{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:41:45Z","timestamp":1790844105365,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.dnarep.2020.102806","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T02:04:18Z","timestamp":1581300258000},"page":"102806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["DNA-protein crosslink formation by endogenous aldehydes and AP sites"],"prefix":"10.1016","volume":"88","author":[{"given":"Jun","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2020.102806_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.dnarep.2014.03.031","article-title":"The endogenous exposome","volume":"19","author":"Nakamura","year":"2014","journal-title":"DNA Repair (Amst)."},{"key":"10.1016\/j.dnarep.2020.102806_bib0010","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/carcin\/20.9.1787","article-title":"Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents","volume":"20","author":"Wu","year":"1999","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.dnarep.2020.102806_bib0015","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1021\/acs.chemrestox.6b00368","article-title":"DNA product formation in female sprague-dawley rats following polyhalogenated aromatic hydrocarbon (PHAH) exposure","volume":"30","author":"Gao","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0020","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1021\/acs.chemrestox.6b00146","article-title":"Polychlorinated biphenyls induce oxidative DNA adducts in female sprague-dawley rats","volume":"29","author":"Mutlu","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0025","doi-asserted-by":"crossref","first-page":"25377","DOI":"10.18632\/oncotarget.8298","article-title":"Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations","volume":"7","author":"Sharma","year":"2016","journal-title":"Oncotarget."},{"key":"10.1016\/j.dnarep.2020.102806_bib0030","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1021\/tx5000602","article-title":"Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells","volume":"27","author":"Sharma","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0035","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/toxsci\/kfq061","article-title":"Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia","volume":"116","author":"Lu","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dnarep.2020.102806_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kft029","article-title":"Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure","volume":"133","author":"Moeller","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dnarep.2020.102806_bib0045","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1158\/0008-5472.CAN-15-2527","article-title":"Measurement of endogenous versus exogenous formaldehyde-induced DNA-Protein crosslinks in animal tissues by stable isotope labeling and ultrasensitive mass spectrometry","volume":"76","author":"Lai","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0050","first-page":"1241","article-title":"Endogenous deoxyribonucleic Acid (DNA) damage in human tissues: a comparison of ethenobases with aldehydic DNA lesions., Cancer epidemiol","volume":"12","author":"Barbin","year":"2003","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.dnarep.2020.102806_bib0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mrfmmm.2010.08.008","article-title":"Accumulation of true single strand breaks and AP sites in base excision repair deficient cells","volume":"694","author":"Luke","year":"2010","journal-title":"Mutat. Res. - Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.dnarep.2020.102806_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.dnarep.2020.102806_bib0065","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2020.102806_bib0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.abb.2003.12.017","article-title":"Reactive nitrogen species in the chemical biology of inflammation","volume":"423","author":"Dedon","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.dnarep.2020.102806_bib0075","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1073\/pnas.85.20.7467","article-title":"7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection","volume":"85","author":"Park","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2020.102806_bib0080","series-title":"N-nitrosamine Formation by Intestinal Bacteria","first-page":"275","author":"Suzuki","year":"1984"},{"key":"10.1016\/j.dnarep.2020.102806_bib0085","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell."},{"key":"10.1016\/j.dnarep.2020.102806_bib0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature23481","article-title":"Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism","volume":"548","author":"Burgos-Barragan","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.dnarep.2020.102806_bib0095","article-title":"Molecular mechanisms of topoisomerase 2 DNA-protein crosslink resolution","author":"Riccio","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.dnarep.2020.102806_bib0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.dnarep.2018.11.004","article-title":"Repair pathway for PARP-1 DNA-protein crosslinks","volume":"73","author":"Prasad","year":"2019","journal-title":"DNA Repair (Amst)."},{"key":"10.1016\/j.dnarep.2020.102806_bib0105","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/tx200447w","article-title":"A new LC-MS\/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats","volume":"25","author":"Mutlu","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0110","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1021\/ja910928n","article-title":"Quantification of the 2-deoxyribonolactone and nucleoside 5\u2019-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA","volume":"132","author":"Chan","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.dnarep.2020.102806_bib0115","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1021\/acs.analchem.9b01351","article-title":"Quantitation of Apurinic\/Apyrimidinic sites in isolated DNA and in mammalian tissue with a reduced level of artifacts","volume":"91","author":"Chen","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/tx700283c","article-title":"The chemical toxicology of 2-deoxyribose oxidation in DNA","volume":"21","author":"Dedon","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0125","first-page":"222","article-title":"Highly sensitive apurinic\/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions","volume":"58","author":"Nakamura","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1021\/tx049853l","article-title":"Analysis of M1G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry","volume":"18","author":"Jeong","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0135","first-page":"2522","article-title":"Endogenous apurinic\/apyrimidinic sites in genomic DNA of mammalian tissues","volume":"59","author":"Nakamura","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0140","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1074\/jbc.275.8.5323","article-title":"5\u2019-nicked apurinic\/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress","volume":"275","author":"Nakamura","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0145","doi-asserted-by":"crossref","first-page":"22475","DOI":"10.1073\/pnas.1012860108","article-title":"Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle","volume":"107","author":"Sczepanski","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2020.102806_bib0150","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/bi00769a018","article-title":"Rate of depurination of native deoxyribonucleic acid","volume":"11","author":"Lindahl","year":"1972","journal-title":"Biochemistry."