{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:41:15Z","timestamp":1772804475007,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.dmpk.2014.12.007","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T11:19:16Z","timestamp":1420197556000},"page":"209-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy"],"prefix":"10.1016","volume":"30","author":[{"given":"Qiuning","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dmpk.2014.12.007_bib1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/j.1528-1167.2011.03075.x","article-title":"Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a \u201cproof of concept,\u201d open label study","volume":"52","author":"Machado","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.dmpk.2014.12.007_bib2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2165\/00003088-200645110-00002","article-title":"Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?","volume":"45","author":"Johannessen","year":"2006","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.dmpk.2014.12.007_bib3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/dmd.106.009340","article-title":"In\u00a0vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction","volume":"34","author":"Rowland","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmpk.2014.12.007_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2011.01.016","article-title":"The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy","volume":"95","author":"Gulcebi","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.dmpk.2014.12.007_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/FTD.0b013e3181633824","article-title":"Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population","volume":"30","author":"Yea","year":"2008","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.dmpk.2014.12.007_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/humu.9432","article-title":"Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus","volume":"27","author":"Thomas","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.dmpk.2014.12.007_bib7","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1007\/s11033-012-1615-y","article-title":"UDP-glucuronosyltransferase 1A4 (UGT1A4) polymorphisms in a Jordanian population","volume":"39","author":"Hakooz","year":"2012","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.dmpk.2014.12.007_bib8","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/hep.20131","article-title":"Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4","volume":"39","author":"Ehmer","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.dmpk.2014.12.007_bib9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/FPC.0b013e3283331637","article-title":"A\u00a0pharmacogenetics study of the human glucuronosyltransferase UGT1A4","volume":"19","author":"Benoit-Biancamano","year":"2009","journal-title":"Pharmacogenet Genom"},{"key":"10.1016\/j.dmpk.2014.12.007_bib10","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1158\/0008-5472.CAN-03-3219","article-title":"Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes","volume":"64","author":"Wiener","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.dmpk.2014.12.007_bib11","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00228-014-1690-1","article-title":"Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China","volume":"70","author":"Chang","year":"2014","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2014.12.007_bib12","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2217\/pgs.11.105","article-title":"Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes","volume":"12","author":"Zhou","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.dmpk.2014.12.007_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2133\/dmpk.20.144","article-title":"Genetic variations and haplotypes of UGT1A4 in a Japanese population","volume":"20","author":"Saeki","year":"2005","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1016\/j.dmpk.2014.12.007_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.taap.2008.02.020","article-title":"Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene","volume":"230","author":"Erichsen","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.dmpk.2014.12.007_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/humu.20946","article-title":"Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population","volume":"30","author":"M\u00e9nard","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.dmpk.2014.12.007_bib16","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1124\/dmd.112.048157","article-title":"Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics","volume":"41","author":"Edavana","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmpk.2014.12.007_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.rvsc.2007.09.009","article-title":"Assessment of the quality and quantity of genomic DNA recovered from canine blood samples by three different extraction methods","volume":"85","author":"Clements","year":"2008","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.dmpk.2014.12.007_bib18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1365-2710.2012.01351.x","article-title":"Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics","volume":"37","author":"Brzakovi\u0107","year":"2012","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.dmpk.2014.12.007_bib19","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/j.1528-1167.2011.03217.x","article-title":"The effect of age and comedication on lamotrigine clearance, tolerability, and efficacy","volume":"52","author":"Arif","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.dmpk.2014.12.007_bib20","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00228-012-1449-5","article-title":"Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients","volume":"69","author":"Singkham","year":"2013","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2014.12.007_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00007691-200106000-00006","article-title":"Single-dose pharmacokinetics of lamotrigine in children: influence of age and antiepileptic comedication","volume":"23","author":"Battino","year":"2001","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.dmpk.2014.12.007_bib22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00228-007-0308-2","article-title":"Lamotrigine in children and adolescents: the impact of age on its serum concentrations and on the extent of drug interactions","volume":"63","author":"Reimers","year":"2007","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2014.12.007_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2125.1996.31610.x","article-title":"Influence of concurrent antiepileptic medication on the pharmacokinetics of lamotrigine as add-on therapy in epileptic children","volume":"41","author":"Vauzelle-Kervroedan","year":"1996","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2014.12.007_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1248\/bpb.35.487","article-title":"Influence of concomitant antiepileptic drugs on plasma lamotrigine concentration in adult Japanese epilepsy patients","volume":"35","author":"Yamamoto","year":"2012","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.dmpk.2014.12.007_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1345\/aph.17332","article-title":"A\u00a0mechanistic approach to antiepileptic drug interactions","volume":"32","author":"Anderson","year":"1998","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.dmpk.2014.12.007_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/dmd.108.022426","article-title":"Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10","volume":"37","author":"Argikar","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmpk.2014.12.007_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/j.1552-4604.1976.tb01491.x","article-title":"The relation of anticonvulsant drug levels to complete seizure control","volume":"16","author":"Feldman","year":"1976","journal-title":"J\u00a0Clin Pharmacol"}],"container-title":["Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436714000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436714000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:51:49Z","timestamp":1761162709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347436714000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S1347436714000287"],"URL":"https:\/\/doi.org\/10.1016\/j.dmpk.2014.12.007","relation":{},"ISSN":["1347-4367"],"issn-type":[{"value":"1347-4367","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Pharmacokinetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmpk.2014.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}