{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:03:58Z","timestamp":1793315038689,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Indigenous Scholarship"},{"name":"Higher Education Commission"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.dnarep.2020.102836","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T11:53:31Z","timestamp":1582718011000},"page":"102836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer"],"prefix":"10.1016","volume":"89","author":[{"given":"Yasir","family":"Raza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaz","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif Ali","family":"Chishti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shakeel","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Mubarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beryl","family":"Zaitlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahana Urooj","family":"Kazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2020.102836_bib0005","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dnarep.2020.102836_bib0010","first-page":"863","article-title":"Helicobacter pylori in normal gastric mucosa","volume":"42","author":"Prabhu","year":"1994","journal-title":"J. Assoc. Physicians India"},{"key":"10.1016\/j.dnarep.2020.102836_bib0015","first-page":"74","article-title":"Normal gastric histology in Helicobacter pylori-infected children","volume":"25","author":"Gottrand","year":"1997","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.dnarep.2020.102836_bib0020","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000200473","article-title":"Presence of Helicobacter pylori in patients with non-ulcer dyspepsia revealing normal antral histological characteristics","volume":"47","author":"Loffeld","year":"1990","journal-title":"Digestion"},{"key":"10.1016\/j.dnarep.2020.102836_bib0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fgene.2017.00020","article-title":"Inflammation, DNA damage, Helicobacter pylori and gastric tumorigenesis","volume":"8","author":"Kalisperati","year":"2017","journal-title":"Front. Genet."},{"key":"10.1016\/j.dnarep.2020.102836_bib0030","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.dnarep.2020.102836_bib0035","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00054-05","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"19","author":"Kusters","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.dnarep.2020.102836_bib0040","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.dnarep.2020.102836_bib0045","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.dnarep.2020.102836_bib0050","doi-asserted-by":"crossref","first-page":"79604","DOI":"10.18632\/oncotarget.18758","article-title":"Positive Helicobacter pylori status is associated with better overall survival for gastric cancer patients: evidence from case-cohort studies","volume":"8","author":"Fang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.dnarep.2020.102836_bib0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15430\/JCP.2015.20.1.25","article-title":"Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer","volume":"20","author":"Park","year":"2015","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.dnarep.2020.102836_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4132\/KoreanJPathol.2012.46.1.1","article-title":"CpG island hypermethylation in gastric carcinoma and its premalignant lesions","volume":"46","author":"Kang","year":"2012","journal-title":"Korean J. Pathol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0065","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.3748\/wjg.v20.i19.5583","article-title":"Immune responses to Helicobacter pylori infection","volume":"20","author":"Moyat","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0070","first-page":"951","article-title":"Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin","volume":"63","author":"Cover","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0075","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1089\/dna.2018.4487","article-title":"Helicobacter pylori-induced DNA damage is a potential driver for human gastric cancer AGS cells","volume":"38","author":"Shi","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0891-5849(02)00868-7","article-title":"Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress","volume":"33","author":"Naito","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.dnarep.2020.102836_bib0085","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012559","article-title":"DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation","volume":"5","author":"Cadet","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0090","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s12253-014-9762-1","article-title":"Oxidative DNA damage as a potential early biomarker of Helicobacter pylori associated carcinogenesis","volume":"20","author":"Raza","year":"2014","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-60761-806-5_12","article-title":"Immunohistochemical analysis of tissue microarrays","volume":"664","author":"Simon","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0100","doi-asserted-by":"crossref","first-page":"6717","DOI":"10.3748\/wjg.14.6717","article-title":"Helicobacter pylori infection and expression of DNA mismatch repair proteins","volume":"14","author":"Mirzaee","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0105","first-page":"1090","article-title":"Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability","volume":"59","author":"Fleisher","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0110","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1053\/j.gastro.2009.12.042","article-title":"CpG methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection","volume":"138","author":"Sepulveda","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dnarep.2020.102836_bib0115","first-page":"1338","article-title":"Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in gastric cancer","volume":"29","author":"Song","year":"2013","journal-title":"Pak. J. Med. Sci."