{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:06:31Z","timestamp":1789934791024,"version":"4.0.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA030155"],"award-info":[{"award-number":["R01AA030155"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dmd.2026.100392","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:51:37Z","timestamp":1787755897000},"page":"100392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of alcohol consumption on CYP1A2 activity in human liver microsomes studied with a new naphthalene-based fluorogenic substrate"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-4362","authenticated-orcid":false,"given":"Kari A.","family":"Gaither","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda Y.","family":"Davydova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-5432","authenticated-orcid":false,"given":"Kannapiran","family":"Ponraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9090-0912","authenticated-orcid":false,"given":"Bhagwat","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-0033","authenticated-orcid":false,"given":"Dmitri R.","family":"Davydov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.dmd.2026.100392_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0163-7258(03)00031-7","article-title":"Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes","volume":"98","author":"Backes","year":"2003","journal-title":"Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.dmd.2026.100392_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pharmthera.2011.11.009","article-title":"Formation of P450\u00b7P450 complexes and their effect on P450 function","volume":"133","author":"Reed","year":"2012","journal-title":"Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.dmd.2026.100392_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1517\/17425255.2011.562194","article-title":"Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions","volume":"7","author":"Davydov","year":"2011","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol Ther"},{"issue":"12","key":"10.1016\/j.dmd.2026.100392_bib5","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.tips.2021.09.004","article-title":"Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism","volume":"42","author":"Davydov","year":"2021","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1134\/S1990750816010042","article-title":"Molecular organization of the microsomal oxidative system: a new connotation for an old term","volume":"10","author":"Davydov","year":"2016","journal-title":"Biochem Moscow Suppl Ser B"},{"issue":"3","key":"10.1016\/j.dmd.2026.100392_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/03602532.2016.1221961","article-title":"The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes","volume":"48","author":"Reed","year":"2016","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.dmd.2026.100392_bib8","series-title":"The Pharmacology of Alcohol Abuse","first-page":"475","article-title":"Interaction of alcohol with therapeutic drugs and drugs of abuse","author":"Sands","year":"1995"},{"issue":"12","key":"10.1016\/j.dmd.2026.100392_bib9","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s40262-014-0190-x","article-title":"Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol)","volume":"53","author":"Chan","year":"2014","journal-title":"Clin Pharmacokinet"},{"issue":"10","key":"10.1016\/j.dmd.2026.100392_bib10","first-page":"760","article-title":"Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens","volume":"46","author":"Djordjevi\u0107","year":"1998","journal-title":"Pathol Biol (Paris)"},{"issue":"9","key":"10.1016\/j.dmd.2026.100392_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0369-8114(01)00235-8","article-title":"Alcohol-xenobiotics interactions. Role of cytochrome P450 2E1","volume":"49","author":"Meskar","year":"2001","journal-title":"Pathol Biol (Paris)"},{"key":"10.1016\/j.dmd.2026.100392_bib12","volume":"24","author":"Tom","year":"2008","journal-title":"Alcohol-related drug interactions Pharmacist\u2019s Letter\/Prescriber\u2019s Letter"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib13","first-page":"40","article-title":"Alcohol and medication interactions","volume":"23","author":"Weathermon","year":"1999","journal-title":"Alcohol Res Health"},{"issue":"3","key":"10.1016\/j.dmd.2026.100392_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1208\/s12248-009-9127-y","article-title":"Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2","volume":"11","author":"Zhou","year":"2009","journal-title":"AAPS J"},{"issue":"6","key":"10.1016\/j.dmd.2026.100392_bib15","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1124\/pharmrev.124.001173","article-title":"Roles of individual human cytochrome P450 enzymes in drug metabolism","volume":"76","author":"Guengerich","year":"2024","journal-title":"Pharmacol Rev"},{"issue":"51","key":"10.1016\/j.dmd.2026.100392_bib16","doi-asserted-by":"crossref","first-page":"15807","DOI":"10.1021\/bi061803n","article-title":"Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions","volume":"45","author":"Kelley","year":"2006","journal-title":"Biochemistry"},{"issue":"23","key":"10.1016\/j.dmd.2026.100392_bib17","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1042\/BCJ20190532","article-title":"Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2","volume":"476","author":"Davydova","year":"2019","journal-title":"Biochem J"},{"issue":"2","key":"10.1016\/j.dmd.2026.100392_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00007691-199204000-00007","article-title":"Persistent impairment of clomipramine demethylation