{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T07:23:14Z","timestamp":1794122594760,"version":"4.8.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL052725"],"award-info":[{"award-number":["R01HL052725"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["DNA Repair"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.dnarep.2026.103958","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:28:17Z","timestamp":1788622097000},"page":"103958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of CHAMP1 in chromatin-mediated DNA damage repair"],"prefix":"10.1016","volume":"167","author":[{"given":"Felix Y.","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinal A.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aindri H.","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisha","family":"Mukkavalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"D\u2019Andrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.dnarep.2026.103958_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrm.2016.48","article-title":"The Fanconi anaemia pathway: new players and new functions.","volume":"17","author":"Ceccaldi","year":"2016","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"18","key":"10.1016\/j.dnarep.2026.103958_bib2","doi-asserted-by":"crossref","first-page":"R986","DOI":"10.1016\/j.cub.2017.07.043","article-title":"Fanconi anemia pathway","volume":"27","author":"Rodriguez","year":"2017","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41573-022-00558-5","article-title":"Targeting replication stress in cancer therapy","volume":"22","author":"da Costa","year":"2023","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.dnarep.2026.103958_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215804","article-title":"Mechanisms used by cancer cells to tolerate drug-induced replication stress","volume":"544","author":"Segeren","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/emboj.2010.276","article-title":"CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment","volume":"30","author":"Itoh","year":"2011","journal-title":"EMBO J."},{"issue":"43","key":"10.1016\/j.dnarep.2026.103958_bib6","doi-asserted-by":"crossref","first-page":"17658","DOI":"10.1074\/jbc.M117.804237","article-title":"Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP)","volume":"292","author":"Hara","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.dnarep.2026.103958_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/EBC20190073","article-title":"Leaving no-one behind: how CENP-E facilitates chromosome alignment","volume":"64","author":"Craske","year":"2020","journal-title":"Essays Biochem."},{"issue":"5","key":"10.1016\/j.dnarep.2026.103958_bib8","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.220269","article-title":"Dynein at the kinetochore","volume":"136","author":"Gassmann","year":"2023","journal-title":"J. Cell. Sci."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2525144122","article-title":"CHAMP1 complex promotes heterochromatin assembly and reduces replication stress","volume":"123","author":"Li","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.dnarep.2026.103958_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111297","article-title":"CHAMP1 binds to REV7\/FANCV and promotes homologous recombination repair","volume":"40","author":"Li","year":"2022","journal-title":"Cell. Rep."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib11","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/s41467-025-56834-6","article-title":"CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.dnarep.2026.103958_bib12","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a006092","article-title":"Neurodevelopmental phenotypes in individuals with pathogenic variants in CHAMP1","volume":"7","author":"Garrity","year":"2021","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41556-019-0442-y","article-title":"TRIP13 regulates DNA repair pathway choice through REV7 conformational change","volume":"22","author":"Clairmont","year":"2020","journal-title":"Nat. Cell. Biol."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF00383316","article-title":"REV7, a new gene concerned with UV mutagenesis in yeast","volume":"200","author":"Lawrence","year":"1985","journal-title":"Mol. Gen. Genet."},{"issue":"12","key":"10.1016\/j.dnarep.2026.103958_bib15","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.tcb.2021.05.009","article-title":"REV7 directs DNA repair pathway choice","volume":"31","author":"Clairmont","year":"2021","journal-title":"Trends Cell. Biol."},{"issue":"2","key":"10.1016\/j.dnarep.2026.103958_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/nar\/gku1385","article-title":"REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase z","volume":"43","author":"Tomida","year":"2015","journal-title":"eta. Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib17","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s42003-023-04757-7","article-title":"Shieldin complex assembly kinetics and DNA binding by SHLD3","volume":"6","author":"Susvirkar","year":"2023","journal-title":"Commun. Biol."