},{"key":"10.1016\/j.dnarep.2020.102806_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and Bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0160","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1007\/s00216-013-6823-3","article-title":"Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS\/MS techniques for the quantification of apurinic\/apyrimidinic sites in cellular DNA","volume":"405","author":"Li","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mrfmmm.2009.09.006","article-title":"Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS","volume":"671","author":"Pachkowski","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0170","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41594-019-0255-5","article-title":"Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link","volume":"26","author":"Thompson","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0175","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cell.2018.10.055","article-title":"HMCES maintains genome integrity by shielding abasic sites in single-strand DNA","volume":"176","author":"Mohni","year":"2019","journal-title":"Cell."},{"key":"10.1016\/j.dnarep.2020.102806_bib0180","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1021\/acs.analchem.8b04306","article-title":"Quantification of a novel DNA-Protein cross-link product formed by reacting Apurinic\/Apyrimidinic sites in DNA with cysteine residues in protein by liquid chromatography-tandem mass spectrometry coupled with the stable isotope-dilution method","volume":"91","author":"Chan","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0185","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/22.4.627","article-title":"Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolites, tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone","volume":"22","author":"Lin","year":"2001","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.dnarep.2020.102806_bib0190","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/carcin\/22.4.635","article-title":"Induction of direct adducts, apurinic\/apyrimidinic sites and oxidized bases in nuclear DNA of human HeLa S3 tumor cells by tetrachlorohydroquinone","volume":"22","author":"Lin","year":"2001","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.dnarep.2020.102806_bib0195","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/nar\/gkg263","article-title":"Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells","volume":"31","author":"Nakamura","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0200","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/carcin\/bgg049","article-title":"Aldehydic DNA lesions induced by catechol estrogens in calf thymus DNA","volume":"24","author":"Lin","year":"2003","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.dnarep.2020.102806_bib0205","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1093\/carcin\/bgh174","article-title":"Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene","volume":"25","author":"Zielinska-Park","year":"2004","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.dnarep.2020.102806_bib0210","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1021\/tx0498511","article-title":"Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells","volume":"18","author":"Lin","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0215","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1021\/tx050018t","article-title":"Effects of naphthalene quinonoids on the induction of oxidative DNA damage and cytotoxicity in calf thymus DNA and in human cultured cells","volume":"18","author":"Lin","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0220","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1667\/RR3344","article-title":"Differential oxidation of deoxyribose in DNA by \u03b3 and \u03b1-Particle radiation","volume":"163","author":"Collins","year":"2005","journal-title":"Radiat. Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0225","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1021\/tx700164y","article-title":"GC\/MS methods to quantify the 2-deoxypentos-4-ulose and 3\u2019-phosphoglycolate pathways of 4\u2019 oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin","volume":"20","author":"Chen","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0230","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1021\/bi020026y","article-title":"Evidence for multiple imino intermediates and identification of reactive nucleophiles in peptide-catalyzed beta-elimination at abasic sites","volume":"41","author":"Kurtz","year":"2002","journal-title":"Biochemistry."},{"key":"10.1016\/j.dnarep.2020.102806_bib0235","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1073\/pnas.1501101112","article-title":"Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase \u03b2 in vivo","volume":"112","author":"Qui\u00f1ones","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2020.102806_bib0240","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1021\/ja003354z","article-title":"The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III","volume":"123","author":"Hashimoto","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.dnarep.2020.102806_bib0245","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1074\/jbc.C100577200","article-title":"Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone","volume":"277","author":"DeMott","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0250","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/bi027168c","article-title":"Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes","volume":"42","author":"Kroeger","year":"2003","journal-title":"Biochemistry."},{"key":"10.1016\/j.dnarep.2020.102806_bib0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102773","article-title":"Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair","author":"Qui\u00f1ones","year":"2020","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.dnarep.2020.102806_bib0260","doi-asserted-by":"crossref","first-page":"16734","DOI":"10.1021\/ja306858m","article-title":"Mechanistic studies on histone catalyzed cleavage of apyrimidinic\/apurinic sites in nucleosome core particles","volume":"134","author":"Zhou","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.dnarep.2020.102806_bib0265","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1021\/tx9000489","article-title":"Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal","volume":"22","author":"Minko","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0270","doi-asserted-by":"crossref","first-page":"15638","DOI":"10.1021\/bi011242u","article-title":"The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene","volume":"40","author":"Schnetz-Boutaud","year":"2001","journal-title":"Biochemistry."