{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:47:02Z","timestamp":1761598022485,"version":"build-2065373602"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006680","name":"Takeda Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.dnarep.2020.102872","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T05:20:17Z","timestamp":1589952017000},"page":"102872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells"],"prefix":"10.1016","volume":"91-92","author":[{"given":"Nakako Izumi","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Kakoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Cuihua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reona","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiara Bunga Mayang","family":"Permata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moito","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Yasuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumitaka","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2020.102872_bib0005","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1073\/pnas.1016045108","article-title":"Unrepaired clustered DNA lesions induce chromosome breakage in human cells","volume":"108","author":"Asaithamby","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2020.102872_bib0010","first-page":"443","article-title":"End-joining, translocations and cancer, Nature reviews","volume":"13","author":"Bunting","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.dnarep.2020.102872_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/PPO.0b013e31803c5415","article-title":"Cancer as a manifestation of aberrant chromatin structure","volume":"13","author":"Brock","year":"2007","journal-title":"Cancer J."},{"key":"10.1016\/j.dnarep.2020.102872_bib0020","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2020.102872_bib0025","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1073\/pnas.0501895102","article-title":"In vivo formation and repair of DNA double-strand breaks after computed tomography examinations","volume":"102","author":"Lobrich","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.dnarep.2020.102872_bib0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrclinonc.2015.120","article-title":"Opportunities and challenges of radiotherapy for treating cancer","volume":"12","author":"Schaue","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.clon.2018.01.006","article-title":"Clinical indications for carbon ion radiotherapy","author":"Mohamad","year":"2018","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/nrclinonc.2017.30","article-title":"Charged-particle therapy in cancer: clinical uses and future perspectives","author":"Durante","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0045","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrclinonc.2013.79","article-title":"Charged particle therapy--optimization, challenges and future directions","volume":"10","author":"Loeffler","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0050","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/jjco\/hys104","article-title":"A review of update clinical results of carbon ion radiotherapy","volume":"42","author":"Tsujii","year":"2012","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0055","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.radonc.2016.08.028","article-title":"Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation","volume":"121","author":"Lorat","year":"2016","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0060","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.dnarep.2013.08.009","article-title":"The complexity of DNA double strand breaks is a critical factor enhancing end-resection","volume":"12","author":"Yajima","year":"2013","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2020.102872_bib0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0360-3016(98)00544-6","article-title":"Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy","volume":"44","author":"Kanai","year":"1999","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.dnarep.2020.102872_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070107","article-title":"Visualisation of gammaH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage","volume":"8","author":"Nakajima","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dnarep.2020.102872_bib0075","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/rpd\/ncq539","article-title":"Monte Carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths","volume":"143","author":"Watanabe","year":"2011","journal-title":"Radiat. Prot. Dosimetry"},{"key":"10.1016\/j.dnarep.2020.102872_bib0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1269\/jrr.07123","article-title":"Formation of clustered DNA damage after high-LET irradiation: a review","volume":"49","author":"Hada","year":"2008","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.dnarep.2020.102872_bib0085","doi-asserted-by":"crossref","first-page":"22275","DOI":"10.1038\/srep22275","article-title":"Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy","volume":"6","author":"Oike","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102872_bib0090","doi-asserted-by":"crossref","first-page":"109370","DOI":"10.18632\/oncotarget.22679","article-title":"3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread gammaH2AX foci after high LET heavy-ion particle radiation","volume":"8","author":"Hagiwara","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.dnarep.2020.102872_bib0095","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1021\/bi049560r","article-title":"Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts","volume":"43","author":"Lomax","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.dnarep.2020.102872_bib0100","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/gcc.22367","article-title":"Identification of DNA double strand breaks at chromosome boundaries along the track of particle irradiation","volume":"55","author":"Niimi","year":"2016","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.dnarep.2020.102872_bib0105","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/emboj.2011.27","article-title":"Factors determining DNA double-strand break repair pathway choice in G2 phase","volume":"30","author":"Shibata","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2020.102872_bib0110","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4161\/15384101.2015.941743","article-title":"DNA end resection is needed for the repair of complex lesions in G1-phase human cells","volume":"13","author":"Averbeck","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2020.102872_bib0115","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/S0273-1177(99)01062-5","article-title":"Genomic instability induced by high and low LET ionizing radiation","volume":"25","author":"Limoli","year":"2000","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.dnarep.2020.102872_bib0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fonc.2016.00028","article-title":"Efficient rejoining of DNA double-strand breaks despite increased cell-killing effectiveness following spread-out bragg peak carbon-ion irradiation","volume":"6","author":"Averbeck","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0125","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.molcel.2016.12.016","article-title":"DNA double-strand break resection occurs during non-homologous end joining in G1 but is distinct from resection during homologous recombination","volume":"65","author":"Biehs","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102872_bib0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mrfmmm.2017.07.011","article-title":"Regulation of repair pathway choice at two-ended DNA double-strand breaks","volume":"803\u2013805","author":"Shibata","year":"2017","journal-title":"Mutat. Res."