{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:01:55Z","timestamp":1791547315777,"version":"4.3.4"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.dnarep.2020.102971","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T02:45:48Z","timestamp":1599792348000},"page":"102971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms"],"prefix":"10.1016","volume":"96","author":[{"given":"Shantanu","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daner A.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos M.","family":"Mombach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2020.102971_bib0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41580-019-0110-x","article-title":"The multiple mechanisms that regulate p53 activity and cell fate","volume":"20","author":"Hafner","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0010","doi-asserted-by":"crossref","first-page":"8990","DOI":"10.1073\/pnas.1100600108","article-title":"Two-phase dynamics of p53 in the DNA damage response","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dnarep.2020.102971_bib0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1126\/science.1905840","article-title":"p53 mutations in human cancers","volume":"253","author":"Hollstein","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2020.102971_bib0020","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1038\/sj.onc.1207116","article-title":"Control of apoptosis by p53","volume":"22","author":"Fridman","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2020.102971_bib0025","doi-asserted-by":"crossref","first-page":"e1624","DOI":"10.1038\/cddis.2014.546","article-title":"DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX","volume":"6","author":"Guan","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.dnarep.2020.102971_bib0030","doi-asserted-by":"crossref","first-page":"e63245","DOI":"10.1371\/journal.pone.0063245","article-title":"DRAM1 regulates autophagy flux through lysosomes","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102971_bib0035","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.3892\/or.2016.4752","article-title":"Radiation induces autophagic cell death via the p53\/DRAM signaling pathway in breast cancer cells","volume":"35","author":"Cui","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0040","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12964-019-0341-7","article-title":"DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway","volume":"17","author":"Lu","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.dnarep.2020.102971_bib0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2006.05.034","article-title":"DRAM, a p53-induced modulator of autophagy, is critical for apoptosis","volume":"126","author":"Crighton","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2020.102971_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2017.00051","article-title":"Autophagy and the Cell Cycle: A Complex Landscape","volume":"7","author":"Mathiassen","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0055","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.4161\/auto.7.12.17802","article-title":"Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation","volume":"7","author":"Mauthe","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.dnarep.2020.102971_bib0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3892\/mmr.2014.2151","article-title":"Temozolomide induces autophagy via ATM\u2011AMPK\u2011ULK1 pathways in glioma","volume":"10","author":"Zou","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0065","doi-asserted-by":"crossref","first-page":"e2063","DOI":"10.1038\/cddis.2015.328","article-title":"Targeting HDAC with a novel inhibitor effectively reverses paclitaxel resistance in non-small cell lung cancer via multiple mechanisms","volume":"7","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.dnarep.2020.102971_bib0070","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.molcel.2006.07.010","article-title":"Wip1 phosphatase modulates ATM-dependent signaling pathways","volume":"23","author":"Shreeram","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102971_bib0075","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.2741\/3999","article-title":"Regulation of the Wip1 phosphatase and its effects on the stress response","volume":"17","author":"Lowe","year":"2012","journal-title":"Front. Biosci.: J. Virtual Lib."},{"key":"10.1016\/j.dnarep.2020.102971_bib0080","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.4161\/auto.21402","article-title":"WIP-ing out atherosclerosis with autophagy","volume":"8","author":"Brichkina","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.dnarep.2020.102971_bib0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2012.06.003","article-title":"Wip1-dependent regulation of autophagy, obesity, and atherosclerosis","volume":"16","author":"Le Guezennec","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.dnarep.2020.102971_bib0090","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.molcel.2011.01.020","article-title":"The ATM kinase induces microRNA biogenesis in the DNA damage response","volume":"41","author":"Zhang","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102971_bib0095","doi-asserted-by":"crossref","first-page":"54788","DOI":"10.18632\/oncotarget.18510","article-title":"MicroRNA16 regulates glioma cell proliferation, apoptosis and invasion by targeting Wip1-ATM-p53 feedback loop","volume":"8","author":"Zhan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.dnarep.2020.102971_bib0100","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1158\/0008-5472.CAN-10-0697","article-title":"Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2020.102971_bib0105","first-page":"2897","article-title":"MicroRNA-16 sensitizes drug-resistant breast cancer cells to Adriamycin