{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:21:11Z","timestamp":1789406471532,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.dnarep.2010.09.003","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T04:47:17Z","timestamp":1287118037000},"page":"1200-1208","source":"Crossref","is-referenced-by-count":9,"title":["A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells"],"prefix":"10.1016","volume":"9","author":[{"given":"Valentina","family":"Turinetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Porcedda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Minieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Lantelme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Accomasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Amoroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"De Marchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Delia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Giachino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2010.09.003_bib0005","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.dnarep.2006.05.002","article-title":"Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome","volume":"5","author":"Porcedda","year":"2006","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0010","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/carcin\/23.5.687","article-title":"Sensing and repairing DNA double-strand breaks","volume":"23","author":"Jackson","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0015","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/35056049","article-title":"Chromosomal stability and the DNA double-stranded break connection","volume":"2","author":"van Gent","year":"2001","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0020","first-page":"155","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nature Reviews"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0025","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1139\/O07-135","article-title":"Regulation of the cellular DNA double-strand break response","volume":"85","author":"Cann","year":"2007","journal-title":"Biochemistry and Cell Biology (Biochimie et biologie cellulaire)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0030","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMra0804615","article-title":"DNA damage, aging, and cancer","volume":"361","author":"Hoeijmakers","year":"2009","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0035","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1038\/sj.onc.1207532","article-title":"DNA damage-induced apoptosis","volume":"23","author":"Norbury","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0040","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2007.08.005","article-title":"Living with p53, dying of p53","volume":"130","author":"Aylon","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0045","first-page":"594","article-title":"Live or let die: the cell's response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nature Reviews"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrm2395","article-title":"Transcriptional control of human p53-regulated genes","volume":"9","author":"Riley","year":"2008","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0055","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nature07986","article-title":"Cytoplasmic functions of the tumour suppressor p53","volume":"458","author":"Green","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0060","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1097-2765(03)00050-9","article-title":"p53 has a direct apoptogenic role at the mitochondria","volume":"11","author":"Mihara","year":"2003","journal-title":"Molecular Cell"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0065","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1092734","article-title":"Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis","volume":"303","author":"Chipuk","year":"2004","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ncb1123","article-title":"Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex","volume":"6","author":"Leu","year":"2004","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0075","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","article-title":"Modes of p53 regulation","volume":"137","author":"Kruse","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0080","doi-asserted-by":"crossref","unstructured":"J.C. Marine, G. Lozano, Mdm2-mediated ubiquitylation: p53 and beyond, Cell Death and Differentiation 17 (2010) 93\u2013102.","DOI":"10.1038\/cdd.2009.68"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0085","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.1091362","article-title":"Mono- versus polyubiquitination: differential control of p53 fate by Mdm2","volume":"302","author":"Li","year":"2003","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0090","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrm2514","article-title":"Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer","volume":"9","author":"Lavin","year":"2008","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-4615-0685-0_26","article-title":"Ataxia-telangiectasia","volume":"495","author":"Becker-Catania","year":"2001","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0100","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.genet.31.1.635","article-title":"Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart","volume":"31","author":"Shiloh","year":"1997","journal-title":"Annual Review of Genetics"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0105","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.dnarep.2004.03.004","article-title":"Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks","volume":"3","author":"Digweed","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1091496","article-title":"Direct activation of the ATM protein kinase by the Mre11\/Rad50\/Nbs1 complex","volume":"304","author":"Lee","year":"2004","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0115","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0120","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.4161\/cc.6.19.4758","article-title":"The NBS1-ATM connection revisited","volume":"6","author":"Difilippantonio","year":"2007","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0125","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.dnarep.2004.04.010","article-title":"Ataxia-telangiectasia, an evolving phenotype","volume":"3","author":"Chun","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-0-387-72005-0_6","article-title":"Nijmegen breakage syndrome","volume":"601","author":"Kondratenko","year":"2007","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejso.2005.09.007","article-title":"Hyperthermic isolated limb perfusion (HILP) in malignant melanoma. Experience with 101 patients","volume":"32","author":"Knorr","year":"2006","journal-title":"European Journal of Surgical Oncology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0140","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/pbc.20822","article-title":"Treatment of Wilms tumor relapsing after initial treatment with vincristine and actinomycin D: a report from the National Wilms Tumor Study Group","volume":"48","author":"Green","year":"2007","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jso.20206","article-title":"Favorable outcome of Ewing sarcoma family tumors to multiagent intensive preoperative chemotherapy: a single institution experience","volume":"89","author":"Moschovi","year":"2005","journal-title":"Journal of Surgical Oncology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0150","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.6093249","article-title":"Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II","volume":"226","author":"Tewey","year":"1984","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0155","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcp.1040760202","article-title":"Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species","volume":"76","author":"Perry","year":"1970","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0160","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-5193(87)80003-6","article-title":"Sensitivity of RNA synthesis to actinomycin D inhibition is dependent on the frequency of transcription: a mathematical model","volume":"129","author":"Miller","year":"1987","journal-title":"Journal of Theoretical Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0165","first-page":"251","article-title":"Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways","volume":"5","author":"Sedletska","year":"2005","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0170","first-page":"1","article-title":"DNA topoisomerases as anticancer drug targets: from the laboratory to the clinic","volume":"1","author":"Holden","year":"2001","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2008.12.030","article-title":"The vital link between the ubiquitin-proteasome pathway and DNA repair: impact on cancer therapy","volume":"283","author":"Motegi","year":"2009","journal-title":"Cancer