{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:11:59Z","timestamp":1778188319208,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304603"],"award-info":[{"award-number":["82304603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20535"],"award-info":[{"award-number":["U23A20535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504888"],"award-info":[{"award-number":["82504888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M761357"],"award-info":[{"award-number":["2024M761357"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012459"],"award-info":[{"award-number":["2025A1515012459"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.dmd.2026.100272","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:54:43Z","timestamp":1773676483000},"page":"100272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnane X receptor, constitutive androstane receptor, or peroxisome proliferator\u2013activated receptor \u03b1 activation does not affect yes-associated protein phase separation under physiological and hyperosmotic conditions"],"prefix":"10.1016","volume":"54","author":[{"family":"Pengfei Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shicheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-2296","authenticated-orcid":false,"given":"Huichang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","article-title":"Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates","volume":"176","author":"Alberti","year":"2019","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.dmd.2026.100272_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6357","key":"10.1016\/j.dmd.2026.100272_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1126\/science.aaf4382","article-title":"Liquid phase condensation in cell physiology and disease","volume":"357","author":"Shin","year":"2017","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.dmd.2026.100272_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115369119","article-title":"Screening membraneless organelle participants with machine-learning models that integrate multimodal features","volume":"119","author":"Chen","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s43556-022-00075-2","article-title":"Post-translational modifications in liquid-liquid phase separation: a comprehensive review","volume":"3","author":"Li","year":"2022","journal-title":"Mol Biomed"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12964-023-01380-1","article-title":"Crosstalk between protein post-translational modifications and phase separation","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun Signal"},{"issue":"7389","key":"10.1016\/j.dmd.2026.100272_bib7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10879","article-title":"Phase transitions in the assembly of multivalent signalling proteins","volume":"483","author":"Li","year":"2012","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.dmd.2026.100272_bib8","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41388-022-02195-z","article-title":"Phase separation drives tumor pathogenesis and evolution: all roads lead to Rome","volume":"41","author":"Gu","year":"2022","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2018.06.006","article-title":"A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins","volume":"174","author":"Wang","year":"2018","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.dmd.2026.100272_bib10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s11427-020-1702-x","article-title":"Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases","volume":"63","author":"Zhang","year":"2020","journal-title":"Sci China Life Sci"},{"issue":"6371","key":"10.1016\/j.dmd.2026.100272_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao5654","article-title":"Phase separation of a yeast prion protein promotes cellular fitness","volume":"359","author":"Franzmann","year":"2018","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.dmd.2026.100272_bib12","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.celrep.2018.05.041","article-title":"Different material states of Pub1 condensates define distinct modes of stress adaptation and recovery","volume":"23","author":"Kroschwald","year":"2018","journal-title":"Cell Rep"},{"issue":"6","key":"10.1016\/j.dmd.2026.100272_bib13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cell.2017.02.027","article-title":"Stress-triggered phase separation is an adaptive, evolutionarily tuned response","volume":"168","author":"Riback","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.dmd.2026.100272_bib14","article-title":"Proteins with prion-like domains can form viscoelastic condensates that enable membrane remodeling and endocytosis","author":"Bergeron-Sandoval","year":"2021","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tibs.2015.11.001","article-title":"Transport selectivity of nuclear pores, phase separation, and membraneless organelles","volume":"41","author":"Schmidt","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41392-021-00678-1","article-title":"Liquid-liquid phase separation in human health and diseases","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.devcel.2020.09.014","article-title":"Phase separation and neurodegenerative diseases: a disturbance in the force","volume":"55","author":"Zbinden","year":"2020","journal-title":"Dev Cell"},{"issue":"19","key":"10.1016\/j.dmd.2026.100272_bib18","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.3390\/cells11193023","article-title":"Liquid-liquid phase separation of biomacromolecules and its roles in metabolic