{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:18:45Z","timestamp":1780726725774,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.dmd.2025.100097","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:33:55Z","timestamp":1747136035000},"page":"100097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Taurodeoxycholic acid impairs the function and expression of organic anion transporter 2 through farnesoid X receptor activation during acute kidney injury to chronic kidney injury transition"],"prefix":"10.1016","volume":"53","author":[{"given":"Yingying","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"10.1016\/j.dmd.2025.100097_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.2011.405","article-title":"Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury","volume":"81","author":"Bucaloiu","year":"2012","journal-title":"Kidney Int"},{"issue":"12","key":"10.1016\/j.dmd.2025.100097_bib3","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/ckj\/sfac178","article-title":"Infectious consequences of the AKI-to-CKD transition","volume":"15","author":"S\u00e1nchez Horrillo","year":"2022","journal-title":"Clin Kidney J"},{"issue":"4","key":"10.1016\/j.dmd.2025.100097_bib4","doi-asserted-by":"crossref","DOI":"10.1177\/00368504241308982","article-title":"Prevalence of cardiovascular instability during hemodialysis therapy in hospitalized patients: a systematic review and meta-analysis","volume":"107","author":"Arcentales-Vera","year":"2024","journal-title":"Sci Prog"},{"issue":"10","key":"10.1016\/j.dmd.2025.100097_bib5","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.2215\/CJN.0000000000000521","article-title":"Antihypertensive drug treatment and the risk for intrahemodialysis hypotension","volume":"19","author":"Zoccali","year":"2024","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib6","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1542\/peds.2014-3380","article-title":"Therapeutic drug monitoring in neonatal HSV infection on continuous renal replacement therapy","volume":"136","author":"Funaki","year":"2015","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/AAC.00892-13","article-title":"Pharmacokinetics of ganciclovir during continuous venovenous hemodiafiltration in critically ill patients","volume":"58","author":"Horvatits","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.dmd.2025.100097_bib8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1053\/ajkd.1998.v31.pm9531178","article-title":"Effect of sertraline hydrochloride on dialysis hypotension","volume":"31","author":"Dheenan","year":"1998","journal-title":"Am J Kidney Dis"},{"issue":"11","key":"10.1016\/j.dmd.2025.100097_bib9","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/ki.2011.322","article-title":"Drug dosing consideration in patients with acute and chronic kidney disease-a clinical update from Kidney Disease: improving Global Outcomes (KDIGO)","volume":"80","author":"Matzke","year":"2011","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.dmd.2025.100097_bib10","doi-asserted-by":"crossref","first-page":"694","DOI":"10.2215\/CJN.0000000000000452","article-title":"Associations between different antivirals and hospital-acquired acute kidney injury in adults with herpes zoster","volume":"19","author":"Xu","year":"2024","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.canlet.2005.06.051","article-title":"Implications of genetic polymorphisms in drug transporters for pharmacotherapy","volume":"234","author":"Kerb","year":"2006","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/healthcare7010010","article-title":"Acute kidney injury pharmacokinetic changes and its impact on drug prescription","volume":"7","author":"Blanco","year":"2019","journal-title":"Healthcare (Basel)"},{"issue":"6","key":"10.1016\/j.dmd.2025.100097_bib13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/sj.ki.5002104","article-title":"Downregulation of organic anion transporters in rat kidney under ischemia\/reperfusion-induced acute [corrected] renal failure","volume":"71","author":"Matsuzaki","year":"2007","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.dmd.2025.100097_bib14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1124\/dmd.111.039115","article-title":"Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats","volume":"39","author":"Naud","year":"2011","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.dmd.2025.100097_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2165\/00003088-199324030-00005","article-title":"Clinical pharmacokinetics of angiotensin converting enzyme (ACE) inhibitors in renal failure","volume":"24","author":"Hoyer","year":"1993","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1517\/17425255.2013.835802","article-title":"The effects of acute renal failure on drug metabolism","volume":"10","author":"Philips","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"6","key":"10.1016\/j.dmd.2025.100097_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/cc7093","article-title":"Clinical review: drug metabolism and nonrenal clearance in acute kidney injury","volume":"12","author":"Vilay","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.dmd.2025.100097_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2147\/IJN.S184804","article-title":"Porous Se@SiO(2) nanospheres attenuate ischemia\/reperfusion (I\/R)-induced acute kidney injury (AKI) and inflammation by antioxidative stress","volume":"14","author":"Zheng","year":"2019","journal-title":"Int J Nanomedicine"},{"issue":"8","key":"10.1016\/j.dmd.2025.100097_bib19","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.21037\/tau-22-505","article-title":"Astragaloside IV protects against ischemia\/reperfusion (I\/R)-induced kidney injury based on the Keap1-Nrf2\/ARE signaling pathway","volume":"11","author":"Su","year":"2022","journal-title":"Transl Androl Urol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41401-019-0283-z","article-title":"Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1\/3 and MRP2","volume":"41","author":"Liao","year":"2020","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib21","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/s41467-021-21714-2","article-title":"Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics","volume":"12","author":"Weng","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.dmd.2025.100097_bib22","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1021\/mp300429e","article-title":"Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures","volume":"10","author":"Dahlin","year":"2013","journal-title":"Mol Pharm"},{"issue":"9887","key":"10.1016\/j.dmd.2025.100097_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"Lameire","year":"2013","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.dmd.2025.100097_bib24","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0006-2952(03)00466-0","article-title":"Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2","volume":"66","author":"Habu","year":"2003","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.dmd.2025.100097_bib25","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/molecules27030704","article-title":"The system profile of renal drug transporters in tubulointerstitial fibrosis model and consequent effect on