},{"key":"10.1016\/j.dnarep.2020.102806_bib0275","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1074\/jbc.M212012200","article-title":"1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage","volume":"278","author":"Kurtz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0280","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ar700246x","article-title":"Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources","volume":"41","author":"Stone","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0285","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1073\/pnas.96.12.6615","article-title":"Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct","volume":"96","author":"Mao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2020.102806_bib0290","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mrfmmm.2016.02.005","article-title":"Aldehydes with high and low toxicities inactivate cells by damaging distinct cellular targets","volume":"786","author":"Xie","year":"2016","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0295","doi-asserted-by":"crossref","first-page":"E11212","DOI":"10.1073\/pnas.1813338115","article-title":"Histone tails decrease N7-methyl-2\u2032-deoxyguanosine depurination and yield DNA\u2013protein cross-links in nucleosome core particles and cells","volume":"115","author":"Yang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.dnarep.2020.102806_bib0300","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.9b00314","article-title":"DNA\u2013Protein cross-link formation in nucleosome core particles treated with methyl methanesulfonate","author":"Yang","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0305","first-page":"3398","article-title":"Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor","volume":"40","author":"Swenberg","year":"1980","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0310","first-page":"1","article-title":"2-butoxyethanol and 1-tert-butoxypropan-2-ol","volume":"88","author":"Formaldehyde","year":"2006","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.dnarep.2020.102806_bib0315","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1158\/1055-9965.EPI-09-0762","article-title":"Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells","volume":"19","author":"Zhang","year":"2010","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.dnarep.2020.102806_bib0320","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1021\/acs.chemrestox.8b00024","article-title":"Simple determination of gaseous and particulate compounds generated from heated tobacco products","volume":"31","author":"Uchiyama","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0325","first-page":"4382","article-title":"Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure","volume":"43","author":"Kerns","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0330","first-page":"1012","article-title":"Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells","volume":"56","author":"Monticello","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0335","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0192623312466459","article-title":"Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment","volume":"41","author":"Swenberg","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0340","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00204-019-02393-x","article-title":"Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA-protein cross-links by liquid chromatography-tandem mass spectrometry","volume":"93","author":"Leng","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0345","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/acs.chemrestox.8b00040","article-title":"Accurate measurement of formaldehyde-induced DNA-Protein cross-links by high-resolution orbitrap mass spectrometry","volume":"31","author":"Liu","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0350","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/tx200426b","article-title":"Use of LC-MS\/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine","volume":"25","author":"Lu","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0355","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cbpa.2017.04.010","article-title":"Fluorescent probes for imaging formaldehyde in biological systems","volume":"39","author":"Bruemmer","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0360","doi-asserted-by":"crossref","first-page":"10787","DOI":"10.1038\/s41598-017-11289-8","article-title":"Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes","volume":"7","author":"Nakamura","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102806_bib0365","series-title":"Biochim. Biophys. Acta - Proteins Proteomics","first-page":"193","article-title":"Physiological and pathological implications of semicarbazide-sensitive amine oxidase","author":"Yu","year":"2003"},{"key":"10.1016\/j.dnarep.2020.102806_bib0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15298668591394275","article-title":"Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions","volume":"46","author":"Heck","year":"1985","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"10.1016\/j.dnarep.2020.102806_bib0375","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0378-4347(00)00552-1","article-title":"Determination of formaldehyde in blood plasma by high-performance liquid chromatography with fluorescence detection","volume":"753","author":"Luo","year":"2001","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.dnarep.2020.102806_bib0380","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/rcm.1648","article-title":"Atmospheric pressure chemical ionization mass spectrometry of aldehydes in biological matrices","volume":"18","author":"Nagy","year":"2004","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.dnarep.2020.102806_bib0385","first-page":"i","article-title":"Final report on carcinogens background document for formaldehyde","author":"National Toxicology Program","year":"2010","journal-title":"Rep. Carcinog. Backgr. Doc."},{"key":"10.1016\/j.dnarep.2020.102806_bib0390","doi-asserted-by":"crossref","first-page":"11117","DOI":"10.1158\/0008-5472.CAN-07-3028","article-title":"Cells deficient in the FANC\/BRCA pathway are hypersensitive to plasma levels of formaldehyde","volume":"67","author":"Ridpath","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0395","doi-asserted-by":"crossref","DOI":"10.1186\/s41021-019-0136-5","article-title":"Acid-specific formaldehyde donor is a potential, dual targeting cancer chemotherapeutic\/chemo preventive drug for FANC\/BRCA-mutant cancer","volume":"41","author":"Ridpath","year":"2019","journal-title":"Genes Environ."