{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:54:04Z","timestamp":1791500044820,"version":"4.3.4"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Government Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dld.2026.09.020","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:07:04Z","timestamp":1791432424000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel heterozygous CPA1 variant (p.Tyr275His) associated with hereditary pancreatitis susceptibility in a familial cluster"],"prefix":"10.1016","author":[{"given":"Simonetta","family":"Rosato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7821-8198","authenticated-orcid":false,"given":"Filomena Tiziana","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-0751","authenticated-orcid":false,"given":"Marzia","family":"Pollazzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-1123","authenticated-orcid":false,"given":"Marco","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.dld.2026.09.020_bib0001","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/ng.2730","article-title":"Variants in CPA1 are strongly associated with early-onset chronic pancreatitis","volume":"45","author":"Witt","year":"2013","journal-title":"Nat Genet"},{"issue":"7","key":"10.1016\/j.dld.2026.09.020_bib0002","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.gie.2008.07.043","article-title":"EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification","volume":"69","author":"Catalano","year":"2009","journal-title":"Gastrointest Endosc"},{"issue":"2","key":"10.1016\/j.dld.2026.09.020_bib0003","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/gutjnl-2024-332845","article-title":"Familial pancreatitis associated with a splice-site variant in CPA1","volume":"74","author":"Shen","year":"2025","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.dld.2026.09.020_bib0004","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.dld.2026.09.020_bib0005","article-title":"Mutations of Gly277 in CPA1-related chronic pancreatitis: clinical clues for misfolding aetiology","volume":"75","author":"Zheng","year":"2026","journal-title":"Gut"},{"key":"10.1016\/j.dld.2026.09.020_bib0006","article-title":"CPA1 variant pathogenicity and clinical course in pediatric onset chronic pancreatitis","author":"Murari","year":"2026","journal-title":"Belg Week Gastroenterol"},{"issue":"2","key":"10.1016\/j.dld.2026.09.020_bib0007","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gutjnl-2018-315994","article-title":"Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice","volume":"68","author":"Hegyi","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.dld.2026.09.020_bib0008","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/gutjnl-2025-335947","article-title":"Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis","volume":"75","author":"Inamdar","year":"2026","journal-title":"Gut"},{"issue":"20","key":"10.1016\/j.dld.2026.09.020_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011301","article-title":"Genetic variability in the CPA1 gene and its impact on acute pancreatitis risk","volume":"25","author":"G\u0142uszek","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.dld.2026.09.020_bib0010","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1136\/gutjnl-2023-331105","article-title":"Functional predictors of pathogenicity of missense CPA1 variants in chronic pancreatitis","volume":"73","author":"S\u00e1ndor","year":"2024","journal-title":"Gut"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865826009722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865826009722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:23Z","timestamp":1791499223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865826009722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"alternative-id":["S1590865826009722"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2026.09.020","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel heterozygous CPA1 variant (p.Tyr275His) associated with hereditary pancreatitis susceptibility in a familial cluster","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2026.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}