{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:28:24Z","timestamp":1786490904418,"version":"build-2736575974"},"reference-count":90,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["ILP-POR-2022-092"],"award-info":[{"award-number":["ILP-POR-2022-092"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR200056"],"award-info":[{"award-number":["RR200056"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.dld.2026.05.008","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T19:49:41Z","timestamp":1780170581000},"page":"1081-1089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetically predicted gut bacteria, circulating bacteria-associated metabolites and liver cancer: A Mendelian randomisation study"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-7433","authenticated-orcid":false,"given":"Neil","family":"Daniel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-7262","authenticated-orcid":false,"given":"Nikos","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-7542","authenticated-orcid":false,"given":"Anastasia Chrysovalantou","family":"Chatziioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Jenab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-0416","authenticated-orcid":false,"given":"Ana-Lucia","family":"May\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Keski-Rahkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Fedirko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-8770","authenticated-orcid":false,"given":"David J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.dld.2026.05.008_bib0001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA: Cancer J Clin"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0002","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/HEP.0000000000000406","article-title":"The role of the gut microbiome in the development of hepatobiliary cancers","volume":"80","author":"Daniel","year":"2024","journal-title":"Hepatol (Baltim Md)"},{"key":"10.1016\/j.dld.2026.05.008_bib0003","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s003840050236","article-title":"Gut-liver axis","volume":"15","author":"Zeuzem","year":"2000","journal-title":"Int J Colorectal Dis"},{"issue":"Suppl","key":"10.1016\/j.dld.2026.05.008_bib0004","first-page":"77","article-title":"Identification of biliary bile acids in patients with benign biliary diseases, hepatocellular carcinoma and cholangiocarcinoma. Asian Pacific journal of cancer prevention","volume":"13","author":"Jusakul","year":"2012","journal-title":"APJCP"},{"issue":"2","key":"10.1016\/j.dld.2026.05.008_bib0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00008469-199303000-00008","article-title":"Biliary bile acids in cholelithiasis and carcinoma of the gall bladder","volume":"2","author":"Shukla","year":"1993","journal-title":"Eur J Cancer Prev: Off J Eur Cancer Prev Organ (ECP)"},{"key":"10.1016\/j.dld.2026.05.008_bib0006","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1756-8722-4-41","article-title":"Impact of bile acids on the growth of human cholangiocarcinoma via FXR","volume":"4","author":"Dai","year":"2011","journal-title":"J Hematol Oncol"},{"issue":"14","key":"10.1016\/j.dld.2026.05.008_bib0007","first-page":"2637","article-title":"Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer","volume":"127","author":"Wang","year":"2014","journal-title":"Chin Med J"},{"issue":"11","key":"10.1016\/j.dld.2026.05.008_bib0008","article-title":"Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma","volume":"303","author":"Su","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Phys"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0009","first-page":"393","article-title":"Microbiota and nonalcoholic fatty liver disease: promising prospects for clinical interventions?","volume":"22","author":"Knudsen","year":"2019","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"11","key":"10.1016\/j.dld.2026.05.008_bib0010","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20221682","article-title":"Tryptophan metabolism and disposition in cancer biology and immunotherapy","volume":"42","author":"Badawy","year":"2022","journal-title":"Biosci Rep"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0011","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12916-022-02529-4","article-title":"Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis","volume":"20","author":"Alvandi","year":"2022","journal-title":"BMC Med"},{"issue":"7","key":"10.1016\/j.dld.2026.05.008_bib0012","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0013","article-title":"Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study","volume":"14","author":"Daniel","year":"2024","journal-title":"Sci Rep"},{"issue":"7944","key":"10.1016\/j.dld.2026.05.008_bib0014","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/HEP.0000000000000800","article-title":"Genome-wide association study identifies high-impact susceptibility loci for HCC in North America","volume":"80","author":"Hassan","year":"2024","journal-title":"Hepatol (Baltim Md)"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0016","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40168-018-0479-3","article-title":"Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative","volume":"6","author":"Wang","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.dld.2026.05.008_bib0017","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations: