{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:49:59Z","timestamp":1790390999138,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.dmpk.2020.01.005","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T02:40:54Z","timestamp":1580265654000},"page":"266-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1\u20135)"],"prefix":"10.1016","volume":"35","author":[{"given":"Nami","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Furugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Koishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Umazume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Narumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dmpk.2020.01.005_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000052902","article-title":"Pregnancy in women with epilepsy","volume":"51","author":"Laskowska","year":"2001","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.dmpk.2020.01.005_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yebeh.2018.04.009","article-title":"Changes in antiepileptic drug-prescribing patterns in pregnant women with epilepsy","volume":"84","author":"Meador","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.dmpk.2020.01.005_bib3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1528-1157.2000.tb00232.x","article-title":"Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation","volume":"41","author":"Ohman","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.dmpk.2020.01.005_bib4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eplepsyres.2009.02.011","article-title":"Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period","volume":"85","author":"Fotopoulou","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.dmpk.2020.01.005_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.eplepsyres.2010.07.007","article-title":"Serum levels of lamotrigine during delivery in mothers and their infants","volume":"91","author":"Kacirova","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.dmpk.2020.01.005_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00228-002-0544-4","article-title":"Transplacental passage of lamotrigine in a human placental perfusion system in\u00a0vitro and in maternal and cord blood in\u00a0vivo","volume":"58","author":"Myllynen","year":"2003","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1212\/WNL.0000000000002119","article-title":"Developmental effects of antiepileptic drugs and the need for improved regulations","volume":"86","author":"Meador","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.dmpk.2020.01.005_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2016.12.005","article-title":"Review: the blood-brain barrier; protecting the developing fetal brain","volume":"54","author":"Goasdou\u00e9","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.dmpk.2020.01.005_bib9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3109\/1061186X.2012.716847","article-title":"Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure","volume":"20","author":"Staud","year":"2012","journal-title":"J\u00a0Drug Target"},{"key":"10.1016\/j.dmpk.2020.01.005_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bcp.2011.12.032","article-title":"Lamotrigine is a substrate for OCT1 in brain endothelial cells","volume":"83","author":"Dickens","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuropharm.2015.01.015","article-title":"The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2)","volume":"93","author":"R\u00f6mermann","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.dmpk.2020.01.005_bib12","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.neuropharm.2008.08.032","article-title":"Several major antiepileptic drugs are substrates for human P-glycoprotein","volume":"55","author":"Luna-Tort\u00f3s","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.dmpk.2020.01.005_bib13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.eplepsyres.2016.09.004","article-title":"Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy","volume":"127","author":"Shen","year":"2016","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.dmpk.2020.01.005_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.dmpk.2015.05.002","article-title":"Polymorphisms of ABCG2, ABCB1 and HNF4\u03b1 are associated with Lamotrigine trough concentrations in epilepsy patients","volume":"30","author":"Zhou","year":"2015","journal-title":"Drug Metabol Pharmacokinet"},{"key":"10.1016\/j.dmpk.2020.01.005_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/bcp.12984","article-title":"Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: influence of polymorphism of UDP-glucuronosyltransferases and drug transporters","volume":"82","author":"Milosheska","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11095-017-2286-0","article-title":"The placental barrier: the gate and the fate in drug distribution","volume":"35","author":"Tetro","year":"2018","journal-title":"Pharm Res"},{"key":"10.1016\/j.dmpk.2020.01.005_bib17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.tiv.2012.08.027","article-title":"Placental transfer and metabolism: an overview of the experimental models utilizing human placental tissue","volume":"27","author":"Myllynen","year":"2013","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.dmpk.2020.01.005_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.reprotox.2016.11.002","article-title":"Involvement of L-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells","volume":"67","author":"Furugen","year":"2017","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jchromb.2015.08.031","article-title":"Quantification of new antiepileptic drugs by liquid chromatography\/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells","volume":"1002","author":"Furugen","year":"2015","journal-title":"J\u00a0Chromatogr B"},{"key":"10.1016\/j.dmpk.2020.01.005_bib20","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11095-007-9254-z","article-title":"Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications","volume":"24","author":"Koepsell","year":"2007","journal-title":"Pharm Res"},{"key":"10.1016\/j.dmpk.2020.01.005_bib21","article-title":"Genetic heterogeneity of SLC22 family of transporters in drug disposition","volume":"8","author":"Lozano","year":"2018","journal-title":"J\u00a0Personalized Med"},{"key":"10.1016\/j.dmpk.2020.01.005_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.mam.2012.10.010","article-title":"The SLC22 family with transporters of organic cations, anions and zwitterions","volume":"34","author":"Koepsell","year":"2013","journal-title":"Mol Aspect Med"},{"key":"10.1016\/j.dmpk.2020.01.005_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/bdd.1816","article-title":"Pharmacological and pathophysiological roles of