},{"key":"10.1016\/j.dnarep.2020.102806_bib0400","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/nsmb.2173","article-title":"Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway","volume":"18","author":"Rosado","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0405","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molcel.2015.08.020","article-title":"Endogenous formaldehyde is a hematopoietic stem cell genotoxin and metabolic carcinogen","volume":"60","author":"Pontel","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102806_bib0410","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/10408449009029329","article-title":"Formaldehyde toxicity--new understanding","volume":"20","author":"Heck","year":"1990","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0415","doi-asserted-by":"crossref","first-page":"26404","DOI":"10.1074\/jbc.R115.651679","article-title":"Formaldehyde crosslinking: a tool for the study of chromatin complexes","volume":"290","author":"Hoffman","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102806_bib0420","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/toxsci\/kfv079","article-title":"Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage","volume":"146","author":"Yu","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.dnarep.2020.102806_bib0425","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1021\/ja908282f","article-title":"Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers","volume":"132","author":"Lu","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.dnarep.2020.102806_bib0430","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0165-1218(96)90043-9","article-title":"Interlaboratory validation of a new assay for DNA-protein crosslinks","volume":"369","author":"Costa","year":"1996","journal-title":"Mutat. Res. - Genet. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0435","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/carcin\/13.8.1485","article-title":"A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo","volume":"13","author":"Zhitkovich","year":"1992","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.dnarep.2020.102806_bib0440","first-page":"1567","article-title":"Proteins tightly bound to HeLa cell DNA at nuclear matrix attachment sites","volume":"3","author":"Bodnar","year":"1983","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0445","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/bms.1200090808","article-title":"Determination of formaldehyde in biological tissues by gas chromatography\/mass spectrometry","volume":"9","author":"Heck","year":"1982","journal-title":"Biomed. Mass Spectrom."},{"key":"10.1016\/j.dnarep.2020.102806_bib0450","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.molcel.2016.09.031","article-title":"Mechanism and regulation of DNA-Protein crosslink repair by the DNA-Dependent metalloprotease SPRTN","volume":"64","author":"Stingele","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102806_bib0455","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.molcel.2016.09.032","article-title":"Metalloprotease SPRTN\/DVC1 orchestrates replication-coupled DNA-Protein crosslink repair","volume":"64","author":"Vaz","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102806_bib0460","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21491","article-title":"SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks","volume":"5","author":"Lopez-Mosqueda","year":"2016","journal-title":"Elife."},{"key":"10.1016\/j.dnarep.2020.102806_bib0465","first-page":"3172","article-title":"DNA-dependent protease activity of human Spartan facilitates replication of DNA-protein crosslink-containing DNA","volume":"45","author":"M\u00f3rocz","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0470","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/ng.3103","article-title":"Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features","volume":"46","author":"Lessel","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.dnarep.2020.102806_bib0475","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1093\/nar\/gkx107","article-title":"Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis","volume":"45","author":"Maskey","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102806_bib0480","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1289\/ehp.6987","article-title":"Chemical mixtures: considering the evolution of toxicology and chemical assessment","volume":"113","author":"Monosson","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.dnarep.2020.102806_bib0485","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/tx025614r","article-title":"Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links","volume":"16","author":"Cheng","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0490","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1021\/tx000155k","article-title":"Identification of fluorescent 2\u2019-deoxyadenosine adducts formed in reactions of conjugates of malonaldehyde and acetaldehyde, and of malonaldehyde and formaldehyde","volume":"13","author":"Le Curieux","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0495","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.bcp.2005.08.014","article-title":"Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol","volume":"70","author":"Thiele","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.dnarep.2020.102806_bib0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172172","article-title":"A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity","author":"Shimomoto","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102806_bib0505","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1172\/JCI36800","article-title":"Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans","volume":"119","author":"Chou","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.dnarep.2020.102806_bib0510","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.3390\/biom5042987","article-title":"Alcohol, aldehydes, adducts and airways","volume":"5","author":"Sapkota","year":"2015","journal-title":"Biomolecules."},{"key":"10.1016\/j.dnarep.2020.102806_bib0515","first-page":"257","article-title":"Formaldehyde stress responses in bacterial pathogens","volume":"7","author":"Chen","year":"2016","journal-title":"Front. Microbiol."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786419303805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786419303805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:43:22Z","timestamp":1761597802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786419303805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":103,"alternative-id":["S1568786419303805"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102806","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA-protein crosslink formation by endogenous aldehydes and AP sites","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102806"}}