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N. Y. Acad. Sci."},{"key":"10.1016\/j.drudis.2018.06.002_bib0685","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuron.2004.12.046","article-title":"Light activation, adaptation, and cell survival functions of the Na+\/Ca2+ exchanger CalX","volume":"45","author":"Wang","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.drudis.2018.06.002_bib0690","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.mam.2012.07.003","article-title":"The SLC8 gene family of sodium-calcium exchangers (NCX) \u2014 structure, function, and regulation in health and disease","volume":"34","author":"Khananshvili","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.drudis.2018.06.002_bib0695","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.mam.2012.07.008","article-title":"The SLC24 gene family of Na+\/Ca2+-K+ exchangers","volume":"34","author":"Schnetkamp","year":"2013","journal-title":"Mol. 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