{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:46:06Z","timestamp":1761237966520,"version":"build-2065373602"},"reference-count":92,"publisher":"Elsevier BV","issue":"11-12","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.drudis.2013.01.006","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T21:15:48Z","timestamp":1358802948000},"page":"582-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeting the epithelial cells in fibrosis: a new concept for an old disease"],"prefix":"10.1016","volume":"18","author":[{"given":"Solange","family":"Moll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyubov","family":"Chaykovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Budd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Formentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pomposiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Prunotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2013.01.006_bib0005","first-page":"S2","article-title":"Pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies, and chronic interstitial nephritides","volume":"54","author":"Bohle","year":"1996","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.drudis.2013.01.006_bib0010","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1681\/ASN.2006070704","article-title":"Chronic kidney disease progression","volume":"17","author":"Eddy","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2362.1993.tb00771.x","article-title":"Mechanisms of tubulo-interstitial injury in progressive renal diseases","volume":"23","author":"Fine","year":"1993","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0020","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.2010080793","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"21","author":"Zeisberg","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ki.2011.380","article-title":"Treatment of chronic kidney disease","volume":"81","author":"Turner","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0030","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrneph.2012.42","article-title":"Proteinuria should be used as a surrogate in CKD","volume":"8","author":"Cravedi","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0035","first-page":"c407","article-title":"Can ACE inhibitors and angiotensin receptor blockers be detrimental in CKD patients? Nephron","volume":"118","author":"Onuigbo","year":"2011","journal-title":"Clin. Pract."},{"key":"10.1016\/j.drudis.2013.01.006_bib0040","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1681\/ASN.2007090970","article-title":"Role of remission clinics in the longitudinal treatment of CKD","volume":"19","author":"Ruggenenti","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2010040354","article-title":"Risk for ESRD in type 1 diabetes remains high despite renoprotection","volume":"22","author":"Rosolowsky","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0050","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1164\/rccm.201201-0006PP","article-title":"Idiopathic pulmonary fibrosis: clinically meaningful primary endpoints in phase 3 clinical trials","volume":"185","author":"Raghu","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF02147594","article-title":"Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction","volume":"27","author":"Gabbiani","year":"1971","journal-title":"Experientia"},{"key":"10.1016\/j.drudis.2013.01.006_bib0060","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","article-title":"Recent developments in myofibroblast biology: paradigms for connective tissue remodeling","volume":"180","author":"Hinz","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0065","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0070","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jbiomech.2009.09.020","article-title":"The myofibroblast: paradigm for a mechanically active cell","volume":"43","author":"Hinz","year":"2010","journal-title":"J. Biomech."},{"key":"10.1016\/j.drudis.2013.01.006_bib0075","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0080","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The bone marrow functionally contributes to liver fibrosis","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.drudis.2013.01.006_bib0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","article-title":"Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0090","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","article-title":"Evolving challenges in hepatic fibrosis","volume":"7","author":"Friedman","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0095","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI39675","article-title":"EMT: when epithelial cells decide to become mesenchymal-like cells","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1681\/ASN.2009091005","article-title":"Morphometric and visual evaluation of fibrosis in renal biopsies","volume":"22","author":"Farris","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0105","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ki.2009.332","article-title":"Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis","volume":"76","author":"Amdur","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0110","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2007080837","article-title":"Acute kidney injury increases risk of ESRD among elderly","volume":"20","author":"Ishani","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0115","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/ki.2009.289","article-title":"Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease","volume":"76","author":"Lo","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0120","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jama.2009.1322","article-title":"Chronic dialysis and death among survivors of acute kidney injury requiring dialysis","volume":"302","author":"Wald","year":"2009","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.drudis.2013.01.006_bib0125","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ki.2011.42","article-title":"The severity of acute kidney injury predicts progression to chronic kidney disease","volume":"79","author":"Chawla","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0130","first-page":"S48","article-title":"Cell\u2013cell cross-talk in the pathogenesis of renal interstitial fibrosis","volume":"49","author":"Fine","year":"1995","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.drudis.2013.01.006_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1681\/ASN.V52201","article-title":"Human renal cortical interstitial cells with some features of smooth muscle cells participate in tubulointerstitial and crescentic glomerular injury","volume":"5","author":"Alpers","year":"1994","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0140","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0145","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2353\/ajpath.2010.091012","article-title":"Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells","volume":"177","author":"Koesters","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0150","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1172\/JCI43025","article-title":"Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans","volume":"120","author":"Bielesz","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","article-title":"Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis","volume":"82","author":"Grgic","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0165","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1046\/j.1523-1755.2000.00101.x","article-title":"Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult","volume":"57","author":"Nath","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0170","doi-asserted-by":"crossref","first-page":"F1078","DOI":"10.1152\/ajprenal.00017.2010","article-title":"Acute