{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:38:43Z","timestamp":1789378723493,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"23-24","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.drudis.2010.10.006","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T04:56:50Z","timestamp":1288069010000},"page":"1008-1014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Epigenetic therapies for non-oncology indications"],"prefix":"10.1016","volume":"15","author":[{"given":"Jonathan D.","family":"Best","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nessa","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2010.10.006_bib0005","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.1787609","article-title":"An operational definition of epigenetics","volume":"23","author":"Berger","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.drudis.2010.10.006_bib0010","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.10.006_bib0015","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/bi100213t","article-title":"Coordinated chromatin control: structural and functional linkage of DNA and histone methylation","volume":"49","author":"Cheng","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.drudis.2010.10.006_bib0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1387\/ijdb.082741ki","article-title":"Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development","volume":"53","author":"Ikegami","year":"2009","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.drudis.2010.10.006_bib0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","article-title":"A bivalent chromatin structure marks key developmental genes in embryonic stem cells","volume":"125","author":"Bernstein","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.10.006_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.drudis.2009.10.010","article-title":"Epigenetic opportunities and challenges in cancer","volume":"15","author":"Best","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2010.10.006_bib0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.drudis.2010.10.006_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/epi.09.13","article-title":"Evolving role of MeCP2 in Rett syndrome and autism","volume":"1","author":"Lasalle","year":"2009","journal-title":"Epigenomics"},{"key":"10.1016\/j.drudis.2010.10.006_bib0045","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.drudis.2010.10.006_bib0050","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/jmg.2004.029439","article-title":"Mutations in PHF8 are associated with X linked mental retardation and cleft lip\/cleft palate","volume":"42","author":"Laumonnier","year":"2005","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.drudis.2010.10.006_bib0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/hmg\/ddp480","article-title":"PHF8, a gene associated with cleft lip\/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase","volume":"19","author":"Loenarz","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.drudis.2010.10.006_bib0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12031-009-9237-0","article-title":"Nicotinic receptors, amyloid-beta, and synaptic failure in Alzheimer's disease","volume":"40","author":"Jurgensen","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0065","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2896","article-title":"Alzheimer's disease: strategies for disease modification","volume":"9","author":"Citron","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.drudis.2010.10.006_bib0070","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.pneurobio.2010.01.002","article-title":"Epigenetic regulation in the pathophysiology of Alzheimer's disease","volume":"90","author":"Chouliaras","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.drudis.2010.10.006_bib0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2007.12.002","article-title":"Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders","volume":"8","author":"Abel","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.drudis.2010.10.006_bib0080","first-page":"249","article-title":"Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls","volume":"78","author":"De Bellis","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.drudis.2010.10.006_bib0085","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn.2436","article-title":"Dynamic DNA methylation programs persistent adverse effects of early-life stress","volume":"12","author":"Murgatroyd","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0090","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0095","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0100","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.drudis.2010.10.006_bib0105","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature08732","article-title":"A role for the elongator complex in zygotic paternal genome demethylation","volume":"463","author":"Okada","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.10.006_bib0110","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nature08829","article-title":"Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency","volume":"463","author":"Popp","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2010.10.006_bib0115","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nn.2615","article-title":"MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212","volume":"13","author":"Im","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0120","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nn.2614","article-title":"MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants","volume":"13","author":"Deng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0125","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nn0910-1039","article-title":"MeCP2 and drug addiction","volume":"13","author":"Feng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0130","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nn.2619","article-title":"Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens","volume":"13","author":"LaPlant","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.drudis.2010.10.006_bib0135","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1124\/mol.108.054346","article-title":"Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain","volume":"75","author":"Chiechio","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.drudis.2010.10.006_bib0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1742-1241.2009.02296.x","article-title":"Practical steps to improving the management of type 1 diabetes: recommendations from the Global Partnership for Effective Diabetes Management","volume":"64","author":"Aschner","year":"2010","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.drudis.2010.10.006_bib0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2147\/VHRM.S8564","article-title":"Impact of data from recent clinical trials on strategies for treating patients with type 2 diabetes mellitus","volume":"6","author":"Palumbo","year":"2010","journal-title":"Vasc. Health Risk Manage."