{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:21:07Z","timestamp":1781288467316,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D15CA-052"],"award-info":[{"award-number":["D15CA-052"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"AKC Canine Health Foundation","doi-asserted-by":"publisher","award":["02011"],"award-info":[{"award-number":["02011"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Domestic Animal Endocrinology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.domaniend.2017.11.001","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T04:30:14Z","timestamp":1511325014000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: in\u00a0vitro study"],"prefix":"10.1016","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-9853","authenticated-orcid":false,"given":"K.","family":"Sanders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Slob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.S.","family":"Kooistra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-4995","authenticated-orcid":false,"given":"S.","family":"Galac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.domaniend.2017.11.001_bib1","series-title":"Clinical endocrinology of dogs and cats","first-page":"93","article-title":"Adrenals","author":"Galac","year":"2010"},{"key":"10.1016\/j.domaniend.2017.11.001_bib2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1354\/vp.41-5-490","article-title":"Indicators of malignancy of canine adrenocortical tumors: histopathology and proliferation index","volume":"41","author":"Labelle","year":"2004","journal-title":"Vet Pathol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/jvim.12303","article-title":"Long-term survival of dogs with adrenal-dependent hyperadrenocorticism: a comparison between mitotane and twice daily trilostane treatment","volume":"28","author":"Arenas","year":"2014","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.domaniend.2017.11.001_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0195-5616(97)50030-1","article-title":"Medical treatment of pituitary-dependent hyperadrenocorticism. Mitotane","volume":"27","author":"Peterson","year":"1997","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1016\/j.domaniend.2017.11.001_bib5","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.2460\/javma.238.11.1441","article-title":"Evaluation of twice-daily lower-dose trilostane treatment administered orally in dogs with naturally occurring hyperadrenocorticism","volume":"238","author":"Feldman","year":"2011","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.domaniend.2017.11.001_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/vr.160.7.219","article-title":"Histological evaluation of the adrenal glands of seven dogs with hyperadrenocorticism treated with trilostane","volume":"160","author":"Reusch","year":"2007","journal-title":"Vet Rec"},{"key":"10.1016\/j.domaniend.2017.11.001_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tvjl.2008.10.007","article-title":"Effects of trilostane on the pituitary-adrenocortical and renin-aldosterone axis in dogs with pituitary-dependent hypercortisolism","volume":"183","author":"Galac","year":"2010","journal-title":"Vet J"},{"key":"10.1016\/j.domaniend.2017.11.001_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1748-5827.2004.tb00241.x","article-title":"Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism","volume":"45","author":"Chapman","year":"2004","journal-title":"J Small Anim Pract"},{"key":"10.1016\/j.domaniend.2017.11.001_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/vr.163.6.190","article-title":"Trilostane therapy for hyperadrenocorticism in three dogs with adrenocortical metastasis","volume":"163","author":"Benchekroun","year":"2008","journal-title":"Vet Rec"},{"key":"10.1016\/j.domaniend.2017.11.001_bib10","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/me.2009-0519","article-title":"Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease","volume":"24","author":"Schimmer","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib11","first-page":"1249","article-title":"Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I","volume":"6","author":"Lala","year":"1992","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib12","doi-asserted-by":"crossref","first-page":"17913","DOI":"10.1016\/S0021-9258(19)37129-7","article-title":"A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s","volume":"267","author":"Morohashi","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.domaniend.2017.11.001_bib13","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1128\/MCB.25.23.10442-10453.2005","article-title":"SF-1 (nuclear receptor 5A1) activity is activated by cyclic AMP via p300-mediated recruitment to active foci, acetylation, and increased DNA binding","volume":"25","author":"Chen","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(94)90211-9","article-title":"A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation","volume":"77","author":"Luo","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.domaniend.2017.11.001_bib15","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1073\/pnas.92.24.10939","article-title":"Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids","volume":"92","author":"Sadovsky","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.domaniend.2017.11.001_bib16","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1210\/endo.143.8.8944","article-title":"Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy","volume":"143","author":"Beuschlein","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.domaniend.2017.11.001_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-1336-1-8","article-title":"SF-1 a key player in the development and differentiation of steroidogenic tissues","volume":"1","author":"Val","year":"2003","journal-title":"Nucl Recept"},{"key":"10.1016\/j.domaniend.2017.11.001_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3109\/07435800009048563","article-title":"Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress","volume":"26","author":"Bland","year":"2000","journal-title":"Endocr Res"},{"key":"10.1016\/j.domaniend.2017.11.001_bib19","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1210\/me.2007-0120","article-title":"Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer","volume":"21","author":"Doghman","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.domaniend.2014.04.002","article-title":"Expression of steroidogenic factor 1 in canine cortisol-secreting adrenocortical tumors and normal adrenals","volume":"49","author":"Galac","year":"2014","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib21","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1124\/mol.108.045963","article-title":"Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening","volume":"73","author":"Madoux","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib22","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1016\/j.bmcl.2008.03.027","article-title":"Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds","volume":"18","author":"Roth","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.domaniend.2017.11.001_bib23","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1210\/jc.2008-2163","article-title":"Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists","volume":"94","author":"Doghman","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.domaniend.2017.11.001_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.domaniend.2010.07.001","article-title":"Expression of the ACTH receptor, steroidogenic acute regulatory protein, and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors","volume":"39","author":"Galac","year":"2010","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1677\/joe.0.0770111","article-title":"Biochemical characterization of pituitary-dependent hyperadrenocorticism in the dog","volume":"77","author":"Meijer","year":"1978","journal-title":"J Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/jvim.13946","article-title":"New