update for summer 2023","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0018","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.dld.2026.05.008_bib0019","doi-asserted-by":"crossref","first-page":"449","DOI":"10.12688\/wellcomeopenres.19995.2","article-title":"Mendelian randomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data","volume":"8","author":"Patel","year":"2023","journal-title":"Wellcome Open Res"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0020","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1177\/0962280215597579","article-title":"A review of instrumental variable estimators for Mendelian randomization","volume":"26","author":"Burgess","year":"2017","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"10.1016\/j.dld.2026.05.008_bib0021","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/gepi.22295","article-title":"A comparison of robust Mendelian randomization methods using summary data","volume":"44","author":"Slob","year":"2020","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.dld.2026.05.008_bib0022","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s40471-017-0128-6","article-title":"Recent developments in Mendelian randomization studies","volume":"4","author":"Zheng","year":"2017","journal-title":"Curr Epidemiol Rep"},{"issue":"4","key":"10.1016\/j.dld.2026.05.008_bib0023","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ije\/dyy101","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.dld.2026.05.008_bib0024","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.dld.2026.05.008_bib0025","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/jleuko\/qiad035","article-title":"The ketone body acetoacetate activates human neutrophils through FFAR2","volume":"113","author":"M\u00e5rtensson","year":"2023","journal-title":"J Leukoc Biol"},{"issue":"3","key":"10.1016\/j.dld.2026.05.008_bib0026","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/JB.01578-06","article-title":"New insights into acetone metabolism","volume":"189","author":"Hausinger","year":"2007","journal-title":"J Bacteriol"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0027","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1038\/s41598-020-62541-7","article-title":"Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-A(y) mice","volume":"10","author":"Uchikawa","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.dld.2026.05.008_bib0028","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1349-7006.2009.01086.x","article-title":"Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis","volume":"100","author":"Gao","year":"2009","journal-title":"Cancer Sci"},{"issue":"4","key":"10.1016\/j.dld.2026.05.008_bib0029","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jceh.2015.07.205","article-title":"Plasma lipid profiling in a rat model of hepatocellular carcinoma: potential modulation through quinolone administration","volume":"5","author":"Shariff","year":"2015","journal-title":"J Clin Exp Hepatol"},{"issue":"8","key":"10.1016\/j.dld.2026.05.008_bib0030","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.nano.2016.07.014","article-title":"Non-invasive detection of hepatocellular carcinoma serum metabolic profile through surface-enhanced Raman spectroscopy","volume":"12","author":"Xiao","year":"2016","journal-title":"Nanomed: Nanotechnol Biol Med"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0031","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13045-018-0595-3","article-title":"Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity","volume":"11","author":"Yang","year":"2018","journal-title":"J Hematol Oncol"},{"issue":"2","key":"10.1016\/j.dld.2026.05.008_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.10.015","article-title":"Hepatocyte-macrophage acetoacetate shuttle protects against tissue fibrosis","volume":"29","author":"Puchalska","year":"2019","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0033","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-019-0704-8","article-title":"Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health","volume":"7","author":"Oliphant","year":"2019","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0034","doi-asserted-by":"crossref","DOI":"10.1038\/srep18175","article-title":"Serum metabolomics to identify the Liver disease-specific biomarkers for the progression of Hepatitis to Hepatocellular Carcinoma","volume":"5","author":"Gao","year":"2015","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.dld.2026.05.008_bib0035","article-title":"Metabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis","volume":"6","author":"Sanchez","year":"2024","journal-title":"JHEP Rep"},{"issue":"8","key":"10.1016\/j.dld.2026.05.008_bib0036","article-title":"Vitamin C supplementation in healthy individuals leads to shifts of bacterial populations in the gut-A pilot study","volume":"10","author":"Otten","year":"2021","journal-title":"Antioxid (Basel Switz)"},{"key":"10.1016\/j.dld.2026.05.008_bib0037","unstructured":"Hazan S, Dave S, Papoutsis A., et al. Vitamin C improves gut Bifidobacteria in humans. Future Microbiol.1-15."