{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:18:57Z","timestamp":1783646337270,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["numberQYCXZY250303"],"award-info":[{"award-number":["numberQYCXZY250303"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Shanghai Pujiang Program, China"],"award-info":[{"award-number":["Shanghai Pujiang Program, China"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["QYCXZY250303"],"award-info":[{"award-number":["QYCXZY250303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["23PJ1412300"],"award-info":[{"award-number":["23PJ1412300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104494"],"award-info":[{"award-number":["82104494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.dmd.2026.100252","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:30:11Z","timestamp":1770507011000},"page":"100252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Keratinocyte transport of notoginsenoside R1 via ABCG2: A novel mechanism for RNA N-methyladenosine modification in UVB induced skin sunburn injury"],"prefix":"10.1016","volume":"54","author":[{"given":"Xiaokang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-0764","authenticated-orcid":false,"given":"Zizhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dmd.2026.100252_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111322","article-title":"A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes","volume":"190","author":"Martic","year":"2020","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.dmd.2026.100252_bib2","article-title":"Mimicking cigarette smoke exposure to assess cutaneous toxicity","volume":"62","author":"Prieux","year":"2019","journal-title":"Toxicol in Vitro"},{"issue":"5","key":"10.1016\/j.dmd.2026.100252_bib3","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jaad.2020.04.079","article-title":"Photoprotection beyond ultraviolet radiation: a review of tinted sunscreens","volume":"84","author":"Lyons","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.dmd.2026.100252_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.716248","article-title":"Anti-photoaging and anti-inflammatory effects of ginsenoside Rk3 during exposure to UV irradiation","volume":"12","author":"Wan","year":"2021","journal-title":"Front Pharmacol"},{"issue":"26","key":"10.1016\/j.dmd.2026.100252_bib5","doi-asserted-by":"crossref","first-page":"22825","DOI":"10.1074\/jbc.M111.222349","article-title":"Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair","volume":"286","author":"Han","year":"2011","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.dmd.2026.100252_bib6","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1039\/c0pp00244e","article-title":"UVB-Induced p21 degradation promotes apoptosis of human keratinocytes","volume":"9","author":"Lei","year":"2010","journal-title":"Photochem Photobiol Sci"},{"key":"10.1016\/j.dmd.2026.100252_bib7","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v103.11954","article-title":"Evaluating the efficacy and safety of 4% 5-fluorouracil cream in patients with actinic keratosis: an expert opinion","volume":"103","author":"Stockfleth","year":"2023","journal-title":"Acta Derm Venereol"},{"issue":"5","key":"10.1016\/j.dmd.2026.100252_bib8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/phpp.12669","article-title":"Citrulluside H and citrulluside T from young watermelon fruit attenuate ultraviolet B radiation-induced matrix metalloproteinase expression through the scavenging of generated reactive oxygen species in human dermal fibroblasts","volume":"37","author":"Itoh","year":"2021","journal-title":"Photodermatol Photoimmunol Photomed"},{"issue":"3","key":"10.1016\/j.dmd.2026.100252_bib9","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.3892\/mmr.2017.6943","article-title":"Ginsenoside Rc protects against UVB-induced photooxidative damage in epidermal keratinocytes","volume":"16","author":"Oh","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.dmd.2026.100252_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/19768354.2016.1191542","article-title":"Protective effects of Rg2 against UVB-induced DNA damage in HaCaT cells is dependent on p53 expression","volume":"20","author":"Ha","year":"2016","journal-title":"Anim Cells Syst"},{"key":"10.1016\/j.dmd.2026.100252_bib11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fphar.2018.00188","article-title":"Stereoisomers of Saponins in Panax notoginseng (San. Stereoisomers of saponins in Panax notoginseng (Sanqi): a review","volume":"9","author":"Peng","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.dmd.2026.100252_bib12","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fphar.2019.01204","article-title":"Notoginsenoside R1 for organs ischemia\/reperfusion injury: a preclinical systematic review","volume":"10","author":"Tong","year":"2019","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100252_bib13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jgr.2023.02.005","article-title":"Analysis of common and characteristic actions of Panax ginseng and Panax notoginseng in wound healing based on network pharmacology and meta-analysis","volume":"47","author":"Wang","year":"2023","journal-title":"J Ginseng Res"},{"issue":"3","key":"10.1016\/j.dmd.2026.100252_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/wound.2019.1034","article-title":"Skin