{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:36:26Z","timestamp":1793097386924,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1UC2 HD113041"],"award-info":[{"award-number":["1UC2 HD113041"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dmd.2026.100398","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:00:29Z","timestamp":1788537629000},"page":"100398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1731-9754","authenticated-orcid":false,"given":"Vicky L.","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3068-4077","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-9101","authenticated-orcid":false,"given":"Joanne","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-8455","authenticated-orcid":false,"given":"Jashvant D.","family":"Unadkat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-9313","authenticated-orcid":false,"given":"Edward J.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-2347","authenticated-orcid":false,"given":"Samuel L.M.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.dmd.2026.100398_bib1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1152\/physrev.1921.1.3.421","article-title":"On the mechanism of absorption from the intestine","volume":"1","author":"Goldschmidt","year":"1921","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.dmd.2026.100398_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/physrev.1930.10.3.473","article-title":"The r\u00f4le of the small intestine in nutrition","volume":"10","author":"Magee","year":"1930","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.dmd.2026.100398_bib3","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1172\/JCI113987","article-title":"Loosening tight junctions. Lessons from the intestine","volume":"83","author":"Madara","year":"1989","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1542\/peds.75.1.160","article-title":"Development of carbohydrate absorption in the fetus and neonate","volume":"75","author":"Mobassaleh","year":"1985","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.dmd.2026.100398_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ar.1091910302","article-title":"Specialized cell types in the human fetal small intestine","volume":"191","author":"Moxey","year":"1978","journal-title":"Anat Rec"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib6","first-page":"6","article-title":"Histopathology of the small intestine","volume":"52","author":"Morson","year":"1959","journal-title":"Proc R Soc Med"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/gut.8.6.618","article-title":"Surface area of the small intestine in man","volume":"8","author":"Wilson","year":"1967","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00365521.2014.898326","article-title":"Surface area of the digestive tract\u2014revisited","volume":"49","author":"Helander","year":"2014","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib9","doi-asserted-by":"crossref","first-page":"E1183","DOI":"10.1152\/ajpendo.90899.2008","article-title":"Intestinal lipid absorption","volume":"296","author":"Iqbal","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1079\/NRR19950005","article-title":"Molecular biology of intestinal glucose transport","volume":"8","author":"Shirazi-Beechey","year":"1995","journal-title":"Nutr Res Rev"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.me.29.020178.000531","article-title":"Digestion and absorption of protein","volume":"29","author":"Freeman","year":"1978","journal-title":"Annu Rev Med"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-nutr-061121-094344","article-title":"Intestinal amino acid transport and metabolic health","volume":"43","author":"Br\u00f6er","year":"2023","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.ph.42.030180.001105","article-title":"Water-soluble vitamin absorption in intestine","volume":"42","author":"Rose","year":"1980","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.dmd.2026.100398_bib14","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/j.2040-4603.2018.tb00052.x","article-title":"Gastrointestinal handling of water-soluble vitamins","volume":"8","author":"Said","year":"2018","journal-title":"Compr Physiol"},{"key":"10.1016\/j.dmd.2026.100398_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrd4626","article-title":"SLC transporters as therapeutic targets: emerging opportunities","volume":"14","author":"Lin","year":"2015","journal-title":"Nat Rev Drug Discov"},{"issue":"23","key":"10.1016\/j.dmd.2026.100398_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316789","article-title":"ABC transporters 45 years on","volume":"24","author":"George","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.dmd.2026.100398_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1124\/dmd.120.000283","article-title":"In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics","volume":"49","author":"Takayama","year":"2021","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"10.1016\/j.dmd.2026.100398_bib18","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/cpt.1301","article-title":"Protein abundance of clinically relevant drug transporters in the human liver and intestine: a comparative analysis in paired tissue specimens","volume":"105","author":"Drozdzik","year":"2019","journal-title":"Clin Pharmacol Ther"},{"issue":"8","key":"10.1016\/j.dmd.2026.100398_bib19","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1124\/dmd.114.056929","article-title":"Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters","volume":"42","author":"Mooij","year":"2014","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.dmd.2026.100398_bib20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the dependency of cellular protein levels on mRNA abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.dmd.2026.100398_bib21","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1021\/mp500330y","article-title":"Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine","volume":"11","author":"Drozdzik","year":"2014","journal-title":"Mol Pharm"},{"issue":"4","key":"10.1016\/j.dmd.2026.100398_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1124\/dmd.119.089656","article-title":"Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine","volume":"48","author":"Couto","year":"2020","journal-title":"Drug Metab Dispos"},{"issue":"7347","key":"10.1016\/j.dmd.2026.100398_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.dmd.2026.100398_bib24","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/cpt.2097","article-title":"Quantification of proteins involved in intestinal epithelial handling of xenobiotics","volume":"109","author":"Al-Majdoub","year":"2021","journal-title":"Clin Pharmacol Ther"},{"issue":"12","key":"10.1016\/j.dmd.2026.100398_bib25","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1124\/dmd.121.000559","article-title":"Ontogeny of small intestinal drug transporters and metabolizing enzymes based on targeted quantitative