{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:25:30Z","timestamp":1793877930491,"version":"4.7.0"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"am","delay-in-days":328,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI170012"],"award-info":[{"award-number":["R01AI170012"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R21ES032966"],"award-info":[{"award-number":["R21ES032966"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010942","name":"UNC Charlotte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA225637"],"award-info":[{"award-number":["R01CA225637"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R15CA290570"],"award-info":[{"award-number":["R15CA290570"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R03CA270663"],"award-info":[{"award-number":["R03CA270663"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R25GM128571"],"award-info":[{"award-number":["R25GM128571"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R25CA128571"],"award-info":[{"award-number":["R25CA128571"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.dnarep.2024.103776","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T07:11:43Z","timestamp":1729321903000},"page":"103776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["APE1 is a master regulator of the ATR-\/ATM-mediated DNA damage response"],"prefix":"10.1016","volume":"144","author":[{"given":"Haichao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Marriott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2024.103776_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrc3891","article-title":"Therapeutic opportunities within the DNA damage response","volume":"15","author":"Pearl","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.dnarep.2024.103776_bib2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.cmet.2014.10.008","article-title":"DNA damage response and metabolic disease","volume":"20","author":"Shimizu","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.dnarep.2024.103776_bib3","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1007\/s00018-014-1666-4","article-title":"Functional interplay between ATM\/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress","volume":"71","author":"Yan","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/tx060164e","article-title":"Methylating agents and DNA repair responses: methylated bases and sources of strand breaks","volume":"19","author":"Wyatt","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.dnarep.2024.103776_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-genet-110410-132435","article-title":"Double-strand break end resection and repair pathway choice","volume":"45","author":"Symington","year":"2011","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.dnarep.2024.103776_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.tibs.2015.08.006","article-title":"Microhomology-mediated end joining: a cack-up survival mechanism or dedicated pathway?","volume":"40","author":"Sfeir","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41580-021-00405-2","article-title":"Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining","volume":"23","author":"Ramsden","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib8","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1074\/jbc.TM117.000374","article-title":"Nonhomologous DNA end-joining for repair of DNA double-strand breaks","volume":"293","author":"Pannunzio","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib9","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.1007\/s00018-021-03990-9","article-title":"The base excision repair process: comparison between higher and lower eukaryotes","volume":"78","author":"Hindi","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814186","article-title":"Base excision repair: mechanisms and impact in biology, disease, and medicine","volume":"24","author":"Gohil","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib11","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012583","article-title":"Base excision repair","volume":"5","author":"Krokan","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molcel.2007.11.015","article-title":"The DNA damage response: ten years after","volume":"28","author":"Harper","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2024.103776_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.genet.40.051206.105231","article-title":"Surviving the breakup: the DNA damage checkpoint","volume":"40","author":"Harrison","year":"2006","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.dnarep.2024.103776_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrm2852","article-title":"Maintaining genome stability at the replication fork","volume":"11","author":"Branzei","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib15","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nrm1493","article-title":"Checking on DNA damage in S phase","volume":"5","author":"Bartek","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.genet.40.110405.090428","article-title":"Cellular responses to DNA damage: one signal, multiple choices","volume":"40","author":"Su","year":"2006","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.dnarep.2024.103776_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2024.103776_bib18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2024.103776_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1083\/jcb.201204035","article-title":"Loss of ATM kinase activity leads to embryonic lethality in mice","volume":"198","author":"Daniel","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib20","doi-asserted-by":"crossref","first-page":"36194","DOI":"10.1074\/jbc.M104157200","article-title":"Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3","volume":"276","author":"Xie","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib21","doi-asserted-by":"crossref","first-page":"21951","DOI":"10.1074\/jbc.M011303200","article-title":"The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts","volume":"276","author":"Shackelford","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2024.103776_bib23","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1073\/pnas.1416031112","article-title":"ATM prevents DSB formation by coordinating SSB repair and cell cycle progression","volume":"112","author":"Khoronenkova","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2024.103776_bib24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2024.103776_bib26","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2024.103776_bib27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2005.12.041","article-title":"TopBP1 