{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:02:56Z","timestamp":1779793376074,"version":"3.53.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073922"],"award-info":[{"award-number":["82073922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204511"],"award-info":[{"award-number":["82204511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.dmd.2026.100282","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:53:17Z","timestamp":1774486397000},"page":"100282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bile duct ligation impairs function and expression of breast cancer resistance protein in rat blood-retinal barrier mainly due to both the increased ammonia and bilirubin"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-584X","authenticated-orcid":false,"given":"Zijin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.dmd.2026.100282_bib1","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0042-6989(96)00318-5","article-title":"Hepatic retinopathia. Changes in retinal function","volume":"37","author":"Eckstein","year":"1997","journal-title":"Vision Res"},{"issue":"6","key":"10.1016\/j.dmd.2026.100282_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00417-003-0639-3","article-title":"Recovery from hepatic retinopathy after liver transplantation","volume":"241","author":"Uhlmann","year":"2003","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s004010050860","article-title":"Retinal gliopathy accompanying thioacetamide-induced liver insufficiency: light and electron microscopic observations","volume":"96","author":"Albrecht","year":"1998","journal-title":"Acta Neuropathol"},{"issue":"14","key":"10.1016\/j.dmd.2026.100282_bib4","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.3390\/ijms23147666","article-title":"Bile duct ligation impairs function and expression of Mrp1 at rat blood-retinal barrier via bilirubin-induced P38 MAPK pathway activations","volume":"23","author":"Li","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41401-024-01388-4","article-title":"Bile duct ligation impairs visual acuity in rats by ammonia- and bilirubin-induced retinal degeneration","volume":"46","author":"Yang","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.dmd.2026.100282_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-981-13-7647-4_10","article-title":"Roles of drug transporters in blood-retinal barrier","volume":"1141","author":"Liu","year":"2019","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"10.1016\/j.dmd.2026.100282_bib7","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1517\/17425247.2011.628983","article-title":"Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood\u2013retinal barrier","volume":"8","author":"Hosoya","year":"2011","journal-title":"Expert Opin Drug Deliv"},{"issue":"9","key":"10.1016\/j.dmd.2026.100282_bib8","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s11095-009-9930-2","article-title":"Inner blood-retinal barrier transporters: role of retinal drug delivery","volume":"26","author":"Hosoya","year":"2009","journal-title":"Pharm Res"},{"issue":"8","key":"10.1016\/j.dmd.2026.100282_bib9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/aps.2016.25","article-title":"Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats","volume":"37","author":"Xu","year":"2016","journal-title":"Acta Pharmacol Sin"},{"issue":"11","key":"10.1016\/j.dmd.2026.100282_bib10","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1038\/s41401-020-00602-3","article-title":"Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin\/radixin\/moesin proteins","volume":"42","author":"Wu","year":"2021","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/jnc.13666","article-title":"Acute liver failure impairs function and expression of breast cancer-resistant protein (BCRP) at rat blood-brain barrier partly via ammonia-ROS-ERK1\/2 activation","volume":"138","author":"Li","year":"2016","journal-title":"J Neurochem"},{"issue":"6","key":"10.1016\/j.dmd.2026.100282_bib12","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s11095-006-0067-2","article-title":"ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells","volume":"23","author":"Asashima","year":"2006","journal-title":"Pharm Res"},{"key":"10.1016\/j.dmd.2026.100282_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1206104","article-title":"Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice","volume":"14","author":"Berezin","year":"2023","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.dmd.2026.100282_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/bph.13376","article-title":"Blood\u2013brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier","volume":"173","author":"Chapy","year":"2016","journal-title":"Br J Pharmacol"},{"issue":"11","key":"10.1016\/j.dmd.2026.100282_bib15","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1021\/acs.molpharmaceut.7b00493","article-title":"Inner blood\u2013retinal barrier dominantly expresses breast cancer resistance protein: comparative quantitative targeted absolute proteomics study of CNS barriers in pig","volume":"14","author":"Zhang","year":"2017","journal-title":"Mol Pharm"},{"issue":"3","key":"10.1016\/j.dmd.2026.100282_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1517\/17425255.2013.749858","article-title":"The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs","volume":"9","author":"Li","year":"2013","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1567201043480036","article-title":"The