{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:45:05Z","timestamp":1791999905020,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["2024-0021"],"award-info":[{"award-number":["2024-0021"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.dmd.2026.100345","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:07:03Z","timestamp":1781737623000},"page":"100345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytochrome P450 3A-mediated metabolic activation of fibleucin from Tinospora sagittata initiates liver injury in mice"],"prefix":"10.1016","volume":"54","author":[{"given":"Jie","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingmin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-2147","authenticated-orcid":false,"given":"Jiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dmd.2026.100345_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2017.06.013","article-title":"Tinospora species: an overview of their modulating effects on the immune system","volume":"207","author":"Haque","year":"2017","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100345_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12906-020-03077-1","article-title":"Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-\u03baB and COX-2","volume":"20","author":"Xu","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"3","key":"10.1016\/j.dmd.2026.100345_bib3","doi-asserted-by":"crossref","first-page":"L78","DOI":"10.22376\/ijlpr.2023.13.3.SP1.L78-L87","article-title":"Role of guduchi (Tinospora cordifolia) in COVID-19\u2013 a review","volume":"13","author":"Wajpey","year":"2023","journal-title":"Int J Life Sci Pharm Res"},{"key":"10.1016\/j.dmd.2026.100345_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114540","article-title":"Tinospora cordifolia (Willd.) Miers: protection mechanisms and strategies against oxidative stress-related diseases","volume":"283","author":"Arunachalam","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.dmd.2026.100345_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153663","article-title":"Tinospora cordifolia activates PPAR\u03b3 pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease","volume":"91","author":"Patial","year":"2021","journal-title":"Phytomedicine"},{"issue":"8\u20139","key":"10.1016\/j.dmd.2026.100345_bib6","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.phymed.2014.04.031","article-title":"Toxic hepatitis induced by a herbal medicine: Tinospora crispa","volume":"21","author":"Langrand","year":"2014","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.dmd.2026.100345_bib7","first-page":"6","article-title":"Akar kuning (Arcangelisia flava) sebagai inhibitor EGFR: kajian in silico","volume":"3","author":"Pratama","year":"2016","journal-title":"J Farmagazine"},{"issue":"3","key":"10.1016\/j.dmd.2026.100345_bib8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.33263\/BRIAC153.044","article-title":"Integrating the network pharmacology and molecular dynamic simulation to reveal pharmacological mechanism of Arcangelisia flava (L.) Merr in treating inflammation","volume":"15","year":"2025","journal-title":"Biointerface Res Appl Chem"},{"issue":"11","key":"10.1016\/j.dmd.2026.100345_bib9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.22159\/ajpcr.2018.v11i11.29189","article-title":"Antibacterial activity of akar kuning (Arcangelisia flava) secondary metabolites: molecular docking approach","volume":"11","author":"Fadhil Pratama","year":"2018","journal-title":"Asian J Pharm Clin Res"},{"issue":"3","key":"10.1016\/j.dmd.2026.100345_bib10","first-page":"130","article-title":"Sphenocentrum jollyanum furanoditerpenes activates glucagon-like peptide 1 receptor (GLP-1R): a computational evaluation","volume":"4","author":"Abiola","year":"2025","journal-title":"ABUAD Int J Nat Appl Sci"},{"key":"10.1016\/j.dmd.2026.100345_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1491321","article-title":"Tinosporae Radix attenuates acute pharyngitis by regulating glycerophospholipid metabolism and inflammatory responses through PI3K-Akt signaling pathway","volume":"15","author":"Lu","year":"2024","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.dmd.2026.100345_bib12","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1021\/acs.chemrestox.1c00250","article-title":"In vitro and in vivo studies of metabolic activation of marrubiin, a bioactive constituent from marrubium vulgare","volume":"34","author":"Xing","year":"2021","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"10.1016\/j.dmd.2026.100345_bib13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1124\/dmd.121.000458","article-title":"Metabolic activation and hepatotoxicity of furan-containing compounds","volume":"50","author":"Tian","year":"2022","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"10.1016\/j.dmd.2026.100345_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/tx3003824","article-title":"Reactive metabolites in the biotransformation of molecules containing a furan ring","volume":"26","author":"Peterson","year":"2013","journal-title":"Chem Res Toxicol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100345_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/10408440590935620","article-title":"Role of metabolism in drug-induced idiosyncratic hepatotoxicity","volume":"35","author":"Walgren","year":"2005","journal-title":"Crit Rev Toxicol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100345_bib16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00204-015-1495-8","article-title":"Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic","volume":"90","author":"Li","year":"2016","journal-title":"Arch Toxicol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100345_bib17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1021\/acs.chemrestox.9b00486","article-title":"Cytochrome P450 enzyme-mediated bioactivation as an underlying mechanism of columbin-induced hepatotoxicity","volume":"33","author":"Pei","year":"2020","journal-title":"Chem Res Toxicol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100345_bib18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/ph14040344","article-title":"Isofuranodiene, a natural sesquiterpene isolated from wild celery (Smyrnium olusatrum L.), protects rats against acute ischemic stroke","volume":"14","author":"Yousefi-Manesh","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.dmd.2026.100345_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2023.03.003","article-title":"DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo","volume":"379","author":"Liao","year":"2023","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.dmd.2026.100345_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-59745-019-5_13","article-title":"Isolation and culture of adult mouse hepatocytes","volume":"633","author":"Li","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.dmd.2026.100345_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jchromb.2016.06.024","article-title":"Simultaneous assessment of endogenous thiol compounds by LC-MS\/MS","volume":"1029\u20131030","author":"Sun","year":"2016","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.dmd.2026.100345_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2024.12.009","article-title":"Metabolic activation and hepatic cytotoxicity of osthole mediated by cytochrome P450 enzymes","volume":"404","author":"Liu","year":"2025","journal-title":"Toxicol Lett"},{"issue":"21","key":"10.1016\/j.dmd.2026.100345_bib23","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1039\/c39910001553","article-title":"Oxidation of furans with dimethyldioxirane","author":"Adger","year":"1991","journal-title":"J Chem Soc Chem Commun"},{"issue":"10","key":"10.1016\/j.dmd.2026.100345_bib24","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1021\/tx060143k","article-title":"Characterization of the amino acid adducts of the enedial derivative of teucrin A","volume":"19","author":"Druckova","year":"2006","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.dmd.2026.100345_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxlet.2022.03.005","article-title":"Metabolic activation of 3-aminodibenzofuran mediated by P450 enzymes and sulfotransferases","volume":"360","author":"Wang","year":"2022","journal-title":"Toxicol Lett"},{"issue":"1","key":"10.1016\/j.dmd.2026.100345_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22942","article-title":"Imbalanced GSH\/ROS and sequential cell death","volume":"36","author":"Liu","year":"2022","journal-title":"J Biochem Mol Toxicol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:53:31Z","timestamp":1791996811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626006148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0090955626006148"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100345","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytochrome P450 3A-mediated metabolic activation of fibleucin from Tinospora sagittata initiates liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100345","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100345"}}