kidney injury: a springboard for progression in chronic kidney disease","volume":"298","author":"Venkatachalam","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0175","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1513\/pats.200602-019TK","article-title":"Histologic spectrum of idiopathic interstitial pneumonias","volume":"3","author":"Visscher","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.drudis.2013.01.006_bib0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1398-9995.2009.02305.x","article-title":"IPF: new insight on pathogenesis and treatment","volume":"65","author":"Harari","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.drudis.2013.01.006_bib0185","article-title":"Idiopathic pulmonary fibrosis","author":"Hoo","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.drudis.2013.01.006_bib0190","doi-asserted-by":"crossref","first-page":"L442","DOI":"10.1152\/ajplung.00026.2010","article-title":"Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis","volume":"299","author":"Degryse","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0195","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1165\/ajrcmb\/5.2.155","article-title":"Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis","volume":"5","author":"Khalil","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0200","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI114808","article-title":"Platelet-derived growth factor in idiopathic pulmonary fibrosis","volume":"86","author":"Antoniades","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0205","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2559.1993.tb00133.x","article-title":"Expression of tumour necrosis factor-alpha in cryptogenic fibrosing alveolitis","volume":"22","author":"Nash","year":"1993","journal-title":"Histopathology"},{"issue":"Suppl","key":"10.1016\/j.drudis.2013.01.006_bib0210","first-page":"S93","article-title":"The epithelial\/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis","volume":"29","author":"Selman","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0215","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ki.2012.208","article-title":"Acute kidney injury and chronic kidney disease: an integrated clinical syndrome","volume":"82","author":"Chawla","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0220","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1586\/ers.11.52","article-title":"Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY program","volume":"5","author":"Richeldi","year":"2011","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0225","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1517\/13543780903501539","article-title":"Pirfenidone: an anti-fibrotic therapy for progressive kidney disease","volume":"19","author":"Cho","year":"2010","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.drudis.2013.01.006_bib0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1183\/09059180.00001111","article-title":"Antifibrotic activities of pirfenidone in animal models","volume":"20","author":"Schaefer","year":"2011","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.drudis.2013.01.006_bib0235","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ki.2011.33","article-title":"A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis","volume":"79","author":"Trachtman","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0240","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1755-1536-4-4","article-title":"Cooperative interaction of CTGF and TGF-beta in animal models of fibrotic disease","volume":"4","author":"Wang","year":"2011","journal-title":"Fibrogen. Tissue Repair"},{"key":"10.1016\/j.drudis.2013.01.006_bib0245","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.2215\/CJN.09321209","article-title":"Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria","volume":"5","author":"Adler","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0250","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.2741\/3211","article-title":"HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease","volume":"13","author":"Mizuno","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.drudis.2013.01.006_bib0255","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0002-9440(10)62323-1","article-title":"Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis","volume":"166","author":"Kim","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0260","doi-asserted-by":"crossref","first-page":"F349","DOI":"10.1152\/ajprenal.00154.2002","article-title":"Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy","volume":"284","author":"Yang","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0265","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1111\/j.1523-1755.2000.00375.x","article-title":"Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways","volume":"58","author":"Liu","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0270","doi-asserted-by":"crossref","first-page":"F134","DOI":"10.1152\/ajprenal.00199.2003","article-title":"Suppressions of chronic glomerular injuries and TGF-beta 1 production by HGF in attenuation of murine diabetic nephropathy","volume":"286","author":"Mizuno","year":"2004","journal-title":"Am.J. Physiol. Renal Physiol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0275","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2337\/diabetes.53.4.1119","article-title":"Regression of advanced diabetic nephropathy by hepatocyte growth factor gene therapy in rats","volume":"53","author":"Cruzado","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.drudis.2013.01.006_bib0280","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1164\/rccm.200706-806OC","article-title":"Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis","volume":"177","author":"Puthawala","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0285","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2353\/ajpath.2007.060158","article-title":"Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse","volume":"170","author":"Hahm","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0290","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbalip.2008.04.001","article-title":"Lysophosphatidic acid and renal fibrosis","volume":"1781","author":"Pradere","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.drudis.2013.01.006_bib0295","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: subtypes and biological actions","volume":"50","author":"Choi","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0300","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1681\/ASN.V1291853","article-title":"Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP","volume":"12","author":"Heusinger-Ribeiro","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0305","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0310","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199807093390202","article-title":"Reversal of lesions of diabetic nephropathy after pancreas transplantation","volume":"339","author":"Fioretto","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0315","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/sj.ki.5000153","article-title":"Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients","volume":"69","author":"Fioretto","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.drudis.2013.01.006_bib0320","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nm.2685","article-title":"A systems approach identifies HIPK2 as a key regulator of kidney