{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:10:17Z","timestamp":1792717817244,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2023-00224099"],"award-info":[{"award-number":["RS-2023-00224099"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004714","name":"Korean Society of Neurogastroenterology and Mobility","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","award":["C512230"],"award-info":[{"award-number":["C512230"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["22183MFDS366"],"award-info":[{"award-number":["22183MFDS366"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["KSNM-20-03"],"award-info":[{"award-number":["KSNM-20-03"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.dld.2025.07.011","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T19:59:58Z","timestamp":1753473598000},"page":"1927-1937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiomics insights into functional constipation: Exploring microbiome, metabolome, and lipidome independent of transit time"],"prefix":"10.1016","volume":"57","author":[{"given":"Ji Eun","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yong","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-2517","authenticated-orcid":false,"given":"Ji-Seon","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Min","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-2203","authenticated-orcid":false,"given":"Jeongkuk","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Seop","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Been","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonho","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Yeon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SoHee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ki","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hea-Jong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-532X","authenticated-orcid":false,"given":"Chang Hwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Kyoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2025.07.011_bib0001","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1365-2036.2010.04273.x","article-title":"Systematic review: impact of constipation on quality of life in adults and children","volume":"31","author":"Belsey","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2025.07.011_bib0002","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/2050640613494200","article-title":"Factors affecting satisfaction with treatment in European women with chronic constipation: an internet survey","volume":"1","author":"Emmanuel","year":"2013","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.dld.2025.07.011_bib0003","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/gutjnl-2019-320204","article-title":"Interaction between drugs and the gut microbiome","volume":"69","author":"Weersma","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.dld.2025.07.011_bib0004","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5056\/jnm16214","article-title":"What is new in Rome IV","volume":"23","author":"Schmulson","year":"2017","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2025.07.011_bib0005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1053\/j.gastro.2015.10.005","article-title":"Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation","volume":"150","author":"Parthasarathy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2025.07.011_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801187","article-title":"Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion","volume":"63","author":"Zhuang","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.dld.2025.07.011_bib0007","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1007\/s10620-020-06500-2","article-title":"Analysis of gut microbiome and metabolite characteristics in patients with slow transit constipation","volume":"66","author":"Tian","year":"2021","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2025.07.011_bib0008","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ajg.2009.655","article-title":"Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipation without IBS","volume":"105","author":"Attaluri","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2025.07.011_bib0009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gutjnl-2015-309618","article-title":"Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates","volume":"65","author":"Vandeputte","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.dld.2025.07.011_bib0010","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1053\/j.gastro.2016.03.035","article-title":"Rome IV\u2014Functional GI disorders: disorders of gut-brain interaction","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2025.07.011_bib0011","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13762","article-title":"European society of neurogastroenterology and motility guidelines on functional constipation in adults","volume":"32","author":"Serra","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2025.07.011_bib0012","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/gut.33.6.818","article-title":"Defecation frequency and timing, and stool form in the general population: a prospective study","volume":"33","author":"Heaton","year":"1992","journal-title":"Gut"},{"key":"10.1016\/j.dld.2025.07.011_bib0013","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/mbo3.312","article-title":"Evaluation of DNA extraction kits and phylogenetic diversity of the porcine gastrointestinal tract based on Illumina sequencing of two hypervariable regions","volume":"5","author":"Burbach","year":"2016","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.dld.2025.07.011_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-021-02099-0","article-title":"The regional diversity of gut microbiome along the GI tract of male C57BL\/6 mice","volume":"21","author":"Lkhagva","year":"2021","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.dld.2025.07.011_bib0015","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.3390\/microorganisms9122520","article-title":"Host