-title":"Appendectomy and risk for inflammatory bowel disease: effect of age and time post appendectomy - a cohort study","volume":"9","author":"Fantodji","year":"2022","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.dld.2024.09.011_bib0018","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyy011","article-title":"Cohort profile: the quebec birth cohort on immunity and health (QBCIH)","volume":"47","author":"Rousseau","year":"2018","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.dld.2024.09.011_bib0019","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyae014","article-title":"Cohort profile update: the quebec birth cohort on immunity and health (CO.MMUNITY)","volume":"53","author":"Rousseau","year":"2024","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.dld.2024.09.011_bib0020","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jclinepi.2014.02.019","article-title":"Validation of international algorithms to identify adults with inflammatory bowel disease in health administrative data from Ontario, Canada","volume":"67","author":"Benchimol","year":"2014","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.dld.2024.09.011_bib0021","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/gut.2009.188383","article-title":"Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data","volume":"58","author":"Benchimol","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.dld.2024.09.011_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ypmed.2024.108071","article-title":"Association between bacillus calmette-guerin (BCG) vaccination and inflammatory bowel disease: a two-stage sampling design within the quebec birth cohort on immunity and health (CO.MMUNITY)","volume":"186","author":"Fantodji","year":"2024","journal-title":"Prev Med"},{"key":"10.1016\/j.dld.2024.09.011_bib0023","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2190\/1X9F-4Q4H-FE89-5MUE","article-title":"Canadian federalism and the Canadian health care program: a comparison of Ontario and Quebec","volume":"17","author":"Palley","year":"1987","journal-title":"Int J Health Serv"},{"key":"10.1016\/j.dld.2024.09.011_bib0024","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1086\/320037","article-title":"Event history calendars and question list surveys: a direct comparison of interviewing methods","volume":"65","author":"Belli","year":"2001","journal-title":"Public Opin Q"},{"key":"10.1016\/j.dld.2024.09.011_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004476","article-title":"Adapting data collection methods in the Australian Life Histories and Health Survey: a retrospective life course study","volume":"4","author":"Kendig","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.dld.2024.09.011_bib0026","unstructured":"Canada Post. Addressing Guidelines. January 13, 2020 ed2018."},{"key":"10.1016\/j.dld.2024.09.011_bib0027","doi-asserted-by":"crossref","first-page":"178","DOI":"10.24095\/hpcdp.29.4.05","article-title":"A deprivation index for health planning in Canada","volume":"29","author":"Pampalon","year":"2009","journal-title":"Chronic Dis Can"},{"key":"10.1016\/j.dld.2024.09.011_bib0028","article-title":"An area-based material and social deprivation index for public health in Qu\u00e9bec and Canada","volume":"103","author":"Pampalon","year":"2012","journal-title":"Can J Public Health"},{"key":"10.1016\/j.dld.2024.09.011_bib0029","unstructured":"CAPS: Codage Assist\u00e9 des Professions et Secteurs d'activit\u00e9. 2023."},{"key":"10.1016\/j.dld.2024.09.011_bib0030","unstructured":"Eric HaD, Rose. User Guide - Institute for Social and Economic Research (ISER). @iseressex; 2023."},{"key":"10.1016\/j.dld.2024.09.011_bib0031","series-title":"R: a language and environment for statistical computing","author":"Core Team","year":"2022"},{"key":"10.1016\/j.dld.2024.09.011_bib0032","doi-asserted-by":"crossref","unstructured":"Tingley D, Yamamoto T, Hirose K, et al. mediation: R Package for Causal Mediation Analysis. https:\/\/www.jstatsoftorg\/indexphp\/jss 2014.","DOI":"10.18637\/jss.v059.i05"},{"key":"10.1016\/j.dld.2024.09.011_bib0033","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/apt.16703","article-title":"Systematic review with meta-analysis: environmental and dietary differences of inflammatory bowel disease in Eastern and Western populations","volume":"55","author":"Zhao","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2024.09.011_bib0034","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and risk factors for IBD","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2024.09.011_bib0035","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/ajg.2014.246","article-title":"Antibiotics associated with increased risk of new-onset Crohn's disease but not ulcerative colitis: a meta-analysis","volume":"109","author":"Ungaro","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2024.09.011_bib0036","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mrfmmm.2009.09.002","article-title":"Environmental factors in the development of chronic inflammation: a case-control study on risk factors for Crohn's disease within New Zealand","volume":"690","author":"Han","year":"2010","journal-title":"Mutat Res"},{"key":"10.1016\/j.dld.2024.09.011_bib0037","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/imj.13094","article-title":"Influence of food and lifestyle on the risk of developing inflammatory bowel disease","volume":"46","author":"Niewiadomski","year":"2016","journal-title":"Intern Med J"},{"key":"10.1016\/j.dld.2024.09.011_bib0038","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"issue":"Suppl 1","key":"10.1016\/j.dld.2024.09.011_bib0039","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000447283","article-title":"The Search for Causative Environmental Factors in Inflammatory Bowel Disease","volume":"34","author":"Rogler","year":"2016","journal-title":"Dig Dis"},{"key":"10.1016\/j.dld.2024.09.011_bib0040","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thx.2010.153379","article-title":"Exposure to parental and sibling smoking and the risk of smoking uptake in childhood and adolescence: a systematic review and meta-analysis","volume":"66","author":"Leonardi-Bee","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.dld.2024.09.011_bib0041","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00203-018-1506-2","article-title":"Smoking and the intestinal microbiome","volume":"200","author":"Savin","year":"2018","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.dld.2024.09.011_bib0042","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.3748\/wjg.v17.i22.2740","article-title":"Ulcerative colitis in smokers, non-smokers and ex-smokers","volume":"17","author":"Bastida","year":"2011","journal-title":"World J Gastroenterol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824010132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865824010132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T01:50:35Z","timestamp":1735782635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865824010132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1590865824010132"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2024.09.011","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life exposures and risk of inflammatory bowel disease: A nested case-control study in Quebec, Canada","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2024.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}