fibrosis","volume":"18","author":"Jin","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4161\/cc.6.2.3788","article-title":"HIPK2: a versatile switchboard regulating the transcription machinery and cell death","volume":"6","author":"Calzado","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.drudis.2013.01.006_bib0330","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ncb714","article-title":"Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis","volume":"4","author":"D\u2019Orazi","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0335","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1242\/dev.025460","article-title":"Homeodomain-interacting protein kinases (Hipks) promote Wnt\/Wg signaling through stabilization of beta-catenin\/Arm and stimulation of target gene expression","volume":"136","author":"Lee","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.drudis.2013.01.006_bib0340","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ydbio.2008.10.029","article-title":"Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho","volume":"325","author":"Lee","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0345","first-page":"8271","article-title":"HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells","volume":"63","author":"Hofmann","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.drudis.2013.01.006_bib0350","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/bies.20081","article-title":"The ins and outs of lysophosphatidic acid signaling","volume":"26","author":"Moolenaar","year":"2004","journal-title":"Bioessays"},{"key":"10.1016\/j.drudis.2013.01.006_bib0355","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1124\/pr.110.003111","article-title":"International Union of Basic and Clinical Pharmacology, LXXVIII. Lysophospholipid receptor nomenclature","volume":"62","author":"Chun","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.drudis.2013.01.006_bib0360","doi-asserted-by":"crossref","first-page":"14573","DOI":"10.1074\/jbc.275.19.14573","article-title":"Gelsolin binding and cellular presentation of lysophosphatidic acid","volume":"275","author":"Goetzl","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drudis.2013.01.006_bib0365","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/1471-2164-9-387","article-title":"Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling","volume":"9","author":"Stortelers","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.drudis.2013.01.006_bib0370","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2222.2006.02626.x","article-title":"Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge","volume":"37","author":"Georas","year":"2007","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.drudis.2013.01.006_bib0375","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"Tager","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0380","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1165\/rcmb.2010-0155OC","article-title":"The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury","volume":"46","author":"Funke","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0385","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2353\/ajpath.2009.080160","article-title":"Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q)","volume":"174","author":"Xu","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0390","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1172\/JCI27183","article-title":"Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury","volume":"116","author":"Jenkins","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0395","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.ajpath.2012.06.035","article-title":"Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Galphaq-mediated Rho and alphavbeta6 integrin-dependent activation of TGF-beta","volume":"181","author":"Geng","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20071570","article-title":"Liver fibrosis","volume":"411","author":"Wallace","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.drudis.2013.01.006_bib0405","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1084952102001301","article-title":"The role of non-parenchymal cells in liver growth","volume":"13","author":"Malik","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0410","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/nm.2490","article-title":"Stimulating healthy tissue regeneration by targeting the 5-HT(2)B receptor in chronic liver disease","volume":"17","author":"Ebrahimkhani","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0415","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/art.22289","article-title":"Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I\/II trial of CAT-192","volume":"56","author":"Denton","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.drudis.2013.01.006_bib0420","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/jpet.111.187906","article-title":"Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells","volume":"340","author":"Kekewska","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.drudis.2013.01.006_bib0425","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1517\/14728222.2011.600692","article-title":"Terguride for pulmonary arterial hypertension","volume":"15","author":"Antoniu","year":"2011","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.drudis.2013.01.006_bib0430","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nm.2208","article-title":"Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment","volume":"16","author":"Barry-Hamilton","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0435","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/labinvest.2012.68","article-title":"Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy","volume":"92","author":"Du","year":"2012","journal-title":"Lab. Invest."},{"key":"10.1016\/j.drudis.2013.01.006_bib0440","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nm0510-523","article-title":"Fibrosis under arrest","volume":"16","author":"Wynn","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2013.01.006_bib0445","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0455","first-page":"1305","article-title":"Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD","volume":"11","author":"Walsh","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.drudis.2013.01.006_bib0460","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrneph.2011.114","article-title":"Diabetes: bardoxolone improves kidney function in type 2 diabetes","volume":"7","author":"Thomas","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.drudis.2013.01.006_bib0465","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijcard.2010.08.037","article-title":"Effects of high dose aleglitazar on renal function in patients with type 2 diabetes","volume":"151","author":"Herz","year":"2011","journal-title":"Int. J. Cardiol."}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644613000081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644613000081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:14:47Z","timestamp":1761221687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644613000081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":92,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1359644613000081"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2013.01.006","relation":{},"ISSN":["1359-6446"],"issn-type":[{"type":"print","value":"1359-6446"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the epithelial cells in fibrosis: a new concept for an old disease","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2013.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}