},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0038","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1875774","article-title":"Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome\u2013 a pilot study","volume":"13","author":"Pham","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.dld.2026.05.008_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.795391","article-title":"Association of serum vitamin C With NAFLD and MAFLD among adults in the United States","volume":"8","author":"Xie","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.dld.2026.05.008_bib0040","article-title":"Vitamin C and vitamin D3 alleviate metabolic-associated fatty liver disease by regulating the gut microbiota and bile acid metabolism via the gut-liver axis","volume":"14","author":"Chen","year":"2023","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0041","article-title":"Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2","volume":"2","author":"Lv","year":"2018","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.dld.2026.05.008_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.726015","article-title":"Ascorbic acid inhibits Liver Cancer growth and metastasis in vitro and in vivo, independent of stemness gene regulation","volume":"12","author":"Wan","year":"2021","journal-title":"Front Pharmacol"},{"issue":"14","key":"10.1016\/j.dld.2026.05.008_bib0043","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1158\/0008-5472.CAN-22-3561","article-title":"PTTG1 Reprograms asparagine metabolism to promote hepatocellular carcinoma progression","volume":"83","author":"Zhou","year":"2023","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0044","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12920-022-01380-z","article-title":"An asparagine metabolism-based classification reveals the metabolic and immune heterogeneity of hepatocellular carcinoma","volume":"15","author":"Bai","year":"2022","journal-title":"BMC Med Genom"},{"issue":"7","key":"10.1016\/j.dld.2026.05.008_bib0045","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163508","article-title":"Asparagine protects pericentral hepatocytes during acute liver injury","volume":"133","author":"Sun","year":"2023","journal-title":"J Clin Investig"},{"issue":"2","key":"10.1016\/j.dld.2026.05.008_bib0046","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S0007114515001476","article-title":"Asparagine attenuates hepatic injury caused by lipopolysaccharide in weaned piglets associated with modulation of Toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling and their negative regulators","volume":"114","author":"Wu","year":"2015","journal-title":"Br J Nutr"},{"issue":"S3","key":"10.1016\/j.dld.2026.05.008_bib0047","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1124\/jpet.122.156500","article-title":"Asparagine depletion by the antileukemic agent PEGylated asparaginase induces hepatic stellate cell activation and fibrosis","volume":"385","author":"Zhu","year":"2023","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0048","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s12072-019-09971-2","article-title":"Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis","volume":"13","author":"Kamal","year":"2019","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0049","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13722-4","article-title":"Hippurate as a metabolomic marker of gut microbiome diversity: modulation by diet and relationship to metabolic syndrome","volume":"7","author":"Pallister","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.dld.2026.05.008_bib0050","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1021\/pr500494u","article-title":"Colorectal Cancer detection using targeted serum metabolic profiling","volume":"13","author":"Zhu","year":"2014","journal-title":"J Proteome Res"},{"issue":"2","key":"10.1016\/j.dld.2026.05.008_bib0051","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/metabo11020119","article-title":"Untargeted metabolomics reveals major differences in the plasma metabolome between colorectal cancer and colorectal adenomas","volume":"11","author":"Gumpenberger","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.dld.2026.05.008_bib0052","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.csbj.2023.02.048","article-title":"Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches","volume":"21","author":"Lo","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0053","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41522-023-00399-z","article-title":"Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism","volume":"9","author":"Liu","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0054","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s11306-015-0797-4","article-title":"Comprehensive characterization and evaluation of hepatocellular carcinoma by LC\u2013MS based serum metabolomics","volume":"11","author":"Lu","year":"2015","journal-title":"Metabolomics"},{"issue":"9","key":"10.1016\/j.dld.2026.05.008_bib0055","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1111\/liv.12541","article-title":"Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC\/MS and UPLC\/MS-MS","volume":"34","author":"Fitian","year":"2014","journal-title":"Liver Int: Off J Int Assoc Study Liver"},{"issue":"12","key":"10.1016\/j.dld.2026.05.008_bib0056","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1002\/ijc.34229","article-title":"Untargeted