pharmacokinetics","volume":"27","author":"Shi","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.dmd.2025.100097_bib26","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jps.23433","article-title":"Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure","volume":"102","author":"Komazawa","year":"2013","journal-title":"J Pharm Sci"},{"issue":"2","key":"10.1016\/j.dmd.2025.100097_bib27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1124\/dmd.116.072264","article-title":"Organic anion transporter 2: an enigmatic human solute carrier","volume":"45","author":"Shen","year":"2017","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"10.1016\/j.dmd.2025.100097_bib28","doi-asserted-by":"crossref","first-page":"F1599","DOI":"10.1152\/ajprenal.00473.2006","article-title":"Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats","volume":"292","author":"Schneider","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"10.1016\/j.dmd.2025.100097_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000110555","article-title":"Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma membrane transporters and cortical renal blood flow","volume":"81","author":"Di","year":"2008","journal-title":"Pharmacology"},{"issue":"3","key":"10.1016\/j.dmd.2025.100097_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1124\/dmd.111.042036","article-title":"Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs","volume":"40","author":"Cheng","year":"2012","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"10.1016\/j.dmd.2025.100097_bib31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1211\/0022357055966","article-title":"Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])","volume":"57","author":"Kobayashi","year":"2005","journal-title":"J Pharm Pharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1124\/jpet.105.088104","article-title":"A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters","volume":"315","author":"Tahara","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"22","key":"10.1016\/j.dmd.2025.100097_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252212036","article-title":"Are \u0394(9)-tetrahydrocannabinol and its major metabolites substrates or inhibitors of placental or human hepatic drug solute-carrier transporters?","volume":"25","author":"Chen","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.apsb.2022.06.010","article-title":"Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin","volume":"13","author":"Hong","year":"2023","journal-title":"Acta Pharm Sin B"},{"issue":"6","key":"10.1016\/j.dmd.2025.100097_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1124\/dmd.116.074492","article-title":"Increased plasma exposures of conjugated metabolites of morinidazole in renal failure patients: a critical role of uremic toxins","volume":"45","author":"Kong","year":"2017","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"10.1016\/j.dmd.2025.100097_bib36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/CS20171107","article-title":"Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins","volume":"132","author":"Lau","year":"2018","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"10.1016\/j.dmd.2025.100097_bib37","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ki.2013.399","article-title":"Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport","volume":"85","author":"Yeung","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.dmd.2025.100097_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmpk.2022.100448","article-title":"Inhibiting uptake activity of organic anion transporter 2 by bile acids","volume":"43","author":"Wang","year":"2022","journal-title":"Drug Metab Pharmacokinet"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib39","first-page":"5","article-title":"Recent advances in the development of farnesoid X receptor agonists","volume":"3","author":"Ali","year":"2015","journal-title":"Ann Transl Med"},{"issue":"4","key":"10.1016\/j.dmd.2025.100097_bib40","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1074\/jbc.M109326200","article-title":"Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor","volume":"277","author":"Kast","year":"2002","journal-title":"J Biol Chem"},{"issue":"31","key":"10.1016\/j.dmd.2025.100097_bib41","doi-asserted-by":"crossref","first-page":"28857","DOI":"10.1074\/jbc.M011610200","article-title":"Human bile salt export pump promoter is transactivated by the farnesoid X receptor\/bile acid receptor","volume":"276","author":"Ananthanarayanan","year":"2001","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.dmd.2025.100097_bib42","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41419-021-03620-z","article-title":"The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD","volume":"12","author":"Kim","year":"2021","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/gerona\/glac148","article-title":"Diminished tubule epithelial farnesoid X receptor expression exacerbates inflammation and fibrosis response in aged rat kidney","volume":"78","author":"Ha","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"10.1016\/j.dmd.2025.100097_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13005","article-title":"Farnesoid X receptor promotes renal ischaemia-reperfusion injury by inducing tubular epithelial cell apoptosis","volume":"54","author":"Xu","year":"2021","journal-title":"Cell Prolif"},{"issue":"12","key":"10.1016\/j.dmd.2025.100097_bib45","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCRESAHA.109.212969","article-title":"Farnesoid X receptor activation prevents the development of vascular calcification in ApoE-\/- mice with chronic kidney disease","volume":"106","author":"Miyazaki-Anzai","year":"2010","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib46","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12882-023-03239-6","article-title":"Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease","volume":"24","author":"Shi","year":"2023","journal-title":"BMC Nephrol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib47","doi-asserted-by":"crossref","first-page":"F361","DOI":"10.1152\/ajprenal.00207.2006","article-title":"Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones","volume":"292","author":"Ljubojevi\u0107","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100097_bib48","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1124\/jpet.301.1.145","article-title":"Gender-specific and developmental influences on the expression of rat organic anion transporters","volume":"301","author":"Buist","year":"2002","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955625091068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955625091068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:08:26Z","timestamp":1753697306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955625091068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0090955625091068"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2025.100097","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taurodeoxycholic acid impairs the function and expression of organic anion transporter 2 through farnesoid X receptor activation during acute kidney injury to chronic kidney injury transition","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2025.100097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100097"}}