carnitine\/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)","volume":"34","author":"Tamai","year":"2013","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.dmpk.2020.01.005_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00210-008-0369-5","article-title":"Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2)","volume":"379","author":"Zolk","year":"2009","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib25","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bcp.2013.07.008","article-title":"Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine","volume":"86","author":"M\u00fcller","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib26","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1124\/dmd.113.054072","article-title":"Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy","volume":"41","author":"Lee","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.dmpk.2020.01.005_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.placenta.2018.11.010","article-title":"Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: induction of xCT\/SLC7A11 in human placental BeWo cells","volume":"75","author":"Ono","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.dmpk.2020.01.005_bib28","doi-asserted-by":"crossref","first-page":"C263","DOI":"10.1152\/ajpcell.00333.2003","article-title":"L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2","volume":"287","author":"Lahjouji","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.0013-9580.2004.29603.x","article-title":"Interaction between anticonvulsants and human placental carnitine transporter","volume":"45","author":"Wu","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.dmpk.2020.01.005_bib30","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1124\/mol.105.016832","article-title":"Interaction of organic cations with a newly identified plasma membrane monoamine transporter","volume":"68","author":"Engel","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00210-009-0479-8","article-title":"Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics","volume":"381","author":"Haenisch","year":"2010","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/cpt.442","article-title":"The plasma membrane monoamine transporter (PMAT): structure, function, and role in organic cation disposition","volume":"100","author":"Wang","year":"2016","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.dmpk.2020.01.005_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00210-018-1467-7","article-title":"Carrier-mediated uptake of clonidine in cultured human lung cells","volume":"391","author":"Le V\u00e9e","year":"2018","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.dmpk.2020.01.005_bib34","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/jps.24663","article-title":"Chloroquine and hydroxychloroquine are novel inhibitors of human organic anion transporting polypeptide 1A2","volume":"105","author":"Xu","year":"2016","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.dmpk.2020.01.005_bib35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuint.2013.10.009","article-title":"Stereoselective inhibition of serotonin transporters by antimalarial compounds","volume":"73","author":"Beckman","year":"2014","journal-title":"Neurochem Int"},{"key":"10.1016\/j.dmpk.2020.01.005_bib36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s11095-012-0926-y","article-title":"Involvement of a novel organic cation transporter in verapamil transport across the inner blood-retinal barrier","volume":"30","author":"Kubo","year":"2013","journal-title":"Pharm Res"},{"key":"10.1016\/j.dmpk.2020.01.005_bib37","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1002\/jps.23535","article-title":"Propranolol transport across the inner blood-retinal barrier: potential involvement of a novel organic cation transporter","volume":"102","author":"Kubo","year":"2013","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.dmpk.2020.01.005_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.lfs.2017.08.030","article-title":"Nicotine transport in lung and non-lung epithelial cells","volume":"188","author":"Takano","year":"2017","journal-title":"Life Sci"},{"key":"10.1016\/j.dmpk.2020.01.005_bib39","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jps.24627","article-title":"Transport mechanism of nicotine in primary cultured alveolar epithelial cells","volume":"105","author":"Takano","year":"2016","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.dmpk.2020.01.005_bib40","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/js970455v","article-title":"Nicotine transport in a human choriocarcinoma cell line (JAR)","volume":"87","author":"Zevin","year":"1998","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.dmpk.2020.01.005_bib41","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1002\/jps.24453","article-title":"Carrier-mediated transport of nicotine across the inner blood-retinal barrier: involvement of a novel organic cation transporter driven by an outward H(+) gradient","volume":"104","author":"Tega","year":"2015","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.dmpk.2020.01.005_bib42","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1021\/mp500516j","article-title":"Involvement of carrier-mediated transport in the retinal uptake of clonidine at the inner blood-retinal barrier","volume":"11","author":"Kubo","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.dmpk.2020.01.005_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40268-016-0148-6","article-title":"An updated overview on therapeutic drug monitoring of recent antiepileptic drugs","volume":"16","author":"Jacob","year":"2016","journal-title":"Drugs R"},{"key":"10.1016\/j.dmpk.2020.01.005_bib44","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1007\/s00204-017-2008-8","article-title":"Multiple drug transporters mediate the placental transport of sulpiride","volume":"91","author":"Bai","year":"2017","journal-title":"Arch Toxicol"}],"container-title":["Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436720300100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436720300100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:54:54Z","timestamp":1761162894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347436720300100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1347436720300100"],"URL":"https:\/\/doi.org\/10.1016\/j.dmpk.2020.01.005","relation":{},"ISSN":["1347-4367"],"issn-type":[{"value":"1347-4367","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular uptake properties of lamotrigine in human placental cell lines: Investigation of involvement of organic cation transporters (SLC22A1\u20135)","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Pharmacokinetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmpk.2020.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}