},{"key":"10.1016\/j.drudis.2010.10.006_bib0150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1742-1241.2009.02227.x","article-title":"Tailoring treatment to the individual in type 2 diabetes practical guidance from the Global Partnership for Effective Diabetes Management","volume":"64","author":"Prato","year":"2010","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.drudis.2010.10.006_bib0155","doi-asserted-by":"crossref","first-page":"6953","DOI":"10.1371\/journal.pone.0006953","article-title":"Insulin gene expression is regulated by DNA methylation","volume":"4","author":"Kuroda","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.drudis.2010.10.006_bib0160","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2337\/db08-1666","article-title":"Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail","volume":"58","author":"Brasacchio","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.drudis.2010.10.006_bib0165","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/CIRCRESAHA.108.175190","article-title":"Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice","volume":"103","author":"Reddy","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.drudis.2010.10.006_bib0170","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.0803623105","article-title":"Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes","volume":"105","author":"Villeneuve","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drudis.2010.10.006_bib0175","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2337\/db08-0645","article-title":"Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes","volume":"57","author":"Miao","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.drudis.2010.10.006_bib0180","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2337\/db08-1520","article-title":"Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3","volume":"58","author":"Cavener","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.drudis.2010.10.006_bib0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaut.2009.03.007","article-title":"The genetics and epigenetics of autoimmune diseases","volume":"33","author":"Hewagama","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.drudis.2010.10.006_bib0190","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1513\/pats.200907-071DP","article-title":"Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease","volume":"6","author":"Barnes","year":"2009","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.drudis.2010.10.006_bib0195","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/ar2500","article-title":"Epigenetic modifications in rheumatoid arthritis","volume":"10","author":"Strietholt","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.drudis.2010.10.006_bib0200","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1002\/art.23758","article-title":"Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis","volume":"58","author":"Nile","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.drudis.2010.10.006_bib0205","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.4049\/jimmunol.0802412","article-title":"IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation","volume":"182","author":"Garaud","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.drudis.2010.10.006_bib0210","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.drudis.2010.10.006_bib0215","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","author":"HDCRG","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.10.006_bib0220","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1073\/pnas.0437870100","article-title":"Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease","volume":"100","author":"Hockly","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drudis.2010.10.006_bib0225","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pbb.2009.08.001","article-title":"Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease","volume":"94","author":"Zadori","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.drudis.2010.10.006_bib0230","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1074\/jbc.M410210200","article-title":"Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease","volume":"280","author":"Gardian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drudis.2010.10.006_bib0235","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/hmg\/ddp524","article-title":"Huntingtin facilitates polycomb repressive complex 2","volume":"19","author":"Seong","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.drudis.2010.10.006_bib0240","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neulet.2009.10.037","article-title":"HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells","volume":"467","author":"Wang","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.drudis.2010.10.006_bib0245","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/S1461145708009024","article-title":"Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons","volume":"11","author":"Wu","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.drudis.2010.10.006_bib0250","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1471-4159.2009.06212.x","article-title":"The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain","volume":"110","author":"Kim","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.drudis.2010.10.006_bib0255","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/npp.2009.197","article-title":"Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease","volume":"35","author":"Kilgore","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.drudis.2010.10.006_bib0260","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuroscience.2010.04.041","article-title":"Valproic acid enhances microglial phagocytosis of amyloid-beta(1\u201342)","volume":"169","author":"Smith","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.drudis.2010.10.006_bib0265","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2010.10.006_bib0270","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/hmg\/ddq023","article-title":"SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy","volume":"19","author":"Riessland","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"R2","key":"10.1016\/j.drudis.2010.10.006_bib0275","doi-asserted-by":"crossref","first-page":"R216","DOI":"10.1093\/hmg\/ddp401","article-title":"Control of fetal hemoglobin: new insights emerging from genomics and clinical implications","volume":"18","author":"Thein","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.drudis.2010.10.006_bib0280","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1182\/blood.V95.11.3555","article-title":"Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiated by sodium butyrate","volume":"95","author":"Gabbianelli","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.drudis.2010.10.006_bib0285","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/msj.20159","article-title":"Transgenic mouse models of Alzheimer's disease","volume":"77","author":"Elder","year":"2010","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.drudis.2010.10.006_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1734-1140(10)70238-3","article-title":"Huntington's disease: pathogenesis to animal models","volume":"62","author":"Kumar","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.drudis.2010.10.006_bib0295","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1590\/S0001-37652009000300003","article-title":"The pilocarpine model of epilepsy: what have we learned?","volume":"81","author":"Scorza","year":"2009","journal-title":"Ann. Acad. Bras. Cienc."},{"key":"10.1016\/j.drudis.2010.10.006_bib0300","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ncpneuro0199","article-title":"Mechanisms of disease: histone modifications in Huntington's disease","volume":"2","author":"Sadri-Vakili","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644610007762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644610007762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:10:31Z","timestamp":1761221431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644610007762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":60,"journal-issue":{"issue":"23-24","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1359644610007762"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2010.10.006","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic therapies for non-oncology indications","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2010.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}