{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:18:56Z","timestamp":1791299936692,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH\/NIEHS (Comparative Mouse Genomics Centers Consortium)","award":["1UO1 ES11044"],"award-info":[{"award-number":["1UO1 ES11044"]}]},{"name":"STW","award":["STW-LGC.6935"],"award-info":[{"award-number":["STW-LGC.6935"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.dnarep.2013.08.019","type":"journal-article","created":{"date-parts":[[2013,9,29]],"date-time":"2013-09-29T15:00:27Z","timestamp":1380466827000},"page":"1081-1086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Slow accumulation of mutations in Xpc\u2212\/\u2212 mice upon induction of oxidative stress"],"prefix":"10.1016","volume":"12","author":[{"given":"Joost P.M.","family":"Melis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul V.","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Zwart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen L.A.","family":"Pennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conny T.M.","family":"van Oostrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Luijten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Steeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2013.08.019_bib0005","series-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2006"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0010","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrg2663","article-title":"Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity","volume":"10","author":"Cleaver","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0015","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/carcin\/5.4.511","article-title":"DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum","volume":"5","author":"Kraemer","year":"1984","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0020","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archderm.1987.01660260111026","article-title":"Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases","volume":"123","author":"Kraemer","year":"1987","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1073\/pnas.94.1.11","article-title":"Sunlight and skin cancer: another link revealed","volume":"94","author":"Kraemer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrrev.2003.06.002","article-title":"Functional characterization of global genomic DNA repair and its implications for cancer","volume":"544","author":"Hanawalt","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0035","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1158\/0008-5472.CAN-07-6067","article-title":"Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes","volume":"68","author":"Melis","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0040","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.taap.2012.01.006","article-title":"The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells","volume":"259","author":"Abbasi","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0045","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1038\/sj.emboj.7601277","article-title":"New functions of XPC in the protection of human skin cells from oxidative damage","volume":"25","author":"D\u2019Errico","year":"2006","journal-title":"EMBO J."},{"issue":"22","key":"10.1016\/j.dnarep.2013.08.019_bib0050","doi-asserted-by":"crossref","first-page":"18788","DOI":"10.1074\/jbc.M112.363614","article-title":"The Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis","volume":"287","author":"Han","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0055","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bbrc.2007.06.005","article-title":"Deficient base excision repair of oxidative DNA damage induced by methylene blue plus visible light in xeroderma pigmentosum group C fibroblasts","volume":"359","author":"Kassam","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/toxsci\/kfq113","article-title":"XPC silencing sensitizes glioma cells to arsenic trioxide via increased oxidative damage","volume":"116","author":"Liu","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0065","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1083\/jcb.201205149","article-title":"Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo","volume":"199","author":"Menoni","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0070","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1021\/tx700428m","article-title":"Oxidative DNA damage in XPC-knockout and its wild mice treated with equine estrogen","volume":"21","author":"Okamoto","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0075","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.freeradbiomed.2012.08.593","article-title":"The cross talk between pathways in the repair of 8-oxo-7, 8-dihydroguanine in mouse and human cells","volume":"53","author":"Parlanti","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0080","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.bbabio.2010.12.006","article-title":"XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species","volume":"1807","author":"Rezvani","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1172\/JCI40087","article-title":"XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas","volume":"121","author":"Rezvani","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/emboj\/cdg016","article-title":"Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase","volume":"22","author":"Shimizu","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2010\/805698","article-title":"Stimulation of DNA glycosylase activities by XPC protein complex: roles of protein\u2013protein interactions","volume":"2010","author":"Shimizu","year":"2010","journal-title":"J. Nucleic Acids"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0100","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1074\/jbc.M002259200","article-title":"The oxidative DNA lesion 8,5\u2032-(S)-cyclo-2\u2032-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells","volume":"275","author":"Brooks","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0105","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.neuroscience.2006.10.025","article-title":"The case for 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum","volume":"145","author":"Brooks","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0110","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.dnarep.2008.03.016","article-title":"The 8,5\u2032-cyclopurine-2\u2032-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair","volume":"7","author":"Brooks","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0115","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng1297-431","article-title":"Rapid accumulation of genome rearrangements in liver but not in brain of old mice","volume":"17","author":"Dolle","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0120","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/carcin\/22.7.1099","article-title":"DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice","volume":"22","author":"Wijnhoven","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2013.08.019_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(97)00046-8","article-title":"Characterization of defective nucleotide excision repair in XPC mutant mice","volume":"374","author":"Cheo","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/scbi.1996.0031","article-title":"Xpa knockout mice","volume":"7","author":"de Vries","year":"1996","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/toxsci\/58.2.377","article-title":"Chronic toxicity of di(2-ethylhexyl)phthalate in mice","volume":"58","author":"David","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0140","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/019262302753559524","article-title":"Assessment of carcinogenicity of di(2-ethylhexyl)phthalate in a short-term assay using Xpa\u2212\/\u2212 and Xpa\u2212\/\u2212p53+\/\u2212 mice","volume":"30","author":"Mortensen","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrrev.2011.07.001","article-title":"The role of XPC: implications in cancer and oxidative DNA damage","volume":"728","author":"Melis","year":"2011","journal-title":"Mutat. Res."},{"issue":"18","key":"10.1016\/j.dnarep.2013.08.019_bib0150","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1089\/ars.2012.5036","article-title":"Oxidative DNA damage and nucleotide excision repair","volume":"18","author":"Melis","year":"2012","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1021\/tx950085v","article-title":"Structural origins of bulky oxidative DNA adducts (type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence","volume":"9","author":"Randerath","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0160","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1021\/tx700411g","article-title":"Bulky DNA lesions induced by reactive oxygen species","volume":"21","author":"Wang","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0165","doi-asserted-by":"crossref","first-page":"13200","DOI":"10.1073\/pnas.0503133102","article-title":"Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis","volume":"102","author":"Hollander","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0170","first-page":"4402","article-title":"p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C","volume":"58","author":"Giglia","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0175","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1128\/MCB.00781-08","article-title":"Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC","volume":"28","author":"Bernardes de Jesus","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.dnarep.2013.08.019_bib0180","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.taap.2012.11.004","article-title":"Detection of genotoxic and non-genotoxic carcinogens in Xpc(\u2212\/\u2212)p53(+\/\u2212) mice","volume":"266","author":"Melis","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0185","first-page":"17","article-title":"Lipofuscin as an indicator of oxidative stress and aging","volume":"266","author":"Sohal","year":"1989","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-60761-411-1_13","article-title":"Lipofuscin: detection and quantification by microscopic techniques","volume":"594","author":"Jung","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0195","first-page":"346","article-title":"The role of mitochondria in cholestatic liver injury","volume":"32","author":"Tiao","year":"2009","journal-title":"Chang Gung Med. J."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0200","article-title":"Broad segmental progeroid changes in short-lived Ercc1(-\/Delta7) mice","volume":"1","author":"Dolle","year":"2011","journal-title":"Pathobiol. Aging Age Relat. Dis."},{"key":"10.1016\/j.dnarep.2013.08.019_bib0205","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.dnarep.2005.07.002","article-title":"Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction","volume":"4","author":"Wijnhoven","year":"2005","journal-title":"DNA Repair (Amst)"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786413002322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786413002322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T14:26:03Z","timestamp":1539354363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786413002322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1568786413002322"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2013.08.019","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Slow accumulation of mutations in Xpc\u2212\/\u2212 mice upon induction of oxidative stress","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2013.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}