{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:04:10Z","timestamp":1790834650804,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.dnarep.2016.05.020","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T18:17:08Z","timestamp":1463422628000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["ATR-mediated regulation of nuclear and cellular plasticity"],"prefix":"10.1016","volume":"44","author":[{"given":"Gururaj Rao","family":"Kidiyoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Foiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.dnarep.2016.05.020_bib0005","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.93.7.2850","article-title":"cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein","volume":"93","author":"Cimprich","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0010","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0959-437X(97)80125-6","article-title":"Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family","volume":"7","author":"Hoekstra","year":"1997","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"23","key":"10.1016\/j.dnarep.2016.05.020_bib0015","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1002\/j.1460-2075.1996.tb01054.x","article-title":"The Schizosaccharomyces pombe rad3 checkpoint gene","volume":"15","author":"Bentley","year":"1996","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.dnarep.2016.05.020_bib0020","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/gad.14.4.397","article-title":"ATR disruption leads to chromosomal fragmentation and early embryonic lethality","volume":"14","author":"Brown","year":"2000","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.dnarep.2016.05.020_bib0030","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0960-9822(00)00447-4","article-title":"Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice","volume":"10","author":"de Klein","year":"2000","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0035","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/ng1129","article-title":"A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome","volume":"33","author":"O'Driscoll","year":"2003","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/(SICI)1096-8628(19970516)70:2<155::AID-AJMG10>3.0.CO;2-I","article-title":"Central nervous system anomalies in Seckel syndrome: report of a new family and review of the literature","volume":"70","author":"Shanske","year":"1997","journal-title":"Am. J. Med. Genet."},{"issue":"53","key":"10.1016\/j.dnarep.2016.05.020_bib0045","doi-asserted-by":"crossref","first-page":"37538","DOI":"10.1074\/jbc.274.53.37538","article-title":"Substrate specificities and identification of putative substrates of ATM kinase family members","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0050","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3390\/membranes5040553","article-title":"Regulation of the target of rapamycin and other phosphatidylinositol 3-kinase-related kinases by membrane targeting","volume":"5","author":"De Cicco","year":"2015","journal-title":"Membranes (Basel)"},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molcel.2015.08.008","article-title":"ATR plays a direct antiapoptotic role at mitochondria: which is regulated by prolyl isomerase pin1","volume":"60","author":"Hilton","year":"2015","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0060","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2014.05.046","article-title":"ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress","volume":"158","author":"Kumar","year":"2014","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.dnarep.2016.05.020_bib0065","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1242\/jcs.169730","article-title":"ATM and ATR signaling at a glance","volume":"128","author":"Awasthi","year":"2015","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrm2852","article-title":"Maintaining genome stability at the replication fork","volume":"11","author":"Branzei","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress","volume":"16","author":"Zeman","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jmb.2007.07.068","article-title":"RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells","volume":"373","author":"Sleeth","year":"2007","journal-title":"J. Mol. Biol."},{"issue":"32","key":"10.1016\/j.dnarep.2016.05.020_bib0085","doi-asserted-by":"crossref","first-page":"34010","DOI":"10.1074\/jbc.C400242200","article-title":"DNA replication defects: spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells","volume":"279","author":"Dodson","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0090","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/BJ20102162","article-title":"ATR signalling: more than meeting at the fork","volume":"436","author":"Nam","year":"2011","journal-title":"Biochem. J."},{"issue":"5547","key":"10.1016\/j.dnarep.2016.05.020_bib0095","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1065521","article-title":"ATR and ATRIP: partners in checkpoint signaling","volume":"294","author":"Cortez","year":"2001","journal-title":"Science"},{"issue":"5625","key":"10.1016\/j.dnarep.2016.05.020_bib0100","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.dnarep.2016.05.020_bib0105","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/sj.onc.1207199","article-title":"Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing","volume":"23","author":"Lucca","year":"2004","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.dnarep.2016.05.020_bib0110","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2005.12.041","article-title":"TopBP1 activates the ATR-ATRIP