by targeting Wip1 and Bcl-2","volume":"18","author":"Gao","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.dnarep.2020.102971_bib0110","doi-asserted-by":"crossref","first-page":"26406","DOI":"10.1074\/jbc.M114.573592","article-title":"miR-15b\/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung","volume":"289","author":"Rahman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2020.102971_bib0115","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/15384047.2015.1040963","article-title":"MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin","volume":"16","author":"Huang","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.dnarep.2020.102971_bib0120","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4161\/15384101.2014.988019","article-title":"DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase","volume":"14","author":"Brazina","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2020.102971_bib0125","doi-asserted-by":"crossref","first-page":"e1006402","DOI":"10.1371\/journal.pcbi.1006402","article-title":"Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K","volume":"15","author":"Sizek","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0130","doi-asserted-by":"crossref","first-page":"16430","DOI":"10.1038\/s41598-019-52725-1","article-title":"A feedback loop of conditionally stable circuits drives the cell cycle from checkpoint to checkpoint","volume":"9","author":"Deritei","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0135","doi-asserted-by":"crossref","first-page":"giz010","DOI":"10.1093\/gigascience\/giz010","article-title":"Modeling genotypes in their microenvironment to predict single-and multi-cellular behavior","volume":"8","author":"Voukantsis","year":"2019","journal-title":"GigaScience"},{"key":"10.1016\/j.dnarep.2020.102971_bib0140","doi-asserted-by":"crossref","DOI":"10.1088\/2632-072X\/aba3bb","article-title":"P53\/E2F1\/miR-25 axis regulates apoptosis induction in glioblastoma cells: a qualitative model","author":"Silveira","year":"2020","journal-title":"J. Phys. Complex."},{"key":"10.1016\/j.dnarep.2020.102971_bib0145","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.csbj.2020.03.001","article-title":"Concepts in Boolean network modeling: What do they all mean?","volume":"18","author":"Schwab","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.dnarep.2020.102971_bib0150","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41467-017-00268-2","article-title":"Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures","volume":"8","author":"Khan","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2020.102971_bib0155","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fgene.2016.00094","article-title":"Logical modeling and dynamical analysis of cellular networks","volume":"7","author":"Abou-Jaoud\u00e9","year":"2016","journal-title":"Front. Genet."},{"key":"10.1016\/j.dnarep.2020.102971_bib0160","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1093\/bioinformatics\/btl210","article-title":"Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle","volume":"22","author":"Faur\u00e9","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.dnarep.2020.102971_bib0165","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/febs.15062","article-title":"Dynamics of the feedback loops required for the phenotypic stabilization in the epithelial-mesenchymal transition","volume":"287","author":"Silveira","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.dnarep.2020.102971_bib0170","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/bib\/bbm028","article-title":"Dynamical roles of biological regulatory circuits","volume":"8","author":"Thieffry","year":"2007","journal-title":"Brief. Bioinformatics"},{"key":"10.1016\/j.dnarep.2020.102971_bib0175","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1039\/C7ME00032D","article-title":"Computational design of biological circuits: putting parts into context","volume":"2","author":"Karamasioti","year":"2017","journal-title":"Mol. Syst. Des. Eng."},{"key":"10.1016\/j.dnarep.2020.102971_bib0180","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00646","article-title":"Logical modeling and analysis of cellular regulatory networks with GINsim 3.0","volume":"9","author":"Naldi","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0185","doi-asserted-by":"crossref","first-page":"D369","DOI":"10.1093\/nar\/gkw1102","article-title":"The BioGRID interaction database: 2017 update","volume":"45","author":"Chatr-Aryamontri","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102971_bib0190","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.dnarep.2020.102971_bib0195","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/ijms17040564","article-title":"MiRTargetLink\u2014miRNAs, genes and interaction networks","volume":"17","author":"Hamberg","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dnarep.2020.102971_bib0200","first-page":"607","article-title":"The same, only different\u2013DNA damage checkpoints and their reversal throughout the cell cycle","volume":"128","author":"Shaltiel","year":"2015","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.dnarep.2020.102971_bib0205","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.dnarep.2020.102971_bib0210","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/md14080154","article-title":"Tumor protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure","volume":"14","author":"Ratovitski","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.dnarep.2020.102971_bib0215","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1038\/s41598-017-02800-2","article-title":"miR-15a\/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin","volume":"7","author":"Patel","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0220","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1038\/emboj.2009.156","article-title":"MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response","volume":"28","author":"Pothof","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2020.102971_bib0225","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1038\/onc.2015.435","article-title":"MicroRNA-16 