{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:46:59Z","timestamp":1789469219602,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.dmpk.2026.101546","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:06:19Z","timestamp":1782803179000},"page":"101546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development of a method for vancomycin monitoring in interstitial fluid using a novel porous microneedle array patch"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0019-9603","authenticated-orcid":false,"given":"Jo","family":"Terauchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-2350","authenticated-orcid":false,"given":"Jongho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7867-4406","authenticated-orcid":false,"given":"Masataka","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-299X","authenticated-orcid":false,"given":"Beomjoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5136-924X","authenticated-orcid":false,"given":"Erika","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.dmpk.2026.101546_bib1","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.3390\/jcm14186397","article-title":"Peripheral venipuncture in pediatric patients: a mini-review of clinical practice and technological advances","volume":"14","author":"Corneanu","year":"2025","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.dmpk.2026.101546_bib2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/JCP.0000000000001855","article-title":"Microsampling techniques suitable for therapeutic drug monitoring of antipsychotics","volume":"44","author":"Geers","year":"2024","journal-title":"J Clin Psychopharmacol"},{"issue":"10","key":"10.1016\/j.dmpk.2026.101546_bib3","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/clinchem\/41.10.1522","article-title":"Composition of interstitial fluid","volume":"41","author":"Fogh-Andersen","year":"1995","journal-title":"Clin Chem"},{"issue":"2","key":"10.1016\/j.dmpk.2026.101546_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpha.2022.12.004","article-title":"Microneedle-based interstitial fluid extraction for drug analysis: advances, challenges, and prospects","volume":"13","author":"Ma","year":"2023","journal-title":"J Pharm Anal"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib5","article-title":"Microneedle system for tissue engineering and regenerative medicine","volume":"3","author":"Zhang","year":"2023","journal-title":"Exploration (Beijing)"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7827(02)00028-0","article-title":"Structure of the skin barrier and its modulation by vesicular formulations","volume":"42","author":"Bouwstra","year":"2003","journal-title":"Prog Lipid Res"},{"issue":"2","key":"10.1016\/j.dmpk.2026.101546_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s13346-021-01045-x","article-title":"Recent advances in porous microneedles: materials, fabrication, and transdermal applications","volume":"12","author":"Bao","year":"2022","journal-title":"Drug Deliv Transl Res"},{"issue":"4","key":"10.1016\/j.dmpk.2026.101546_bib8","first-page":"1","article-title":"Fabrication of a polyglycolic acid porous microneedle array patch using the nonsolvent induced phase separation method for body fluid extraction","volume":"6","author":"Jing","year":"2024","journal-title":"Nano Select"},{"issue":"16","key":"10.1016\/j.dmpk.2026.101546_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612976","article-title":"Biodegradable polymer-based drug-delivery systems for ocular diseases","volume":"24","author":"Tsung","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.dmpk.2026.101546_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/pharmaceutics9040043","article-title":"Revolutionizing therapeutic drug monitoring with the use of interstitial fluid and microneedles technology","volume":"9","author":"Kiang","year":"2017","journal-title":"Pharmaceutics"},{"issue":"49","key":"10.1016\/j.dmpk.2026.101546_bib11","first-page":"56760","article-title":"Wearable sensor patch with hydrogel microneedles for in situ analysis of interstitial fluid","volume":"15","author":"Dai","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"issue":"12","key":"10.1016\/j.dmpk.2026.101546_bib12","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1002\/jps.23309","article-title":"Therapeutic drug monitoring in interstitial fluid: a feasibility study using a comprehensive panel of drugs","volume":"101","author":"Kiang","year":"2012","journal-title":"J Pharm Sci"},{"issue":"4","key":"10.1016\/j.dmpk.2026.101546_bib13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7150\/ijms.13601","article-title":"Therapeutic drug monitoring of vancomycin in dermal interstitial fluid using dissolving microneedles","volume":"13","author":"Ito","year":"2016","journal-title":"Int J Med Sci"},{"issue":"41","key":"10.1016\/j.dmpk.2026.101546_bib14","article-title":"Integrated electrochemical aptamer biosensing and colorimetric pH monitoring via hydrogel microneedle assays for assessing antibiotic treatment","volume":"11","author":"Keyvani","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"571","key":"10.1016\/j.dmpk.2026.101546_bib15","doi-asserted-by":"crossref","first-page":"eaaw0285","DOI":"10.1126\/scitranslmed.aaw0285","article-title":"Sampling interstitial fluid from human skin using a microneedle patch","volume":"12","author":"Samant","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.dmpk.2026.101546_bib16","series-title":"Encyclopedia of polymer science and technology","article-title":"Solubility of polymers","author":"Eckelt","year":"2011"},{"key":"10.1016\/j.dmpk.2026.101546_bib17","article-title":"Flexible, integrated-porous microneedle sensor for biofluid sampling and on-site biomarker detection","volume":"8","author":"Deng","year":"2025","journal-title":"Adv Mater Technol"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2005.02.002","article-title":"Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery","volume":"104","author":"Park","year":"2005","journal-title":"J Contr