{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:34:03Z","timestamp":1789187643000,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.dld.2024.10.007","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T17:43:47Z","timestamp":1730137427000},"page":"630-635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety of endoscopist-directed nurse-administered sedation in an Italian referral hospital: An audit of 2 years and 19,407 procedures"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-5952","authenticated-orcid":false,"given":"R.","family":"Conigliaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-0802","authenticated-orcid":false,"given":"F.","family":"Pig\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-7078","authenticated-orcid":false,"given":"M.","family":"Gottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-9740","authenticated-orcid":false,"given":"G.","family":"Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8537-1852","authenticated-orcid":false,"given":"S.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marsico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sculli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-7167","authenticated-orcid":false,"given":"H.","family":"Bertani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2024.10.007_bib0001","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-0042-105560","article-title":"Non-anesthesiologist administration of propofol sedation for colonoscopy is safe in low risk patients: results of a noninferiority randomized controlled trial","volume":"48","author":"Ferreira","year":"2016","journal-title":"Endoscopy"},{"issue":"7","key":"10.1016\/j.dld.2024.10.007_bib0002","doi-asserted-by":"crossref","first-page":"981","DOI":"10.4253\/wjge.v7.i10.981","article-title":"Current role of non-anesthesiologist administered propofol sedation in advanced interventional endoscopy","volume":"10","author":"Burtea","year":"2015","journal-title":"World J Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0003","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/den.12219","article-title":"Propofol versus traditional sedative agents for advanced endoscopic procedures: a meta-analysis","volume":"26","author":"Sethi","year":"2014","journal-title":"Dig Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0004","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1007\/s10620-015-3608-x","article-title":"Safety of non-anesthesia provider-administered propofol (NAAP) sedation in advanced gastrointestinal endoscopic procedures: comparative meta-analysis of pooled results","volume":"60","author":"Goudra","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2024.10.007_bib0005","first-page":"E107","article-title":"High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures","volume":"4","author":"Jensen","year":"2016","journal-title":"Endosc Int Open"},{"key":"10.1016\/j.dld.2024.10.007_bib0006","doi-asserted-by":"crossref","first-page":"E51","DOI":"10.1055\/s-0043-122225","article-title":"Efficacy and safety of sedation during endoscopic submucosal dissection of gastric cancers using a comparative trial of propofol versus midazolam","volume":"6","author":"Kikuchi","year":"2018","journal-title":"Endosc Int Open"},{"key":"10.1016\/j.dld.2024.10.007_bib0007","first-page":"240","article-title":"Safety and risk factors for difficult endoscopist-directed ERCP sedation in daily practice: a hospital-based case-control study","volume":"108","author":"E","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.dld.2024.10.007_bib0008","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/685476","article-title":"Feasibility of non-anesthesiologist-administered propofol sedation for emergency endoscopic retrograde colangiopancreatography","author":"Ikeuchi","year":"2015","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.dld.2024.10.007_bib0009","first-page":"217","article-title":"Safety of deep sedation with propofol controlled by the endoscopist in endoscopic retrograde cholangiopancreatography (ERCP): prospective study in a tertiary hospital","volume":"11","author":"Luz\u00f3n Solanas","year":"2018","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.dld.2024.10.007_bib0010","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.dld.2017.08.038","article-title":"Italian Society of Digestive Endoscopy (SIED). Position paper on the nonanaesthesiologist administration of propofol for gastrointestinal endoscopy","volume":"49","author":"Conigliaro","year":"2017","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2024.10.007_bib0011","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2036.2010.04352.x","article-title":"Sedation in digestive endoscopy: the Athens international position statements","volume":"32","author":"Cohen","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2024.10.007_bib0012","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5107(04)00349-9","article-title":"Moderate level sedation during endoscopy: a prospective study using low-dose propofol, meperidine\/fentanyl, and midazolam","volume":"58","author":"Cohen","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0013","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/rccm.2107138","article-title":"The richmond agitation\u2013sedation scale validity and reliability in adult intensive care unit patients","volume":"166","author":"Sessler","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.dld.2024.10.007_bib0014","doi-asserted-by":"crossref","first-page":"237","DOI":"10.17235\/reed.2018.5282\/2017","article-title":"Severe cardiorespiratory complications derived from propofol sedation monitored by an endoscopist","volume":"110","author":"Maestro Antol\u00edn","year":"2018","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.dld.2024.10.007_bib0015","first-page":"244","article-title":"Validity and reliability of the observer's assessment of alertness\/sedation scale: study with intravenous midazolam","volume":"10","author":"Chernik","year":"1990","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.dld.2024.10.007_bib0016","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.gie.2017.07.018","article-title":"Guidelines for sedation and anesthesia in GI endoscopy","volume":"87","author":"Early","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0017","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1055\/s-0034-1393414","article-title":"Non-anesthesiologist administration of propofol for gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates Guideline\u2013Updated June 2015","volume":"47","author":"Dumonceau","year":"2015","journal-title":"Endoscopy"},{"key":"10.1016\/j.dld.2024.10.007_bib0018","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.gie.2007.12.046","article-title":"A systematic review and meta-analysis of randomized, controlled trials of moderate sedation for routine endoscopic procedures","volume":"67","author":"McQuaid","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0019","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1097\/MCG.0000000000001630","article-title":"Safety profile of endoscopist-directed balanced propofol sedation for procedural sedation: an experience