{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:35:11Z","timestamp":1791038111413,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.dmd.2025.100134","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T15:56:55Z","timestamp":1753286215000},"page":"100134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Organic cation transporter 1 and cytochrome P450s play crucial roles in coptisine- and worenine-induced hepatotoxicity"],"prefix":"10.1016","volume":"53","author":[{"given":"Hengbin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4139-4622","authenticated-orcid":false,"given":"Luexiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-9436","authenticated-orcid":false,"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbiao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dmd.2025.100134_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115511","article-title":"The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo","volume":"167","author":"Feng","year":"2023","journal-title":"Biomed. Pharmacother"},{"issue":"18","key":"10.1016\/j.dmd.2025.100134_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810330","article-title":"Isoquinoline alkaloids from Coptis chinensis Franch: focus on coptisine as a potential therapeutic candidate against gastric cancer cells","volume":"23","author":"Nakonieczna","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"21","key":"10.1016\/j.dmd.2025.100134_bib3","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1111\/bph.16489","article-title":"Coptisine exerts anti-tumour effects in triple-negative breast cancer by targeting mitochondrial complex I","volume":"181","author":"Shen","year":"2024","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dmd.2025.100134_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2024.117480","article-title":"Coptisine inhibits neointimal hyperplasia through attenuating Pak1\/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization","volume":"391","author":"Chen","year":"2024","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dmd.2025.100134_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2020.101392","article-title":"Coptisine alleviates ischemia\/reperfusion-induced myocardial damage by regulating apoptosis-related proteins","volume":"66","author":"Sun","year":"2020","journal-title":"Tissue Cell"},{"key":"10.1016\/j.dmd.2025.100134_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113941","article-title":"Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K\/Akt signaling pathway","volume":"156","author":"Liu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.dmd.2025.100134_bib7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejphar.2017.06.027","article-title":"Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-\u03baB and MAPK signaling pathways","volume":"811","author":"Chen","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.dmd.2025.100134_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172523","article-title":"Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice","volume":"859","author":"Shi","year":"2019","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2025.100134_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s11658-021-00263-y","article-title":"Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1\u03b1","volume":"26","author":"Ji","year":"2021","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.dmd.2025.100134_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.881042","article-title":"Worenine prevents solar ultraviolet\u2013induced sunburn by inhibiting JNK2","volume":"13","author":"Xiao","year":"2022","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.dmd.2025.100134_bib11","doi-asserted-by":"crossref","DOI":"10.1503\/cmaj.202026","article-title":"Drug-induced liver injury","volume":"193","author":"Kumachev","year":"2021","journal-title":"CMAJ"},{"issue":"6","key":"10.1016\/j.dmd.2025.100134_bib12","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL clinical practice guidelines: drug-induced liver injury","volume":"70","year":"2019","journal-title":"J Hepatol"},{"issue":"16-18","key":"10.1016\/j.dmd.2025.100134_bib13","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1089\/ars.2022.0134","article-title":"New insights into herb-induced liver injury","volume":"38","author":"Ma","year":"2023","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.dmd.2025.100134_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.etap.2014.11.006","article-title":"Pharmacological and safety evaluation of fibrous root of Rhizoma Coptidis","volume":"39","author":"Ning","year":"2015","journal-title":"Environ. Toxicol. Pharmacol"},{"key":"10.1016\/j.dmd.2025.100134_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2019.01.006","article-title":"Systematic review of published data on herb induced liver injury","volume":"233","author":"Byeon","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.dmd.2025.100134_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jep.2014.12.021","article-title":"Acute and subchronic toxicity as well as evaluation of safety pharmacology of Galla chinensis solution","volume":"162","author":"Xiang","year":"2015","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"10.1016\/j.dmd.2025.100134_bib17","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0016-5085(99)70410-5","article-title":"Acute hepatitis induced by greater celandine (Chelidonium