proteomics","volume":"49","author":"Kiss","year":"2021","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmd.2026.100398_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123962","article-title":"Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients","volume":"654","author":"De Waal","year":"2024","journal-title":"Int J Pharm"},{"key":"10.1016\/j.dmd.2026.100398_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejpb.2023.08.011","article-title":"Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS\/MS proteomics using a QconCAT technique","volume":"191","author":"Goelen","year":"2023","journal-title":"Eur J Pharm Biopharm"},{"issue":"5","key":"10.1016\/j.dmd.2026.100398_bib28","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1021\/acs.molpharmaceut.5c01755","article-title":"Advanced age-related changes in intestinal drug transporters and metabolizing enzymes: a targeted proteomics study","volume":"23","author":"Harder","year":"2026","journal-title":"Mol Pharm"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib29","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1038\/s41467-018-07454-w","article-title":"Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry","volume":"9","author":"Searle","year":"2018","journal-title":"Nat Commun"},{"issue":"15\u201316","key":"10.1016\/j.dmd.2026.100398_bib30","article-title":"Comparison of fractionation proteomics for local SWATH library building","volume":"17","author":"Govaert","year":"2017","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib31","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41467-020-15346-1","article-title":"Generating high quality libraries for DIA MS with empirically corrected peptide predictions","volume":"11","author":"Searle","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","article-title":"Single-pot, solid-phase-enhanced sample preparation for proteomics experiments","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat Protoc"},{"issue":"7","key":"10.1016\/j.dmd.2026.100398_bib33","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.dmd.2026.100398_bib34","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat Biotechnol"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41592-019-0426-7","article-title":"Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning","volume":"16","author":"Gessulat","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.dmd.2026.100398_bib36","article-title":"Koina: democratizing machine learning for proteomics research","author":"Lautenbacher","year":"2024","journal-title":"Preprint"},{"issue":"11","key":"10.1016\/j.dmd.2026.100398_bib37","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"K\u00e4ll","year":"2007","journal-title":"Nat Methods"},{"issue":"17","key":"10.1016\/j.dmd.2026.100398_bib38","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1093\/bioinformatics\/btu305","article-title":"MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments","volume":"30","author":"Choi","year":"2014","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib39","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1074\/mcp.RA117.000543","article-title":"Panorama Public: a public repository for quantitative data sets processed in Skyline","volume":"17","author":"Sharma","year":"2018","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"10.1016\/j.dmd.2026.100398_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"Vizca\u00edno","year":"2014","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.dmd.2026.100398_bib41","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00424-024-02914-3","article-title":"Bicarbonate secretion and acid\/base sensing by the intestine","volume":"476","author":"Becker","year":"2024","journal-title":"Pflugers Arch"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib42","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1021\/acs.molpharmaceut.2c01002","article-title":"Regional transcriptomics and proteomics of pharmacokinetics-related genes in human intestine","volume":"20","author":"Murata","year":"2023","journal-title":"Mol Pharm"},{"issue":"7","key":"10.1016\/j.dmd.2026.100398_bib43","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1124\/dmd.120.090738","article-title":"Regional proteomic quantification of clinically relevant noncytochrome P450 enzymes along the human small intestine","volume":"48","author":"Zhang","year":"2020","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.dmd.2026.100398_bib44","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.2042-7158.2011.01399.x","article-title":"Mucus thickness in the gastrointestinal tract of laboratory animals","volume":"64","author":"Varum","year":"2012","journal-title":"J Pharm Pharmacol"},{"issue":"10","key":"10.1016\/j.dmd.2026.100398_bib45","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1023\/A:1026183200740","article-title":"P-glycoprotein increases from proximal to distal regions of human small intestine","volume":"20","author":"Mouly","year":"2003","journal-title":"Pharm Res"},{"key":"10.1016\/j.dmd.2026.100398_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.624324","article-title":"Targeting SLC1A5 and SLC3A2\/SLC7A5 as a potential strategy to strengthen anti-tumor immunity in the tumor microenvironment","volume":"12","author":"Nachef","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.dmd.2026.100398_bib47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fchem.2018.00243","article-title":"The Human SLC7A5 (LAT1): the intriguing histidine\/large neutral amino acid transporter and its relevance to human health","volume":"6","author":"Scalise","year":"2018","journal-title":"Front Chem"},{"issue":"1","key":"10.1016\/j.dmd.2026.100398_bib48","first-page":"G157","article-title":"Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter","volume":"274","author":"Craddock","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.dmd.2026.100398_bib49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1289\/ehp.793379","article-title":"Properties and biological significance of the ileal bile salt transport system","volume":"33","author":"Lack","year":"1979","journal-title":"Environ Health Perspect"},{"issue":"5","key":"10.1016\/j.dmd.2026.100398_bib50","doi-asserted-by":"crossref","first-page":"G887","DOI":"10.1152\/ajpgi.00318.2017","article-title":"Intestinal IMINO transporter SIT1 is not expressed in human newborns","volume":"315","author":"Meier","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"6","key":"10.1016\/j.dmd.2026.100398_bib51","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/0016-5085(91)90664-7","article-title":"Multiple pathways for amino acid transport in brush border membrane vesicles isolated from the human fetal small intestine","volume":"100","author":"Malo","year":"1991","journal-title":"Gastroenterology"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:20:11Z","timestamp":1793096411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626006677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0090955626006677"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100398","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"100398"}}