biomechanics and miRNA expression following chronic UVB irradiation","volume":"9","author":"Blackstone","year":"2020","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"10","key":"10.1016\/j.dmd.2026.100252_bib15","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.jid.2021.03.015","article-title":"Mechanisms of broad-band UVB irradiation\u2012induced itch in mice","volume":"141","author":"Cao","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.dmd.2026.100252_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102143","article-title":"Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure","volume":"47","author":"Vats","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.dmd.2026.100252_bib17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.dnarep.2018.01.008","article-title":"Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation","volume":"63","author":"Drigeard Desgarnier","year":"2018","journal-title":"DNA Repair (Amst)"},{"issue":"2","key":"10.1016\/j.dmd.2026.100252_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/bjd.17253","article-title":"Novel therapeutic approaches to xeroderma pigmentosum","volume":"181","author":"Weon","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.dmd.2026.100252_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2016.12.028","article-title":"The cyclopurine deoxynucleosides: DNA repair, biological effects, mechanistic insights, and unanswered questions","volume":"107","author":"Brooks","year":"2017","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"10.1016\/j.dmd.2026.100252_bib20","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc1652","article-title":"Cancer in xeroderma pigmentosum and related disorders of DNA repair","volume":"5","author":"Cleaver","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"10.1016\/j.dmd.2026.100252_bib21","doi-asserted-by":"crossref","first-page":"E1236","DOI":"10.1073\/pnas.1519444113","article-title":"Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect","volume":"113","author":"Fassihi","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.dmd.2026.100252_bib22","doi-asserted-by":"crossref","first-page":"6220","DOI":"10.3390\/ijms22126220","article-title":"Nucleotide excision repair: from molecular defects to neurological abnormalities","volume":"22","author":"Krasikova","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dmd.2026.100252_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2051-5960-1-4","article-title":"The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D)","volume":"1","author":"Lai","year":"2013","journal-title":"Acta Neuropathol Commun"},{"issue":"9","key":"10.1016\/j.dmd.2026.100252_bib24","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrg.2017.33","article-title":"TET-mediated active DNA demethylation: mechanism, function and beyond","volume":"18","author":"Wu","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"35","key":"10.1016\/j.dmd.2026.100252_bib25","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025948118","article-title":"METTL14 facilitates global genome repair and suppresses skin tumorigenesis","volume":"118","author":"Yang","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.dmd.2026.100252_bib26","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1093\/nar\/gky239","article-title":"Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair","volume":"46","author":"Shah","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.dmd.2026.100252_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2005.02.035","article-title":"UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex","volume":"121","author":"Sugasawa","year":"2005","journal-title":"Cell"},{"issue":"1-2","key":"10.1016\/j.dmd.2026.100252_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11010-020-03700-2","article-title":"Resveratrol potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid transport and\/or its intracellular reduction in HaCaT cells","volume":"467","author":"Saitoh","year":"2020","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"10.1016\/j.dmd.2026.100252_bib29","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1124\/dmd.117.079061","article-title":"Interindividual differences in the expression of ATP-binding cassette and solute carrier family transporters in human skin: DNA methylation regulates transcriptional activity of the human ABCC3 gene","volume":"46","author":"Takechi","year":"2018","journal-title":"Drug Metab Dispos"},{"issue":"12","key":"10.1016\/j.dmd.2026.100252_bib30","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1158\/0008-5472.CAN-04-0078","article-title":"Phytoestrogens\/flavonoids reverse breast cancer resistance protein\/ABCG2-mediated multidrug resistance","volume":"64","author":"Imai","year":"2004","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.dmd.2026.100252_bib31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1124\/mol.113.088609","article-title":"Molecular pharmacology of ABCG2 and its role in chemoresistance","volume":"84","author":"Stacy","year":"2013","journal-title":"Mol Pharmacol"},{"issue":"21","key":"10.1016\/j.dmd.2026.100252_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113261","article-title":"Characterization of a potent, selective, and safe inhibitor, Ac15(Az8)2, in reversing