{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:19:09Z","timestamp":1791418749072,"version":"4.3.3"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.dnarep.2014.04.008","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T12:31:11Z","timestamp":1399725071000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["DNA-PK phosphorylation of RPA32 Ser4\/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe"],"prefix":"10.1016","volume":"21","author":[{"given":"Amanda K.","family":"Ashley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Shrivastav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Amerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Troksa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Glanzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen O.","family":"Opiyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana D.","family":"Dimitrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brock","family":"Sishc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg G.","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8606-7545","authenticated-orcid":false,"given":"Jac A.","family":"Nickoloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2014.04.008_bib0005","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cell.2013.01.006","article-title":"Identification of early replicating fragile sites that contribute to genome instability","volume":"152","author":"Barlow","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0010","series-title":"DNA Repair, Genetic Instability, and Cancer","first-page":"119","article-title":"Mammalian homologous recombination repair and cancer intervention","author":"Shen","year":"2007"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/nar\/gkg919","article-title":"RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult","volume":"32","author":"Bosco","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1073\/pnas.231611798","article-title":"UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, \u03b3-H2AX formation, and Mre11 relocalization","volume":"99","author":"Limoli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0025","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1038\/emboj.2013.211","article-title":"How unfinished business from S-phase affects mitosis and beyond","volume":"32","author":"Mankouri","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mrrev.2009.12.001","article-title":"Dealing with DNA damage: relationships between checkpoint and repair pathways","volume":"704","author":"Warmerdam","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0035","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jmcb\/mjq049","article-title":"More forks on the road to replication stress recovery","volume":"3","author":"Allen","year":"2011","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12013-008-9039-y","article-title":"Mechanisms of dealing with DNA damage-induced replication problems","volume":"53","author":"Budzowska","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0045","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1038\/sj.onc.1210872","article-title":"Activation and regulation of ATM kinase activity in response to DNA double-strand breaks","volume":"26","author":"Lee","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0050","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.dnarep.2007.02.015","article-title":"The ATR pathway: fine-tuning the fork","volume":"6","author":"Paulsen","year":"2007","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.biochem.052308.093131","article-title":"The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway","volume":"79","author":"Lieber","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0060","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/cr.2007.111","article-title":"Regulation of DNA double-strand break repair pathway choice","volume":"18","author":"Shrivastav","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0065","doi-asserted-by":"crossref","first-page":"35910","DOI":"10.1074\/jbc.M704645200","article-title":"Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair","volume":"282","author":"Anantha","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0070","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature03442","article-title":"Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage","volume":"434","author":"Falck","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0075","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4161\/cc.6.4.3886","article-title":"ATM and ATR: components of an integrated circuit","volume":"6","author":"Hurley","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0080","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ncb1337","article-title":"ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks","volume":"8","author":"Jazayeri","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0085","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0090","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.1074\/jbc.M513265200","article-title":"Rapid activation of ATR by ionizing radiation requires ATM and Mre11","volume":"281","author":"Myers","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0095","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1158\/0008-5472.CAN-03-3207","article-title":"ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation","volume":"64","author":"Stiff","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0100","first-page":"8554","article-title":"Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase","volume":"61","author":"Wang","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0105","first-page":"7520","article-title":"ATR-dependent DNA-PKcs phosphorylation in response to UV-induced replication stress Mol","volume":"26","author":"Yajima","year":"2006","journal-title":"Cell. Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0110","doi-asserted-by":"crossref","first-page":"17501","DOI":"10.1074\/jbc.M701770200","article-title":"Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM","volume":"282","author":"Yoo","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0115","doi-asserted-by":"crossref","first-page":"37112","DOI":"10.1074\/jbc.M113.514398","article-title":"DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM)","volume":"288","author":"Zhou","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0120","series-title":"Editor Encyclopedia of Cancer","first-page":"49","article-title":"Recombination: mechanisms and roles in tumorigenesis","author":"Nickoloff","year":"2002"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0125","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrg2593","article-title":"Mechanisms of change in gene copy number","volume":"10","author":"Hastings","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0130","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.dnarep.2006.05.028","article-title":"Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells","volume":"5","author":"Weinstock","year":"2006","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0135","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrm2851","article-title":"Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis","volume":"11","author":"Moynahan","year":"2010","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0140","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nature02253","article-title":"The Bloom's syndrome helicase suppresses crossing over during homologous recombination","volume":"426","author":"Wu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0145","doi-asserted-by":"crossref","first-page":"5166","DOI":"10.1128\/MCB.19.7.5166","article-title":"Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells","volume":"19","author":"Sonoda","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0150","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrfmmm.2006.11.017","article-title":"Molecular mechanisms of sister-chromatid exchange","volume":"616","author":"Wilson","year":"2007","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2009.02.016","article-title":"Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation","volume":"137","author":"Doksani","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0160","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/nar\/gkh265","article-title":"Phosphatidyl inositol 3-kinase-like serine\/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32kDa subunit of replication protein A at threonine 