role of ABC transporters in drug resistance, metabolism and toxicity","volume":"1","author":"Glavinas","year":"2004","journal-title":"Curr Drug Deliv"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.addr.2008.08.007","article-title":"Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice","volume":"61","author":"Vlaming","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.dmd.2026.100282_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105593","article-title":"Inhibition of ABCG2\/BCRP-mediated transport\u2013correlation analysis of various expression systems and probe substrates","volume":"156","author":"S\u00e1f\u00e1r","year":"2021","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1124\/jpet.104.073320","article-title":"Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein","volume":"312","author":"Lee","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"10.1016\/j.dmd.2026.100282_bib21","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1182\/blood-2004-04-1566","article-title":"Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels","volume":"105","author":"Zhou","year":"2005","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.dmd.2026.100282_bib22","doi-asserted-by":"crossref","first-page":"15649","DOI":"10.1073\/pnas.202607599","article-title":"The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria","volume":"99","author":"Jonker","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.dmd.2026.100282_bib23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s004170050069","article-title":"Photosensitization of retinal pigment epithelium by protoporphyrin IX","volume":"236","author":"Bynoe","year":"1998","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"10.1016\/j.dmd.2026.100282_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3390\/pharmaceutics12050397","article-title":"Quercetin is a flavonoid breast cancer resistance protein inhibitor with an impact on the oral pharmacokinetics of sulfasalazine in rats","volume":"12","author":"Song","year":"2020","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1124\/jpet.102.046243","article-title":"Delivery of peptide drugs to the brain by adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier","volume":"305","author":"Toyobuku","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"issue":"9","key":"10.1016\/j.dmd.2026.100282_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/bdd.681","article-title":"Genetic deficiency of carnitine\/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice","volume":"30","author":"Kato","year":"2009","journal-title":"Biopharm Drug Dispos"},{"issue":"4","key":"10.1016\/j.dmd.2026.100282_bib27","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2147\/OPTH.S3967","article-title":"Glial and endothelial blood-retinal barrier responses to amyloid-\u03b2 in the neural retina of the rat","volume":"2","author":"Anderson","year":"2008","journal-title":"Clin Ophthalmol"},{"issue":"9","key":"10.1016\/j.dmd.2026.100282_bib28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1007\/s00125-003-1177-6","article-title":"Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina","volume":"46","author":"Park","year":"2003","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.dmd.2026.100282_bib29","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.bcp.2007.08.021","article-title":"Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats","volume":"74","author":"Liu","year":"2007","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3797\/scipharm.1311-15","article-title":"Degradation study on sulfasalazine and a validated HPLC-UV method for its stability testing","volume":"82","author":"Saini","year":"2014","journal-title":"Sci Pharm"},{"issue":"4","key":"10.1016\/j.dmd.2026.100282_bib31","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3346\/jkms.2013.28.4.608","article-title":"Chlorogenic acid decreases retinal vascular hyperpermeability in diabetic rat model","volume":"28","author":"Shin","year":"2013","journal-title":"J Korean Med Sci"},{"issue":"5","key":"10.1016\/j.dmd.2026.100282_bib32","first-page":"4","article-title":"Isolation and culture of rat retinal capillary endothelial cells in vitro","volume":"25","author":"Han","year":"2005","journal-title":"Recent Advances in Ophthalmology"},{"issue":"005","key":"10.1016\/j.dmd.2026.100282_bib33","first-page":"413","article-title":"Isolation and culture of rat retinal microvascular endothelial cells and inducing cells to form new blood vessels","volume":"030","author":"Dan","year":"2009","journal-title":"J Jinzhou Med Univ"},{"issue":"4","key":"10.1016\/j.dmd.2026.100282_bib34","first-page":"261","article-title":"Improved primary culture and identification of rat retinal microvascular endothelial cells in vitro","volume":"21","author":"Jian-Yan","year":"2012","journal-title":"Ophthalmology in China"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s11011-022-01093-3","article-title":"The effects of ibuprofen and 1, 8- cineol on anxiety and spatial memory in hyperammonemic rats","volume":"38","author":"Bahrami","year":"2023","journal-title":"Metab Brain