{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:27:15Z","timestamp":1790980035611,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.dnarep.2012.08.006","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T21:00:30Z","timestamp":1349730030000},"page":"864-873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells"],"prefix":"10.1016","volume":"11","author":[{"given":"Z.","family":"Korwek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sewastianik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bielak-Zmijewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mosieniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Alster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Moreno-Villaneuva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Burkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2012.08.006_bib0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1126\/science.2683079","article-title":"Checkpoints: controls that ensure the order of cell cycle events","volume":"246","author":"Hartwell","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0010","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc2440","article-title":"Living on a break: cellular senescence as a DNA-damage response","volume":"8","author":"d\u2019Adda di Fagagna","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0015","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0020","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nrc2523","article-title":"GammaH2AX and cancer","volume":"8","author":"Bonner","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0025","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1083\/jcb.151.7.1381","article-title":"Halazonetis, p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks","volume":"151","author":"Schultz","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrm1276","article-title":"From polyploidy to aneuploidy, genome instability and cancer","volume":"5","author":"Storchova","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0035","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1054\/drup.2001.0213","article-title":"If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells","volume":"4","author":"Roninson","year":"2001","journal-title":"Drug Resist. Updat."},{"issue":"Suppl.","key":"10.1016\/j.dnarep.2012.08.006_bib0040","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1007\/BF00684866","article-title":"Pharmacodynamics and long-term toxicity of etoposide","volume":"34","author":"Kobayashi","year":"1994","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0045","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrc2607","article-title":"Targeting DNA topoisomerase II in cancer chemotherapy","volume":"9","author":"Nitiss","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0050","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.1204117","article-title":"Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide","volume":"333","author":"Wu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/35096590","article-title":"DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates","volume":"413","author":"Mondal","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0060","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1126\/science.1127196","article-title":"A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription","volume":"312","author":"Ju","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0065","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrc2608","article-title":"DNA topoisomerase II and its growing repertoire of biological functions","volume":"9","author":"Nitiss","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2131\/jts.27.191","article-title":"In vitro cytotoxicity assay to screen compounds for apoptosis-inducing potential on lymphocytes and neutrophils","volume":"27","author":"Nagami","year":"2002","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0075","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3109\/09553002.2011.577504","article-title":"Long time persistence of residual 53BP1\/gamma-H2AX foci in human lymphocytes in relationship to apoptosis, chromatin condensation and biological dosimetry","volume":"87","author":"Markova","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"issue":"12","key":"10.1016\/j.dnarep.2012.08.006_bib0080","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1002\/ijc.25953","article-title":"Prolonged expression of the gamma-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment","volume":"129","author":"Bourton","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0085","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1158\/0008-5472.CAN-04-2727","article-title":"Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM","volume":"64","author":"Hickson","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0090","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1472-6750-9-39","article-title":"A modified and automated version of the \u2018Fluorimetric Detection of Alkaline DNA Unwinding\u2019 method to quantify formation and repair of DNA strand breaks","volume":"9","author":"Moreno-Villanueva","year":"2009","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4161\/cc.6.3.3835","article-title":"Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase","volume":"6","author":"Tanaka","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0105","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0047-6374(03)00012-5","article-title":"Proliferation of CD8+ in culture of human T cells derived from peripheral blood of adult donors and cord blood of newborns","volume":"124","author":"Brzezinska","year":"2003","journal-title":"Mech. Ageing Dev."},{"issue":"2","key":"10.1016\/j.dnarep.2012.08.006_bib0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s10495-009-0440-9","article-title":"Cellular responses to etoposide: cell death despite cell cycle arrest and repair of DNA damage","volume":"15","author":"Schonn","year":"2010","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.dnarep.2012.08.006_bib0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.14573\/altex.2011.4.295","article-title":"The automated FADU-assay, a potential high-throughput in vitro method for early screening of DNA breakage","volume":"28","author":"Moreno-Villanueva","year":"2011","journal-title":"Altex"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0120","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/cc.4.2.1486","article-title":"Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis","volume":"4","author":"Halicka","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2184.2006.00364.x","article-title":"ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis","volume":"39","author":"Tanaka","year":"2006","journal-title":"Cell Prolif."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-59745-190-1_11","article-title":"Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs)","volume":"523","author":"Tanaka","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0135","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1016\/j.febslet.2006.07.038","article-title":"Curcumin abolishes apoptosis resistance of calcitriol-differentiated HL-60 cells","volume":"580","author":"Mosieniak","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0140","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molcel.2006.05.023","article-title":"Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3","volume":"23","author":"Lu","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0145","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.dnarep.2006.01.011","article-title":"DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells","volume":"5","author":"Mukherjee","year":"2006","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0150","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/embor.2009.97","article-title":"Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks","volume":"10","author":"Sordet","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.arr.2010.10.002","article-title":"Impact of cellular senescence signature on ageing research","volume":"10","author":"Sikora","year":"2010","journal-title":"Ageing Res. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.dnarep.2012.08.006_bib0160","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1038\/onc.2009.45","article-title":"PUMA, a potent killer with or without p53","volume":"27","author":"Yu","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bcp.2005.09.029","article-title":"Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated","volume":"71","author":"Cowell","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0170","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1158\/1535-7163.MCT-09-0519","article-title":"Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion","volume":"8","author":"Golding","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.dnarep.2012.08.006_bib0175","doi-asserted-by":"crossref","first-page":"e20311","DOI":"10.1371\/journal.pone.0020311","article-title":"Targeting the DNA double strand break repair machinery in prostate cancer","volume":"6","author":"Shaheen","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0185","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1182\/blood-2007-04-085399","article-title":"ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells","volume":"111","author":"Stagni","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0190","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2008.05.017","article-title":"ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin","volume":"31","author":"Goodarzi","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0195","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.1069398","article-title":"Genomic instability in mice lacking histone H2AX","volume":"296","author":"Celeste","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2012.08.006_bib0200","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1568-7864(01)00019-2","article-title":"DNA repair capacity after gamma-irradiation and expression profiles of DNA repair genes in resting and proliferating human peripheral blood lymphocytes","volume":"1","author":"Mayer","year":"2002","journal-title":"DNA Repair (Amst.)"}],"updated-by":[{"DOI":"10.1016\/j.dnarep.2013.09.005","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000}}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786412002029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786412002029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:38:53Z","timestamp":1761597533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786412002029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1568786412002029"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2012.08.006","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2012.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}