{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:05:16Z","timestamp":1784102716123,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.dnarep.2026.103946","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:41:05Z","timestamp":1781023265000},"page":"103946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["DNA-repair and transcriptional defects drive hematologic malignancies in xeroderma pigmentosum group C patients: A new hypothesis"],"prefix":"10.1016","volume":"164","author":[{"given":"Alain","family":"Sarasin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dnarep.2026.103946_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI195732","article-title":"TFIIH-p52\u0394C defines a ninth xeroderma pigmentosum complementation-group XP-J and restores TFIIH stability to p8-defective trichothiodystrophy","volume":"135","author":"Nakazawa","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.dnarep.2026.103946_bib2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nrm2549","article-title":"Transcription-coupled DNA repair: two decades of progress and surprises","volume":"9","author":"Hanawalt","year":"2008","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.dnarep.2026.103946_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/humu.22462","article-title":"Correlation of phenotype\/genotype in a cohort of 23 xeroderma pigmentosum-variant patients reveals 12 new disease-causing POLH mutations","volume":"35","author":"Opletalova","year":"2014","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.dnarep.2026.103946_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archderm.1987.01660260111026","article-title":"Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases","volume":"123","author":"Kraemer","year":"1987","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.dnarep.2026.103946_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13023-022-02203-1","article-title":"Increased risk of internal tumors in DNA repair-deficient xeroderma pigmentosum patients: analysis of four international cohorts","volume":"17","author":"Nikolaev","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.dnarep.2026.103946_bib6","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1182\/blood-2019-01-895698","article-title":"Familial predisposition to TP53\/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum","volume":"133","author":"Sarasin","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.dnarep.2026.103946_bib7","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.3324\/haematol.2019.223370","article-title":"Predisposition to hematologic malignancies in patients with xeroderma pigmentosum","volume":"105","author":"Oetjen","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.dnarep.2026.103946_bib8","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.3390\/cancers15102706","article-title":"The French Cohort of DNA Repair-Deficient Xeroderma Pigmentosum Patients: Risk of Hematological Malignancies","volume":"15","author":"Sarasin","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.dnarep.2026.103946_bib9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/carcin\/bgx002","article-title":"DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression","volume":"38","author":"Biechonski","year":"2017","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2026.103946_bib10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(87)90151-6","article-title":"Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene","volume":"51","author":"Mellon","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.dnarep.2026.103946_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107053","article-title":"Predicting the number of lifetime divisions for hematopoietic stem cells from telomere length measurements","volume":"26","author":"Boyle","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.dnarep.2026.103946_bib12","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1038\/s41467-020-19633-9","article-title":"XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature","volume":"11","author":"Yurchenko","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2026.103946_bib13","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1038\/sj.onc.1203844","article-title":"Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair","volume":"19","author":"Wijnhoven","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2026.103946_bib14","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1182\/blood-2017-01-764274","article-title":"Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions","volume":"130","author":"Mart\u00edn-Pardillos","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.dnarep.2026.103946_bib15","first-page":"538","article-title":"Deficiency in the catalase activity of xeroderma pigmentosum cell and simian virus 40-transformed human cell extracts","volume":"46","author":"Vuillaume","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.dnarep.2026.103946_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/carcin\/bgh046","article-title":"Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes","volume":"25","author":"Arbault","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.dnarep.2026.103946_bib17","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/jid.2014.511","article-title":"Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice","volume":"135","author":"Hosseini","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.dnarep.2026.103946_bib18","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41467-025-67072-1","article-title":"Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Pol\u03ba and DNA repair","volume":"17","author":"Jiang","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2026.103946_bib19","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/nar\/gkq983","article-title":"GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage","volume":"39","author":"Guo","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.dnarep.2026.103946_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molcel.2010.03.004","article-title":"NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack","volume":"38","author":"Le May","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1016\/j.dnarep.2026.103946_bib21","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1038\/s41467-018-05010-0","article-title":"XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1","volume":"9","author":"Bidon","year":"2018","journal-title":"Nat. Comm."},{"key":"10.1016\/j.dnarep.2026.103946_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000322593","article-title":"Aberrant methylation of death-associated protein kinase 1 CpG islands in myelodysplastic syndromes","volume":"125","author":"Wu","year":"2011","journal-title":"Acta Haematol."},{"key":"10.1016\/j.dnarep.2026.103946_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1091\/mbc.e13-05-0293","article-title":"XPC promotes MDM2-mediated degradation of the p53 tumor suppressor","volume":"25","author":"Krzeszinski","year":"2014","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.dnarep.2026.103946_bib24","doi-asserted-by":"crossref","first-page":"a026070","DOI":"10.1101\/cshperspect.a026070","article-title":"p53 in the DNA-Damage-Repair Process","volume":"6","author":"Williams","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":".1","key":"10.1016\/j.dnarep.2026.103946_bib25","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1182\/blood-2025-6749","article-title":"Xeroderma pigmentosum as a germline predisposition syndrome for haematological malignancies","volume":"146","author":"Alfaham","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.dnarep.2026.103946_bib26","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1365-2133.2008.08791.x","article-title":"Xeroderma pigmentosum group C in a French Caucasian patient with multiple melanoma and unusual long-term survival","volume":"159","author":"Jacobelli","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.dnarep.2026.103946_bib27","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1038\/s41467-023-38311-0","article-title":"Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients","volume":"14","author":"Yurchenko","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2026.103946_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.semcdb.2020.10.009","article-title":"Transcription blockage by DNA damage in nucleotide excision repair-related neurological dysfunctions","volume":"114","author":"Kajitani","year":"2021","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.dnarep.2026.103946_bib29","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/bjd.12523","article-title":"Patients with xeroderma pigmentosum complementation groups C, E and V do not have abnormal sunburn reactions","volume":"169","author":"Sethi","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.dnarep.2026.103946_bib30","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","article-title":"Aging and neurodegeneration are associated with increased mutations in single human neurons","volume":"359","author":"Lodato","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.dnarep.2026.103946_bib31","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1038\/s41467-022-33642-w","article-title":"Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders","volume":"13","author":"Kim","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.dnarep.2026.103946_bib32","doi-asserted-by":"crossref","first-page":"E1236","DOI":"10.1073\/pnas.1519444113","article-title":"Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect","volume":"113","author":"Fassihi","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.dnarep.2026.103946_bib33","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/ajh.70273","article-title":"Feasibility of Allogeneic Stem Cell Transplantation in Xeroderma Pigmentosum Patients with Hematologic Malignancies, a report from the SFGM-TC (Soci\u00e9t\u00e9 Francophone de Greffe de Moelle et de Th\u00e9rapie Cellulaire)","volume":"101","author":"Chevillon","year":"2026","journal-title":"Am. J. Hematol."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156878642600025X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156878642600025X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:11:18Z","timestamp":1784099478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156878642600025X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"alternative-id":["S156878642600025X"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2026.103946","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA-repair and transcriptional defects drive hematologic malignancies in xeroderma pigmentosum group C patients: A new hypothesis","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2026.103946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103946"}}