Dis"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12987-023-00484-7","article-title":"miRNA-ome plasma analysis unveils changes in blood-brain barrier integrity associated with acute liver failure in rats","volume":"20","author":"Orze\u0142-Gajowik","year":"2023","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s12871-025-03244-2","article-title":"Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Anesthesiol"},{"issue":"6","key":"10.1016\/j.dmd.2026.100282_bib38","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/hep.29107","article-title":"Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis","volume":"65","author":"Kumar","year":"2017","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41401-019-0242-8","article-title":"Bile duct ligation enhances AZT CNS toxicity partly by impairing the expression and function of BCRP in rat brain","volume":"41","author":"Qin","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.dmd.2026.100282_bib40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10254-003-0017-x","article-title":"Organic cation transporters","volume":"150","author":"Koepsell","year":"2003","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"10","key":"10.1016\/j.dmd.2026.100282_bib41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s11095-020-02895-9","article-title":"Characterization and validation of canine P-glycoprotein-deficient MDCK II cell lines for efflux substrate screening","volume":"37","author":"Ye","year":"2020","journal-title":"Pharm Res"},{"issue":"12","key":"10.1016\/j.dmd.2026.100282_bib42","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1167\/iovs.11-8264","article-title":"Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis","volume":"52","author":"Gnana-Prakasam","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"10.1016\/j.dmd.2026.100282_bib43","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41423-025-01309-3","article-title":"FXR inhibition functions as a checkpoint blockade of the pathogenic Tfh cell response in lupus","volume":"22","author":"Wang","year":"2025","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"10.1016\/j.dmd.2026.100282_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142865","article-title":"Suppressing the intestinal farnesoid X receptor\/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis","volume":"131","author":"Wu","year":"2021","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.dmd.2026.100282_bib45","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1021\/mp300178a","article-title":"Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins","volume":"9","author":"Herraez","year":"2012","journal-title":"Mol Pharm"},{"key":"10.1016\/j.dmd.2026.100282_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103019","article-title":"Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation","volume":"69","author":"Yang","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.dmd.2026.100282_bib47","series-title":"Neurobiology and Clinical Aspects of the Outer Retina","first-page":"395","article-title":"The involvement of M\u00fcller cells in the outer retina","author":"Reichenbach","year":"1995"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib48","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.22345","article-title":"Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo","volume":"48","author":"G\u00f6rg","year":"2008","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/156720211795495358","article-title":"Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity","volume":"8","author":"Palmela","year":"2011","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.dmd.2026.100282_bib50","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fphar.2012.00131","article-title":"Endothelial cells derived from the blood-brain barrier and islets of langerhans differ in their response to the effects of bilirubin on oxidative stress under hyperglycemic conditions","volume":"3","author":"Kapitulnik","year":"2012","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/15376516.2017.1357775","article-title":"Tet1-mediated DNA demethylation involves in neuron damage induced by bilirubin in vitro","volume":"28","author":"Gou","year":"2018","journal-title":"Toxicol Mech Methods"},{"issue":"21","key":"10.1016\/j.dmd.2026.100282_bib52","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.3390\/ijms21218101","article-title":"The extent of intracellular accumulation of bilirubin determines its anti- or pro-oxidant effect","volume":"21","author":"Bianco","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.dmd.2026.100282_bib53","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2174\/1573403X14666180702152436","article-title":"Reactive oxygen species as intracellular signaling molecules in the cardiovascular system","volume":"14","author":"Krylatov","year":"2018","journal-title":"Curr Cardiol Rev"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3350\/cmh.2021.0141","article-title":"Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats","volume":"28","author":"Yoon","year":"2022","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41419-020-03353-5","article-title":"Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNF\u03b1","volume":"12","author":"Kurosawa","year":"2021","journal-title":"Cell Death