{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:36:30Z","timestamp":1793097390891,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373945"],"award-info":[{"award-number":["82373945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073921"],"award-info":[{"award-number":["82073921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dmd.2026.100399","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:58:43Z","timestamp":1788879523000},"page":"100399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Submicellar aggregates of deoxycholate and glycodeoxycholate suppress in vitro CYP3A oxidation via membrane perturbation"],"prefix":"10.1016","volume":"54","author":[{"given":"Cuitong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-9219","authenticated-orcid":false,"given":"Ke","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu Rev Biochem"},{"issue":"8","key":"10.1016\/j.dmd.2026.100399_bib2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1194\/jlr.R049437","article-title":"Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades","volume":"55","author":"Hofmann","year":"2014","journal-title":"J Lipid Res"},{"issue":"4","key":"10.1016\/j.dmd.2026.100399_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41574-024-01067-8","article-title":"Bile acid metabolism in type 2 diabetes mellitus","volume":"21","author":"Cadena Sandoval","year":"2025","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1016\/j.dmd.2026.100399_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/19490976.2015.1127483","article-title":"Consequences of bile salt biotransformations by intestinal bacteria","volume":"7","author":"Ridlon","year":"2016","journal-title":"Gut microbes"},{"issue":"8","key":"10.1016\/j.dmd.2026.100399_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100392","article-title":"The Hylemon-Bjorkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology","volume":"64","author":"Ridlon","year":"2023","journal-title":"J Lipid Res"},{"issue":"3\u20134","key":"10.1016\/j.dmd.2026.100399_bib7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1081\/DMR-200033475","article-title":"Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity","volume":"36","author":"Hofmann","year":"2004","journal-title":"Drug Metab Rev"},{"issue":"2","key":"10.1016\/j.dmd.2026.100399_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.dmd.2026.100399_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/dmd.118.085670","article-title":"Continuum of host-gut microbial co-metabolism: host CYP3A4\/3A7 are responsible for tertiary oxidations of deoxycholate species","volume":"47","author":"Zhang","year":"2019","journal-title":"Drug Metab Dispos"},{"issue":"6","key":"10.1016\/j.dmd.2026.100399_bib10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1124\/dmd.119.086637","article-title":"Stereoselective oxidation kinetics of deoxycholate in recombinant and microsomal CYP3A enzymes: deoxycholate 19-hydroxylation is an in vitro marker of CYP3A7 activity","volume":"47","author":"Chen","year":"2019","journal-title":"Drug Metab Dispos"},{"issue":"6","key":"10.1016\/j.dmd.2026.100399_bib11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1124\/dmd.122.000864","article-title":"Reevaluate in vitro CYP3A index reactions of benzodiazepines and steroids between humans and dogs","volume":"50","author":"Wu","year":"2022","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.dmd.2026.100399_bib12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1124\/dmd.123.001513","article-title":"Comparison of 1beta- and 5beta-hydroxylation of deoxycholate and glycodeoxycholate as in vitro index reactions for cytochrome P450 3A activities","volume":"52","author":"Wang","year":"2024","journal-title":"Drug Metab Dispos"},{"issue":"8","key":"10.1016\/j.dmd.2026.100399_bib13","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1124\/dmd.120.000011","article-title":"Urinary bile acid profile of newborns born by cesarean section is characterized by oxidative metabolism of primary bile acids: limited roles of fetal-specific CYP3A7 in cholate oxidations","volume":"48","author":"Wang","year":"2020","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.dmd.2026.100399_bib14","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1021\/acsptsci.1c00052","article-title":"Compensatory transition of bile acid metabolism from fecal disposition of secondary bile acids to urinary excretion of primary bile acids underlies rifampicin-induced cholestasis in beagle dogs","volume":"4","author":"Gui","year":"2021","journal-title":"ACS Pharmacol Transl Sci"},{"issue":"11","key":"10.1016\/j.dmd.2026.100399_bib15","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1021\/acs.jproteome.5c00343","article-title":"Primary-secondary-tertiary