majus)","volume":"117","author":"Benninger","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dmd.2025.100134_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2019.04.031","article-title":"Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes","volume":"311","author":"Gao","year":"2019","journal-title":"Toxico Lett"},{"issue":"13","key":"10.1016\/j.dmd.2025.100134_bib19","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.3390\/molecules24132410","article-title":"Intracellular accumulation as an indicator of cytotoxicity to screen hepatotoxic components of Chelidonium majus L. by LC\u2013MS\/MS","volume":"24","author":"Wu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.dmd.2025.100134_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10254-003-0017-x","article-title":"Organic cation transporters","volume":"150","author":"Koepsell","year":"2003","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"4","key":"10.1016\/j.dmd.2025.100134_bib21","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/hep.23103","article-title":"Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver","volume":"50","author":"Nies","year":"2009","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.dmd.2025.100134_bib22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tips.2006.09.001","article-title":"The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations","volume":"27","author":"Omote","year":"2006","journal-title":"Trends Pharmacol. Sci"},{"issue":"7","key":"10.1016\/j.dmd.2025.100134_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103621","article-title":"Preclinical evaluation of chemically reactive metabolites and mitigation of bioactivation in drug discovery","volume":"28","author":"He","year":"2023","journal-title":"Drug Discov Today"},{"issue":"5","key":"10.1016\/j.dmd.2025.100134_bib24","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/med.21273","article-title":"The generation, detection, and effects of reactive drug metabolites","volume":"33","author":"Stachulski","year":"2013","journal-title":"Med Res Rev"},{"key":"10.1016\/j.dmd.2025.100134_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154174","article-title":"Diosbulbin B: an important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L","volume":"102","author":"Tan","year":"2022","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.dmd.2025.100134_bib26","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1021\/acs.est.2c01307","article-title":"Covalent protein modification: an unignorable factor for bisphenol A-induced hepatotoxicity","volume":"56","author":"Hu","year":"2022","journal-title":"Environ Sci Technol"},{"issue":"19","key":"10.1016\/j.dmd.2025.100134_bib27","doi-asserted-by":"crossref","first-page":"10897","DOI":"10.1021\/acs.jafc.4c00400","article-title":"Metabolic activation and cytotoxicity of gramine mediated by CYP3A in Rats","volume":"72","author":"Gao","year":"2024","journal-title":"J Agric Food Chem"},{"issue":"3","key":"10.1016\/j.dmd.2025.100134_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jpha.2020.05.006","article-title":"Rapid bioluminescence assay for monitoring rat CES1 activity and its alteration by traditional Chinese medicines","volume":"10","author":"Zhang","year":"2020","journal-title":"J Pharm Anal"},{"issue":"3","key":"10.1016\/j.dmd.2025.100134_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cclet.2018.12.013","article-title":"Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe","volume":"30","author":"Ding","year":"2019","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.dmd.2025.100134_bib30","author":"Bioanalytical"},{"key":"10.1016\/j.dmd.2025.100134_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2014.04.007","article-title":"Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity","volume":"322","author":"Tu","year":"2014","journal-title":"Toxicology"},{"issue":"16","key":"10.1016\/j.dmd.2025.100134_bib32","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1111\/bph.13537","article-title":"Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride","volume":"173","author":"Li","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dmd.2025.100134_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.toxlet.2019.08.013","article-title":"Up-regulation of hepatic fatty acid transporters and inhibition\/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis","volume":"316","author":"Jiang","year":"2019","journal-title":"Toxicol Lett"},{"issue":"3","key":"10.1016\/j.dmd.2025.100134_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tox.2013.06.009","article-title":"Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity","volume":"311","author":"Tu","year":"2013","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.dmd.2025.100134_bib35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/aps.2016.10","article-title":"An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s","volume":"37","author":"Chen","year":"2016","journal-title":"Acta Pharmacol. Sin"},{"issue":"7","key":"10.1016\/j.dmd.2025.100134_bib36","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1124\/dmd.113.056689","article-title":"The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride\u2013induced hepatocellular toxicity","volume":"42","author":"Li","year":"2014","journal-title":"Drug Metab. Dispos"},{"key":"10.1016\/j.dmd.2025.100134_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpba.2019.05.006","article-title":"Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS\/MS-based targeted proteomics","volume":"173","author":"Grangeon","year":"2019","journal-title":"J Pharm Biomed Anal"},{"issue":"5","key":"10.1016\/j.dmd.2025.100134_bib38","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/cpt.1301","article-title":"Protein