Dis"},{"issue":"3","key":"10.1016\/j.dmd.2026.100282_bib56","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41401-020-0402-x","article-title":"Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine","volume":"42","author":"Xie","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.dmd.2026.100282_bib57","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.brainres.2009.05.095","article-title":"Expression of ATP-binding cassette transporters at the inner blood\u2013retinal barrier in a neonatal mouse model of oxygen-induced retinopathy","volume":"1283","author":"Tagami","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.dmd.2026.100282_bib58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2017.08.018","article-title":"Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier","volume":"264","author":"Pascual-Pasto","year":"2017","journal-title":"J Control Release"},{"key":"10.1016\/j.dmd.2026.100282_bib59","article-title":"Common bile duct ligation as model for secondary biliary cirrhosis","volume":"1981","author":"Van Campenhout","year":"2019"},{"issue":"7","key":"10.1016\/j.dmd.2026.100282_bib60","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/liv.14911","article-title":"2021 ISHEN guidelines on animal models of hepatic encephalopathy","volume":"41","author":"DeMorrow","year":"2021","journal-title":"Liver Int"},{"issue":"4","key":"10.1016\/j.dmd.2026.100282_bib61","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1124\/dmd.105.008219","article-title":"Breast cancer resistance protein (BCRP\/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion","volume":"34","author":"Merino","year":"2006","journal-title":"Drug Metab Dispos"},{"issue":"7","key":"10.1016\/j.dmd.2026.100282_bib62","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1124\/dmd.106.014274","article-title":"Abcg2\/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine","volume":"35","author":"Pan","year":"2007","journal-title":"Drug Metab Dispos"},{"issue":"9","key":"10.1016\/j.dmd.2026.100282_bib63","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1124\/dmd.121.000430","article-title":"Comparative hepatic and intestinal efflux transport of statins","volume":"49","author":"Deng","year":"2021","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.dmd.2026.100282_bib64","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00166611","article-title":"Effects of norfloxacin on the retina in rabbits","volume":"233","author":"Mochizuki","year":"1995","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/jop.1993.9.69","article-title":"Toxicity and pharmacokinetics of ciprofloxacin","volume":"9","author":"Marchese","year":"1993","journal-title":"J Ocul Pharmacol"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1463-5224.2001.00182.x","article-title":"Enrofloxacin-associated retinal degeneration in cats","volume":"4","author":"Gelatt","year":"2001","journal-title":"Vet Ophthalmol"},{"issue":"11","key":"10.1016\/j.dmd.2026.100282_bib67","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.2460\/javma.2002.221.1568","article-title":"Fluoroquinolone-induced retinal degeneration in cats","volume":"221","author":"Wiebe","year":"2002","journal-title":"J Am Vet Med Assoc"},{"issue":"2","key":"10.1016\/j.dmd.2026.100282_bib68","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/FPC.0b013e3283425f44","article-title":"Molecular genetic basis for fluoroquinolone-induced retinal degeneration in cats","volume":"21","author":"Ramirez","year":"2011","journal-title":"Pharmacogenet Genomics"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib69","first-page":"31","article-title":"Statins, fibrates, and other peroxisome proliferator-activated receptor agonists for the treatment of cholestatic liver diseases","volume":"16","author":"Dubrovsky","year":"2020","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"3","key":"10.1016\/j.dmd.2026.100282_bib70","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/a-1869-7607","article-title":"Early diagnosis and prevention of infections in cirrhosis","volume":"42","author":"Kulkarni","year":"2022","journal-title":"Semin Liver Dis"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib71","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.apsb.2022.06.010","article-title":"Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin","volume":"13","author":"Hong","year":"2023","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"10.1016\/j.dmd.2026.100282_bib72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1021\/mp800100e","article-title":"Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion","volume":"6","author":"Yue","year":"2009","journal-title":"Mol Pharm"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626000516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626000516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:14:29Z","timestamp":1779790469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626000516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0090955626000516"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100282","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bile duct ligation impairs function and expression of breast cancer resistance protein in rat blood-retinal barrier mainly due to both the increased ammonia and bilirubin","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100282"}}