factors affect the gut microbiome more significantly than diet shift","volume":"9","author":"Lkhagva","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.dld.2025.07.011_bib0016","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/microorganisms10051062","article-title":"Comparative analysis of original and replaced gut microbiomes within same individuals identified the intestinal microbes associated with weight gaining","volume":"10","author":"Zhai","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.dld.2025.07.011_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6868417","article-title":"Fecal microbiome does not represent whole gut microbiome","volume":"2023","author":"Ahn","year":"2023","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.dld.2025.07.011_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411392","article-title":"Identification of the intestinal microbes associated with locomotion","volume":"24","author":"Ahn","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dld.2025.07.011_bib0019","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/nmeth.2658","article-title":"Differential abundance analysis for microbial marker-gene surveys","volume":"10","author":"Paulson","year":"2013","journal-title":"Nat Methods"},{"key":"10.1016\/j.dld.2025.07.011_bib0020","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.12688\/f1000research.8986.2","article-title":"Bioconductor workflow for microbiome data analysis: from raw reads to community analyses","volume":"5","author":"Callahan","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.dld.2025.07.011_bib0021","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1093\/bioinformatics\/btac438","article-title":"microbiomeMarker: an R\/bioconductor package for microbiome marker identification and visualization","volume":"38","author":"Cao","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.dld.2025.07.011_bib0022","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1038\/s41598-019-39990-w","article-title":"Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.dld.2025.07.011_bib0023","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1038\/s41598-017-08433-9","article-title":"Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling","volume":"7","author":"Kim","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.dld.2025.07.011_bib0024","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.dld.2025.07.011_bib0025","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.dld.2025.07.011_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.dld.2025.07.011_bib0027","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/1462-2920.15431","article-title":"Impact of manipulation of glycerol\/diol dehydratase activity on intestinal microbiota ecology and metabolism","volume":"23","author":"Ramirez Garcia","year":"2021","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.dld.2025.07.011_bib0028","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/nu9050514","article-title":"Dietary intake of meat cooking-related mutagens (HCAs) and risk of colorectal adenoma and cancer: a systematic review and meta-analysis","volume":"9","author":"Chiavarini","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2025.07.011_bib0029","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1158\/1055-9965.EPI-17-1017","article-title":"Dietary heterocyclic amine intake and colorectal adenoma risk: a systematic review and meta-analysis","volume":"28","author":"Mart\u00ednez G\u00f3ngora","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.dld.2025.07.011_bib0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1574-6941.2011.01085.x","article-title":"Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species","volume":"76","author":"Mu\u00f1oz-Tamayo","year":"2011","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.dld.2025.07.011_bib0031","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mSystems.00857-19","article-title":"Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening","volume":"5","author":"Ben\u00edtez-P\u00e1ez","year":"2020","journal-title":"mSystems"},{"key":"10.1016\/j.dld.2025.07.011_bib0032","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1736974","article-title":"Probiotic-directed modulation of gut microbiota is basal microbiome dependent","volume":"12","author":"Hou","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.dld.2025.07.011_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1109889","article-title":"Profiling Blautia at high taxonomic resolution reveals correlations with cognitive dysfunction in Chinese children with Down syndrome","volume":"13","author":"Hou","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.dld.2025.07.011_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2020.110890","article-title":"Effect of multispecies probiotic on gut microbiota composition in individuals with intestinal constipation: A double-blind, placebo-controlled randomized trial","volume":"78","author":"Botelho","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.dld.2025.07.011_bib0035","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.3945\/jn.114.197723","article-title":"Modulation of fecal clostridiales bacteria and butyrate by probiotic intervention with Lactobacillus paracasei DG varies among healthy adults","volume":"144","author":"Ferrario","year":"2014","journal-title":"J Nutr"},{"key":"10.1016\/j.dld.2025.07.011_bib0036","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2007.04.005","article-title":"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects","volume":"133","author":"Kassinen","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2025.07.011_bib0037","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12934-020-01319-y","article-title":"Metatranscriptomic analysis to define the secrebiome, and 16S rRNA profiling of the gut microbiome in obesity and metabolic syndrome of Mexican