in recently detoxified alcoholic patients","volume":"14","author":"Balant-Gorgia","year":"1992","journal-title":"Ther Drug Monit"},{"issue":"5","key":"10.1016\/j.dmd.2026.100392_bib19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/clpt.1988.66","article-title":"Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers","volume":"43","author":"Ciraulo","year":"1988","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.dmd.2026.100392_bib20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF01037943","article-title":"Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction","volume":"25","author":"Dorian","year":"1983","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.dmd.2026.100392_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2710.2003.00459.x","article-title":"Toxicological interactions involving psychiatric drugs and alcohol: an update","volume":"28","author":"Tanaka","year":"2003","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.dmd.2026.100392_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108677","article-title":"Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4","volume":"698","author":"Dangi","year":"2021","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.dmd.2026.100392_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108937","article-title":"Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics","volume":"708","author":"Dangi","year":"2021","journal-title":"Arch Biochem Biophys"},{"issue":"Pt 1","key":"10.1016\/j.dmd.2026.100392_bib24","article-title":"Non-additivity of the functional properties of individual P450 species and its manifestation in the effects of alcohol consumption on the metabolism of ketamine and amitriptyline","volume":"230","author":"Ponraj","year":"2024","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-3565(25)38136-X","article-title":"Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2","volume":"265","author":"Tassaneeyakul","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.dmd.2026.100392_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213600","article-title":"Molecular probes for human cytochrome P450 enzymes: recent progress and future perspectives","volume":"427","author":"Wu","year":"2021","journal-title":"Coord Chem Rev"},{"issue":"5","key":"10.1016\/j.dmd.2026.100392_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/1389200211209050667","article-title":"Measurement of CYP1A2 activity: a focus on caffeine as a probe","volume":"13","author":"Perera","year":"2012","journal-title":"Curr Drug Metab"},{"issue":"4","key":"10.1016\/j.dmd.2026.100392_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/ht7040029","article-title":"Current high-throughput approaches of screening modulatory effects of xenobiotics on cytochrome P450 (CYP) enzymes","volume":"7","author":"Ung","year":"2018","journal-title":"High Throughput"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/med.21982","article-title":"CYP1A inhibitors: recent progress, current challenges, and future perspectives","volume":"44","author":"Dai","year":"2024","journal-title":"Med Res Rev"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2003.12.040","article-title":"The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism","volume":"424","author":"Liu","year":"2004","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"10.1016\/j.dmd.2026.100392_bib31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.tips.2004.02.005","article-title":"Historical review: molecular and cellular mechanisms of opiate and cocaine addiction","volume":"25","author":"Nestler","year":"2004","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"10.1016\/j.dmd.2026.100392_bib32","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0006-2952(94)90363-8","article-title":"Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver","volume":"48","author":"Burke","year":"1994","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"10.1016\/j.dmd.2026.100392_bib33","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1124\/dmd.119.087718","article-title":"Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1\/1A2 and Cyp1a1\/Cyp1a2 knockout mice","volume":"47","author":"Kapelyukh","year":"2019","journal-title":"Drug Metab Dispos"},{"issue":"8","key":"10.1016\/j.dmd.2026.100392_bib34","doi-asserted-by":"crossref","first-page":"PL119","DOI":"10.1016\/S0024-3205(98)00323-3","article-title":"Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes","volume":"63","author":"Zhai","year":"1998","journal-title":"Life Sci"},{"issue":"12","key":"10.1016\/j.dmd.2026.100392_bib35","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/BCJ20253130","article-title":"A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11","volume":"482","author":"Davydov","year":"2025","journal-title":"Biochem J"},{"issue":"8","key":"10.1016\/j.dmd.2026.100392_bib36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0006-2952(96)85085-4","article-title":"Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen","volume":"51","author":"Miners","year":"1996","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100392_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s002280050293","article-title":"Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation","volume":"52","author":"Tracy","year":"1997","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/jox15010020","article-title":"Effects of chronic alcohol intake on the composition of the ensemble of drug-metabolizing enzymes and transporters in the human liver","volume":"15","author":"Gaither","year":"2025","journal-title":"J