diseases","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.dmd.2026.100272_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tibs.2021.01.002","article-title":"Biomolecular condensates and their links to cancer progression","volume":"46","author":"Cai","year":"2021","journal-title":"Trends Biochem Sci"},{"issue":"23","key":"10.1016\/j.dmd.2026.100272_bib20","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1016\/j.cell.2021.09.032","article-title":"Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome","volume":"184","author":"Shen","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12929-024-00993-z","article-title":"Physiology and pharmacological targeting of phase separation","volume":"31","author":"Wang","year":"2024","journal-title":"J Biomed Sci"},{"issue":"4","key":"10.1016\/j.dmd.2026.100272_bib22","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The biology of YAP\/TAZ: hippo signaling and beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol Rev"},{"issue":"8","key":"10.1016\/j.dmd.2026.100272_bib23","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","article-title":"The Hippo pathway: biology and pathophysiology","volume":"88","author":"Ma","year":"2019","journal-title":"Annu Rev Biochem"},{"issue":"23","key":"10.1016\/j.dmd.2026.100272_bib25","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1016\/j.cell.2022.09.036","article-title":"Multiphase coalescence mediates Hippo pathway activation","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.dmd.2026.100272_bib26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.molcel.2016.10.034","article-title":"Characterization of Hippo pathway components by gene inactivation","volume":"64","author":"Plouffe","year":"2016","journal-title":"Mol Cell"},{"issue":"23","key":"10.1016\/j.dmd.2026.100272_bib27","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr Biol"},{"issue":"6","key":"10.1016\/j.dmd.2026.100272_bib28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.dmd.2026.100272_bib29","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1124\/dmd.121.000454","article-title":"Nuclear receptor-mediated hepatomegaly and liver regeneration: an update","volume":"50","author":"Zhao","year":"2022","journal-title":"Drug Metab Dispos"},{"issue":"21","key":"10.1016\/j.dmd.2026.100272_bib30","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev"},{"issue":"11","key":"10.1016\/j.dmd.2026.100272_bib31","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.humpath.2008.04.012","article-title":"Expression of Yes-associated protein in common solid tumors","volume":"39","author":"Steinhardt","year":"2008","journal-title":"Hum Pathol"},{"issue":"19","key":"10.1016\/j.dmd.2026.100272_bib32","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1002\/cncr.24495","article-title":"Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma","volume":"115","author":"Xu","year":"2009","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.dmd.2026.100272_bib33","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/j.1349-7006.2010.01511.x","article-title":"Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer","volume":"101","author":"Wang","year":"2010","journal-title":"Cancer Sci"},{"issue":"12","key":"10.1016\/j.dmd.2026.100272_bib34","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1038\/s41556-019-0433-z","article-title":"Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression","volume":"21","author":"Cai","year":"2019","journal-title":"Nat Cell Biol"},{"issue":"6","key":"10.1016\/j.dmd.2026.100272_bib35","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.molcel.2021.01.010","article-title":"Interferon-\u03b3 induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation","volume":"81","author":"Yu","year":"2021","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.dmd.2026.100272_bib36","first-page":"323","article-title":"Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis","volume":"25","author":"Hu","year":"2023","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.dmd.2026.100272_bib38","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbagrm.2016.02.009","article-title":"PXR- and CAR-mediated herbal effect on human diseases","volume":"1859","author":"Xu","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.dmd.2026.100272_bib39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biochi.2016.12.019","article-title":"The role and regulation of the peroxisome proliferator activated receptor alpha in human liver","volume":"136","author":"Kersten","year":"2017","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1517\/17425255.2013.754010","article-title":"Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond","volume":"9","author":"Chai","year":"2013","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib41","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3109\/03602532.2013.795585","article-title":"PXR cross-talks with internal and external signals in physiological and pathophysiological responses","volume":"45","author":"Kodama","year":"2013","journal-title":"Drug Metab Rev"},{"issue":"7","key":"10.1016\/j.dmd.2026.100272_bib42","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1517\/17425255.2015.1043887","article-title":"Small-molecule modulators of the constitutive androstane