activates the ATR-ATRIP complex","volume":"124","author":"Kumagai","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2024.103776_bib28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1083\/jcb.200810185","article-title":"TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks","volume":"184","author":"Yan","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib29","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.1547007","article-title":"The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1","volume":"21","author":"Delacroix","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.dnarep.2024.103776_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1158\/0008-5472.CAN-21-1756","article-title":"DNA-PKcs: a targetable protumorigenic protein kinase","volume":"82","author":"Dylgjeri","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2024.103776_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.dnarep.2018.08.012","article-title":"APE1: A skilled nucleic acid surgeon","volume":"71","author":"Whitaker","year":"2018","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2024.103776_bib33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1089\/ars.2013.5492","article-title":"Human apurinic\/apyrimidinic endonuclease 1","volume":"20","author":"Li","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.dnarep.2024.103776_bib34","first-page":"151","article-title":"APE1\/Ref-1 - one target with multiple indications: emerging aspects and new directions","volume":"2","author":"Mijit","year":"2021","journal-title":"J. Cell Signal"},{"key":"10.1016\/j.dnarep.2024.103776_bib35","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/jmbi.2001.5382","article-title":"Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III","volume":"316","author":"Hadi","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jmb.2014.12.001","article-title":"Human apurinic\/apyrimidinic endonuclease 1 (APE1) has 3\u2032 RNA phosphatase and 3\u2032 exoribonuclease activities","volume":"427","author":"Chohan","year":"2015","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41467-017-00842-8","article-title":"Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism","volume":"8","author":"Antoniali","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib38","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/MCB.01337-08","article-title":"APE1\/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process","volume":"29","author":"Vascotto","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126308","article-title":"Molecular mechanisms regulating the DNA repair protein APE1: a focus on its flexible N-terminal tail domain","volume":"22","author":"Lopez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/415183a","article-title":"Alternative nucleotide incision repair pathway for oxidative DNA damage","volume":"415","author":"Ischenko","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2024.103776_bib41","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1073\/pnas.0508582103","article-title":"Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles","volume":"103","author":"Ishchenko","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2024.103776_bib42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41467-017-02175-y","article-title":"Molecular snapshots of APE1 proofreading mismatches and removing DNA damage","volume":"9","author":"Whitaker","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/nar\/gkh165","article-title":"The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway","volume":"32","author":"Gros","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib44","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nsmb.3105","article-title":"Capturing snapshots of APE1 processing DNA damage","volume":"22","author":"Freudenthal","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib45","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.1093\/nar\/gkad481","article-title":"Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics","volume":"51","author":"Hoitsma","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-33057-7","article-title":"Structural basis for APE1 processing DNA damage in the nucleosome","volume":"13","author":"Weaver","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.drudis.2020.10.015","article-title":"The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease","volume":"26","author":"Caston","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.dnarep.2024.103776_bib48","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/nar\/gkz1175","article-title":"APE1 senses DNA single-strand breaks for repair and signaling","volume":"48","author":"Lin","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib49","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1093\/nar\/gkac853","article-title":"APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus","volume":"50","author":"Li","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib50","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41467-020-20853-2","article-title":"APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/35000249","article-title":"DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]","volume":"403","author":"Mol","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2024.103776_bib52","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1093\/nar\/gkac695","article-title":"Processing oxidatively damaged bases at DNA strand breaks by APE1","volume":"50","author":"Whitaker","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib53","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.1093\/emboj\/16.21.6548","article-title":"The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites","volume":"16","author":"Gorman","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2024.103776_bib54","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1016\/j.csbj.2021.06.036","article-title":"Understanding APE1 cellular functions by the structural preference of exonuclease activities","volume":"19","author":"Liu","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.dnarep.2024.103776_bib55","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2024.103776_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82324","article-title":"APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response","volume":"12","author":"Lin","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.dnarep.2024.103776_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102698","article-title":"Mechanism