Xenobiot"},{"issue":"11","key":"10.1016\/j.dmd.2026.100392_bib39","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1124\/dmd.124.001477","article-title":"Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics","volume":"52","author":"Singh","year":"2024","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmd.2026.100392_bib40","article-title":"Proteomic analysis of pooled and individual preparations of human liver microsomes [dataset]","volume":"v 2","author":"Singh","year":"2024","journal-title":"Mendeley Data"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib41","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/jpet.102.043323","article-title":"Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling","volume":"304","author":"Spatzenegger","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"10.1016\/j.dmd.2026.100392_bib42","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1124\/dmd.108.023770","article-title":"Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes","volume":"36","author":"DeVore","year":"2008","journal-title":"Drug Metab Dispos"},{"issue":"9","key":"10.1016\/j.dmd.2026.100392_bib43","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1124\/dmd.112.045161","article-title":"Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes","volume":"40","author":"Stephens","year":"2012","journal-title":"Drug Metab Dispos"},{"issue":"8","key":"10.1016\/j.dmd.2026.100392_bib44","first-page":"1055","article-title":"High-throughput assay of cytochrome P450-dependent drug demethylation reactions and its use to re-evaluate the pathways of ketamine metabolism","volume":"12","author":"Davydova","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.dmd.2026.100392_bib45","series-title":"Principal Component Analysis","author":"Dunteman","year":"1989"},{"issue":"9","key":"10.1016\/j.dmd.2026.100392_bib46","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1042\/BCJ20260456","article-title":"The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure","volume":"483","author":"Davydov","year":"2026","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1039\/B510875F","article-title":"Combined kinetics and iterative target transformation factor analysis for spectroscopic monitoring of reactions","volume":"131","author":"Carvalho","year":"2006","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0003-2670(98)00380-8","article-title":"A method for the determination of reaction mechanisms and rate constants from two-way spectroscopic data","volume":"373","author":"Furusj\u00f6","year":"1998","journal-title":"Anal Chim Acta"},{"issue":"2","key":"10.1016\/j.dmd.2026.100392_bib49","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0003-9861(95)90017-9","article-title":"High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution\u2014evidence for conformational inhomogeneity in the oligomers","volume":"320","author":"Davydov","year":"1995","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"10.1016\/j.dmd.2026.100392_bib50","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bpj.2016.02.026","article-title":"Conformational mobility in cytochrome P450 3A4 explored by pressure-perturbation EPR spectroscopy","volume":"110","author":"Davydov","year":"2016","journal-title":"Biophys J"},{"issue":"1-2","key":"10.1016\/j.dmd.2026.100392_bib51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0003-2670(94)80037-5","article-title":"Simultaneous determination of naproxen and its desmethyl metabolite in human serum by second-derivative synchronous fluorescence spectrometry","volume":"290","author":"Konstantianos","year":"1994","journal-title":"Anal Chim Acta"},{"issue":"6","key":"10.1016\/j.dmd.2026.100392_bib53","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2165\/00003088-199936060-00004","article-title":"Drug interactions with tobacco smoking. An update","volume":"36","author":"Zevin","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.dmd.2026.100392_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2025.1509785","article-title":"Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets","volume":"13","author":"Zhu","year":"2025","journal-title":"Front Chem"},{"issue":"9","key":"10.1016\/j.dmd.2026.100392_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105112","article-title":"Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain","volume":"299","author":"Burris-Hiday","year":"2023","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.dmd.2026.100392_bib56","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3390\/biom13071083","article-title":"Single mutations in cytochrome P450 oxidoreductase can alter the specificity of human cytochrome P450 1A2-mediated caffeine metabolism","volume":"13","author":"Esteves","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.dmd.2026.100392_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmd.2025.100210","article-title":"Mass spectrometry footprinting reveals microsomal CYP2A6 structural changes induced by interaction with its reductase flavin mononucleotide domain","volume":"54","author":"Chai","year":"2026","journal-title":"Drug Metab Dispos"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:28:52Z","timestamp":1789932532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626006616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0090955626006616"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100392","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of alcohol consumption on CYP1A2 activity in human liver microsomes studied with a new naphthalene-based fluorogenic substrate","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"100392"}}