at a hospital-based endoscopy unit","volume":"56","author":"Fatima","year":"2022","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2024.10.007_bib0020","first-page":"1479","article-title":"Quality performance measures in upper gastrointestinal endoscopy for lesion detection: italian AIGO-SIED-SIGE joint position statement","volume":"54","author":"Francesco","year":"2022"},{"key":"10.1016\/j.dld.2024.10.007_bib0021","first-page":"309","article-title":"Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative","volume":"5","author":"Kaminski","year":"2017","journal-title":"Endoscopy"},{"key":"10.1016\/j.dld.2024.10.007_bib0022","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4253\/wjge.v11.i12.573","article-title":"Propofol vs traditional sedatives for sedation in endoscopy: a systematic review and meta-analysis","volume":"11","author":"Delgado","year":"2019","journal-title":"World J Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0023","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.gie.2019.12.047","article-title":"Propofol versus midazolam with or without short-acting opioids for sedation in colonoscopy: a systematic review and meta-analysis of safety, satisfaction, and efficiency outcomes","volume":"91","author":"Dossa","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0024","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000285570","article-title":"The use of propofol by gastroenterologists: medico-legal issues","volume":"82","author":"Axon","year":"2010","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2024.10.007_bib0025","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.dld.2017.08.038","article-title":"Italian Society of Digestive Endoscopy (SIED) Sedation Group. Italian Society of Digestive Endoscopy (SIED) position paper on the non-anaesthesiologist administration of propofol for gastrointestinal endoscopy","volume":"49","author":"Conigliaro","year":"2017","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2024.10.007_bib0026","first-page":"4670","article-title":"Rethink analgo-sedation in digestive endoscopy: the role of scientific societies in tracing training path","volume":"27","author":"Rossi","year":"2023","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.dld.2024.10.007_bib0027","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.gie.2023.12.023","article-title":"Safety and tolerability outcomes of nonanesthesiologist-administered propofol using target-controlled infusion in routine GI endoscopy","volume":"99","author":"Mandarino","year":"2024","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0028","unstructured":"University hospitals bristol NHS Foundation Trust. Trust's clinical governance manager, research & development manager and head of innovation (February 2012)."},{"key":"10.1016\/j.dld.2024.10.007_bib0029","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1055\/s-0032-1330441","article-title":"Sedation-associated complications in endoscopy - Prospective multicentre survey of 191142 patients","volume":"51","author":"Frieling","year":"2013","journal-title":"Article. Zeitschrift fur Gastroenterologie"},{"key":"10.1016\/j.dld.2024.10.007_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.gie.2016.02.007","article-title":"Patient safety during sedation by anesthesia professionals during routine upper endoscopy and colonoscopy: an analysis of 1.38 million procedures","volume":"85","author":"Vargo","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0031","article-title":"Safety of endoscopist-guided sedation in a low-risk collective - a randomised multicentre study (Prosed3 study)","author":"Behrens","year":"2023","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.dld.2024.10.007_bib0032","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.gie.2020.11.027","article-title":"Safety of endoscopist-directed nurse-administered balanced propofol sedation in patients with severe systemic disease (ASA class III)","volume":"94","author":"McKenzie","year":"2021","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2024.10.007_bib0033","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cgh.2018.06.025","article-title":"Safety and effectiveness of nurse-administered propofol sedation in outpatients undergoing gastrointestinal endoscopy","volume":"17","author":"Sato","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2024.10.007_bib0034","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/jgh.12458","article-title":"Safety analysis of endoscopist-directed propofol sedation: a prospective, national multicenter study of 24 441 patients in German outpatient practices","volume":"29","author":"Sieg","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2024.10.007_bib0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/jgh.15204","article-title":"Prospective audit of the safety of endoscopist-directed nurse-administered propofol sedation in an Australian referral hospital","volume":"36","author":"Gururatsakul","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2024.10.007_bib0036","doi-asserted-by":"crossref","first-page":"E393","DOI":"10.1055\/s-0034-1392511","article-title":"Morbidity and mortality of endoscopist-directed nurse-administered propofol sedation (EDNAPS) in a tertiary referral center","volume":"3","author":"Ooi","year":"2015","journal-title":"Endosc Int Open"},{"key":"10.1016\/j.dld.2024.10.007_bib0037","first-page":"A5049","article-title":"Moderate and deep nurse-administered propofol sedation is safe","volume":"62","author":"Jensen","year":"2015","journal-title":"Dan Med J"},{"key":"10.1016\/j.dld.2024.10.007_bib0038","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/jcag\/gwz011","article-title":"Endoscopist-directed propofol as an adjunct to standard sedation: a Canadian experience","volume":"3","author":"Heron","year":"2020","journal-title":"J Can Assoc Gastroenterol"},{"key":"10.1016\/j.dld.2024.10.007_bib0039","first-page":"259","article-title":"Endoscopist-administered propofol sedation is safe - a prospective evaluation of 10,000 patients in an outpatient practice","volume":"21","author":"Friedrich","year":"2012","journal-title":"J Gastrointestin Liver Dis"},{"issue":"10","key":"10.1016\/j.dld.2024.10.007_bib0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-230X-10-11","article-title":"Combined sedation with midazolam\/propofol for gastrointestinal endoscopy in elderly patients","volume":"27","author":"Kerker","year":"2010","journal-title":"BMC Gastroenterol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S159086582401051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S159086582401051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:49:06Z","timestamp":1741178946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S159086582401051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S159086582401051X"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2024.10.007","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of endoscopist-directed nurse-administered sedation in an Italian referral hospital: An audit of 2 years and 19,407 procedures","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2024.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}