{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:49:06Z","timestamp":1784958546253,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.dld.2025.01.200","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:35:42Z","timestamp":1739248542000},"page":"1046-1053","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-term validation of intra-cystic biomarkers for pancreatic cysts"],"prefix":"10.1016","volume":"57","author":[{"given":"Ana","family":"L\u00f3pez-Pe\u00f1a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Herreros-Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abian","family":"Olga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Hermoso-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goel","family":"Ajay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sarasqueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dld.2025.01.200_bib0001","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pan.2018.11.014","article-title":"Systematic review and meta-analysis: prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals","volume":"19","author":"Zerboni","year":"2019","journal-title":"Pancreatology"},{"issue":"1","key":"10.1016\/j.dld.2025.01.200_bib0002","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/gutjnl-2016-313127","article-title":"Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study","volume":"67","author":"Kromrey","year":"2018","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.dld.2025.01.200_bib0003","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1056\/NEJMra2309041","article-title":"Pancreatic Cysts","volume":"391","author":"Gonda","year":"2024","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.dld.2025.01.200_bib0004","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1053\/j.gastro.2012.01.005","article-title":"Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals","volume":"142","author":"Canto","year":"2012","journal-title":"Gastroenterology"},{"issue":"16","key":"10.1016\/j.dld.2025.01.200_bib0005","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.3390\/jcm13164644","article-title":"Diagnostics and Management of Pancreatic Cystic Lesions-New Techniques and Guidelines","volume":"13","author":"Rogowska","year":"2024","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.dld.2025.01.200_bib0006","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.dld.2025.01.200_bib0007","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"30","key":"10.1016\/j.dld.2025.01.200_bib0008","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.2217\/fon-2019-0264","article-title":"Optimized modification of the eighth edition of AJCC TNM staging system for resected pancreatic ductal adenocarcinoma","volume":"15","author":"Pu","year":"2019","journal-title":"Future Oncol"},{"issue":"5","key":"10.1016\/j.dld.2025.01.200_bib0009","first-page":"571","article-title":"Diagnosis and Management of Pancreatic Cystic Neoplasms: current Status and Future Directions","volume":"9","author":"Prevalence","year":"2015","journal-title":"Gut Liver"},{"issue":"9","key":"10.1016\/j.dld.2025.01.200_bib0010","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1038\/ajg.2010.122","article-title":"Prevalence of incidental pancreatic cysts in the adult population on MR imaging","volume":"105","author":"Lee","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2025.01.200_bib0011","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000171909","article-title":"Cystic neoplasms of the pancreas: a clinicopathological study of 38 cases","volume":"6","author":"Tarpila","year":"1989","journal-title":"Dig Surg"},{"key":"10.1016\/j.dld.2025.01.200_bib0012","unstructured":"Castro P\u00e9rez R., Lizano Ampudia M., Dopico Reyes E., Delgado Fern\u00e1ndez J.C., Castro Caballero K. Neoplasias qu\u00edsticas del p\u00e1ncreas. Presentaci\u00f3n de 2 casos y revisi\u00f3n de la literatura."},{"issue":"2","key":"10.1016\/j.dld.2025.01.200_bib0013","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/cncy.21226","article-title":"Optimizing the multimodal approach to pancreatic cyst fluid diagnosis: developing a volume-based triage protocol","volume":"121","author":"Chai","year":"2013","journal-title":"Cancer Cytopathol"},{"key":"10.1016\/j.dld.2025.01.200_bib0014","doi-asserted-by":"crossref","DOI":"10.1177\/17562848221133581","article-title":"Pancreatic cyst fluid glucose: a rapid on-site diagnostic test for mucinous cysts","volume":"15","author":"Zamir","year":"2022","journal-title":"Therap Adv Gastroenterol"},{"issue":"6","key":"10.1016\/j.dld.2025.01.200_bib0015","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/MPA.0000000000001324","article-title":"Next-Generation Sequencing in Pancreatic Cancer","volume":"48","author":"Shen","year":"2019","journal-title":"Pancreas"},{"issue":"7","key":"10.1016\/j.dld.2025.01.200_bib0016","first-page":"509","article-title":"Cystic neoplasms of the