{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:08:24Z","timestamp":1768831704623,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.dnarep.2017.08.007","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T10:45:35Z","timestamp":1503571535000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Proximity effects in chromosome aberration induction by low-LET ionizing radiation"],"prefix":"10.1016","volume":"58","author":[{"given":"John James","family":"Tello Cajiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Pietro","family":"Carante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Antonio","family":"Bernal Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ballarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2017.08.007_bib0005","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20130685","article-title":"DNA DSB repair pathway choice: an orchestrated handover mechanism","volume":"87","author":"Kakarougkas","year":"2014","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.semcancer.2016.03.003","article-title":"DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: cell cycle and proliferation-dependent regulation","volume":"37\u201338","author":"Mladenov","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0027-5107(94)90308-5","article-title":"On the scoring of FISH-painted chromosome-type exchange aberrations","volume":"307","author":"Savage","year":"1994","journal-title":"Mutat. Res. \u2013 Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0020","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/3576926","article-title":"A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts","volume":"111","author":"Cornforth","year":"1987","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/372143a0","article-title":"Chromosomal translocations in human cancer","volume":"372","author":"Rabbits","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2017.08.007_bib0030","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/09553000010022382","article-title":"Time-course of translocation and dicentric frequencies in a radiation accident case","volume":"77","author":"Bauchinger","year":"2001","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0035","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1667\/0033-7587(2001)156[0731:CAITBL]2.0.CO;2","article-title":"Chromosome aberrations in the blood lymphocytes of astronauts after space flight","volume":"156","author":"George","year":"2001","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0040","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000076288","article-title":"Chromosome aberration dosimetry in cosmonauts after single or multiple space flights","volume":"103","author":"Durante","year":"2003","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.asr.2005.01.090","article-title":"The FLUKA code: new developments and application to 1GeV\/n Iron beams","volume":"35","author":"Aiginger","year":"2005","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0050","doi-asserted-by":"crossref","DOI":"10.1088\/1367-2630\/10\/7\/075008","article-title":"Heavy-ion effects: from track structure to DNA and chromosome damage","volume":"10","author":"Ballarini","year":"2008","journal-title":"New J. Phys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.actaastro.2012.05.001","article-title":"Cytogenetic biodosimetry using the blood lymphocytes of astronauts","volume":"92","author":"George","year":"2013","journal-title":"Acta Astronaut."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.mrgentox.2013.04.007","article-title":"Cytogenetic damage in the blood lymphocytes of astronauts: effects of repeat long-duration space missions","volume":"756","author":"George","year":"2013","journal-title":"Mutat. Res. \u2013 Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0065","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0360-3016(00)00455-7","article-title":"X-rays vs. carbon-ion tumor therapy: cytogenetic damage in lymphocytes","volume":"47","author":"Durante","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0070","series-title":"Actions of Radiations on Living Cells","author":"Lea","year":"1946"},{"key":"10.1016\/j.dnarep.2017.08.007_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004110050132","article-title":"Modelling radiation-induced biological lesions: from initial energy depositions to chromosome aberrations","volume":"38","author":"Ottolenghi","year":"1999","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0080","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0273-1177(01)00004-7","article-title":"Modelling chromosomal aberration induction by ionising radiation: the influence of interphase chromosome architecture","volume":"27","author":"Ottolenghi","year":"2001","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00411-004-0246-7","article-title":"A model of chromosome aberration induction and chronic myeloid leukaemia incidence at low doses","volume":"43","author":"Ballarini","year":"2004","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1667\/RR3365.1","article-title":"A model of chromosome aberration induction: applications to space research","volume":"164","author":"Ballarini","year":"2005","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0095","doi-asserted-by":"crossref","first-page":"e350608","DOI":"10.4061\/2010\/350608","article-title":"From DNA radiation damage to cell death: theoretical approaches","volume":"2010","author":"Ballarini","year":"2010","journal-title":"J. Nucleic Acids"},{"key":"10.1016\/j.dnarep.2017.08.007_bib0100","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00411-014-0537-6","article-title":"The BIANCA model\/code of radiation-induced cell death: application to human cells exposed to different radiation types","volume":"53","author":"Ballarini","year":"2014","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0105","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00411-015-0601-x","article-title":"Modeling radiation-induced cell death: role of different levels of DNA damage clustering","volume":"54","author":"Carante","year":"2015","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fonc.2016.00076","article-title":"Calculating variations in biological effectiveness for a 62MeV proton beam","volume":"6","author":"Carante","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radphyschem.2016.06.009","article-title":"Chromosome aberrations and cell death by ionizing radiation: evolution of a biophysical model","volume":"128","author":"Ballarini","year":"2016","journal-title":"Radiat. Phys. Chem."},{"issue":"3","key":"10.1016\/j.dnarep.2017.08.007_bib0120","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3934\/biophy.2017.3.465","article-title":"Modelling cell death for cancer hadrontherapy","volume":"4","author":"Carante","year":"2017","journal-title":"AIMS Biophys."