children","volume":"19","author":"Gallardo-Becerra","year":"2020","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.dld.2025.07.011_bib0038","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13104-021-05466-2","article-title":"Could dysbiosis of inflammatory and anti-inflammatory gut bacteria have an implications in the development of type 2 diabetes? A pilot investigation","volume":"14","author":"Kulkarni","year":"2021","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.dld.2025.07.011_bib0039","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.jaci.2021.03.025","article-title":"Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1","volume":"148","author":"Petersen","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.dld.2025.07.011_bib0040","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/1346-8138.14933","article-title":"Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls","volume":"46","author":"Shapiro","year":"2019","journal-title":"J Dermatol"},{"key":"10.1016\/j.dld.2025.07.011_bib0041","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2298246","article-title":"Collinsella aerofaciens as a predictive marker of response to probiotic treatment in non-constipated irritable bowel syndrome","volume":"16","author":"Gargari","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.dld.2025.07.011_bib0042","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1097\/MIB.0000000000000972","article-title":"A single species of Clostridium subcluster XIVa decreased in ulcerative colitis patients","volume":"22","author":"Takeshita","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2025.07.011_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gm228","article-title":"Gut microbiome-host interactions in health and disease","volume":"3","author":"Kinross","year":"2011","journal-title":"Genome Med"},{"key":"10.1016\/j.dld.2025.07.011_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1133685","article-title":"Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming","volume":"14","author":"Fan","year":"2023","journal-title":"Front pharmacol"},{"key":"10.1016\/j.dld.2025.07.011_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112801","article-title":"Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders","volume":"207","author":"Ramesh","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.dld.2025.07.011_bib0046","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/nu7042930","article-title":"The role of microbial amino acid metabolism in host metabolism","volume":"7","author":"Neis","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2025.07.011_bib0047","first-page":"1","article-title":"Amino acids in intestinal physiology and health","author":"Beaumont","year":"2020","journal-title":"Amino Acids in Nutrition and Health: Amino Acids in Systems Function and Health"},{"key":"10.1016\/j.dld.2025.07.011_bib0048","article-title":"Integrated metagenomics and targeted-metabolomics analysis of the effects of phenylalanine on loperamide-induced constipation in rats","volume":"13","author":"Yang","year":"2022","journal-title":"Front microbiol"},{"key":"10.1016\/j.dld.2025.07.011_bib0049","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3136\/fstr.6.280","article-title":"A resistant protein, sericin improves atropine-induced constipation in rats","volume":"6","author":"Sasaki","year":"2000","journal-title":"Food Sci Technol Res"},{"key":"10.1016\/j.dld.2025.07.011_bib0050","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.pbb.2011.08.008","article-title":"Overview of glutamatergic neurotransmission in the nervous system","volume":"100","author":"Niciu","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.dld.2025.07.011_bib0051","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s00726-014-1773-4","article-title":"Glutamine and intestinal barrier function","volume":"47","author":"Wang","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.dld.2025.07.011_bib0052","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S2468-1253(18)30214-0","article-title":"Inhibiting glucose absorption to treat constipation","volume":"3","author":"Spiller","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2025.07.011_bib0053","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5056\/jnm.2011.17.2.185","article-title":"Slow transit constipation associated with excess methane production and its improvement following rifaximin therapy: a case report","volume":"17","author":"Ghoshal","year":"2011","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2025.07.011_bib0054","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of rome foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2025.07.011_bib0055","first-page":"35","article-title":"Effects of phosphatidylcholine and phosphatidylinositol on acetic-acid-lnduced colitis in the rat","volume":"53","author":"Fabia","year":"1992","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2025.07.011_bib0056","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/eji.201040899","article-title":"Anti-inflammatory actions of phosphatidylinositol","volume":"41","author":"van Dieren","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.dld.2025.07.011_bib0057","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI114267","article-title":"Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose","volume":"84","author":"Hammer","year":"1989","journal-title":"J Clin Invest"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865825009065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865825009065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:00:05Z","timestamp":1778522405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865825009065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1590865825009065"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2025.07.011","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiomics insights into functional constipation: Exploring microbiome, metabolome, and lipidome independent of transit time","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2025.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}