mediates the regulation of a senescence\u2013apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas","volume":"35","author":"Kitadate","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2020.102971_bib0230","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan5598","article-title":"ATM directs DNA damage responses and proteostasis via genetically separable pathways","volume":"11","author":"Lee","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.dnarep.2020.102971_bib0235","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/nar\/gki154","article-title":"Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines","volume":"33","author":"Jacob","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102971_bib0240","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102971_bib0245","doi-asserted-by":"crossref","first-page":"11250","DOI":"10.1073\/pnas.210171597","article-title":"Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study","volume":"97","author":"Bar-Or","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dnarep.2020.102971_bib0250","doi-asserted-by":"crossref","first-page":"e0200768","DOI":"10.1371\/journal.pone.0200768","article-title":"Modeling the role of microRNA-449a in the regulation of the G2\/M cell cycle checkpoint in prostate LNCaP cells under ionizing radiation","volume":"13","author":"Gupta","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102971_bib0255","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/1873-3468.13615","article-title":"ATM\/miR-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: a Boolean model of G1\/S checkpoint regulation","volume":"594","author":"Gupta","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dnarep.2020.102971_bib0260","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/s41598-020-59339-y","article-title":"Integrative data modeling from lung and lymphatic cancer predicts functional roles for miR-34a and miR-16 in cell fate regulation","volume":"10","author":"Gupta","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0265","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2008.03.016","article-title":"Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage","volume":"30","author":"Batchelor","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2020.102971_bib0270","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1073\/pnas.97.20.10978","article-title":"Rapid induction of senescence in human cervical carcinoma cells","volume":"97","author":"Goodwin","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dnarep.2020.102971_bib0275","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.dnarep.2020.102971_bib0280","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","article-title":"mTOR regulation of autophagy","volume":"584","author":"Jung","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dnarep.2020.102971_bib0285","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-biochem-061516-044820","article-title":"Mechanisms of autophagy initiation","volume":"86","author":"Hurley","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.dnarep.2020.102971_bib0290","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ncb2708","article-title":"mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6","volume":"15","author":"Nazio","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0295","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0300","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1093\/nar\/gkn522","article-title":"miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes","volume":"36","author":"Liu","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102971_bib0305","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1073\/pnas.0506654102","article-title":"miR-15 and miR-16 induce apoptosis by targeting BCL2","volume":"102","author":"Cimmino","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.dnarep.2020.102971_bib0310","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.4049\/jimmunol.1401875","article-title":"MicroRNA-15b\/16 enhances the induction of regulatory T cells by regulating the expression of rictor and mTOR","volume":"195","author":"Singh","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0315","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.283","article-title":"Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide","volume":"4","author":"Biasoli","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.dnarep.2020.102971_bib0320","first-page":"247","article-title":"miR-16 mimics inhibit TGF-\u03b21-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells","volume":"39","author":"Wang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0325","doi-asserted-by":"crossref","first-page":"21148","DOI":"10.1038\/srep21148","article-title":"Volatile Oil of Acori Graminei Rhizoma -Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0330","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1038\/bjc.2013.672","article-title":"MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways","volume":"109","author":"Wu","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.dnarep.2020.102971_bib0335","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1038\/onc.2014.461","article-title":"Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy","volume":"34","author":"Gomes","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2020.102971_bib0340","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2007.07.003","article-title":"Cellular senescence in cancer and aging","volume":"130","author":"Collado","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2020.102971_bib0345","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.18632\/oncotarget.6980","article-title":"Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers","volume":"7","author":"Law","year":"2016","journal-title":"Oncotarget."