complex","volume":"124","author":"Kumagai","year":"2006","journal-title":"Cell"},{"issue":"5828","key":"10.1016\/j.dnarep.2016.05.020_bib0115","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.molcel.2013.11.002","article-title":"PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry","volume":"53","author":"Marechal","year":"2014","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0125","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1074\/jbc.M115.691170","article-title":"The SUMO (Small Ubiquitin-like Modifier) ligase PIAS3 primes ATR for checkpoint activation","volume":"291","author":"Wu","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.dnarep.2016.05.020_bib0130","doi-asserted-by":"crossref","first-page":"31390","DOI":"10.1074\/jbc.M504961200","article-title":"ATRIP oligomerization is required for ATR-dependent checkpoint signaling","volume":"280","author":"Ball","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.dnarep.2016.05.020_bib0135","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1182\/blood-2012-09-456897","article-title":"Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions","volume":"121","author":"Ambrose","year":"2013","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/cge.12453","article-title":"Ataxia telangiectasia: more variation at clinical and cellular levels","volume":"87","author":"Taylor","year":"2015","journal-title":"Clin. Genet."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/jcb.21195","article-title":"Centrosomal localization of DNA damage checkpoint proteins","volume":"101","author":"Zhang","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"24","key":"10.1016\/j.dnarep.2016.05.020_bib0150","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.cub.2009.10.039","article-title":"Cytoplasmic ATM in neurons modulates synaptic function","volume":"19","author":"Li","year":"2009","journal-title":"Curr. Biol."},{"issue":"8","key":"10.1016\/j.dnarep.2016.05.020_bib0155","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/hmg\/dds563","article-title":"ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice","volume":"22","author":"Valdes-Sanchez","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0160","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BJ20101303","article-title":"ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53","volume":"435","author":"Roobol","year":"2011","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.dnarep.2016.05.020_bib0165","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1091\/mbc.e12-12-0881","article-title":"The nucleolus stress response is coupled to an ATR-Chk1-mediated G2 arrest","volume":"24","author":"Ma","year":"2013","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.dnarep.2016.05.020_bib0170","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.dnarep.2009.04.006","article-title":"Common mechanisms of PIKK regulation","volume":"8","author":"Lovejoy","year":"2009","journal-title":"DNA Repair (Amst.)"},{"issue":"20","key":"10.1016\/j.dnarep.2016.05.020_bib0175","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1038\/emboj.2009.281","article-title":"Emerging common themes in regulation of PIKKs and PI3 Ks","volume":"28","author":"Lempiainen","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2016.05.020_bib0180","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev-biochem-060614-034335","article-title":"Mechanisms of ATM activation","volume":"84","author":"Paull","year":"2015","journal-title":"Annu. Rev. Biochem"},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0092-8674(03)00033-3","article-title":"The ATRs, ATMs, and TORs are giant HEAT repeat proteins","volume":"112","author":"Perry","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2016.05.020_bib0190","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.sbi.2014.11.003","article-title":"PIKKs\u2014the solenoid nest where partners and kinases meet","volume":"29","author":"Baretic","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"7277","key":"10.1016\/j.dnarep.2016.05.020_bib0195","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature08648","article-title":"Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats","volume":"463","author":"Sibanda","year":"2010","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0200","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.str.2007.12.014","article-title":"Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding","volume":"16","author":"Williams","year":"2008","journal-title":"Structure"},{"issue":"10","key":"10.1016\/j.dnarep.2016.05.020_bib0205","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1073\/pnas.102167799","article-title":"Preferential binding of ATR protein to UV-damaged DNA","volume":"99","author":"Unsal-Kacmaz","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.dnarep.2016.05.020_bib0210","doi-asserted-by":"crossref","first-page":"e99397","DOI":"10.1371\/journal.pone.0099397","article-title":"Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase","volume":"9","author":"Luzwick","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.dnarep.2016.05.020_bib0215","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1073\/pnas.0914073107","article-title":"PR65, the HEAT-repeat scaffold of phosphatase PP2 A, is an elastic connector that links force and catalysis","volume":"107","author":"Grinthal","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"14","key":"10.1016\/j.dnarep.2016.05.020_bib0220","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1038\/emboj.2008.127","article-title":"Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress","volume":"27","author":"Wu","year":"2008","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.dnarep.2016.05.020_bib0225","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1101\/gad.1666208","article-title":"TopBP1 activates ATR through ATRIP and a PIKK regulatory domain","volume":"22","author":"Mordes","year":"2008","journal-title":"Genes Dev."