},{"key":"10.1016\/j.dnarep.2020.102836_bib0120","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1007\/s12032-014-0988-2","article-title":"p16 Methylation is associated with chemosensitivity to fluorouracil in patients with advanced gastric cancer","volume":"31","author":"Wang","year":"2014","journal-title":"Med. Oncol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0125","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1128\/IAI.02368-14","article-title":"Helicobacter pylori infection introduces DNA double-strand breaks in host cells","volume":"82","author":"Hanada","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.dnarep.2020.102836_bib0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4419-9967-2_1","article-title":"DNA methyltransferases, DNA damage repair, and cancer","volume":"754","author":"Jin","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ceb.2013.11.003","article-title":"Changes in cell and tissue organization in cancer of the breast and colon","volume":"26","author":"Hinck","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0140","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.celrep.2015.05.030","article-title":"Helicobacter pylori infection causes characteristic DNA damage patterns in human cells","volume":"11","author":"Koeppel","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.dnarep.2020.102836_bib0145","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1074\/mcp.M400055-MCP200","article-title":"Integrated genomic and proteomic analyses of gene expression in mammalian cells","volume":"3","author":"Tian","year":"2004","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.dnarep.2020.102836_bib0150","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2020.102836_bib0155","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1158\/1078-0432.CCR-11-0790","article-title":"Molecular characteristics of ERCC1-negative versus ERCC1-positive tumors in resected NSCLC","volume":"17","author":"Friboulet","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0160","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJMoa060570","article-title":"IALT Bio Investigators. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy","volume":"355","author":"Olaussen","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.dnarep.2020.102836_bib0165","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1158\/1078-0432.CCR-07-4848","article-title":"Patients with ERCC1-negative locally advanced esophageal cancers may benefit from preoperative chemoradiotherapy","volume":"14","author":"Kim","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0170","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1007\/s00405-015-3710-x","article-title":"The prognostic and predictive value of excision repair cross-complementation group 1 (ERCC1) protein in 1288 patients with head and neck squamous cell carcinoma treated with platinum-based therapy: a meta-analysis","volume":"273","author":"Bi\u0161of","year":"2016","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0175","article-title":"High\/positive expression of ERCC1 predicts poor treatment response and survival prognosis in nasopharyngeal carcinoma: a systematic meta-analysis from 21 studies","volume":"98","author":"Yang","year":"2019","journal-title":"Bull. Sch. Med. Md"},{"key":"10.1016\/j.dnarep.2020.102836_bib0180","first-page":"e9402","article-title":"ERCC1 expression status predicts the response and survival of patients with metastatic or recurrent cervical cancer treated via platinum-based chemotherapy","volume":"96","author":"Ryu","year":"2017","journal-title":"Bull. Sch. Med. Md"},{"key":"10.1016\/j.dnarep.2020.102836_bib0185","first-page":"323","article-title":"Prognostic significance of ERCC1 expression in postoperative patients with gastric cancer","volume":"26","author":"Wang","year":"2014","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0190","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/annonc\/mdl430","article-title":"Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil\/oxaliplatin chemotherapy in advanced gastric cancer","volume":"18","author":"Kwon","year":"2007","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2041-9414-3-3","article-title":"Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer","volume":"3","author":"Facista","year":"2012","journal-title":"Genome Integr."},{"issue":"May (5)","key":"10.1016\/j.dnarep.2020.102836_bib0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-3163-5-14","article-title":"Reactive oxygen species: role in the development of cancer and various chronic conditions","volume":"11","author":"Waris","year":"2006","journal-title":"J. Carcinog."},{"key":"10.1016\/j.dnarep.2020.102836_bib0205","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1093\/nar\/29.10.2117","article-title":"A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA","volume":"29","author":"Hamilton","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0210","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/acs.chemrestox.6b00265","article-title":"Occurrence, Biological consequences, and human health relevance of oxidative stress-induced DNA damage","volume":"29","author":"Yu","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0215","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3390\/cancers6031597","article-title":"DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment","volume":"6","author":"Bridge","year":"2014","journal-title":"Cancers (Basel)."