pancreas","volume":"60","author":"Grieshop","year":"1994","journal-title":"Am Surg"},{"issue":"2","key":"10.1016\/j.dld.2025.01.200_bib0019","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02785890","article-title":"Solitary true cyst of the pancreas in adults. Report of three cases and review of the literature","volume":"18","author":"Sperti","year":"1995","journal-title":"Int J Pancreatol"},{"issue":"3","key":"10.1016\/j.dld.2025.01.200_bib0017","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cncy.20027","article-title":"Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis","volume":"117","author":"Shen","year":"2009","journal-title":"Cancer Cytopathol"},{"issue":"5","key":"10.1016\/j.dld.2025.01.200_bib0018","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1053\/j.gastro.2004.02.013","article-title":"Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study","volume":"126","author":"Brugge","year":"2004","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.dld.2025.01.200_bib0020","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4253\/wjge.v14.i6.402","article-title":"Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions","volume":"14","author":"Okasha","year":"2022","journal-title":"World J Gastrointest Endosc"},{"issue":"2","key":"10.1016\/j.dld.2025.01.200_bib0021","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1097\/MCG.0000000000001507","article-title":"Intracystic Glucose Levels in Differentiating Mucinous From Nonmucinous Pancreatic Cysts: a Systematic Review and Meta-analysis","volume":"56","author":"Mohan","year":"2022","journal-title":"J Clin Gastroenterol"},{"issue":"7","key":"10.1016\/j.dld.2025.01.200_bib0022","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.pan.2020.08.024","article-title":"The utility of intracystic glucose levels in differentiating mucinous from non-mucinous pancreatic cysts","volume":"20","author":"Simons-Linares","year":"2020","journal-title":"Pancreatology"},{"issue":"1","key":"10.1016\/j.dld.2025.01.200_bib0023","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.dld.2020.10.031","article-title":"Pancreatic intra-cystic CA 19-9 dosage in the management of pancreatic cysts: useful or confounding?","volume":"53","author":"Stigliano","year":"2021","journal-title":"Digestive and Liver Disease"},{"issue":"1","key":"10.1016\/j.dld.2025.01.200_bib0024","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cncy.21775","article-title":"Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts","volume":"125","author":"Rosenbaum","year":"2017","journal-title":"Cancer Cytopathol"},{"key":"10.1016\/j.dld.2025.01.200_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2023-329961","article-title":"Impact of age, comorbidities and relevant changes on surveillance strategy of intraductal papillary mucinous neoplasms: a competing risk analysis","author":"Crippa","year":"2024","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.dld.2025.01.200_bib0026","first-page":"907","article-title":"[Cystadenoma of the pancreas: 4 cases in our clinical experience]","volume":"55","author":"Roviello","year":"2003","journal-title":"Chir Ital"},{"issue":"4","key":"10.1016\/j.dld.2025.01.200_bib0029","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1053\/j.gastro.2023.06.022","article-title":"Surveillance for Presumed BD-IPMN of the Pancreas: stability, Size, and Age Identify Targets for Discontinuation","volume":"165","author":"Marchegiani","year":"2023","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.dld.2025.01.200_bib0030","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.pan.2024.11.006","article-title":"Next-generation sequencing improves diagnostic accuracy of imaging and carcinoembryonic antigen alone for pancreatic cystic neoplasms","volume":"24","author":"Belfrage","year":"2024","journal-title":"Pancreatology"},{"issue":"23","key":"10.1016\/j.dld.2025.01.200_bib0031","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.3390\/cancers16234024","article-title":"Thermal Liquid Biopsy: a Promising Tool for the Differential Diagnosis of Pancreatic Cystic Lesions and Malignancy Detection","volume":"16","author":"Millastre","year":"2024","journal-title":"Cancers (Basel)"}],"updated-by":[{"DOI":"10.1016\/j.dld.2025.05.018","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000}}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865825002129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865825002129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:05:28Z","timestamp":1748001928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865825002129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1590865825002129"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2025.01.200","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term validation of intra-cystic biomarkers for pancreatic cysts","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2025.01.200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}