},{"issue":"27","key":"10.1016\/j.dnarep.2016.05.020_bib0230","doi-asserted-by":"crossref","first-page":"20046","DOI":"10.1074\/jbc.M113.467233","article-title":"NMR- and circular dichroism-monitored lipid binding studies suggest a general role for the FATC domain as membrane anchor of phosphatidylinositol 3-kinase-related kinases (PIKK)","volume":"288","author":"Sommer","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.dnarep.2016.05.020_bib0235","doi-asserted-by":"crossref","first-page":"15741","DOI":"10.1074\/jbc.M513172200","article-title":"The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM","volume":"281","author":"Jiang","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.dnarep.2016.05.020_bib0240","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1534\/g3.113.006841","article-title":"The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization: stability, and function","volume":"3","author":"DaSilva","year":"2013","journal-title":"G3 (Bethesda)"},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0245","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.molcel.2011.06.019","article-title":"ATR autophosphorylation as a molecular switch for checkpoint activation","volume":"43","author":"Liu","year":"2011","journal-title":"Mol. Cell"},{"issue":"33","key":"10.1016\/j.dnarep.2016.05.020_bib0250","doi-asserted-by":"crossref","first-page":"28707","DOI":"10.1074\/jbc.M111.248914","article-title":"Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase","volume":"286","author":"Nam","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0255","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10522-010-9261-z","article-title":"Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428)","volume":"11","author":"Chandris","year":"2010","journal-title":"Biogerontology"},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0260","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ceb.2005.12.004","article-title":"The nuclear envelope: form and reformation","volume":"18","author":"Prunuske","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.dnarep.2016.05.020_bib0265","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-bioeng-071910-124736","article-title":"Nuclear mechanics in disease","volume":"13","author":"Zwerger","year":"2011","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"5","key":"10.1016\/j.dnarep.2016.05.020_bib0270","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.devcel.2009.10.016","article-title":"The nuclear envelope as a signaling node in development and disease","volume":"17","author":"Dauer","year":"2009","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.dnarep.2016.05.020_bib0275","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tcb.2012.05.007","article-title":"Preserving the genome by regulating chromatin association with the nuclear envelope","volume":"22","author":"Bermejo","year":"2012","journal-title":"Trends Cell Biol."},{"issue":"Pt. 10","key":"10.1016\/j.dnarep.2016.05.020_bib0280","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1242\/jcs.037333","article-title":"Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly","volume":"122","author":"Webster","year":"2009","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.dnarep.2016.05.020_bib0285","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1042\/BST20110656","article-title":"Nuclear envelope influences on cell-cycle progression","volume":"39","author":"Srsen","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.dnarep.2016.05.020_bib0290","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/978-1-4899-8032-8_10","article-title":"Nuclear envelope: connecting structural genome organization to regulation of gene expression","volume":"773","author":"Stancheva","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.dnarep.2016.05.020_bib0295","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/978-1-4899-8032-8_1","article-title":"The nuclear envelope and cancer: a diagnostic perspective and historical overview","volume":"773","author":"de Las Heras","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"Pt. A (19)","key":"10.1016\/j.dnarep.2016.05.020_bib0300","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1016\/j.febslet.2015.06.011","article-title":"LINC'ing form and function at the nuclear envelope","volume":"589","author":"Meinke","year":"2015","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0305","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1534\/g3.114.015685","article-title":"Condensins exert force on chromatin-nuclear envelope tethers to mediate nucleoplasmic reticulum formation in Drosophila melanogaster","volume":"5","author":"Bozler","year":"2015","journal-title":"G3 (Bethesda)"},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0310","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cell.2011.06.033","article-title":"The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores","volume":"146","author":"Bermejo","year":"2011","journal-title":"Cell"},{"issue":"Pt. 23","key":"10.1016\/j.dnarep.2016.05.020_bib0315","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1242\/jcs.015834","article-title":"The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR","volume":"120","author":"Zhang","year":"2007","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0320","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bpj.2013.01.006","article-title":"Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes","volume":"104","author":"Irianto","year":"2013","journal-title":"Biophys. J ."