{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:45:27Z","timestamp":1775306727825,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.drudis.2014.04.013","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T15:00:15Z","timestamp":1398870015000},"page":"949-950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Huntington's disease: from disease mechanisms to therapies"],"prefix":"10.1016","volume":"19","author":[{"given":"Craig","family":"Blackstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2014.04.013_bib0005","series-title":"Huntington's Disease","first-page":"3","article-title":"Huntington's disease: a historical background","author":"Harper","year":"2002"},{"key":"10.1016\/j.drudis.2014.04.013_bib0010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/263244a0","article-title":"Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea","volume":"263","author":"Coyle","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2014.04.013_bib0015","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"HD Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2014.04.013_bib0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2014.04.013_bib0025","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2014.04.013_bib0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","article-title":"Transcriptional dysregulation in Huntington's disease","volume":"23","author":"Cha","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.drudis.2014.04.013_bib0035","doi-asserted-by":"crossref","first-page":"a007476","DOI":"10.1101\/cshperspect.a007476","article-title":"Huntington's disease","volume":"3","author":"Finkbeiner","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.drudis.2014.04.013_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.03.005","article-title":"Genetics of Huntington disease and related disorders","author":"Burgunder","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2014.04.013_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.02.006","article-title":"Mechanisms of synaptic dysfunction and excitotoxicity in Huntington disease","author":"Sepers","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2014.04.013_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.03.020","article-title":"Increased mitochondrial fission, synaptic damage, and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission","author":"Reddy","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2014.04.013_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.03.016","article-title":"Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis","author":"Kumar","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2014.04.013_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.02.014","article-title":"The many faces of autophagy dysfunction in Huntington's disease: from mechanistic pathways to therapeutic opportunities","author":"Cortes","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2014.04.013_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.03.002","article-title":"Biomarker development in Huntington's disease","author":"Andre","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.drudis.2014.04.013_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2014.02.012","article-title":"Cell-based therapies for Huntington's disease","author":"Chan","year":"2014","journal-title":"Drug Discov. Today"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644614001500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644614001500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:19:18Z","timestamp":1761221958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644614001500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1359644614001500"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2014.04.013","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Huntington's disease: from disease mechanisms to therapies","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2014.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}