},{"key":"10.1016\/j.dnarep.2020.102872_bib0135","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tcb.2015.07.009","article-title":"Repair pathway choices and consequences at the double-strand break","volume":"26","author":"Ceccaldi","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0140","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1128\/MCB.23.16.5706-5715.2003","article-title":"Pathways of DNA double-strand break repair during the mammalian cell cycle","volume":"23","author":"Rothkamm","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0145","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1158\/0008-5472.CAN-03-3207","article-title":"ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation","volume":"64","author":"Stiff","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102872_bib0150","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/MCB.01644-09","article-title":"Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)\/M checkpoint arrest","volume":"30","author":"Shibata","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0155","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/nsmb.2729","article-title":"A mediator methylation mystery: JMJD1C demethylates MDC1 to regulate DNA repair","volume":"20","author":"Lu","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0160","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/emboj.2009.400","article-title":"A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses","volume":"29","author":"Lilley","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2020.102872_bib0165","doi-asserted-by":"crossref","first-page":"31608","DOI":"10.1074\/jbc.M801082200","article-title":"Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation","volume":"283","author":"Shi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102872_bib0170","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41556-018-0071-x","article-title":"L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage","volume":"20","author":"Nowsheen","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0175","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nsmb.2078","article-title":"Chfr and RNF8 synergistically regulate ATM activation","volume":"18","author":"Wu","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ncb2017","article-title":"53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair","volume":"12","author":"Noon","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0185","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cell.2018.08.056","article-title":"Human Rad52 promotes XPG-mediated R-loop processing to initiate transcription-associated homologous recombination repair","volume":"175","author":"Yasuhara","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2020.102872_bib0190","doi-asserted-by":"crossref","first-page":"17238","DOI":"10.1074\/jbc.M112.446351","article-title":"Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells","volume":"288","author":"Shimizu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102872_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122582","article-title":"Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair","volume":"10","author":"Nakajima","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dnarep.2020.102872_bib0200","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbrc.2011.11.006","article-title":"Mode of ATM-dependent suppression of chromosome translocation","volume":"416","author":"Yamauchi","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.dnarep.2020.102872_bib0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.dnarep.2018.06.001","article-title":"Regulation of DNA repair in the absence of classical non-homologous end joining","volume":"68","author":"Kang","year":"2018","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2020.102872_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.clon.2014.02.004","article-title":"DNA double-strand break repair in a cellular context","author":"Shibata","year":"2014","journal-title":"Clin. Oncol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0215","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molcel.2004.10.029","article-title":"A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci","volume":"16","author":"Riballo","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102872_bib0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13014-015-0464-y","article-title":"VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation","volume":"10","author":"Fujisawa","year":"2015","journal-title":"Radiat. Oncol."},{"issue":"Suppl 1","key":"10.1016\/j.dnarep.2020.102872_bib0225","doi-asserted-by":"crossref","first-page":"i33","DOI":"10.1093\/jrr\/rrw027","article-title":"Opposing roles of RNF8\/RNF168 and deubiquitinating enzymes in ubiquitination-dependent DNA double-strand break response signaling and DNA-repair pathway choice","volume":"57","author":"Nakada","year":"2016","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.dnarep.2020.102872_bib0230","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1126\/science.1150034","article-title":"Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase","volume":"318","author":"Kolas","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2020.102872_bib0235","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/emboj.2012.104","article-title":"A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure","volume":"31","author":"Luijsterburg","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2020.102872_bib0240","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cell.2007.09.041","article-title":"RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly","volume":"131","author":"Huen","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2020.102872_bib0245","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cell.2008.12.042","article-title":"The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage","volume":"136","author":"Stewart","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2020.102872_bib0250","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102872_bib0255","doi-asserted-by":"crossref","first-page":"33845","DOI":"10.1074\/jbc.M111.274159","article-title":"Human Mre11\/human Rad50\/Nbs1 and DNA ligase IIIalpha\/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway","volume":"286","author":"Della-Maria","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102872_bib0260","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/jrr\/rry096","article-title":"Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation","volume":"60","author":"Hagiwara","year":"2019","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.dnarep.2020.102872_bib0265","doi-asserted-by":"crossref","first-page":"41812","DOI":"10.1038\/srep41812","article-title":"Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1","volume":"7","author":"Yamauchi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102872_bib0270","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.molcel.2014.08.002","article-title":"Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining","volume":"55","author":"Ghezraoui","year":"2014","journal-title":"Mol. Cell"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786420301208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786420301208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:44:26Z","timestamp":1761597866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786420301208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":54,"alternative-id":["S1568786420301208"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102872","relation":{},"ISSN":["1568-7864"],"issn-type":[{"type":"print","value":"1568-7864"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102872","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102872"}}