},{"key":"10.1016\/j.dnarep.2020.102836_bib0220","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1038\/s41598-018-22640-y","article-title":"Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102836_bib0225","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1471-2407-10-58","article-title":"Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3beta is implicated in the treatment of cervical carcinoma","volume":"10","author":"Zhang","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.dnarep.2020.102836_bib0230","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1053\/j.gastro.2005.01.056","article-title":"Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer","volume":"128","author":"Truninger","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dnarep.2020.102836_bib0235","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1073\/pnas.1002472107","article-title":"Modulation of mismatch repair and genomic stability by miR-155","volume":"107","author":"Valeri","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.dnarep.2020.102836_bib0240","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/jcb.20711","article-title":"Regulation of DNA repair gene expression in human cancer cell lines","volume":"97","author":"McGurk","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.dnarep.2020.102836_bib0245","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/393015","article-title":"Helicobacter pylori-induced chronic gastritis and assessing risks for gastric cancer","volume":"2013","author":"Carrasco","year":"2013","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.dnarep.2020.102836_bib0250","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijid.2006.06.007","article-title":"Human papillomavirus subtype 16 is common in Pakistani women with cervical carcinoma","volume":"11","author":"Khan","year":"2007","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.dnarep.2020.102836_bib0255","series-title":"R: a Language and Environment for Statistical Computing","author":"R Core Team","year":"2017"},{"key":"10.1016\/j.dnarep.2020.102836_bib0260","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/147323000503300604","article-title":"Is the remarkable contradiction between histology and 14C urea breath test in the detection of Helicobacter pylori due to false-negative histology or false-positive 14C urea breath test?","volume":"33","author":"Gurbuz","year":"2005","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0265","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.3748\/wjg.v21.i40.11221","article-title":"Diagnosis of Helicobacter pylori infection: current options and developments","volume":"21","author":"Wang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0270","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1128\/JCM.01563-08","article-title":"Unreliability of results of PCR detection of Helicobacter pylori in clinical or environmental samples","volume":"47","author":"Sugimoto","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0275","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1383-5742(02)00009-1","article-title":"DNA repair\/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis","volume":"511","author":"Bernstein","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0280","first-page":"50","article-title":"Highly elevated ultraviolet-induced mutation frequency in isolated Chinese Hamster cell Lines defective in nucleotide excision repair and mismatch repair proteins","volume":"61","author":"Nara","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0285","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/cncr.28643","article-title":"Choline phosphate cytidylyltransferase-\u03b1 is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas","volume":"120","author":"Vaezi","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.dnarep.2020.102836_bib0290","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.5858\/arpa.2016-0006-OA","article-title":"Development and validation of an ERCC1 immunohistochemistry assay for solid tumors","volume":"140","author":"Bahamon","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.dnarep.2020.102836_bib0295","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.7150\/jca.28959","article-title":"Cisplatin based induction chemotherapy modified by ERCC1 improved the outcome of young adults with locally advanced oral squamous cell carcinoma","volume":"10","author":"Gong","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.dnarep.2020.102836_bib0300","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1158\/0008-5472.CAN-09-1237","article-title":"Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue","volume":"69","author":"Bhagwat","year":"2009","journal-title":"Cancer Res."},{"issue":"41","key":"10.1016\/j.dnarep.2020.102836_bib0305","doi-asserted-by":"crossref","DOI":"10.3791\/1931","article-title":"Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer","author":"Nguyen","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.dnarep.2020.102836_bib0310","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/den.12471","article-title":"Helicobacter pylori-negative gastric cancer: characteristics and endoscopic findings","volume":"27","author":"Yamamoto","year":"2015","journal-title":"Dig. Endosc."},{"key":"10.1016\/j.dnarep.2020.102836_bib0315","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fcimb.2017.00302","article-title":"Molecular characterization of the human stomach microbiota in gastric cancer patients","volume":"7","author":"Yu","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"September(9)","key":"10.1016\/j.dnarep.2020.102836_bib0320","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s10096-019-03564-5","article-title":"Suicide journey of H. Pylori through gastric carcinogenesis: the role of non-H. Pylori microbiome and potential consequences for clinical practice","volume":"38","author":"de Assump\u00e7\u00e3o","year":"2019","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"March (3)","key":"10.1016\/j.dnarep.2020.102836_bib0325","article-title":"Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients","volume":"6","author":"Ahmad","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.dnarep.2020.102836_bib0330","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biochi.2017.11.013","article-title":"DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway","volume":"146","author":"de