plasma metabolomics for risk prediction of hepatocellular carcinoma: a prospective study in two Chinese cohorts","volume":"151","author":"Hang","year":"2022","journal-title":"Int J Cancer"},{"key":"10.1016\/j.dld.2026.05.008_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.104990","article-title":"Prediagnostic plasma metabolite concentrations and liver cancer risk: a population-based study of Chinese men","volume":"100","author":"Li","year":"2024","journal-title":"eBioMedicine"},{"issue":"8","key":"10.1016\/j.dld.2026.05.008_bib0058","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/ijc.33885","article-title":"Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma","volume":"150","author":"Stepien","year":"2022","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.dld.2026.05.008_bib0059","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ijc.33236","article-title":"Metabolic perturbations prior to hepatocellular carcinoma diagnosis: findings from a prospective observational cohort study","volume":"148","author":"Stepien","year":"2021","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0060","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1038\/s41467-019-12476-z","article-title":"Interplay between the human gut microbiome and host metabolism","volume":"10","author":"Visconti","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.dld.2026.05.008_bib0061","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/s11306-015-0804-9","article-title":"Identification of serum biomarkers associated with hepatitis B virus-related hepatocellular carcinoma and liver cirrhosis using mass-spectrometry-based metabolomics","volume":"11","author":"Lu","year":"2015","journal-title":"Metabolomics"},{"issue":"2","key":"10.1016\/j.dld.2026.05.008_bib0062","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/lci2.25","article-title":"Salivary metabolites are promising non-invasive biomarkers of hepatocellular carcinoma and chronic liver disease","volume":"2","author":"Hershberger","year":"2021","journal-title":"Liver Cancer Int"},{"issue":"null","key":"10.1016\/j.dld.2026.05.008_bib0063","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2147\/JHC.S370255","article-title":"Vitamin B6 metabolic pathway is involved in the pathogenesis of Liver diseases via multi-omics analysis","volume":"Volume 9","author":"Mei","year":"2022","journal-title":"J Hepatocell Carcinoma"},{"issue":"7","key":"10.1016\/j.dld.2026.05.008_bib0064","article-title":"Association of disease condition with changes in intestinal flora, and plasma endotoxin and vascular endothelial growth factor levels in patients with liver cancer","volume":"24","author":"Jiang","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.dld.2026.05.008_bib0065","first-page":"35","volume":"13","author":"Zhang","year":"2023"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0066","doi-asserted-by":"crossref","DOI":"10.1186\/s13099-018-0281-6","article-title":"Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma","volume":"11","author":"Liu","year":"2019","journal-title":"Gut Pathog"},{"issue":"Suppl 3","key":"10.1016\/j.dld.2026.05.008_bib0067","article-title":"Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocyte and generating quinolinic acid","volume":"74","author":"Zhang","year":"2025","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0068","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1186\/s12885-024-13161-1","article-title":"Machine learning based on alcohol drinking-gut microbiota-liver axis in predicting the occurrence of early-stage hepatocellular carcinoma","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.dld.2026.05.008_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.129052","article-title":"Gut microbial dysbiosis is associated with metabolism and immune factors in liver fibrosis mice","volume":"258","author":"Zhao","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.dld.2026.05.008_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.788558","article-title":"Ursodeoxycholic acid treatment restores gut microbiota and alleviates liver inflammation in non-alcoholic steatohepatitic mouse model","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0071","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-13640-0","article-title":"Profiling gut microbiota and bile acid metabolism in critically ill children","volume":"12","author":"Kean","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.dld.2026.05.008_bib0072","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nmni.2017.09.003","article-title":"Accurate differentiation of Escherichia coli and Shigella serogroups: challenges and strategies","volume":"21","author":"Devanga Ragupathi","year":"2018","journal-title":"New Microbes New Infect"},{"issue":"6","key":"10.1016\/j.dld.2026.05.008_bib0073","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/microorganisms10061231","article-title":"Escherichia\/Shigella, SCFAs, and metabolic pathways-the triad that orchestrates intestinal dysbiosis in patients with decompensated alcoholic cirrhosis from Western Mexico","volume":"10","author":"Baltazar-D\u00edaz","year":"2022","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0074","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2201159","article-title":"A