of stimulation of DNA binding of the transcription factors by human apurinic\/apyrimidinic endonuclease 1, APE1","volume":"82","author":"Bazlekowa-Karaban","year":"2019","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2024.103776_bib58","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.1619809114","article-title":"Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair","volume":"114","author":"Fleming","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2024.103776_bib59","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/acsbiomedchemau.1c00031","article-title":"Binding of AP endonuclease-1 to G-quadruplex DNA depends on the N-terminal domain, Mg2+, and ionic strength","volume":"1","author":"Fleming","year":"2021","journal-title":"ACS Bio Med. Chem. Au"},{"key":"10.1016\/j.dnarep.2024.103776_bib60","doi-asserted-by":"crossref","first-page":"11409","DOI":"10.1073\/pnas.1912355117","article-title":"Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome","volume":"117","author":"Roychoudhury","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2024.103776_bib61","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1093\/nar\/gkac172","article-title":"The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells","volume":"50","author":"Pramanik","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib62","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.dnarep.2018.11.010","article-title":"Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence","volume":"73","author":"Burra","year":"2019","journal-title":"DNA Repair"},{"issue":"1","key":"10.1016\/j.dnarep.2024.103776_bib63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/em.22570","article-title":"Oxidative DNA damage on the VEGF G-quadruplex forming promoter is repaired via long-patch BER","volume":"65","author":"Hussen","year":"2024","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.dnarep.2024.103776_bib64","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1093\/emboj\/20.22.6530","article-title":"XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions","volume":"20","author":"Vidal","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2024.103776_bib65","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2741\/4555","article-title":"Base excision repair of oxidative DNA damage: from mechanism to disease","volume":"22","author":"Whitaker","year":"2017","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.dnarep.2024.103776_bib66","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/82818","article-title":"Passing the baton in base excision repair","volume":"7","author":"Wilson","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib67","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.dnarep.2006.10.010","article-title":"Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein","volume":"6","author":"Mitra","year":"2007","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2024.103776_bib68","doi-asserted-by":"crossref","first-page":"8239","DOI":"10.1093\/nar\/gkq691","article-title":"Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions","volume":"38","author":"Fantini","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib69","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tcb.2023.02.003","article-title":"Molecular mechanisms of nucleolar DNA damage checkpoint response","volume":"33","author":"Li","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib70","article-title":"Distinct regulation of ATM signaling by DNA single-strand breaks and APE1","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib71","article-title":"Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic","volume":"1","author":"Shah","year":"2017","journal-title":"NPJ Precis Oncol."},{"key":"10.1016\/j.dnarep.2024.103776_bib72","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1158\/1535-7163.MCT-11-0107","article-title":"Impact of APE1\/Ref-1 redox inhibition on pancreatic tumor growth","volume":"10","author":"Fishel","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.dnarep.2024.103776_bib73","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1158\/1535-7163.MCT-16-0253","article-title":"Regulation of HIF1alpha under hypoxia by APE1\/Ref-1 impacts CA9 expression: dual targeting in patient-derived 3D pancreatic cancer models","volume":"15","author":"Logsdon","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.dnarep.2024.103776_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111992","article-title":"The redox function of apurinic\/apyrimidinic endonuclease 1 as key modulator in photodynamic therapy","volume":"211","author":"Franchi","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.dnarep.2024.103776_bib75","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/1874467211205010036","article-title":"APE1\/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair\/redox protein APE1\/Ref-1","volume":"5","author":"Kelley","year":"2012","journal-title":"Curr. Mol. Pharm."},{"key":"10.1016\/j.dnarep.2024.103776_bib76","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/nar\/gkv1520","article-title":"3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair","volume":"44","author":"Schuermann","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib77","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1158\/1535-7163.679.3.6","article-title":"Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition","volume":"3","author":"Wang","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.dnarep.2024.103776_bib78","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1124\/jpet.118.248088","article-title":"Ref-1\/APE1 inhibition with novel small molecules blocks ocular neovascularization","volume":"367","author":"Sardar Pasha","year":"2018","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.dnarep.2024.103776_bib79","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1093\/nar\/gkh846","article-title":"Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic\/apyrimidinic endonuclease from human placenta","volume":"32","author":"Beloglazova","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib80","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1074\/jbc.272.2.1302","article-title":"Substrate binding by human