abundance of clinically relevant drug transporters in the human liver and intestine: a comparative analysis in paired tissue specimens","volume":"105","author":"Drozdzik","year":"2019","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.dmd.2025.100134_bib39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/clpt.2012.138","article-title":"N-methylnicotinamide is an endogenous probe for evaluation of drug\u2013drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)","volume":"92","author":"Ito","year":"2012","journal-title":"Clin. Pharmacol. Ther"},{"issue":"2-3","key":"10.1016\/j.dmd.2025.100134_bib40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cbi.2011.02.025","article-title":"Effect of cryopreservation on the activity of OATP1B1\/3 and OCT1 in isolated human hepatocytes","volume":"190","author":"Badolo","year":"2011","journal-title":"Chem Biol Interact"},{"issue":"12","key":"10.1016\/j.dmd.2025.100134_bib41","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1248\/bpb.b16-00581","article-title":"Inhibitory effect of hesperetin and naringenin on human UDP-glucuronosyltransferase enzymes: implications for herb\u2013drug interactions","volume":"39","author":"Liu","year":"2016","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"10.1016\/j.dmd.2025.100134_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/03602532.2019.1655570","article-title":"Bioactivation of herbal constituents: mechanisms and toxicological relevance","volume":"51","author":"Wen","year":"2019","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.dmd.2025.100134_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112377","article-title":"CYP450 drug inducibility in NAFLD via an in vitro hepatic model: understanding drug-drug interactions in the fatty liver","volume":"146","author":"Rey-Bedon","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.dmd.2025.100134_bib44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bcp.2018.06.026","article-title":"Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines","volume":"155","author":"Kvist","year":"2018","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"10.1016\/j.dmd.2025.100134_bib45","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.tiv.2007.05.014","article-title":"Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells","volume":"21","author":"Westerink","year":"2007","journal-title":"Toxicol in Vitro"},{"issue":"1","key":"10.1016\/j.dmd.2025.100134_bib46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/2277-9175.183664","article-title":"Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines","volume":"5","author":"Louisa","year":"2016","journal-title":"Adv Biomed Res"},{"issue":"6","key":"10.1016\/j.dmd.2025.100134_bib47","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1124\/dmd.109.031831","article-title":"A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues","volume":"38","author":"Hart","year":"2010","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.dmd.2025.100134_bib48","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/j.gastro.2020.10.002","article-title":"High-fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids","volume":"160","author":"Shinozawa","year":"2021","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.dmd.2025.100134_bib49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3390\/molecules28020621","article-title":"Drug metabolism of hepatocyte-like organoids and their applicability in in vitro toxicity testing","volume":"28","author":"Bouwmeester","year":"2023","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.dmd.2025.100134_bib50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/17425255.2023.2203857","article-title":"Approaching strategy to increase the oral bioavailability of berberine, a quaternary ammonium isoquinoline alkaloid: part 1. Physicochemical and pharmacokinetic properties","volume":"19","author":"Murakami","year":"2023","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"5","key":"10.1016\/j.dmd.2025.100134_bib51","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.3892\/mmr.2015.4288","article-title":"Poor permeability and absorption affect the activity of four alkaloids from Coptis","volume":"12","author":"Cui","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.dmd.2025.100134_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104510","article-title":"Potential of herb-drug \/ herb interactions between substrates and inhibitors of UGTs derived from herbal medicines","volume":"150","author":"Liu","year":"2019","journal-title":"Pharmacol Res"},{"issue":"3","key":"10.1016\/j.dmd.2025.100134_bib53","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/ptr.4990","article-title":"Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-Glucuronosyltransferase (UGT) isoforms","volume":"28","author":"Ma","year":"2014","journal-title":"Phytother Res"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955625091433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955625091433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:09:56Z","timestamp":1772798996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955625091433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0090955625091433"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2025.100134","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organic cation transporter 1 and cytochrome P450s play crucial roles in coptisine- and worenine-induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2025.100134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100134"}}