},{"issue":"10","key":"10.1016\/j.dnarep.2026.103958_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110089","article-title":"Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes","volume":"37","author":"Markenscoff-Papadimitriou","year":"2021","journal-title":"Cell. Rep."},{"issue":"8","key":"10.1016\/j.dnarep.2026.103958_bib19","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/ajmg.a.61206","article-title":"POGZ-related epilepsy: case report and review of the literature","volume":"179","author":"Ferretti","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.dnarep.2026.103958_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40303-016-0016-x","article-title":"De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ","volume":"4","author":"Matsumura","year":"2016","journal-title":"J. Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib21","doi-asserted-by":"crossref","first-page":"a000455","DOI":"10.1101\/mcs.a000455","article-title":"De novo POGZ mutations are associated with neurodevelopmental disorders and microcephaly","volume":"1","author":"Ye","year":"2015","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"issue":"4","key":"10.1016\/j.dnarep.2026.103958_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4161\/epi.5.4.11683","article-title":"HP1: heterochromatin binding proteins working the genome","volume":"5","author":"Zeng","year":"2010","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051041","article-title":"POGZ promotes homology-directed DNA repair in an HP1-dependent manner","volume":"23","author":"Heath","year":"2022","journal-title":"EMBO Rep."},{"issue":"19","key":"10.1016\/j.dnarep.2026.103958_bib24","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1038\/s41388-022-02299-6","article-title":"CHAMP1-POGZ counteracts the inhibitory effect of 53BP1 on homologous recombination and affects PARP inhibitor resistance","volume":"41","author":"Fujita","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.dnarep.2026.103958_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-genet-110410-132435","article-title":"Double-strand break end resection and repair pathway choice","volume":"45","author":"Symington","year":"2011","journal-title":"Annu. Rev. Genet."},{"issue":"7716","key":"10.1016\/j.dnarep.2026.103958_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-018-0324-7","article-title":"53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polalpha-dependent fill-in","volume":"560","author":"Mirman","year":"2018","journal-title":"Nature"},{"issue":"19-20","key":"10.1016\/j.dnarep.2026.103958_bib27","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1101\/gad.348667.121","article-title":"Role of 53BP1 in end protection and DNA synthesis at DNA breaks","volume":"35","author":"Paiano","year":"2021","journal-title":"Genes. Dev."},{"issue":"15","key":"10.1016\/j.dnarep.2026.103958_bib28","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3701","article-title":"SMART (Single molecule analysis of resection tracks) technique for assessing dna end-resection in response to DNA damage","volume":"10","author":"Altieri","year":"2020","journal-title":"Bio Protoc."},{"issue":"8","key":"10.1016\/j.dnarep.2026.103958_bib29","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1093\/nar\/gkx126","article-title":"RAD51 interconnects between DNA replication, DNA repair and immunity","volume":"45","author":"Bhattacharya","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.dnarep.2026.103958_bib30","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41556-023-01167-z","article-title":"Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability","volume":"25","author":"Gaggioli","year":"2023","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.dnarep.2026.103958_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4939-6747-6_3","article-title":"Proteome characterization of a chromatin locus using the proteomics of isolated chromatin segments approach","volume":"1550","author":"Kan","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.dnarep.2026.103958_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nchembio0309-129","article-title":"Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex","volume":"5","author":"Garner","year":"2009","journal-title":"Nat. Chem. Biol."},{"issue":"48","key":"10.1016\/j.dnarep.2026.103958_bib33","doi-asserted-by":"crossref","first-page":"E6624","DOI":"10.1073\/pnas.1508543112","article-title":"Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation","volume":"112","author":"Vallerga","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.dnarep.2026.103958_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112867","article-title":"POGZ suppresses 2C transcriptional program and retrotransposable elements","volume":"42","author":"Sun","year":"2023","journal-title":"Cell. Rep."