{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:01:11Z","timestamp":1789707671722,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PS 168846"],"award-info":[{"award-number":["PS 168846"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.dmd.2025.100035","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T19:04:16Z","timestamp":1736276656000},"page":"100035","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigating the sexual dimorphism in isoproterenol-induced cardiac hypertrophy in Sprague Dawley rats"],"prefix":"10.1016","volume":"53","author":[{"given":"Sara A.","family":"Helal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-0056","authenticated-orcid":false,"given":"Samar H.","family":"Gerges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh","family":"Panahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.B.","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-0400","authenticated-orcid":false,"given":"Ayman O.S.","family":"El-Kadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dmd.2025.100035_bib1","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1111\/j.1476-5381.2009.00461.x","article-title":"3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats","volume":"158","author":"Aboutabl","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1124\/dmd.124.001705","article-title":"Modulation of angiotensin II-induced cellular hypertrophy by cannflavin-C: Unveiling the impact on cytochrome P450 1B1 and arachidonic acid metabolites","volume":"52","author":"Alammari","year":"2024","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmd.2025.100035_bib3","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1124\/dmd.115.063776","article-title":"Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol","volume":"43","author":"Althurwi","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmd.2025.100035_bib4","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/bph.12066","article-title":"Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy","volume":"168","author":"Althurwi","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1110119","article-title":"Transcriptome data analysis of primary cardiomyopathies reveals perturbations in arachidonic acid metabolism","volume":"10","author":"Chauhan","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.dmd.2025.100035_bib6","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/acs.molpharmaceut.5b00873","article-title":"Repurposing resveratrol and fluconazole to modulate human cytochrome P450-mediated arachidonic acid metabolism","volume":"13","author":"El-Sherbeni","year":"2016","journal-title":"Mol Pharm"},{"key":"10.1016\/j.dmd.2025.100035_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.taap.2015.10.003","article-title":"19-Hydroxyeicosatetraenoic acid and isoniazid protect against angiotensin II-induced cardiac hypertrophy","volume":"289","author":"Elkhatali","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/03602532.2022.2162075","article-title":"Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy","volume":"55","author":"ElKhatib","year":"2023","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.dmd.2025.100035_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/pharmaceutics9010009","article-title":"Clinical implications of 20-hydroxyeicosatetraenoic acid in the kidney, liver, lung and brain: An emerging therapeutic target","volume":"9","author":"Elshenawy","year":"2017","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.dmd.2025.100035_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116534","article-title":"The isoproterenol-induced myocardial fibrosis: A biochemical and histological investigation","volume":"174","author":"Flori","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.dmd.2025.100035_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1124\/dmd.122.000915","article-title":"Sexual dimorphism in the expression of cytochrome P450 enzymes in rat heart, liver, kidney, lung, brain, and small intestine","volume":"51","author":"Gerges","year":"2023","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmd.2025.100035_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2024.106851","article-title":"Changes in cardiovascular arachidonic acid metabolism in experimental models of menopause and implications on postmenopausal cardiac hypertrophy","volume":"173","author":"Gerges","year":"2024","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.dmd.2025.100035_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13293-016-0124-4","article-title":"Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl\/6 mice","volume":"8","author":"Grant","year":"2017","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.dmd.2025.100035_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/mutage\/gen035","article-title":"Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls","volume":"23","author":"Green","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.dmd.2025.100035_bib15","first-page":"253","article-title":"Soluble epoxide hydrolase: a new target for cardioprotection","volume":"10","author":"Gross","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.dmd.2025.100035_bib16","doi-asserted-by":"crossref","unstructured":"Gupta S, Das B, and Sen S (2007) Cardiac hypertrophy: mechanisms and therapeutic opportunities. 9:623\u2013652.","DOI":"10.1089\/ars.2007.1474"},{"key":"10.1016\/j.dmd.2025.100035_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63425","article-title":"Sex differences in biological aging with a focus on human studies","volume":"10","author":"Hagg","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.dmd.2025.100035_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1438567","article-title":"11-Hydroxyeicosatetraenoics induces cellular hypertrophy in an enantioselective manner","volume":"15","author":"Helal","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/03602532.2023.2284110","article-title":"Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids","volume":"56","author":"Helal","year":"2024","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.dmd.2025.100035_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/03602532.2023.2219035","article-title":"Physiological and pathophysiological roles of hepoxilins and their analogs","volume":"55","author":"Helal","year":"2023","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.dmd.2025.100035_bib21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s13318-023-00857-1","article-title":"The Effects of 16-HETE enantiomers on hypertrophic markers in human fetal ventricular cardiomyocytes, RL-14 Cells","volume":"48","author":"Hidayat","year":"2023","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.dmd.2025.100035_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.00021.2011","article-title":"Epoxides and soluble epoxide hydrolase in cardiovascular physiology","volume":"92","author":"Imig","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.dmd.2025.100035_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2022.106701","article-title":"The enantioselective separation and quantitation of the hydroxy-metabolites of arachidonic acid by liquid chromatography - tandem mass spectrometry","volume":"165","author":"Isse","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.dmd.2025.100035_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2023.106749","article-title":"17-(R\/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners","volume":"168","author":"Isse","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.dmd.2025.100035_bib53","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-alpha) in