apurinic\/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism","volume":"272","author":"Strauss","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib81","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.dnarep.2014.03.022","article-title":"The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once","volume":"19","author":"Tsutakawa","year":"2014","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2024.103776_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/cells12141895","article-title":"Revisiting two decades of research focused on targeting APE1 for cancer therapy: the pros and cons","volume":"12","author":"Malfatti","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.dnarep.2024.103776_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103133","article-title":"Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing\/decay","volume":"104","author":"Malfatti","year":"2021","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.dnarep.2024.103776_bib84","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1007\/s00018-010-0486-4","article-title":"Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment","volume":"67","author":"Tell","year":"2010","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib85","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1093\/nar\/gkl259","article-title":"Human Ape2 protein has a 3\u2032-5\u2032 exonuclease activity that acts preferentially on mismatched base pairs","volume":"34","author":"Burkovics","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib86","doi-asserted-by":"crossref","first-page":"14222","DOI":"10.1074\/jbc.RA120.014228","article-title":"A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage","volume":"295","author":"Ha","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib87","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1021\/bi401218r","article-title":"Transient-state kinetics of apurinic\/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly used substrate analogs: the effect of diverse metal ions and base mismatches","volume":"52","author":"Schermerhorn","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.dnarep.2024.103776_bib88","doi-asserted-by":"crossref","first-page":"30577","DOI":"10.1074\/jbc.M704341200","article-title":"Pre-steady-state kinetic characterization of the AP endonuclease activity of human AP endonuclease 1","volume":"282","author":"Maher","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.21892","article-title":"Recognition and repair of chemically heterogeneous structures at DNA ends","volume":"56","author":"Andres","year":"2015","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.dnarep.2024.103776_bib90","doi-asserted-by":"crossref","first-page":"36242","DOI":"10.1074\/jbc.M306065200","article-title":"Modulation of the 3\u2032-->5\u2032-exonuclease activity of human apurinic endonuclease (Ape1) by its 5\u2032-incised Abasic DNA product","volume":"278","author":"Wong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib91","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/415655a","article-title":"An exonucleolytic activity of human apurinic\/apyrimidinic endonuclease on 3\u2032 mispaired DNA","volume":"415","author":"Chou","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2024.103776_bib92","doi-asserted-by":"crossref","first-page":"18289","DOI":"10.1074\/jbc.M212143200","article-title":"The exonuclease activity of human apurinic\/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G","volume":"278","author":"Chou","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib93","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14045","article-title":"Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair","volume":"8","author":"Caglayan","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib94","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1093\/nar\/27.20.4028","article-title":"Delayed DNA joining at 3\u2032 mismatches by human DNA ligases","volume":"27","author":"Bhagwat","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib95","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1093\/nar\/22.10.1866","article-title":"Removal of 3\u2032-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic\/apyrimidinic endonuclease 1","volume":"22","author":"Winters","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib96","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1242\/jcs.075325","article-title":"UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways","volume":"124","author":"Vrouwe","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082389","article-title":"Single-strand break end resection in genome integrity: mechanism and regulation by APE2","volume":"19","author":"Hossain","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.dnarep.2024.103776_bib98","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm.2017.67","article-title":"The essential kinase ATR: ensuring faithful duplication of a challenging genome","volume":"18","author":"Saldivar","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib99","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.4161\/cc.8.18.9485","article-title":"TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation","volume":"8","author":"Yan","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.dnarep.2024.103776_bib100","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/nar\/gky020","article-title":"APE2 promotes DNA damage response pathway from a single-strand break","volume":"46","author":"Lin","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10399","article-title":"Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells","volume":"7","author":"Nassour","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib102","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1073\/pnas.1301445110","article-title":"APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress","volume":"110","author":"Willis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2024.103776_bib103","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.15252\/embj.201694920","article-title":"A new sub-pathway of long-patch base excision repair involving 5\u2032 gap formation","volume":"36","author":"Woodrick","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.dnarep.2024.103776_bib104","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.tcb.2022.04.010","article-title":"DNA single-strand break repair and human genetic