distinct microbiota signature precedes the clinical diagnosis of hepatocellular carcinoma","volume":"15","author":"Yang","year":"2023","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0075","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1038\/s41598-023-34765-w","article-title":"Dysbiosis of the gut microbiome in elderly patients with hepatocellular carcinoma","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.dld.2026.05.008_bib0076","first-page":"311","article-title":"Quantitative and qualitative measurements of K vitamins in human intestinal contents","volume":"87","author":"Conly","year":"1992","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0077","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/toxins13050346","article-title":"Shining a light on colibactin biology","volume":"13","author":"Dougherty","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.dld.2026.05.008_bib0078","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.canlet.2020.11.030","article-title":"Alterations of circulating bacterial DNA in colorectal cancer and adenoma: a proof-of-concept study","volume":"499","author":"Xiao","year":"2021","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0079","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13099-020-00396-z","article-title":"Eubacterium rectale contributes to colorectal cancer initiation via promoting colitis","volume":"13","author":"Wang","year":"2021","journal-title":"Gut Pathog"},{"key":"10.1016\/j.dld.2026.05.008_bib0080","unstructured":"Zhang D, Wang Q, Li D, et al. Comprehensive analysis of gut microbiota and plasma metabolites in patients with metabolic associated fatty liver disease. Available SSRN 4877159."},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0081","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s10330-022-0575-5","article-title":"Analysis of the intestinal flora in patients with primary liver cancer*","volume":"9","author":"Liu","year":"2023","journal-title":"Oncol Transl Med"},{"key":"10.1016\/j.dld.2026.05.008_bib0082","article-title":"Association between gut microbiota and gastrointestinal cancer: a two-sample bi-directional Mendelian randomization study","volume":"14","author":"Su","year":"2023","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.dld.2026.05.008_bib0083","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/cancers15010210","article-title":"Multi-omics analyses identify signatures in patients with liver cirrhosis and hepatocellular carcinoma","volume":"15","author":"Lai","year":"2023","journal-title":"Cancers"},{"issue":"9","key":"10.1016\/j.dld.2026.05.008_bib0084","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3390\/biomedicines12091946","article-title":"Circulating gut microbe-derived metabolites are associated with hepatocellular carcinoma","volume":"12","author":"Banerjee","year":"2024","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.dld.2026.05.008_bib0085","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00394-019-02036-y","article-title":"Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations","volume":"59","author":"Genoni","year":"2020","journal-title":"Eur J Nutr"},{"issue":"8","key":"10.1016\/j.dld.2026.05.008_bib0086","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.3390\/ijms25084387","article-title":"Alteration of gut microbiota composition in the progression of Liver damage in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"25","author":"Zazueta","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.dld.2026.05.008_bib0087","article-title":"Comprehensive genome analyses of Sellimonas intestinalis, a potential biomarker of homeostasis gut recovery","volume":"6","author":"Mu\u00f1oz","year":"2020","journal-title":"Microb Genom"},{"issue":"6","key":"10.1016\/j.dld.2026.05.008_bib0088","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/1759-7714.15220","article-title":"Causal effects of gut microbiota in the development of lung cancer and its histological subtypes: a Mendelian randomization study","volume":"15","author":"Ma","year":"2024","journal-title":"Thorac Cancer"},{"issue":"6","key":"10.1016\/j.dld.2026.05.008_bib0089","doi-asserted-by":"crossref","first-page":"558","DOI":"10.14740\/wjon1737","article-title":"Genetically predicted causal effects of gut microbiota and gut metabolites on digestive tract cancer: a two-sample Mendelian randomization analysis","volume":"14","author":"Li","year":"2023","journal-title":"World J Oncol"},{"issue":"16","key":"10.1016\/j.dld.2026.05.008_bib0090","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"Jama"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865826007474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865826007474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:40:34Z","timestamp":1786488034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865826007474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1590865826007474"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2026.05.008","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetically predicted gut bacteria, circulating bacteria-associated metabolites and liver cancer: A Mendelian randomisation study","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2026.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}