{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:07:39Z","timestamp":1790978859666,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.dnarep.2005.10.009","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T08:37:01Z","timestamp":1133944621000},"page":"324-335","source":"Crossref","is-referenced-by-count":49,"title":["Closely opposed apurinic\/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage"],"prefix":"10.1016","volume":"5","author":[{"given":"Lynn","family":"Harrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Brame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Geltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April M.","family":"Landry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2005.10.009_bib1","first-page":"573","article-title":"Radiation induced DNA damage and its repair","volume":"51","author":"Teoule","year":"1987","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/09553009414550021","article-title":"Initial events in the cellular effects of ionizing radiations: clustered damage in DNA","volume":"61","author":"Goodhead","year":"1994","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2307\/3579145","article-title":"Radiation mutagenesis: the initial DNA lesions responsible","volume":"142","author":"Ward","year":"1995","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2307\/3579782","article-title":"Tandem lesions and other products in X-irradiated DNA oligomers","volume":"149","author":"Box","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib5","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1021\/ja994282i","article-title":"Tandem base lesions are generated by hydroxyl radical within isolated DNA in aerated aqueous solution","volume":"122","author":"Bourdat","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.dnarep.2005.10.009_bib6","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1021\/bi9927989","article-title":"Clustered damages and total lesions induced in DNA by ionizing radiation: oxidized bases and strand breaks","volume":"39","author":"Sutherland","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.dnarep.2005.10.009_bib7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1667\/0033-7587(2002)157[0611:CDDIBX]2.0.CO;2","article-title":"Clustered DNA damages induced by X-rays in human cells","volume":"157","author":"Sutherland","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/oxfordjournals.rpd.a006634","article-title":"Base excision repair processing of radiation-induced clustered DNA lesions","volume":"97","author":"Blaisdell","year":"2001","journal-title":"Radiat. Protection Dosimetry"},{"key":"10.1016\/j.dnarep.2005.10.009_bib9","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1667\/0033-7587(2001)156[0584:ROBERE]2.0.CO;2","article-title":"Response of base excision repair enzymes to complex DNA lesions","volume":"156","author":"Weinfeld","year":"2001","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0928-4680(01)00079-7","article-title":"Can DNA repair cause enhanced cell killing following treatment with ionizing radiation?","volume":"8","author":"Harrison","year":"2002","journal-title":"Pathophysiology"},{"key":"10.1016\/j.dnarep.2005.10.009_bib11","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1093\/nar\/gkg493","article-title":"Repair of clustered uracil DNA damages in Escherichia coli","volume":"31","author":"D'souza","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib12","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1093\/nar\/gkh911","article-title":"Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli","volume":"32","author":"Malyarchuk","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S1568-7864(03)00040-5","article-title":"The mutation frequency of 8-oxo-7,8 dihydroguanine (8-oxodG) situated in a multiply damaged site: comparison of a single and two closely opposed 8-oxodG in Escherichia coli","volume":"2","author":"Malyarchuk","year":"2003","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2005.10.009_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/nar\/gkh150","article-title":"Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site","volume":"32","author":"Pearson","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/BF00261686","article-title":"Repair of uracil residues closely spaced on the opposite strand of plasmid DNA results in double-strand break and deletion formation","volume":"225","author":"Dianov","year":"1991","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.dnarep.2005.10.009_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0921-8777(97)00008-6","article-title":"DNA glycosylases","volume":"383","author":"Cunningham","year":"1997","journal-title":"Mutation Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib17","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1016\/S0021-9258(17)34002-4","article-title":"Purification and characterization of a novel deoxyinosine-specific enzyme, deoxyinosine 3\u2032 endonuclease, from Escherichia coli","volume":"269","author":"Yao","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2005.10.009_bib18","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1021\/bi00446a002","article-title":"A new mechanism for repairing oxidative DNA damage to DNA: (A)BC exonuclease removes AP sites and thymine glycols from DNA","volume":"28","author":"Lin","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.dnarep.2005.10.009_bib19","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1021\/bi00483a013","article-title":"Damage repertoire of the Escherichia coli UvrABC nuclease complex includes abasic sites, base-damage analogues, and lesions containing adjacent 5\u2032 or 3\u2032 nicks","volume":"29","author":"Snowden","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.dnarep.2005.10.009_bib20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/JB.164.2.689-695.1985","article-title":"Isolation of insertion, deletion, and nonsense mutations of the uracil-DNA glycosylase (ung) gene of Escherichia coli K-12","volume":"164","author":"Duncan","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib21","series-title":"Introduction of Plasmid DNA into Cells, in Current Protocols in Molecular Biology, vol. 1","author":"Seidman","year":"1997"},{"key":"10.1016\/j.dnarep.2005.10.009_bib22","series-title":"Molecular Cloning a Laboratory Manual","author":"Sambrook","year":"2001"},{"key":"10.1016\/j.dnarep.2005.10.009_bib23","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1128\/jb.171.5.2542-2546.1989","article-title":"Role of exonuclease III and endonuclease IV in repair of pyrimidine dimers initiated by bacteriophage T4 pyrimidine-DNA glycosylase","volume":"171","author":"Saporito","year":"1989","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1128\/jb.168.3.1120-1127.1986","article-title":"Endonuclease