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0125","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-1110(96)90031-7","article-title":"Nuclear architecture and the induction of chromosomal aberrations","volume":"366","author":"Cremer","year":"1996","journal-title":"Mutat. Res. \u2013 Rev. Genet. Toxicol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0130","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.2307\/3579722","article-title":"Computer simulation of data on chromosome aberrations produced by X rays or alpha particles and detected by fluorescence in situ hybridization","volume":"148","author":"Chen","year":"1997","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/095530000138790","article-title":"Underprediction of visibly complex chromosome aberrations by a recombinational-repair (\u2019one-hit\u2019) model","volume":"76","author":"Sachs","year":"2000","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0140","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2307\/3579518","article-title":"Intra-arm and interarm chromosome intrachanges: tools for probing the geometry and dynamics of chromatin","volume":"148","author":"Sachs","year":"1997","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0145","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1080\/09553000600979092","article-title":"Analysis of gamma-rays induced chromosome aberrations: a fingerprint evaluation with a combination of pan-centromeric and pan-telomeric probes","volume":"82","author":"Benkhaled","year":"2006","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2307\/3579154","article-title":"Comparison of gamma-ray-induced chromosome ring and inversion frequencies","volume":"143","author":"Muhlmann-Diaz","year":"1995","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0155","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1667\/RR2659.1","article-title":"Computational model of chromosome aberration yield induced by high- and low-LET radiation exposures","volume":"177","author":"Ponomarev","year":"2012","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0160","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2307\/3574835","article-title":"A generalized formulation of dual radiation action a generalized formulation of dual radiation action1","volume":"75","author":"Kellerer","year":"1978","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0165","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1080\/09553000050201064","article-title":"Random breakage and reunion chromosome aberration formation model; an interaction-distance version based on chromatin geometry","volume":"76","author":"Sachs","year":"2000","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0170","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1667\/0033-7587(2002)158[0568:AMFICA]2.0.CO;2","article-title":"A model for interphase chromosomes and evaluation of radiation-Induced aberrations","volume":"158","author":"Holley","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1667\/0033-7587(2002)158[0043:DRFCAP]2.0.CO;2","article-title":"Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose rates","volume":"158","author":"Cornforth","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0180","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1667\/0033-7587(2002)158[0032:SDAYOD]2.0.CO;2","article-title":"Spatial distribution and yield of DNA double-strand breaks induced by 3\u20137MeV helium ions in human fibroblasts","volume":"158","author":"Rydberg","year":"2002","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0185","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1667\/RR1442.1","article-title":"DNA fragmentation induced in human fibroblasts by 56Fe ions: experimental data and Monte Carlo simulations","volume":"171","author":"Campa","year":"2009","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0190","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0027-5107(73)90006-7","article-title":"Chromosome aberrations and radiation-induced cell death I. Transmission and survival parameters of aberrations","volume":"17","author":"Carrano","year":"1973","journal-title":"Mutat. Res. \u2013 Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0195","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1080\/09553000802499212","article-title":"Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci","volume":"84","author":"Ponomarev","year":"2008","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/095530098141681","article-title":"LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes","volume":"74","author":"Bauchinger","year":"1998","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0205","doi-asserted-by":"crossref","first-page":"7589","DOI":"10.1093\/nar\/gkt556","article-title":"DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice","volume":"41","author":"Schipler","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0210","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1667\/RR3235.1","article-title":"Laboratory intercomparison of the dicentric chromosome analysis assay","volume":"180","author":"Beinke","year":"2013","journal-title":"Radiat. Res. Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0215","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0273-1177(03)00091-7","article-title":"Chromosome aberrations as biomarkers of radiation exposure: modelling basic mechanisms","volume":"31","author":"Ballarini","year":"2003","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0220","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/095530097143815","article-title":"Centric rings: acentric rings and excess acentric fragments based on a random-walk interphase chromosome model","volume":"71","author":"Wu","year":"1997","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0225","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1667\/RR1520.1","article-title":"Positional stability of damaged chromatin domains along radiation tracks in mammalian cells","volume":"171","author":"Jakob","year":"2009","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0230","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/rpd\/ncv174","article-title":"Chromosome aberration model combining radiation tracks, chromatin structure, DSB repair and chromatin mobility","volume":"166","author":"Friedland","year":"2015","journal-title":"Radiat. Prot. Dosim."},{"key":"10.1016\/j.dnarep.2017.08.007_bib0235","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.mrgentox.2013.06.013","article-title":"Track structure based modelling of chromosome aberrations after photon and alpha-particle irradiation","volume":"756","author":"Friedland","year":"2013","journal-title":"Mutat. Res. \u2013 Genet. Toxicol. Environ. Mutagen."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786417301647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786417301647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T10:24:06Z","timestamp":1535451846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786417301647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":47,"alternative-id":["S1568786417301647"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2017.08.007","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proximity effects in chromosome aberration induction by low-LET ionizing radiation","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2017.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}