},{"issue":"10","key":"10.1016\/j.dnarep.2016.05.020_bib0325","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00018-004-3414-7","article-title":"Metabolism and signaling activities of nuclear lipids","volume":"61","author":"Martelli","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"issue":"28","key":"10.1016\/j.dnarep.2016.05.020_bib0330","doi-asserted-by":"crossref","first-page":"25879","DOI":"10.1074\/jbc.M303948200","article-title":"Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R","volume":"278","author":"Roshal","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"5544","key":"10.1016\/j.dnarep.2016.05.020_bib0335","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1126\/science.1063957","article-title":"Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr","volume":"294","author":"de Noronha","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2016.05.020_bib0340","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1742-4690-4-84","article-title":"Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages","volume":"4","author":"Jacquot","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.dnarep.2016.05.020_bib0345","first-page":"177","article-title":"Vpr and its interactions with cellular proteins","volume":"339","author":"Planelles","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0350","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.molcel.2010.09.024","article-title":"The nucleolus under stress","volume":"40","author":"Boulon","year":"2010","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0355","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/nar\/gkv1312","article-title":"Nucleolar responses to DNA double-strand breaks","volume":"44","author":"Larsen","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0360","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2010.09.026","article-title":"Regulation of the mTOR complex 1 pathway by nutrients: growth factors, and stress","volume":"40","author":"Sengupta","year":"2010","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.dnarep.2016.05.020_bib0365","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1093\/nar\/gkv371","article-title":"High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation","volume":"43","author":"Sokka","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"Pt. 5","key":"10.1016\/j.dnarep.2016.05.020_bib0370","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1242\/jcs.091124","article-title":"Rad9 B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition","volume":"125","author":"Perez-Castro","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.dnarep.2016.05.020_bib0375","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1101\/sqb.2005.70.004","article-title":"p53-Dependent and -independent functions of the Arf tumor suppressor","volume":"70","author":"Sherr","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0380","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1097-2765(03)00223-5","article-title":"p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor","volume":"12","author":"Rocha","year":"2003","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.dnarep.2016.05.020_bib0385","first-page":"1046","article-title":"Arf induces p53-dependent and -independent antiproliferative genes","volume":"63","author":"Kuo","year":"2003","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.dnarep.2016.05.020_bib0390","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/sj.emboj.7600608","article-title":"Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor","volume":"24","author":"Rocha","year":"2005","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0395","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cellsig.2010.09.010","article-title":"ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation","volume":"23","author":"Wei","year":"2011","journal-title":"Cell. Signal."},{"issue":"8","key":"10.1016\/j.dnarep.2016.05.020_bib0400","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/sj.onc.1209148","article-title":"ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function","volume":"25","author":"Wu","year":"2006","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0405","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2009.10.036","article-title":"Centrioles, centrosomes, and cilia in health and disease","volume":"139","author":"Nigg","year":"2009","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.dnarep.2016.05.020_bib0410","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm4062","article-title":"Centrosome function and assembly in animal cells","volume":"16","author":"Conduit","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2016.05.020_bib0415","series-title":"Kobayashi The Potential Roles of DNA-Repair Proteins in Centrosome Maintenance","author":"Shimada","year":"2011"},{"issue":"5","key":"10.1016\/j.dnarep.2016.05.020_bib0420","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1158\/0008-5472.CAN-08-3016","article-title":"Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR\/BRCA1 pathway","volume":"69","author":"Shimada","year":"2009","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0425","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ng.2007.80","article-title":"Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling","volume":"40","author":"Griffith","year":"2008","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.dnarep.2016.05.020_bib0430","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.200810159","article-title":"Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1","volume":"185","author":"Tibelius","year":"2009","journal-title":"J. Cell Biol."