{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:30:29Z","timestamp":1778005829673,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.dmpk.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T10:28:38Z","timestamp":1558175318000},"page":"287-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats"],"prefix":"10.1016","volume":"34","author":[{"given":"Yuka","family":"Ogata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayuko","family":"Imaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Akiyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisakazu","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dmpk.2019.05.002_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2125.1997.tb00134.x","article-title":"Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal administration","volume":"43","author":"Laine","year":"1997","journal-title":"Br J Clin Pharmacol"},{"issue":"7","key":"10.1016\/j.dmpk.2019.05.002_bib2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1177\/0091270007301622","article-title":"Effects of dosing interval on the pharmacokinetic interaction between oral small spherical activated charcoal and amlodipine in humans","volume":"47","author":"Tanaka","year":"2007","journal-title":"J\u00a0Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.dmpk.2019.05.002_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.dmpk.2018.08.008","article-title":"The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats","volume":"34","author":"Imaoka","year":"2019","journal-title":"Drug Metab Pharmacokinet"},{"issue":"1","key":"10.1016\/j.dmpk.2019.05.002_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00561677","article-title":"Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man","volume":"17","author":"Neuvonen","year":"1980","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.dmpk.2019.05.002_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1345\/aph.1D241","article-title":"Decreased phenobaribital absorption with charcoal administration for chronic renal failure","volume":"38","author":"Tanaka","year":"2004","journal-title":"Ann Pharmacother"},{"issue":"11","key":"10.1016\/j.dmpk.2019.05.002_bib6","first-page":"1","article-title":"Food intake attenuates the drug interaction between new quinolones and aluminum","volume":"4","author":"Imaoka","year":"2018","journal-title":"J\u00a0Pharm Health Care Sci"},{"key":"10.1016\/j.dmpk.2019.05.002_bib7","series-title":"Linda S costanzo physiology","first-page":"340","year":"2009"},{"key":"10.1016\/j.dmpk.2019.05.002_bib8","series-title":"Daiichi Sankyo Co. Ltd., \u201cinterview form\u201d (a drug information booklet) of PHENOBAL\u00ae POWDER, TABLETS, ELIXIRS","year":"2017"},{"key":"10.1016\/j.dmpk.2019.05.002_bib9","series-title":"Mitsubishi Tanabe Pharma corporation., \u201cInterview form\u201d (a drug information booklet) of KREMEZIN\u00ae capsules 200 mg\u2022fine Granules 2 g","year":"2016"},{"issue":"11","key":"10.1016\/j.dmpk.2019.05.002_bib10","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1016\/S0021-9258(17)34757-9","article-title":"Lipid composition of the gastric mucous barrier in the rat","volume":"253","author":"Slomiany","year":"1978","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.dmpk.2019.05.002_bib11","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/j.1552-4604.1989.tb03260.x","article-title":"Ciprofloxacin pharmacokinetics after a standard or high-fat\/high-calcium breakfast","volume":"29","author":"Frost","year":"1989","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2019.05.002_bib12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0026-265X(76)90007-2","article-title":"Micromethod for the simultaneous analysis of phenobarbital, diphenylhydantoin, carbamazepine, and primidone in blood","volume":"21","author":"Abraham","year":"1976","journal-title":"Microchem J"},{"key":"10.1016\/j.dmpk.2019.05.002_bib13","first-page":"512","article-title":"Simultaneous liquid chromatographic analysis of phenobarbital, phenytoin and carbamazepine in human serum - an application to therapeutic drug monitoring","volume":"1","author":"Thiyagu","year":"2010","journal-title":"Pharmacologyonline"},{"issue":"6","key":"10.1016\/j.dmpk.2019.05.002_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.5649\/jjphcs1975.21.483","article-title":"Examination of utility Kremezin as an antidote for acute drug poisoning","volume":"21","author":"Myotoku","year":"1995","journal-title":"Jpn J Hosp Pharm"},{"issue":"6","key":"10.1016\/j.dmpk.2019.05.002_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.addr.2007.08.043","article-title":"Predicting drug disposition, absorption\/elimination\/transporter interplay nad the role of food on drug absorption","volume":"60","author":"Custodio","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.dmpk.2019.05.002_bib16","first-page":"163","article-title":"Fundamentals of activated carbon","volume":"37","author":"Abe","year":"1993","journal-title":"J\u00a0Urban Living Health Assoc"}],"container-title":["Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436718304968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436718304968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:54:59Z","timestamp":1761162899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347436718304968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1347436718304968"],"URL":"https:\/\/doi.org\/10.1016\/j.dmpk.2019.05.002","relation":{},"ISSN":["1347-4367"],"issn-type":[{"value":"1347-4367","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Pharmacokinetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmpk.2019.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd on behalf of The Japanese Society for the Study of Xenobiotics.","name":"copyright","label":"Copyright"}]}}