axis of bile acid metabolism in healthy subjects","volume":"24","author":"Cheng","year":"2025","journal-title":"J Proteome Res"},{"issue":"5","key":"10.1016\/j.dmd.2026.100399_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/dmd.121.000385","article-title":"Tertiary oxidation of deoxycholate is predictive of CYP3A activity in dogs","volume":"49","author":"Zeng","year":"2021","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"10.1016\/j.dmd.2026.100399_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.1241","article-title":"Relevance of plasma lenvatinib concentrations and endogenous urinary cytochrome P450 3A activity biomarkers in clinical practice","volume":"12","author":"Kumondai","year":"2024","journal-title":"Pharmacol Res Perspect"},{"issue":"9","key":"10.1016\/j.dmd.2026.100399_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2026.e44955","article-title":"Clinical association among tacrolimus dose requirement, CYP3A genotypes, and the concentrations of urinary endogenous CYP3A biomarkers in lung transplant recipients: a cross-sectional study","volume":"12","author":"Kumondai","year":"2026","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.dmd.2026.100399_bib19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1124\/dmd.124.001680","article-title":"1\u03b2-Hydroxydeoxycholic acid as an endogenous biomarker in human plasma for assessment of CYP3A clinical drug-drug interaction potential","volume":"52","author":"Xue","year":"2024","journal-title":"Drug Metab Dispos"},{"issue":"9","key":"10.1016\/j.dmd.2026.100399_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmd.2025.100141","article-title":"1\u03b2-Hydroxydeoxycholic acid as an endogenous biomarker in human plasma for assessment of drug-drug interaction with moderate CYP3A inhibitor","volume":"53","author":"Chen","year":"2025","journal-title":"Drug Metab Dispos"},{"issue":"11","key":"10.1016\/j.dmd.2026.100399_bib21","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1002\/jcph.70069","article-title":"Use of integrated data sets supports the static model-based prediction of oral contraceptive victim drug interactions","volume":"65","author":"Rodrigues","year":"2025","journal-title":"J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbapap.2010.07.017","article-title":"Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations","volume":"1814","author":"Hendrychov\u00e1","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.dmd.2026.100399_bib23","series-title":"Molecular Association in Biological and Related Systems. Advances in Chemistry","first-page":"31","article-title":"Size and structure of bile salt micelles: influence of structure, concentration, counterion concentration, pH, and temperature","author":"Small","year":"1968"},{"issue":"4","key":"10.1016\/j.dmd.2026.100399_bib24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archinte.1972.03650040040005","article-title":"Micelle formation by bile salts physical-chemical and thermodynamic considerations","volume":"130","author":"Carey","year":"1972","journal-title":"Arch Intern Med"},{"issue":"10","key":"10.1016\/j.dmd.2026.100399_bib25","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1016\/S0021-9258(18)32418-9","article-title":"The influence of bile salt structure on self-association in aqueous solutions","volume":"258","author":"Roda","year":"1983","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.dmd.2026.100399_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cocis.2009.11.010","article-title":"Self-assembly in aqueous bile salt solutions","volume":"15","author":"Madenci","year":"2010","journal-title":"Curr Opin Colloid Interface Sci"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib27","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1021\/jp030899h","article-title":"Two-dimensional NMR study on the structures of micelles of sodium taurocholate","volume":"108","author":"Funasaki","year":"2004","journal-title":"J Phys Chem B"},{"issue":"19","key":"10.1016\/j.dmd.2026.100399_bib28","doi-asserted-by":"crossref","first-page":"9849","DOI":"10.1021\/jp0477708","article-title":"Comment on \"Two-dimensional NMR study on the structures of micelles of sodium taurocholate.\"","volume":"109","author":"Galantini","year":"2005","journal-title":"J Phys Chem B"},{"issue":"19","key":"10.1016\/j.dmd.2026.100399_bib29","doi-asserted-by":"crossref","first-page":"9851","DOI":"10.1021\/jp0455374","article-title":"Reply to the comment on \"Two-dimensional NMR study on the structures of micelles of sodium taurocholate.