insights in the functional zonation of the canine adrenal cortex","volume":"30","author":"Sanders","year":"2016","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.domaniend.2017.11.001_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ab.2006.06.001","article-title":"Development and evaluation of canine reference genes for accurate quantification of gene expression","volume":"356","author":"Brinkhof","year":"2006","journal-title":"Anal Biochem"},{"key":"10.1016\/j.domaniend.2017.11.001_bib28","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1186\/s13104-015-1628-4","article-title":"Reference genes for reverse transcription quantitative PCR in canine brain tissue","volume":"8","author":"Stassen","year":"2015","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.domaniend.2017.11.001_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.domaniend.2017.11.001_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2003.12.020","article-title":"Adrenocortical cell lines","volume":"228","author":"Rainey","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/me.2006-0478","article-title":"Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7","volume":"22","author":"Lewis","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1210\/me.2005-0215","article-title":"Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation","volume":"20","author":"Winnay","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib34","doi-asserted-by":"crossref","first-page":"37659","DOI":"10.1074\/jbc.M104427200","article-title":"Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5","volume":"276","author":"Jacob","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.domaniend.2017.11.001_bib35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cell.2005.01.024","article-title":"Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1","volume":"120","author":"Krylova","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.domaniend.2017.11.001_bib36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2005.02.002","article-title":"Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1","volume":"17","author":"Li","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.domaniend.2017.11.001_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/me.2007-0508","article-title":"Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands","volume":"23","author":"Sablin","year":"2009","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib38","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1210\/endo.143.4.8748","article-title":"Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)\/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription","volume":"143","author":"Sewer","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.domaniend.2017.11.001_bib39","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1210\/en.2006-0355","article-title":"Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1","volume":"147","author":"Urs","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.domaniend.2017.11.001_bib40","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1128\/MCB.00355-07","article-title":"Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17","volume":"27","author":"Li","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jbior.2016.10.006","article-title":"Phospholipid regulation of the nuclear receptor superfamily","volume":"63","author":"Crowder","year":"2017","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.domaniend.2017.11.001_bib42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/endo.143.1.8599","article-title":"Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1","volume":"143","author":"Aes\u00f8y","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.domaniend.2017.11.001_bib43","first-page":"147","article-title":"The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3\u2032,5\u2032-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase\/c17-20 lyase)","volume":"10","author":"Zhang","year":"1996","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1095\/biolreprod57.4.765","article-title":"Role of steroidogenic-factor 1 in basal and 3\u2032,5\u2032-cyclic adenosine monophosphate-mediated regulation of cytochrome P450 side-chain cleavage enzyme in the mouse","volume":"57","author":"Chau","year":"1997","journal-title":"Biol Reprod"},{"key":"10.1016\/j.domaniend.2017.11.001_bib45","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1095\/biolreprod60.3.628","article-title":"Hormonal regulation of messenger ribonucleic acid expression for steroidogenic factor-1, steroidogenic acute regulatory protein, and cytochrome P450 side-chain cleavage in bovine luteal cells","volume":"60","author":"Mamluk","year":"1999","journal-title":"Biol Reprod"},{"key":"10.1016\/j.domaniend.2017.11.001_bib46","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1677\/joe.0.1680475","article-title":"The role of the pituitary gland and ACTH in the regulation of mRNAs encoding proteins essential for adrenal steroidogenesis in the late-gestation ovine fetus","volume":"168","author":"Simmonds","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib47","doi-asserted-by":"crossref","first-page":"41259","DOI":"10.1074\/jbc.M206595200","article-title":"Repression of DAX-1 and induction of SF-1 expression. Two mechanisms contributing to the activation of aldosterone biosynthesis in adrenal glomerulosa cells","volume":"277","author":"Osman","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.domaniend.2017.11.001_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-015-2489-9","article-title":"SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells","volume":"408","author":"Kulcenty","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.domaniend.2017.11.001_bib49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0303-7207(96)03938-X","article-title":"ACTH and AII differentially stimulate steroid hormone orphan receptor mRNAs in adrenal cortical cells","volume":"124","author":"Enyeart","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib50","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1210\/me.2003-0159","article-title":"DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation","volume":"17","author":"Lalli","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/jc.2010-0653","article-title":"High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors","volume":"95","author":"Sbiera","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.domaniend.2017.11.001_bib52","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.humpath.2012.07.025","article-title":"Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates","volume":"44","author":"Duregon","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.domaniend.2017.11.001_bib53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/bmc-2017-0002","article-title":"Circulating cell-free microRNAs as clinical cancer biomarkers","volume":"8","author":"Armand Labit","year":"2017","journal-title":"Biomol Concepts"}],"container-title":["Domestic Animal Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0739724017301480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0739724017301480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T23:13:49Z","timestamp":1659914029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0739724017301480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":53,"alternative-id":["S0739724017301480"],"URL":"https:\/\/doi.org\/10.1016\/j.domaniend.2017.11.001","relation":{},"ISSN":["0739-7240"],"issn-type":[{"value":"0739-7240","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steroidogenic factor-1 inverse agonists as a treatment option for canine hypercortisolism: in\u00a0vitro study","name":"articletitle","label":"Article Title"},{"value":"Domestic Animal Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.domaniend.2017.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}