receptor","volume":"11","author":"Cherian","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"18","key":"10.1016\/j.dmd.2026.100272_bib43","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1128\/MCB.24.18.7931-7940.2004","article-title":"Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes","volume":"24","author":"Kodama","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/dmd.106.013243","article-title":"Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation","volume":"35","author":"Senekeo-Effenberger","year":"2007","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib45","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/hep.30131","article-title":"Pregnane x receptor regulates liver aize and liver xell fate by yes-associated protein activation in mice","volume":"69","author":"Jiang","year":"2019","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib46","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.apsb.2020.11.021","article-title":"Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation","volume":"11","author":"Gao","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/hep.32105","article-title":"YAP-TEAD mediates PPAR \u03b1-induced hepatomegaly and liver regeneration in mice","volume":"75","author":"Fan","year":"2022","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.dmd.2026.100272_bib48","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.apsb.2024.03.030","article-title":"Fenofibrate-promoted hepatomegaly and liver regeneration are PPAR\u03b1-dependent and partially related to the YAP pathway","volume":"14","author":"Fan","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.dmd.2026.100272_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106666","article-title":"PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice","volume":"188","author":"Zhang","year":"2023","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/jpet.124.002174","article-title":"Constitutive androstane receptor and peroxisome proliferator-activated receptor \u03b1 do not perform liquid-liquid phase separation in cells","volume":"390","author":"Zhao","year":"2024","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"10.1016\/j.dmd.2026.100272_bib51","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1124\/dmd.123.001570","article-title":"Exogenous pregnane x receptor does not undergo liquid-liquid phase separation in nucleus under cell-based in vitro conditions","volume":"52","author":"Zhao","year":"2024","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"10.1016\/j.dmd.2026.100272_bib52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41418-017-0013-3","article-title":"Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12915-025-02163-5","article-title":"PPAR\u03b1 regulates YAP protein levels and activity by affecting its ubiquitination modification","volume":"23","author":"Zhou","year":"2025","journal-title":"BMC Biol"},{"issue":"8","key":"10.1016\/j.dmd.2026.100272_bib54","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1248\/bpb.b19-00267","article-title":"Role of nuclear receptors PXR and CAR in xenobiotic-induced hepatocyte proliferation and chemical carcinogenesis","volume":"42","author":"Yoshinari","year":"2019","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"10.1016\/j.dmd.2026.100272_bib55","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/jpet.119.258632","article-title":"Functional interaction between pregnane x receptor and yes-associated protein in xenobiotic-dependent liver hypertrophy and drug metabolism","volume":"371","author":"Abe","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/toxsci\/kfad129","article-title":"Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation","volume":"198","author":"Shizu","year":"2024","journal-title":"Toxicol Sci"},{"issue":"4","key":"10.1016\/j.dmd.2026.100272_bib57","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/17425255.2020.1746268","article-title":"Nuclear receptor CAR-mediated liver cancer and its species differences","volume":"16","author":"Shizu","year":"2020","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tox.2007.09.030","article-title":"PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators","volume":"246","author":"Gonzalez","year":"2008","journal-title":"Toxicology"},{"issue":"11","key":"10.1016\/j.dmd.2026.100272_bib59","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1158\/0008-5472.CAN-04-0322","article-title":"Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha","volume":"64","author":"Cheung","year":"2004","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.dmd.2026.100272_bib60","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfm206","article-title":"The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha","volume":"101","author":"Yang","year":"2008","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.dmd.2026.100272_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2025.111728","article-title":"Constitutive androstane receptor activation modulates YAP expression and activity through ubiquitination and sumoylation","volume":"413","author":"Liang","year":"2025","journal-title":"Toxicol Lett"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626000413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626000413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:46:00Z","timestamp":1778186760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626000413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0090955626000413"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100272","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnane X receptor, constitutive androstane receptor, or peroxisome proliferator\u2013activated receptor \u03b1 activation does not affect yes-associated protein phase separation under physiological and hyperosmotic conditions","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100272"}}