Letters"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0180","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1471-2407-9-281","article-title":"The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status","volume":"9","author":"Turinetto","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0185","first-page":"3307","article-title":"Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells","volume":"8","author":"Khanna","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0190","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1128\/MCB.17.9.5016","article-title":"Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation","volume":"17","author":"Jongmans","year":"1997","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0165-4608(94)90142-2","article-title":"Reduced induction of P53 protein by gamma-irradiation in ataxia telangiectasia cells without constitutional mutations in exons 5,6, 7, and 8 of the p53 gene","volume":"77","author":"Nasrin","year":"1994","journal-title":"Cancer Genetics and Cytogenetics"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0200","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molcel.2004.10.029","article-title":"A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci","volume":"16","author":"Riballo","year":"2004","journal-title":"Molecular Cell"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0205","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3109\/09553000903261263","article-title":"Cellular radiosensitivity: how much better do we understand it?","volume":"85","author":"Jeggo","year":"2009","journal-title":"International Journal of Radiation Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0210","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.4049\/jimmunol.164.7.3455","article-title":"Cutting edge: recombinase-activating gene expression and V(D)J recombination in CD4+CD3low mature T lymphocytes","volume":"164","author":"Lantelme","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0215","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/sj.emboj.7601560","article-title":"Monoubiquitylation promotes mitochondrial p53 translocation","volume":"26","author":"Marchenko","year":"2007","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0220","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1128\/MCB.10.10.5502","article-title":"Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines","volume":"10","author":"Cheng","year":"1990","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0225","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.285.5434.1733","article-title":"A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy","volume":"285","author":"Komarov","year":"1999","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0230","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nchembio809","article-title":"Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation","volume":"2","author":"Strom","year":"2006","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0235","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1093","article-title":"The codon 72 polymorphic variants of p53 have markedly different apoptotic potential","volume":"33","author":"Dumont","year":"2003","journal-title":"Nature Genetics"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0240","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1096\/fj.01-0617fje","article-title":"Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage","volume":"16","author":"Shirangi","year":"2002","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0245","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/1-4020-3764-3_16","article-title":"Atm and cellular response to DNA damage","volume":"570","author":"Lavin","year":"2005","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cancergencyto.2006.07.006","article-title":"Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia","volume":"171","author":"Ripolles","year":"2006","journal-title":"Cancer Genetics and Cytogenetics"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0255","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.1200\/JCO.2007.11.2649","article-title":"Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion","volume":"25","author":"Austen","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0260","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.1815309","article-title":"The combined status of ATM and p53 link tumor development with therapeutic response","volume":"23","author":"Jiang","year":"2009","journal-title":"Genes & Development"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0265","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejcb.2007.09.002","article-title":"Extreme variation in apoptosis capacity amongst lymphoid cells of Nijmegen breakage syndrome patients","volume":"87","author":"Thierfelder","year":"2008","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00001756-200302100-00011","article-title":"NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein","volume":"14","author":"Macleod","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0275","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1523\/JNEUROSCI.21-17-06687.2001","article-title":"Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status","volume":"21","author":"Lee","year":"2001","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0280","doi-asserted-by":"crossref","first-page":"37782","DOI":"10.1074\/jbc.M304049200","article-title":"Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage","volume":"278","author":"Keramaris","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0285","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/cercor\/bhn167","article-title":"Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex","volume":"19","author":"Martin","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0290","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/ncb1562","article-title":"C-terminal modifications regulate MDM2 dissociation and nuclear export of p53","volume":"9","author":"Carter","year":"2007","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0295","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.4161\/cc.6.14.4503","article-title":"The role of ubiquitination in the direct mitochondrial death program of p53","volume":"6","author":"Marchenko","year":"2007","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0300","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/sj.emboj.7600675","article-title":"Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis","volume":"24","author":"Annis","year":"2005","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0305","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.dnarep.2008.06.013","article-title":"NBS1 regulates a novel apoptotic pathway through Bax activation","volume":"7","author":"Iijima","year":"2008","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0310","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1101\/gad.886901","article-title":"ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage","volume":"15","author":"Maya","year":"2001","journal-title":"Genes & Development"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0315","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.4161\/cc.4.9.1981","article-title":"ATM-mediated phosphorylations inhibit Mdmx\/Mdm2 stabilization by HAUSP in favor of p53 activation","volume":"4","author":"Meulmeester","year":"2005","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0320","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/emboj.2009.294","article-title":"ATM activates p53 by regulating MDM2 oligomerization and E3 processivity","volume":"28","author":"Cheng","year":"2009","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0325","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1093\/emboj\/cdf384","article-title":"Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation","volume":"21","author":"Goldberg","year":"2002","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0330","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1073\/pnas.0408595102","article-title":"Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage","volume":"102","author":"Pereg","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0335","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molcel.2005.04.024","article-title":"Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2","volume":"18","author":"Meulmeester","year":"2005","journal-title":"Molecular Cell"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0340","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.1127335","article-title":"ATM, engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage","volume":"313","author":"Dornan","year":"2006","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0345","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/ncb1927","article-title":"Axin determines cell fate by controlling the p53 activation threshold after DNA damage","volume":"11","author":"Li","year":"2009","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.dnarep.2010.09.003_bib0350","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1074\/jbc.M805658200","article-title":"MSL2 promotes Mdm2-independent cytoplasmic localization of p53","volume":"284","author":"Kruse","year":"2009","journal-title":"The Journal of Biological Chemistry"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786410003083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786410003083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T10:23:26Z","timestamp":1559730206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786410003083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S1568786410003083"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2010.09.003","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}