{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:40:15Z","timestamp":1769928015836,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Institutional Development Award (IDeA)","award":["P20GM121307"],"award-info":[{"award-number":["P20GM121307"]}]},{"name":"Institutional Development Award (IDeA)","award":["HL113303"],"award-info":[{"award-number":["HL113303"]}]},{"DOI":"10.13039\/100015194","name":"Feist-Weiller Cancer Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015194","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.dnarep.2018.11.002","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T07:45:41Z","timestamp":1542095141000},"page":"55-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations"],"prefix":"10.1016","volume":"73","author":[{"given":"Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinggui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibile","family":"Pardue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-7497","authenticated-orcid":false,"given":"Andrew T.","family":"Meram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saranya","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghali E.","family":"Ghali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Kevil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney E.","family":"Shackelford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2018.11.002_bib0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-genet-121415-121658","article-title":"Functions, regulation, and therapeutic implications of the ATR checkpoint pathway","volume":"50","author":"Yazinski","year":"2016","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.aan6490","article-title":"A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation","volume":"359","author":"Kabeche","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0015","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.molcel.2015.07.029","article-title":"Distinct but concerted roles of ATR, DNA-PK, and Chk1 in countering replication stress during S phase","volume":"59","author":"Buisson","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0955-0674(00)00201-5","article-title":"DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?","volume":"13","author":"Durocher","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.dnarep.2015.10.001","article-title":"Historical perspective on the DNA damage response","volume":"36","author":"Hanawalt","year":"2015","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0030","doi-asserted-by":"crossref","first-page":"37538","DOI":"10.1074\/jbc.274.53.37538","article-title":"Substrate specificities and identification of putative substrates of ATM kinase family members","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0035","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.molcel.2008.07.007","article-title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle","volume":"31","author":"Daub","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0040","doi-asserted-by":"crossref","first-page":"10762","DOI":"10.1073\/pnas.0805139105","article-title":"A quantitative atlas of mitotic phosphorylation","volume":"105","author":"Dephoure","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0045","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.molcel.2014.05.030","article-title":"PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-Induced DNA damage","volume":"54","author":"Jarrett","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0050","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1038\/jid.2015.280","article-title":"Defining the contribution of MC1R physiological ligands to ATR phosphorylation at Ser435, a predictor of DNA repair in melanocytes","volume":"135","author":"Jarrett","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0055","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.celrep.2017.09.059","article-title":"Proteomics reveals global regulation of protein SUMOylation by ATM and ATR kinases during replication stress","volume":"21","author":"Munk","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0060","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/gad.14.4.397","article-title":"ATR disruption leads to chromosomal fragmentation and early embryonic lethality","volume":"14","author":"Brown","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0065","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0960-9822(00)00447-4","article-title":"Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice","volume":"10","author":"de Klein","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0070","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/ng1129","article-title":"A splicing mutation affecting expression of ataxia-telangiectasia and Rad3related protein (ATR) results in Seckel syndrome","volume":"33","author":"O\u2019Driscoll","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0075","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1242\/jcs.169730","article-title":"ATM and ATR signaling at a glance","volume":"128","author":"Awasthi","year":"2015","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0080","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0085","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/sj.onc.1207199","article-title":"Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing","volume":"23","author":"Lucca","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0090","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2005.12.041","article-title":"TopBP1 activates the ATR-ATRIP complex","volume":"124","author":"Kumagai","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0095","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0100","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1074\/jbc.M212360200","article-title":"ATR\/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation","volume":"278","author":"Hammond","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0105","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1073\/pnas.1301445110","article-title":"APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress","volume":"110","author":"Jeremy","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0110","doi-asserted-by":"crossref","first-page":"L998","DOI":"10.1152\/ajplung.00004.2008","article-title":"Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation","volume":"294","author":"Kulkarni","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0115","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1038\/sj.onc.1210049","article-title":"Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation","volume":"26","author":"Hurley","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0120","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1089\/ars.2016.6909","article-title":"Gasotransmitter heterocellular signaling","volume":"26","author":"Kolluru","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0125","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and physiological effects of hydrogen sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1158\/1541-7786.MCR-06-0439","article-title":"Hydrogen sulfide induces direct radical-associated DNA damage","volume":"5","author":"Attene-Ramos","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0135","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/em.20546","article-title":"DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 int cells","volume":"51","author":"Attene-Ramos","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0140","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1096\/fj.02-0883fje","article-title":"Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells","volume":"17","author":"Deplancke","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0145","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.taap.2011.09.026","article-title":"Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells","volume":"257","author":"Pei","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0150","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-3-319-18144-8_12","article-title":"Hydrogen sulfide and cancer","volume":"230","author":"Hellmich","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"issue":"2007","key":"10.1016\/j.dnarep.2018.11.002_bib0155","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1038\/sj.onc.1210049","article-title":"Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation","volume":"26","author":"Hurley","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0160","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.dnarep.2006.05.041","article-title":"Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells","volume":"5","author":"Shackelford","year":"2006","journal-title":"DNA Repair"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0165","doi-asserted-by":"crossref","first-page":"H256","DOI":"10.1152\/ajpheart.00723.2016","article-title":"Role of thiosulfate in hydrogen sulfide-dependent redox signaling in endothelial cells","volume":"313","author":"Leskova","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0170","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.freeradbiomed.2012.04.007","article-title":"Analytical measurement of discrete hydrogen sulfide pools in biological specimens","volume":"15","author":"Shen","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108537","article-title":"A H2S-Nampt dependent energetic circuit is critical to survival and cytoprotection from damage in cancer cells","volume":"9","author":"Sanokawa-Akakura","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2018.11.002_bib0180","first-page":"3423","article-title":"Increased nicotinamide phosphoribosyltransferase and cystathionine \u03b2-Synthase in renal oncocytomas, renal transitional cell carcinoma and renal clear cell carcinoma","volume":"37","author":"Shackelford","year":"2017","journal-title":"Anticancer Res."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0185","first-page":"702","article-title":"Increased nicotinamide phosphoribosyltransferase and Cystathionine-Beta-Synthase in oral cavity squamous cell carcinomas","volume":"10","author":"Patel","year":"2017","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0190","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1242\/jcs.00133","article-title":"Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest","volume":"115","author":"Capasso","year":"2002","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0195","doi-asserted-by":"crossref","first-page":"42462","DOI":"10.1074\/jbc.C100466200","article-title":"ATM phosphorylates histone H2AX in response to DNA double-strand breaks","volume":"276","author":"Burma","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0200","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.radonc.2017.09.043","article-title":"ATR\/CHK1 inhibitors and cancer therapy","volume":"126","author":"Qiu","year":"2018","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.dnarep.2018.11.002_bib0205","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2015.08.004","article-title":"Hydrogen sulfide in cancer: friend or foe?","volume":"50","author":"Wu","year":"2015","journal-title":"Nitric Oxide"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786418301034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786418301034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T09:29:10Z","timestamp":1720776550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786418301034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":41,"alternative-id":["S1568786418301034"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2018.11.002","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2018.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}