Release"},{"issue":"2","key":"10.1016\/j.dmpk.2026.101546_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1570-0232(03)00068-0","article-title":"Highly sensitive quantification of vancomycin in plasma samples using liquid chromatography-tandem mass spectrometry and oral bioavailability in rats","volume":"789","author":"Shibata","year":"2003","journal-title":"J Chromatogr, B: Anal Technol Biomed Life Sci"},{"issue":"2","key":"10.1016\/j.dmpk.2026.101546_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jchromb.2007.07.041","article-title":"Determination of vancomycin in serum by liquid chromatography-high resolution full scan mass spectrometry","volume":"857","author":"Zhang","year":"2007","journal-title":"J Chromatogr, B: Anal Technol Biomed Life Sci"},{"issue":"12","key":"10.1016\/j.dmpk.2026.101546_bib21","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3390\/pharmaceutics13121992","article-title":"Compartmentalized polymeric nanoparticles deliver vancomycin in a pH-Responsive manner","volume":"13","author":"Ural","year":"2021","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.dmpk.2026.101546_bib22","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.xphs.2020.09.045","article-title":"Comparison of in vivo transportability of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents into intracellular and extracellular tissue spaces in rats","volume":"110","author":"Kobuchi","year":"2021","journal-title":"J Pharm Sci"},{"issue":"6","key":"10.1016\/j.dmpk.2026.101546_bib23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/AAC.20.6.718","article-title":"Comparison of vancomycin disposition in rats with normal and abnormal renal functions","volume":"20","author":"Engineer","year":"1981","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"10.1016\/j.dmpk.2026.101546_bib24","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/jn\/129.8.1593","article-title":"Energy intake and utilization vary during development in rats","volume":"129","author":"Iossa","year":"1999","journal-title":"J Nutr"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s10544-019-0363-3","article-title":"Monitoring drug pharmacokinetics and immunologic biomarkers in dermal interstitial fluid using a microneedle patch","volume":"21","author":"Kolluru","year":"2019","journal-title":"Biomed Microdevices"},{"key":"10.1016\/j.dmpk.2026.101546_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41232-017-0042-9","article-title":"Regulation of blood vascular permeability in the skin","volume":"37","author":"Ono","year":"2017","journal-title":"Inflamm Regen"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib27","doi-asserted-by":"crossref","DOI":"10.5812\/ijpr-160885","article-title":"Vancomycin insights: an update on mechanism, activity, toxicity, resistance, and novel drug delivery systems","volume":"24","author":"Tabarzad","year":"2025","journal-title":"Iran J Pharm Res"},{"issue":"4","key":"10.1016\/j.dmpk.2026.101546_bib28","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1748-1716.1981.tb06768.x","article-title":"Regional differences in skin blood flow as measured by radioactive microspheres","volume":"111","author":"Lundberg","year":"1981","journal-title":"Acta Physiol Scand"},{"issue":"7","key":"10.1016\/j.dmpk.2026.101546_bib29","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.3390\/s26072233","article-title":"Seconds-resolved measurements of vancomycin transport from the plasma to the interstitial fluid highlight a path towards real-time therapeutic drug monitoring","volume":"26","author":"Gerson","year":"2026","journal-title":"Sensors (Basel)"},{"issue":"3","key":"10.1016\/j.dmpk.2026.101546_bib30","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1748-1716.1973.tb05464.x","article-title":"Protein concentration of interstitial fluid collected from rat skin by a wick method","volume":"88","author":"Aukland","year":"1973","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.dmpk.2026.101546_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114171","article-title":"Pharmacokinetics and pharmacodynamics of peptide antibiotics","volume":"183","author":"Bian","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11095-010-0122-x","article-title":"Formation and closure of microchannels in skin following microporation","volume":"28","author":"Kalluri","year":"2011","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.dmpk.2026.101546_bib33","article-title":"Enhanced extraction of skin interstitial fluid using a 3D printed device enabling tilted microneedle penetration","volume":"11","author":"Kim","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.dmpk.2026.101546_bib34","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ejpb.2017.04.029","article-title":"Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo","volume":"117","author":"Vicente-Perez","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"10.1016\/j.dmpk.2026.101546_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijantimicag.2018.09.021","article-title":"Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically ill patients with sepsis","volume":"53","author":"Abraham","year":"2019","journal-title":"Int J Antimicrob Agents"}],"container-title":["Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436726000327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1347436726000327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:55:16Z","timestamp":1789466116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347436726000327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S1347436726000327"],"URL":"https:\/\/doi.org\/10.1016\/j.dmpk.2026.101546","relation":{},"ISSN":["1347-4367"],"issn-type":[{"value":"1347-4367","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a method for vancomycin monitoring in interstitial fluid using a novel porous microneedle array patch","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Pharmacokinetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dmpk.2026.101546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101546"}}