autoimmune disease and current TNF-alpha inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dmd.2025.100035_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/JOE-19-0561","article-title":"Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice","volume":"245","author":"Konstandi","year":"2020","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.dmd.2025.100035_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00041433-200206000-00007","article-title":"Cytochrome P450 pathways of arachidonic acid metabolism","volume":"13","author":"Kroetz","year":"2002","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.dmd.2025.100035_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11897-017-0351-y","article-title":"Acute heart failure: Definition, classification and epidemiology","volume":"14","author":"Kurmani","year":"2017","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.dmd.2025.100035_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.642470","article-title":"The role of epoxyeicosatrienoic acids in cardiac remodeling","volume":"12","author":"Lai","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.dmd.2025.100035_bib29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.dmd.2025.100035_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.dmd.2025.100035_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11010-017-2943-y","article-title":"The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol","volume":"429","author":"Maayah","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.dmd.2025.100035_bib32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-014-1419-z","article-title":"5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-\u03baB-dependent mechanism","volume":"90","author":"Maayah","year":"2016","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.dmd.2025.100035_bib33","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1038\/s41598-018-20613-9","article-title":"2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy","volume":"8","author":"Maayah","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.dmd.2025.100035_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCHEARTFAILURE.114.001180","article-title":"Sexual dimorphism of doxorubicin-mediated cardiotoxicity: Potential role of energy metabolism remodeling","volume":"8","author":"Moulin","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.dmd.2025.100035_bib35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/FJC.0000000000001013","article-title":"Unraveling the role of 12- and 20- HETE in cardiac pathophysiology: G-protein-coupled receptors, pharmacological inhibitors, and transgenic approaches","volume":"77","author":"Pascale","year":"2021","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib36","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1134\/S1990750824600158","article-title":"The role of arachidonic acid metabolizing cytochromes P450 in the control of cardiovascular functions","volume":"18","author":"Perepechaeva","year":"2024","journal-title":"Biochem (Mosc) Suppl B: Biomed Chem"},{"key":"10.1016\/j.dmd.2025.100035_bib37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.dmd.2025.100035_bib38","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/FJC.0000000000001258","article-title":"Ameliorative role of fluconazole against abdominal aortic constriction-induced cardiac hypertrophy in rats","volume":"79","author":"Shoieb","year":"2022","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib39","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/carcin\/bgu190","article-title":"Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway","volume":"35","author":"Smerdova","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dmd.2025.100035_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yjmcc.2018.02.005","article-title":"Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation","volume":"117","author":"Soler","year":"2018","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.dmd.2025.100035_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2023.101604","article-title":"Gender and CVD- does it really matters?","volume":"48","author":"Suman","year":"2023","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.dmd.2025.100035_bib42","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.dmd.2025.100035_bib43","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.vph.2013.02.004","article-title":"Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line","volume":"58","author":"Tse","year":"2013","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.canlet.2004.10.007","article-title":"Cytochrome P450-mediated metabolism of estrogens and its regulation in human","volume":"227","author":"Tsuchiya","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.dmd.2025.100035_bib45","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1161\/hc3601.095577","article-title":"17beta-estradiol attenuates the development of pressure-overload hypertrophy","volume":"104","author":"van Eickels","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.dmd.2025.100035_bib46","series-title":"World Heart Report 2023","year":"2023"},{"key":"10.1016\/j.dmd.2025.100035_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12265-019-09907-z","article-title":"Gender differences in cardiac hypertrophy","volume":"13","author":"Wu","year":"2020","journal-title":"J\u00a0Cardiovasc Transl Res"},{"key":"10.1016\/j.dmd.2025.100035_bib48","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/bcp.12603","article-title":"The role of epoxyeicosatrienoic acids in the cardiovascular system","volume":"80","author":"Yang","year":"2015","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.dmd.2025.100035_bib49","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/antiox10010052","article-title":"Cytochrome P450 CYP2E1 suppression ameliorates cerebral ischemia reperfusion injury","volume":"10","author":"Yu","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.dmd.2025.100035_bib50","first-page":"393","article-title":"Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin","volume":"21","author":"Zhang","year":"2020","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.dmd.2025.100035_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222112029","article-title":"Effects of arachidonic acid metabolites on cardiovascular health and disease","volume":"22","author":"Zhou","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dmd.2025.100035_bib52","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1124\/dmd.108.023077","article-title":"Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats","volume":"36","author":"Zordoky","year":"2008","journal-title":"Drug Metab Dispos"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955625001102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955625001102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:58:47Z","timestamp":1777474727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955625001102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0090955625001102"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2025.100035","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the sexual dimorphism in isoproterenol-induced cardiac hypertrophy in Sprague Dawley rats","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2025.100035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100035"}}