Barros","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.dnarep.2020.102836_bib0335","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/genetics\/148.4.1491","article-title":"DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae","volume":"148","author":"Kunz","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.dnarep.2020.102836_bib0340","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nature07943","article-title":"The cancer genome","volume":"458","author":"Stratton","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2020.102836_bib0345","first-page":"4863","article-title":"Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis","volume":"16","author":"Pan","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.dnarep.2020.102836_bib0350","first-page":"1","article-title":"Group on the Evaluation of Carcinogenic Risks to Humans. Schistosomes, liver flukes and Helicobacter pylori. Lyon, June 7\u201314, 1994","volume":"61","author":"Working","year":"1994","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.dnarep.2020.102836_bib0355","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1053\/gast.2001.27999","article-title":"Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection","volume":"121","author":"Ekstr\u00f6m","year":"2001","journal-title":"Gastroenterology"},{"issue":"August (32)","key":"10.1016\/j.dnarep.2020.102836_bib0360","doi-asserted-by":"crossref","first-page":"52307","DOI":"10.18632\/oncotarget.10740","article-title":"Metastatic spread in patients with gastric cancer","volume":"7","author":"Riihim\u00e4ki","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.dnarep.2020.102836_bib0365","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-med-050913-022545","article-title":"Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors","volume":"66","author":"Lord","year":"2015","journal-title":"Annu. Rev. Med."},{"issue":"8","key":"10.1016\/j.dnarep.2020.102836_bib0370","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/ijc.24772","article-title":"Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas","volume":"126","author":"Chen","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.dnarep.2020.102836_bib0375","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.gene.2017.10.056","article-title":"Promoter methylation and expression of DNA repair genes MGMT and ERCC1 in tissue and blood of rectal cancer patients","volume":"644","author":"Shalaby","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.dnarep.2020.102836_bib0380","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1038\/srep04186","article-title":"A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma","volume":"4","author":"Do","year":"2014","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.dnarep.2020.102836_bib0385","first-page":"1131","article-title":"miR-138-5p modulates the expression of excision repair cross-complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin","volume":"41","author":"Ning","year":"2019","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.dnarep.2020.102836_bib0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084453","article-title":"Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs","volume":"9","author":"Hinrichsen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102836_bib0395","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.cellsig.2016.05.021","article-title":"OGG1 is essential in oxidative stress induced DNA demethylation","volume":"28","author":"Zhou","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.dnarep.2020.102836_bib0400","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13072-018-0205-1","article-title":"Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species","volume":"11","author":"Anastasiadi","year":"2018","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.dnarep.2020.102836_bib0405","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1158\/1078-0432.CCR-05-2096","article-title":"High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk","volume":"12","author":"Maekita","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102836_bib0410","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4251\/wjgo.v5.i3.43","article-title":"Epigenetic field defects in progression to cancer","volume":"5","author":"Bernstein","year":"2013","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.dnarep.2020.102836_bib0415","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/path.4132","article-title":"Whole-genome methylation analysis of benign and malignant colorectal tumours","volume":"229","author":"Beggs","year":"2013","journal-title":"J. Pathol."},{"issue":"July(3)","key":"10.1016\/j.dnarep.2020.102836_bib0420","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10120-015-0544-6","article-title":"Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan","volume":"19","author":"Mori","year":"2016","journal-title":"Gastric Cancer"},{"issue":"September (1)","key":"10.1016\/j.dnarep.2020.102836_bib0425","doi-asserted-by":"crossref","first-page":"14369","DOI":"10.1038\/s41598-018-32717-3","article-title":"Long-term effects of H. Pylori eradication on epigenetic alterations related to gastric carcinogenesis","volume":"8","author":"Michigami","year":"2018","journal-title":"Sci. Rep."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786419303799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786419303799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:44:36Z","timestamp":1761597876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786419303799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":85,"alternative-id":["S1568786419303799"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102836","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102836"}}