\"","volume":"109","author":"Funasaki","year":"2005","journal-title":"J Phys Chem B"},{"issue":"8","key":"10.1016\/j.dmd.2026.100399_bib30","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1016\/S0021-9258(18)83762-0","article-title":"Membrane topology of mammalian cytochromes P-450 from liver endoplasmic reticulum: determination by trypsinolysis of phenobarbital-treated microsomes","volume":"264","author":"Brown","year":"1989","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/bi00215a011","article-title":"Orientation of cytochromes P450 in the endoplasmic reticulum","volume":"30","author":"Edwards","year":"1991","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.dmd.2026.100399_bib32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jbt.10052","article-title":"The roles of cytochrome b5 in cytochrome P450 reactions","volume":"16","author":"Porter","year":"2002","journal-title":"J Biochem Mol Toxicol"},{"issue":"24","key":"10.1016\/j.dmd.2026.100399_bib33","doi-asserted-by":"crossref","first-page":"17082","DOI":"10.1074\/jbc.R113.452805","article-title":"Structural diversity of eukaryotic membrane cytochrome p450s","volume":"288","author":"Johnson","year":"2013","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.dmd.2026.100399_bib34","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1023\/B:PHAM.0000036927.37888.93","article-title":"Insertion and partition of sodium taurocholate into egg phosphatidylcholine vesicles","volume":"21","author":"Andrieux","year":"2004","journal-title":"Pharm Res"},{"issue":"4","key":"10.1016\/j.dmd.2026.100399_bib35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1248\/cpb.c18-01029","article-title":"Molecular mechanisms for protection of hepatocytes against bile salt cytotoxicity","volume":"67","author":"Morita","year":"2019","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.dmd.2026.100399_bib36","series-title":"Yamazaki H, eds. Fifty Years of Cytochrome P450 Research","first-page":"17","article-title":"Fifty years of progress in drug metabolism and toxicology: What do we still need to know about cytochrome P450 enzymes?","author":"Guengerich","year":"2014"},{"issue":"89","key":"10.1016\/j.dmd.2026.100399_bib37","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.1039\/C9CC05904K","article-title":"Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b5, and reductase","volume":"55","author":"Gentry","year":"2019","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.dmd.2026.100399_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2023.107092","article-title":"Direct interaction between the transmembrane helices stabilize cytochrome P450 2B4 and cytochrome b5 redox complex","volume":"301","author":"Sahoo","year":"2023","journal-title":"Biophys Chem"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ab.2004.07.017","article-title":"Noninvasive methods to determine the critical micelle concentration of some bile acid salts","volume":"334","author":"Reis","year":"2004","journal-title":"Anal Biochem"},{"issue":"5566","key":"10.1016\/j.dmd.2026.100399_bib40","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/262326a0","article-title":"Structure of bilirubin","volume":"262","author":"Bonnett","year":"1976","journal-title":"Nature"},{"issue":"1147","key":"10.1016\/j.dmd.2026.100399_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1098\/rspb.1978.0066","article-title":"The structure of bilirubin","volume":"202","author":"Bonnett","year":"1978","journal-title":"Proc R Soc Lond B Biol Sci"},{"issue":"10","key":"10.1016\/j.dmd.2026.100399_bib42","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1039\/C5CP06971H","article-title":"Ultrafast deactivation of bilirubin: dark intermediates and two-photon isomerization","volume":"18","author":"Carreira-Blanco","year":"2016","journal-title":"Phys Chem Chem Phys"},{"issue":"4","key":"10.1016\/j.dmd.2026.100399_bib43","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365517209080263","article-title":"Binding of bilirubin to low-affinity sites of human serum albumin in vitro followed by co-crystallization","volume":"29","author":"Brodersen","year":"1972","journal-title":"Scand J Clin Lab Invest"},{"issue":"7","key":"10.1016\/j.dmd.2026.100399_bib44","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0021-9258(17)30230-2","article-title":"Solubility and interaction with albumin and phospholipid","volume":"254","author":"Brodersen R. Bilirubin","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dmd.2026.100399_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochemrev.2023.100585","article-title":"Absorption and fluorescence spectra of open-chain tetrapyrrole pigments\u2013bilirubins, biliverdins, phycobilins, and synthetic analogues","volume":"55","author":"Taniguchi","year":"2023","journal-title":"J Photochem