{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:06:26Z","timestamp":1761894386898},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.dnarep.2006.05.041","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:52:19Z","timestamp":1157730739000},"page":"1327-1336","source":"Crossref","is-referenced-by-count":19,"title":["Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells"],"prefix":"10.1016","volume":"5","author":[{"given":"Rodney E.","family":"Shackelford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan P.","family":"Manuszak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torrie C.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian P.","family":"Sequeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Lowery-Nordberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2006.05.041_bib1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.dnarep.2004.04.010","article-title":"Ataxia-telangiectasia, an evolving phenotype","volume":"3","author":"Chun","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2006.05.041_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2006.05.041_bib3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.dnarep.2004.12.008","article-title":"Harmonizing the response to DSBs: a new string in the ATM bow","volume":"12","author":"Lobrich","year":"2005","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2006.05.041_bib4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/15230860260196254","article-title":"Elevated oxidative stress in patients with ataxia telangiectasia","volume":"4","author":"Reichenbach","year":"2002","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.dnarep.2006.05.041_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/09553008714551461","article-title":"Some aspects of glutathione metabolism in ataxia-telangiectasia fibroblasts","volume":"52","author":"Dean","year":"1987","journal-title":"Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med."},{"key":"10.1016\/j.dnarep.2006.05.041_bib6","doi-asserted-by":"crossref","first-page":"21951","DOI":"10.1074\/jbc.M011303200","article-title":"The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts","volume":"276","author":"Shackelford","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2006.05.041_bib7","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2006.05.041_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.onc.1204111","article-title":"Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid","volume":"20","author":"Gatei","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2006.05.041_bib9","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1073\/pnas.1332809100","article-title":"Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase\/catalase mimetics","volume":"100","author":"Liu","year":"2003","journal-title":"Proc Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2006.05.041_bib10","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1158\/0008-5472.CAN-04-0442","article-title":"Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice","volume":"64","author":"Reliene","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2006.05.041_bib11","doi-asserted-by":"crossref","first-page":"11453","DOI":"10.1523\/JNEUROSCI.23-36-11453.2003","article-title":"Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice","volume":"23","author":"Chen","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.dnarep.2006.05.041_bib12","doi-asserted-by":"crossref","first-page":"34277","DOI":"10.1074\/jbc.274.48.34277","article-title":"Localization of a portion of extranuclear ATM to peroxisomes","volume":"274","author":"Watters","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2006.05.041_bib13","first-page":"4576","article-title":"Impaired glutathione biosynthesis in cultured human ataxia-telangiectasia cells","volume":"47","author":"Meredith","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2006.05.041_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1667\/RR3047","article-title":"ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation","volume":"160","author":"Heinloth","year":"2003","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2006.05.041_bib15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1089\/ars.2005.7.940","article-title":"Cellular and molecular targets of protein S-glutathiolation","volume":"7\u20138","author":"Shackelford","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.dnarep.2006.05.041_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0891-5849(01)00608-6","article-title":"Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage","volume":"31","author":"Barbouti","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2006.05.041_bib17","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1568-7864(03)00090-9","article-title":"Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells","volume":"2","author":"Shackelford","year":"2003","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2006.05.041_bib18","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dnarep.2004.01.015","article-title":"Iron chelators increase the resistance of Ataxia telangiectasia cells to oxidative stress","volume":"3","author":"Shackelford","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2006.05.041_bib19","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.biocel.2004.02.007","article-title":"Transferrin receptor 1","volume":"36","author":"Aisen","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.dnarep.2006.05.041_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.onc.1201319","article-title":"Recombinant ATM protein complements the cellular A-T phenotype","volume":"15","author":"Ziv","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2006.05.041_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.semcancer.2004.04.009","article-title":"In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia","volume":"14","author":"Shiloh","year":"2004","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.dnarep.2006.05.041_bib22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0005-2760(96)00122-1","article-title":"Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes","volume":"1304","author":"Guo","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.dnarep.2006.05.041_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1179\/135100001101536472","article-title":"Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis","volume":"6","author":"Persson","year":"2001","journal-title":"Redox Rep."},{"key":"10.1016\/j.dnarep.2006.05.041_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0891-5849(96)00269-9","article-title":"Neuroprotection by the metabolic antioxidant alpha-lipoic acid","volume":"22","author":"Packer","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2006.05.041_bib25","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0891-5849(02)01137-1","article-title":"Uptake and metabolism of epicatechin and its access to the brain after oral ingestion","volume":"33","author":"El Abd Mohsen","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2006.05.041_bib26","doi-asserted-by":"crossref","first-page":"29194","DOI":"10.1074\/jbc.M500984200","article-title":"Superoxide dismutase\/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease","volume":"280","author":"Peng","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2006.05.041_bib27","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.freeradbiomed.2004.01.003","article-title":"Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice","volume":"36","author":"Browne","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2006.05.041_bib28","doi-asserted-by":"crossref","first-page":"19738","DOI":"10.1074\/jbc.M100245200","article-title":"Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts","volume":"276","author":"Caltagirone","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2006.05.041_bib29","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1182\/blood-2003-07-2440","article-title":"A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients","volume":"103","author":"Moura","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.dnarep.2006.05.041_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2006.05.041_bib31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1620\/tjem.205.297","article-title":"Acquisition, mobilization and utilization of cellular iron and heme: endless findings and growing evidence of tight regulation","volume":"205","author":"Taketani","year":"2005","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.dnarep.2006.05.041_bib32","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1073\/pnas.98.4.1676","article-title":"ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response","volume":"98","author":"Peretz","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2006.05.041_bib33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/labinvest.3700235","article-title":"Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma","volume":"85","author":"Liu","year":"2005","journal-title":"Lab Invest."},{"key":"10.1016\/j.dnarep.2006.05.041_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/bj3560061","article-title":"Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells","volume":"356","author":"Petrat","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.dnarep.2006.05.041_bib35","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1039\/b512440a","article-title":"An, Strong red fluorescent probes suitable for detecting hydrogen peroxide generated by mice peritoneal macrophages","volume":"48","author":"Xu","year":"2005","journal-title":"Chem. Commun."},{"key":"10.1016\/j.dnarep.2006.05.041_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0955-2863(02)00251-6","article-title":"Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation","volume":"14","author":"Loo","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.dnarep.2006.05.041_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000064748","article-title":"Evaluation of the incidence of sensorineural hearing loss in beta-thalassemia major patients under regular chelation therapy with desferrioxamine","volume":"108","author":"Karimi","year":"2002","journal-title":"Acta Haematol."},{"key":"10.1016\/j.dnarep.2006.05.041_bib38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.mehy.2004.08.029","article-title":"Pharmacological manipulation of ataxia-telangiectasia kinase activity as a treatment for Parkinson's disease","volume":"64","author":"Edwin Shackelford","year":"2005","journal-title":"Med. Hypotheses"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786406001820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786406001820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T22:53:01Z","timestamp":1555800781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786406001820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S1568786406001820"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2006.05.041","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}