disease","volume":"32","author":"Caldecott","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib105","doi-asserted-by":"crossref","first-page":"37768","DOI":"10.1074\/jbc.M304914200","article-title":"Human apurinic\/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis","volume":"278","author":"Yoshida","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib106","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ni885","article-title":"Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A","volume":"4","author":"Fan","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.dnarep.2024.103776_bib107","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1065521","article-title":"ATR and ATRIP: partners in checkpoint signaling","volume":"294","author":"Cortez","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2024.103776_bib108","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1128\/MCB.24.3.1292-1300.2003","article-title":"Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities","volume":"24","author":"Unsal-Kacmaz","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib109","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1097-2765(03)00045-5","article-title":"Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17","volume":"11","author":"Lee","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.dnarep.2024.103776_bib110","doi-asserted-by":"crossref","first-page":"13346","DOI":"10.1074\/jbc.M311098200","article-title":"A novel protein activity mediates DNA binding of an ATR-ATRIP complex","volume":"279","author":"Bomgarden","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib111","doi-asserted-by":"crossref","first-page":"38355","DOI":"10.1074\/jbc.M508673200","article-title":"Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP","volume":"280","author":"Kim","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib112","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1093\/nar\/gkv371","article-title":"High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation","volume":"43","author":"Sokka","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib113","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1091\/mbc.e12-04-0299","article-title":"Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells","volume":"23","author":"Lirussi","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.dnarep.2024.103776_bib114","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1038\/onc.2013.251","article-title":"Functional regulation of the apurinic\/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology","volume":"33","author":"Vascotto","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2024.103776_bib115","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae598","article-title":"Monitoring nucleolar-nucleoplasmic protein shuttling in living cells by high-content microscopy and automated image analysis","volume":"52","author":"Engbrecht","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2024.103776_bib116","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/bmc-2020-0019","article-title":"Role of phase partitioning in coordinating DNA damage response: focus on the Apurinic Apyrimidinic Endonuclease 1 interactome","volume":"11","author":"Tosolini","year":"2020","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.dnarep.2024.103776_bib117","article-title":"Nucleolar accumulation of APE1 through condensates is mediated by rRNA forming G-quadruplex structure","author":"Dall\u2019Agnese","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.dnarep.2024.103776_bib118","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/ncb3422","article-title":"Activation of the ATR kinase by the RPA-binding protein ETAA1","volume":"18","author":"Haahr","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib119","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/ncb3415","article-title":"ETAA1 acts at stalled replication forks to maintain genome integrity","volume":"18","author":"Bass","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.dnarep.2024.103776_bib120","doi-asserted-by":"crossref","first-page":"8395","DOI":"10.1074\/jbc.RA119.008154","article-title":"Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation","volume":"294","author":"Thada","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.dnarep.2024.103776_bib121","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.dnarep.2024.103776_bib122","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev-biochem-060614-034335","article-title":"Mechanisms of ATM activation","volume":"84","author":"Paull","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.dnarep.2024.103776_bib123","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1091496","article-title":"Direct activation of the ATM protein kinase by the Mre11\/Rad50\/Nbs1 complex","volume":"304","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2024.103776_bib124","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1038\/cdd.2012.53","article-title":"DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity","volume":"19","author":"Fortini","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.dnarep.2024.103776_bib125","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15104","article-title":"DNA single-strand break-induced DNA damage response causes heart failure","volume":"8","author":"Higo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2024.103776_bib126","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/carcin\/bgv079","article-title":"Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway","volume":"36","author":"Chou","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2024.103776_bib127","first-page":"161","article-title":"Methods for studying DNA single-strand break repair and signaling in Xenopus laevis egg extracts","volume":"2019","author":"Lin","year":"1999","journal-title":"Methods Mol. Biol."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786424001526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786424001526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T07:17:51Z","timestamp":1733037471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786424001526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":127,"alternative-id":["S1568786424001526"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2024.103776","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"APE1 is a master regulator of the ATR-\/ATM-mediated DNA damage response","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2024.103776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103776"}}