Photobiol C Photochem Rev"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib46","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0016-5085(78)90358-X","article-title":"Unconjugated bilirubin, and the hydrolysis of conjugated bilirubin, in gallbladder bile of patients with cholelithiasis","volume":"74","author":"Boonyapisit","year":"1978","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.dmd.2026.100399_bib47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.1840030207","article-title":"Analysis of bilirubins in biological fluids by extraction and thin-layer chromatography of the intact tetrapyrroles: application to bile of patients with Gilbert's syndrome, hemolysis, or cholelithiasis","volume":"3","author":"Fevery","year":"1983","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dmd.2026.100399_bib48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfn268","article-title":"Bile acid sulfation: a pathway of bile acid elimination and detoxification","volume":"108","author":"Alnouti","year":"2009","journal-title":"Toxicol Sci"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/09168451.2016.1222266","article-title":"Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation","volume":"81","author":"Suiko","year":"2017","journal-title":"Biosci Biotechnol Biochem"},{"issue":"6","key":"10.1016\/j.dmd.2026.100399_bib50","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/00365521.1974.12096876","article-title":"Duodenal bile acids after a test meal","volume":"9","author":"Fausa","year":"1974","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-2275(20)32342-7","article-title":"Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry","volume":"42","author":"Perwaiz","year":"2001","journal-title":"J Lipid Res"},{"issue":"11","key":"10.1016\/j.dmd.2026.100399_bib52","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1194\/jlr.D120000726","article-title":"Quantification of common and planar bile acids in tissues and cultured cells","volume":"61","author":"Shiffka","year":"2020","journal-title":"J Lipid Res"},{"issue":"6","key":"10.1016\/j.dmd.2026.100399_bib53","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.051014398","article-title":"An essential role for nuclear receptors SXR\/PXR in detoxification of cholestatic bile acids","volume":"98","author":"Xie","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.dmd.2026.100399_bib54","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.bbamem.2013.05.021","article-title":"Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations","volume":"1828","author":"Mello-Vieira","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"10.1016\/j.dmd.2026.100399_bib55","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1194\/jlr.M062653","article-title":"Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties","volume":"56","author":"Sousa","year":"2015","journal-title":"J Lipid Res"},{"issue":"8","key":"10.1016\/j.dmd.2026.100399_bib56","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3390\/membranes12080748","article-title":"Molecular mechanism of cellular membranes for signal transduction","volume":"12","author":"Schumann","year":"2022","journal-title":"Membranes (Basel)"},{"key":"10.1016\/j.dmd.2026.100399_bib57","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fimmu.2016.00536","article-title":"Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates DSS-induced colitis in mice","volume":"7","author":"Zhao","year":"2016","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.dmd.2026.100399_bib58","article-title":"Deoxycholic acid-mediated sphingosine-1-phosphate receptor 2 signaling exacerbates DSS-induced colitis through promoting cathepsin B release","volume":"2018","author":"Zhao","year":"2018","journal-title":"J Immunol Res"},{"issue":"3","key":"10.1016\/j.dmd.2026.100399_bib59","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/molecules27030723","article-title":"Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction","volume":"27","author":"Zeng","year":"2022","journal-title":"Molecules"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955626006689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:20:57Z","timestamp":1793096457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955626006689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0090955626006689"],"URL":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100399","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Submicellar aggregates of deoxycholate and glycodeoxycholate suppress in vitro CYP3A oxidation via membrane perturbation","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmd.2026.100399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100399"}}