},{"issue":"2","key":"10.1016\/j.dnarep.2026.103958_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/biom12020248","article-title":"PrimPol: a breakthrough among DNA replication enzymes and a potential new target for cancer therapy","volume":"12","author":"Diaz-Talavera","year":"2022","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.dnarep.2026.103958_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.dnarep.2026.103958_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fgene.2013.00026","article-title":"The DNA damage checkpoint response to replication stress: a game of forks","volume":"4","author":"Jossen","year":"2013","journal-title":"Front. Genet."},{"issue":"9","key":"10.1016\/j.dnarep.2026.103958_bib38","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012716","article-title":"DNA damage sensing by the ATM and ATR kinases","volume":"5","author":"Marechal","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"15","key":"10.1016\/j.dnarep.2026.103958_bib39","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1093\/hmg\/ddac018","article-title":"CHAMP1 disorder is associated with a complex neurobehavioral phenotype including autism, ADHD, repetitive behaviors and sensory symptoms","volume":"31","author":"Levy","year":"2022","journal-title":"Hum. Mol. Genet."},{"issue":"7542","key":"10.1016\/j.dnarep.2026.103958_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature14135","article-title":"Large-scale discovery of novel genetic causes of developmental disorders.","volume":"519","author":"Deciphering Developmental Disorders, S","year":"2015","journal-title":"Nature"},{"issue":"7509","key":"10.1016\/j.dnarep.2026.103958_bib41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature13394","article-title":"Genome sequencing identifies major causes of severe intellectual disability","volume":"511","author":"Gilissen","year":"2014","journal-title":"Nature"},{"issue":"7526","key":"10.1016\/j.dnarep.2026.103958_bib42","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature13908","article-title":"The contribution of de novo coding mutations to autism spectrum disorder","volume":"515","author":"Iossifov","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.dnarep.2026.103958_bib43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ajhg.2015.08.003","article-title":"De Novo mutations in CHAMP1 cause intellectual disability with severe speech impairment","volume":"97","author":"Hempel","year":"2015","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.dnarep.2026.103958_bib44","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/humu.22952","article-title":"De Novo Truncating mutations in the kinetochore-microtubules attachment gene CHAMP1 cause syndromic intellectual disability","volume":"37","author":"Isidor","year":"2016","journal-title":"Hum. Mutat."},{"issue":"5","key":"10.1016\/j.dnarep.2026.103958_bib45","doi-asserted-by":"crossref","first-page":"fcac220","DOI":"10.1093\/braincomms\/fcac220","article-title":"Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype","volume":"4","author":"Nagai","year":"2022","journal-title":"Brain Commun."},{"issue":"1","key":"10.1016\/j.dnarep.2026.103958_bib46","doi-asserted-by":"crossref","first-page":"a000661","DOI":"10.1101\/mcs.a000661","article-title":"De novo pathogenic variants in CHAMP1 are associated with global developmental delay, intellectual disability, and dysmorphic facial features","volume":"2","author":"Tanaka","year":"2016","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"issue":"7353","key":"10.1016\/j.dnarep.2026.103958_bib47","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Cancer Genome Atlas Research, N., Integrated genomic analyses of ovarian carcinoma.","volume":"474","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.dnarep.2026.103958_bib48","doi-asserted-by":"crossref","DOI":"10.4081\/ejh.2021.3264","article-title":"Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma","volume":"65","author":"Zheng","year":"2021","journal-title":"Eur. J. Histochem."},{"issue":"22","key":"10.1016\/j.dnarep.2026.103958_bib49","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1158\/0008-5472.CAN-23-3887","article-title":"The neurodevelopmental protein POGZ suppresses metastasis in triple-negative breast cancer by attenuating TGFbeta signaling,","volume":"84","author":"Heath","year":"2024","journal-title":"Cancer Res."}],"container-title":["DNA Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786426000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568786426000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T06:59:39Z","timestamp":1794121179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568786426000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S1568786426000376"],"URL":"https:\/\/doi.org\/10.1016\/j.dnarep.2026.103958","relation":{},"ISSN":["1568-7864"],"issn-type":[{"value":"1568-7864","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of CHAMP1 in chromatin-mediated DNA damage repair","name":"articletitle","label":"Article Title"},{"value":"DNA Repair","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dnarep.2026.103958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103958"}}