},{"issue":"5864","key":"10.1016\/j.dnarep.2016.05.020_bib0435","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1151174","article-title":"Mutations in the pericentrin (PCNT) gene cause primordial dwarfism","volume":"319","author":"Rauch","year":"2008","journal-title":"Science"},{"issue":"19","key":"10.1016\/j.dnarep.2016.05.020_bib0440","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1101\/gad.169037","article-title":"Mechanisms and pathways of growth failure in primordial dwarfism","volume":"25","author":"Klingseisen","year":"2011","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.dnarep.2016.05.020_bib0445","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0960-9822(03)00295-1","article-title":"Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos","volume":"13","author":"Brauchle","year":"2003","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0450","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ng0598-39","article-title":"Duplication of ATR inhibits MyoD: induces aneuploidy and eliminates radiation-induced G1 arrest","volume":"19","author":"Smith","year":"1998","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0455","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1534\/genetics.108.090704","article-title":"Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1","volume":"180","author":"Mori","year":"2008","journal-title":"Genetics"},{"issue":"6","key":"10.1016\/j.dnarep.2016.05.020_bib0460","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.mito.2013.02.004","article-title":"Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance","volume":"13","author":"Suetomi","year":"2013","journal-title":"Mitochondrion"},{"issue":"9","key":"10.1016\/j.dnarep.2016.05.020_bib0465","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/gerona\/gls336","article-title":"Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts","volume":"68","author":"Tivey","year":"2013","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"issue":"4","key":"10.1016\/j.dnarep.2016.05.020_bib0470","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1475-4924-2-27","article-title":"A functional genomic analysis of cell morphology using RNA interference","volume":"2","author":"Kiger","year":"2003","journal-title":"J. Biol."},{"issue":"21","key":"10.1016\/j.dnarep.2016.05.020_bib0475","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.4161\/15384101.2014.956529","article-title":"The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling","volume":"13","author":"Beveridge","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2016.05.020_bib0480","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.mce.2015.04.034","article-title":"A novel role of the checkpoint kinase ATR in leptin signaling","volume":"412","author":"Ericson","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.dnarep.2016.05.020_bib0485","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/humu.22245","article-title":"Primary microcephaly: impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations","volume":"34","author":"Mokrani-Benhelli","year":"2013","journal-title":"Hum. Mutat."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0490","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajmg.a.30786","article-title":"Interstitial deletion in 3q in a patient with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and microcephaly, mild mental retardation and growth delay: clinical report and review of the literature","volume":"137","author":"de Ru","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"issue":"8","key":"10.1016\/j.dnarep.2016.05.020_bib0495","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/ng.420","article-title":"A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging","volume":"41","author":"Murga","year":"2009","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0500","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.stem.2007.03.002","article-title":"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss","volume":"1","author":"Ruzankina","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0505","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2013.12.028","article-title":"Progeria: a paradigm for translational medicine","volume":"156","author":"Gordon","year":"2014","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.dnarep.2016.05.020_bib0510","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/nsmb.2189","article-title":"Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors","volume":"18","author":"Murga","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2016.05.020_bib0515","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ctrv.2013.03.002","article-title":"Targeting ATR in DNA damage response and cancer therapeutics","volume":"40","author":"Fokas","year":"2014","journal-title":"Cancer Treat Rev."},{"issue":"3","key":"10.1016\/j.dnarep.2016.05.020_bib0520","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ajhg.2012.01.007","article-title":"Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome","volume":"90","author":"Tanaka","year":"2012","journal-title":"Am. J. Hum. Genet."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786416301008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786416301008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T05:10:52Z","timestamp":1655961052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786416301008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":104,"alternative-id":["S1568786416301008"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2016.05.020","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATR-mediated regulation of nuclear and cellular plasticity","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2016.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}