{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:31:38Z","timestamp":1786710698588,"version":"build-2736575974"},"reference-count":10,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"AIRC Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.dld.2026.06.008","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:17:04Z","timestamp":1783163824000},"page":"1223-1224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel approaches to liquid biopsy in pancreatic cancer"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-6762","authenticated-orcid":false,"given":"Alessandro","family":"Mannucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Puzzono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Frattura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duyen","family":"Prina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Giorgio","family":"Arcidiacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-9368","authenticated-orcid":false,"given":"Giulia Martina","family":"Cavestro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.dld.2026.06.008_bib0001","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.dld.2026.03.002","article-title":"Liquid biopsy in pancreatic cancer: current advances, limitations, and future perspectives","volume":"58","author":"Carrara","year":"2026","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2026.06.008_bib0002","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.semcancer.2024.02.001","article-title":"Extracellular vesicles associated microRNAs: their biology and clinical significance as biomarkers in gastrointestinal cancers","volume":"99","author":"Li","year":"2024","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"10.1016\/j.dld.2026.06.008_bib0003","article-title":"Advances in pancreatic cancer early diagnosis, prevention, and treatment: the past, the present, and the future","volume":"76","author":"Mannucci","year":"2026","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"10.1016\/j.dld.2026.06.008_bib0004","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2022.06.090","article-title":"An exosome-based transcriptomic signature for noninvasive, early detection of patients with pancreatic ductal adenocarcinoma: a multicenter cohort study","volume":"163","author":"Nakamura","year":"2022","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.dld.2026.06.008_bib0005","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1001\/jamasurg.2025.2493","article-title":"Exosomal liquid biopsy for the early detection of gastric cancer: the DESTINEX multicenter study","volume":"160","author":"Sui","year":"2025","journal-title":"JAMA Surg"},{"issue":"2","key":"10.1016\/j.dld.2026.06.008_bib0008","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1053\/j.gastro.2025.08.013","article-title":"An exosome-based liquid biopsy for the detection of early-onset colorectal cancer: the ENCODER multicenter study","volume":"170","author":"Mannucci","year":"2026","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.dld.2026.06.008_bib0006","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1158\/1078-0432.CCR-24-1934","article-title":"An exosome-based liquid biopsy predicts depth of response and survival outcomes to cetuximab and panitumumab in metastatic colorectal cancer: the EXONERATE study","volume":"31","author":"Xu","year":"2025","journal-title":"Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.dld.2026.06.008_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2022.12.006","article-title":"Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines","volume":"21","author":"Cavestro","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"10.1016\/j.dld.2026.06.008_bib0009","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S2468-1253(25)00191-8","article-title":"A DEF perspective on the METAPAC study","volume":"10","author":"Mannucci","year":"2025","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2026.06.008_bib0010","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.dld.2020.11.024","article-title":"Low-frequency of RABL3 pathogenetic variants in hereditary and familial pancreatic cancer","volume":"53","author":"Puzzono","year":"2021","journal-title":"Dig Liver Dis"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865826007747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865826007747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:37:24Z","timestamp":1786707444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865826007747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1590865826007747"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2026.06.008","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel approaches to liquid biopsy in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2026.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2026.03.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}