IV (nfo) mutant of Escherichia coli","volume":"168","author":"Cunningham","year":"1986","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib25","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1016\/S0021-9258(18)61093-2","article-title":"Oligodeoxynucleotides containing synthetic abasic sites: model substrates for DNA polymerases and apurinic\/apyrimidinic endonucleases","volume":"262","author":"Takeshita","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2005.10.009_bib26","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1073\/pnas.90.14.6601","article-title":"Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerases","volume":"90","author":"Zhou","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2005.10.009_bib27","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1093\/nar\/22.10.1897","article-title":"Mechanism of mutation on DNA templates containing abasic sites: study with a double strand vector","volume":"22","author":"Takeshita","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib28","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1093\/emboj\/21.11.2833","article-title":"Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1\/Rad10 in Saccharomyces cerevisiae","volume":"21","author":"Guillet","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2005.10.009_bib29","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1073\/pnas.83.20.7731","article-title":"Exonuclease III and endonuclease IV remove 3\u2032 blocks from DNA synthesis primers in H2O2-damaged Escherichia coli","volume":"83","author":"Demple","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2005.10.009_bib30","doi-asserted-by":"crossref","first-page":"8066","DOI":"10.1016\/S0021-9258(18)68442-X","article-title":"Homogeneous Escherichia coli endonuclease IV characterization of an enzyme that recognizes oxidative damage in DNA","volume":"263","author":"Levin","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2005.10.009_bib31","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1073\/pnas.77.8.4602","article-title":"Apurinic\/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA","volume":"77","author":"Warner","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2005.10.009_bib32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0021-9258(19)68402-4","article-title":"Characterization of the action of Escherichia coli DNA polymerase I at incisions produced by repair endodeoxyribonucleases","volume":"257","author":"Mosbaugh","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2005.10.009_bib33","doi-asserted-by":"crossref","first-page":"11865","DOI":"10.1074\/jbc.275.16.11865","article-title":"Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins","volume":"275","author":"David-Cordonnier","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2005.10.009_bib34","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/nar\/26.4.932","article-title":"Multiply damaged sites in DNA: interactions with Escherichia coli endonuclease III and VIII","volume":"26","author":"Harrison","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib35","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1006\/jmbi.1995.0348","article-title":"The action of Escherichia coli endonuclease III on multiply damaged sites in DNA","volume":"249","author":"Chaudhry","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.biochem.68.1.255","article-title":"Initiation of base excision repair: Glycosylase mechanisms and structures","volume":"68","author":"McCullough","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.dnarep.2005.10.009_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/jmbi.2001.4587","article-title":"NMR characterization of clustered bistrand abasic site lesions: effect of orientation on their solution structure","volume":"308","author":"Lin","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib38","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1021\/bi00173a024","article-title":"Electrophoretic evidence that single-stranded regions of one or more nucleotides dramatically increase the flexibility of DNA","volume":"33","author":"Mills","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.dnarep.2005.10.009_bib39","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1006\/jmbi.1994.1057","article-title":"Conformational analysis of a 139 base-pair DNA fragment containing a single strand break and its interaction with human poly(ADP-ribose) polymerase","volume":"235","author":"Le Cam","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib40","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1073\/pnas.85.4.1043","article-title":"Illegitimate recombination induced by benzo[a]pyrene diol epoxide in Escherichia coli","volume":"85","author":"Kokontis","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2005.10.009_bib41","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1139\/m82-064","article-title":"Recombination-deficient mutations and thymineless death in Escherichia coli K12: reciprocal effects of recBC and recF and indifference of recA mutations","volume":"28","author":"Nakayama","year":"1982","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.micro.52.1.591","article-title":"Thymine metabolism and thymineless death in prokaryotes and eukaryotes","volume":"52","author":"Ahmad","year":"1998","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib43","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/jb.172.8.4719-4720.1990","article-title":"Escherichia coli strains with multiple DNA repair defects are hyperinduced for the SOS response","volume":"172","author":"Foster","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.dnarep.2005.10.009_bib44","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1093\/nar\/gkh873","article-title":"A comprehensive comparison of DNA replication past 2-deoxyribose and its tetrahydrofuran analog in Escherichia coli","volume":"32","author":"Kroeger","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2005.10.009_bib45","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1021\/bi00410a049","article-title":"Effect of apurinic\/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: specific formation of closely opposed lesions in complementary strands","volume":"27","author":"Povirk","year":"1988","journal-title":"Biochemistry"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786405002879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786405002879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T22:39:35Z","timestamp":1626820775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786405002879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1568786405002879"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2005.10.009","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}