21","volume":"32","author":"Block","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0165","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1093\/nar\/gks849","article-title":"Distinct roles for DNA-PK, ATM, and ATR in RPA phosphorylation and checkpoint activation in response to replication stress","volume":"40","author":"Liu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0170","doi-asserted-by":"crossref","first-page":"39517","DOI":"10.1074\/jbc.M605121200","article-title":"RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint","volume":"281","author":"Olson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0175","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4161\/cc.8.3.7496","article-title":"Mitotic crisis: the unmasking of a novel role for RPA","volume":"8","author":"Anantha","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0180","doi-asserted-by":"crossref","first-page":"23896","DOI":"10.1074\/jbc.272.38.23896","article-title":"Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells","volume":"272","author":"Zernik-Kobak","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0185","doi-asserted-by":"crossref","first-page":"e21424","DOI":"10.1371\/journal.pone.0021424","article-title":"DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange","volume":"6","author":"Liaw","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0190","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1073\/pnas.052545899","article-title":"DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination","volume":"99","author":"Allen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0195","doi-asserted-by":"crossref","first-page":"9025","DOI":"10.1038\/sj.onc.1207982","article-title":"The interaction of p53 with replication protein A mediates suppression of homologous recombination","volume":"23","author":"Romanova","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0200","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/onc.2012.257","article-title":"DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair","volume":"32","author":"Serrano","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0205","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1242\/jcs.004580","article-title":"NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse","volume":"120","author":"Manthey","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0210","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.dnarep.2009.05.006","article-title":"DNA-PKcs and ATM co-regulate DNA double-strand break repair","volume":"8","author":"Shrivastav","year":"2009","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0215","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1093\/nar\/gkq339","article-title":"Metnase promotes restart and repair of stalled and collapsed replication forks","volume":"38","author":"De Haro","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0220","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1038\/onc.2008.276","article-title":"DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals","volume":"27","author":"Hagelstrom","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0225","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/emboj\/18.5.1397","article-title":"Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes","volume":"18","author":"Shao","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0230","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2741\/3652","article-title":"Replication protein A: directing traffic at the intersection of replication and repair","volume":"15","author":"Oakley","year":"2010","journal-title":"Front. Biosci."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0235","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0921-8777(00)00052-5","article-title":"Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells","volume":"461","author":"Arnaudeau","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0240","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1006\/jmbi.2001.4564","article-title":"DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells","volume":"307","author":"Arnaudeau","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0245","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1158\/0008-5472.CAN-04-3451","article-title":"Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM","volume":"65","author":"Peng","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0250","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1128\/MCB.22.16.5869-5878.2002","article-title":"Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells","volume":"22","author":"Lundin","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0255","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1091\/mbc.12.5.1199","article-title":"UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein","volume":"12","author":"Oakley","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0260","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.dnarep.2007.12.012","article-title":"Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase \u03b7-deficient human cells treated with cisplatin and oxaliplatin","volume":"7","author":"Cruet-Hennequart","year":"2008","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0265","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/BJ20050379","article-title":"Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage","volume":"391","author":"Wu","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0270","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1242\/jcs.053702","article-title":"Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress","volume":"122","author":"Vassin","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0275","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb1145","article-title":"ATR and ATM regulate the timing of DNA replication origin firing","volume":"6","author":"Shechter","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0280","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4161\/cc.4.2.1466","article-title":"ATM and ATR check in on origins: a dynamic model for origin selection and activation","volume":"4","author":"Shechter","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0285","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1101\/gad.1067403","article-title":"Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance","volume":"17","author":"Brown","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0290","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1128\/MCB.25.9.3553-3562.2005","article-title":"Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage","volume":"25","author":"Syljuasen","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0295","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1158\/0008-5472.CAN-03-2384","article-title":"A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity","volume":"64","author":"Kuhne","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0300","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/emboj\/19.3.463","article-title":"The controlling role of ATM in homologous recombinational repair of DNA damage","volume":"19","author":"Morrison","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0305","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1074\/jbc.271.8.4497","article-title":"High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines","volume":"271","author":"Luo","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2014.04.008_bib0310","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.molcel.2004.12.007","article-title":"Control of sister chromatid recombination by histone H2AX","volume":"16","author":"Xie","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0315","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/carcin\/bgq035","article-title":"The role of RPA2 phosphorylation in homologous recombination in response to replication arrest","volume":"31","author":"Shi","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2014.04.008_bib0320","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786414001219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786414001219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T02:59:29Z","timestamp":1538621969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786414001219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":64,"alternative-id":["S1568786414001219"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2014.04.008","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA-PK phosphorylation of RPA32 Ser4\/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2014.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}