multidrug resistance mediated by breast cancer resistance protein (BCRP\/ABCG2)","volume":"23","author":"Chong","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dmd.2026.100252_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1380371","article-title":"Deciphering the functional role of clinical mutations in ABCB1, ABCC1, and ABCG2 ABC transporters in endometrial cancer","volume":"15","author":"Gupta","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.dmd.2026.100252_bib34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.phrs.2017.11.006","article-title":"P-glycoprotein (MDR1\/ABCB1) and breast cancer resistance protein (BCRP\/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice","volume":"129","author":"Wang","year":"2018","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.dmd.2026.100252_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114346","article-title":"Targeting breast cancer resistance protein (BCRP\/ABCG2): functional inhibitors and expression modulators","volume":"237","author":"Zattoni","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.dmd.2026.100252_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109718","article-title":"A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP\/ABCG2)","volume":"351","author":"Zattoni","year":"2022","journal-title":"Chem Biol Interact"},{"issue":"6","key":"10.1016\/j.dmd.2026.100252_bib37","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1528-1167.2005.66604.x","article-title":"Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain","volume":"46","author":"Aronica","year":"2005","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.dmd.2026.100252_bib38","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.bcp.2012.01.002","article-title":"Role of breast cancer resistance protein (BCRP\/ABCG2) in cancer drug resistance","volume":"83","author":"Natarajan","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.dmd.2026.100252_bib39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.phymed.2018.09.217","article-title":"Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2","volume":"54","author":"Bi","year":"2019","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.dmd.2026.100252_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2008.12.001","article-title":"The role of human ABC transporter ABCG2 (BCRP) in pharmacotherapy","volume":"61","author":"Ishikawa","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"10.1016\/j.dmd.2026.100252_bib41","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00204-014-1224-8","article-title":"Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics","volume":"88","author":"Jani","year":"2014","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.dmd.2026.100252_bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking m6A readers, writers, and erasers","volume":"33","author":"Meyer","year":"2017","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.dmd.2026.100252_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.semcancer.2020.02.013","article-title":"Small-molecule drug repurposing to target DNA damage repair and response pathways","volume":"68","author":"Brinkman","year":"2021","journal-title":"Semin Cancer Biol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100252_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035487","article-title":"Overcoming multidrug resistance via photodestruction of ABCG2-rich extracellular vesicles sequestering photosensitive chemotherapeutics","volume":"7","author":"Goler-Baron","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.dmd.2026.100252_bib45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40880-015-0003-0","article-title":"ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel","volume":"34","author":"Kathawala","year":"2015","journal-title":"Chin J Cancer"},{"key":"10.1016\/j.dmd.2026.100252_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113697","article-title":"Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression","volume":"171","author":"Nakano","year":"2020","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"10.1016\/j.dmd.2026.100252_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41389-020-0229-9","article-title":"TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the \u03b2-catenin\/ABCC9 axis via p62-selective autophagic degradation of Daple","volume":"9","author":"Zhang","year":"2020","journal-title":"Oncogenesis"},{"key":"10.1016\/j.dmd.2026.100252_bib48","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3389\/fphar.2018.01312","article-title":"ABCC10 plays a significant role in the transport of gefitinib and contributes to acquired resistance to gefitinib in NSCLC","volume":"9","author":"Zhao","year":"2018","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.dmd.2026.100252_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29894","article-title":"Small HBV surface antigen drives regorafenib resistance in HCC via KIAA1429-dependent m6A modification of CCR9","volume":"96","author":"Lv","year":"2024","journal-title":"J Med Virol"},{"issue":"10","key":"10.1016\/j.dmd.2026.100252_bib50","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/cbin.70059","article-title":"YTHDF1-mediated m6A methylation of GLUT1 promotes progress and suppresses propranolol sensitivity in infantile