},{"key":"10.1016\/j.dnarep.2020.102971_bib0350","doi-asserted-by":"crossref","first-page":"e0116550","DOI":"10.1371\/journal.pone.0116550","article-title":"Computational analysis of an autophagy\/translation switch based on mutual inhibition of MTORC1 and ULK1","volume":"10","author":"Szyma\u0144ska","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102971_bib0355","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.celrep.2015.07.016","article-title":"A positive feedback loop between Akt and mTORC2 via SIN1 phosphorylation","volume":"12","author":"Yang","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0360","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/sj.onc.1202426","article-title":"Caspase-mediated cleavage of p21 Waf1\/Cip1 converts cancer cells from growth arrest to undergoing apoptosis","volume":"18","author":"Zhang","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2020.102971_bib0365","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4161\/cc.6.4.3855","article-title":"The multiple battles fought by anti-apoptotic p21","volume":"6","author":"J\u00e4nicke","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2020.102971_bib0370","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1371\/journal.pgen.0030146","article-title":"\u201cMyc\u2019ed messages\u201d: myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron","volume":"3","author":"Coller","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.dnarep.2020.102971_bib0375","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1016\/j.febslet.2009.10.001","article-title":"Positive-feedback loops in cell cycle progression","volume":"583","author":"Pomerening","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.dnarep.2020.102971_bib0380","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/ncb1468","article-title":"Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage","volume":"8","author":"Wang","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2020.102971_bib0385","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1101\/gad.1291305","article-title":"PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints","volume":"19","author":"Lu","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.dnarep.2020.102971_bib0390","doi-asserted-by":"crossref","first-page":"e65242","DOI":"10.1371\/journal.pone.0065242","article-title":"Mechanisms that enhance sustainability of p53 pulses","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102971_bib0395","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-Activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2020.102971_bib0400","doi-asserted-by":"crossref","first-page":"e0213736","DOI":"10.1371\/journal.pone.0213736","article-title":"R package for a Boolean sensitivity analysis against various types of mutations","volume":"14","author":"Trinh","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.dnarep.2020.102971_bib0405","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.celrep.2013.05.038","article-title":"DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway","volume":"3","author":"Wan","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.dnarep.2020.102971_bib0410","first-page":"3227","article-title":"Effect of mir-16 on proliferation and apoptosis in human A549 lung adenocarcinoma cells","volume":"8","author":"Gu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.dnarep.2020.102971_bib0415","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.3892\/ol.2017.6685","article-title":"Role of wild-type p53-induced phosphatase 1 in cancer","volume":"14","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.dnarep.2020.102971_bib0420","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/onc.2009.501","article-title":"Wip1 phosphatase is associated with chromatin and dephosphorylates \u03b3H2AX to promote checkpoint inhibition","volume":"29","author":"Mac\u016frek","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2020.102971_bib0425","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1093\/nar\/gkn550","article-title":"\u03b3-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin","volume":"36","author":"Kinner","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2020.102971_bib0430","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.canlet.2019.05.042","article-title":"p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma","volume":"459","author":"Zhang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.dnarep.2020.102971_bib0435","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/15548627.2015.1009795","article-title":"Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage","volume":"11","author":"Filippi-Chiela","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.dnarep.2020.102971_bib0440","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4161\/auto.8.2.18600","article-title":"Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress","volume":"8","author":"Singh","year":"2012","journal-title":"Autophagy"}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786420302202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786420302202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:48:23Z","timestamp":1761598103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786420302202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":88,"alternative-id":["S1568786420302202"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102971","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2020.102971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102971"}}