hemangioma","volume":"49","author":"Du","year":"2025","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.dmd.2026.100252_bib51","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.7150\/ijbs.100518","article-title":"METTL3-mediated m6A modification of SLC7A11 enhances nasopharyngeal carcinoma radioresistance by inhibiting ferroptosis","volume":"21","author":"Dai","year":"2025","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.dmd.2026.100252_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2025.113153","article-title":"Collagen type III resists UVB induced photoaging of HaCaT cells by regulating mTOR signaling pathway","volume":"267","author":"Liu","year":"2025","journal-title":"J Photochem Photobiol B"},{"issue":"1","key":"10.1016\/j.dmd.2026.100252_bib53","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41420-025-02353-8","article-title":"Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagy","volume":"11","author":"Asare","year":"2025","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.dmd.2026.100252_bib54","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41420-025-02471-3","article-title":"UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity","volume":"11","author":"Hu","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.dmd.2026.100252_bib55","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.canlet.2018.01.021","article-title":"Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters","volume":"421","author":"Fan","year":"2018","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.dmd.2026.100252_bib56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-014-9668-6","article-title":"Role of the breast cancer resistance protein (BCRP\/ABCG2) in drug transport--an update","volume":"17","author":"Mao","year":"2015","journal-title":"AAPS J"},{"key":"10.1016\/j.dmd.2026.100252_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114628","article-title":"Updated chemical scaffolds of ABCG2 inhibitors and their structure-inhibition relationships for future development","volume":"241","author":"Moinul","year":"2022","journal-title":"Eur J Med Chem"},{"issue":"2","key":"10.1016\/j.dmd.2026.100252_bib58","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5732\/cjc.011.10320","article-title":"Breast cancer resistance protein (BCRP\/ABCG2): its role in multidrug resistance and regulation of its gene expression","volume":"31","author":"Nakanishi","year":"2012","journal-title":"Chin J Cancer"},{"key":"10.1016\/j.dmd.2026.100252_bib59","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fphar.2018.00463","article-title":"Pharmacogenetic aspects of the interaction of AT1 receptor antagonists with ATP-binding cassette transporter ABCG2","volume":"9","author":"Ripperger","year":"2018","journal-title":"Front Pharmacol"},{"issue":"10","key":"10.1016\/j.dmd.2026.100252_bib60","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1021\/acs.jmedchem.3c00168","article-title":"In vitro and in vivo evaluation of ABCG2 (BCRP) inhibitors derived from KO-143","volume":"66","author":"Zechner","year":"2023","journal-title":"J Med Chem"},{"issue":"2","key":"10.1016\/j.dmd.2026.100252_bib61","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1182\/blood-2005-10-4020","article-title":"Complex interaction of BCRP\/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression","volume":"108","author":"Nakanishi","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.dmd.2026.100252_bib62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1142\/S0192415X25500090","article-title":"Pharmacokinetics and biological activities of notoginsenoside R1: a systematical review","volume":"53","author":"Wen","year":"2025","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.dmd.2026.100252_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115385","article-title":"Notoginsenoside R1 attenuates idiopathic pulmonary fibrosis through neuropilin-1\/type 2 innate lymphoid cells pathway","volume":"164","author":"Yang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.dmd.2026.100252_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114839","article-title":"The roles and mechanism of m6A RNA methylation regulators in cancer immunity","volume":"163","author":"Chen","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"7397","key":"10.1016\/j.dmd.2026.100252_bib65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"issue":"7685","key":"10.1016\/j.dmd.2026.100252_bib66","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature24007","article-title":"Corrigendum: RNA m6A methylation regulates the ultraviolet-induced DNA damage response","volume":"552","author":"Xiang","year":"2017","journal-title":"Nature"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626000218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626000218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:59:21Z","timestamp":1777474761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626000218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0090955626000218"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100252","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Keratinocyte transport of notoginsenoside R1 via ABCG2: A novel mechanism for RNA N6-methyladenosine modification in UVB induced skin sunburn injury","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100252"}}