{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:39:38Z","timestamp":1781303978116,"version":"3.54.1"},"reference-count":123,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Department of Science and Technology, Government of India","award":["#ECR\/2016\/001964"],"award-info":[{"award-number":["#ECR\/2016\/001964"]}]},{"DOI":"10.13039\/100011062","name":"N-PDF","doi-asserted-by":"publisher","award":["PDF\/2016\/003329"],"award-info":[{"award-number":["PDF\/2016\/003329"]}],"id":[{"id":"10.13039\/100011062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SERB, Department of Science and Technology (DST), Government of India","award":["SB\/YS\/LS-196\/2014"],"award-info":[{"award-number":["SB\/YS\/LS-196\/2014"]}]},{"name":"International Society for Neurochemistry (ISN) Return Home"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.drudis.2018.10.012","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T12:01:24Z","timestamp":1541419284000},"page":"584-594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Growing synergy of nanodiamonds in neurodegenerative interventions"],"prefix":"10.1016","volume":"24","author":[{"given":"Jackson","family":"Saraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-3148","authenticated-orcid":false,"given":"Rakesh Kumar","family":"Tekade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2018.10.012_bib0005","series-title":"World Population Prospects: The 2015 Revision, Key Findings and Advance Tables","author":"United Nations Department of Economicand Social Affairs","year":"2015"},{"key":"10.1016\/j.drudis.2018.10.012_bib0010","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1212\/WNL.0000000000000610","article-title":"The global burden of neurologic diseases","volume":"83","author":"Chin","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.drudis.2018.10.012_bib0015","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions (1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010)","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2018.10.012_bib0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI200317522","article-title":"Series Introduction: Neurodegeneration: what is it and where are we?","volume":"11","author":"Przedborski","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2018.10.012_bib0025","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"539","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2018.10.012_bib0030","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1289\/ehp.7567","article-title":"Neurodegenerative diseases: an overview of environmental risk factors","volume":"113","author":"Brown","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.drudis.2018.10.012_bib0035","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1136\/bmj.324.7352.1465","article-title":"Defining neurodegenerative diseases: disorders will be named after responsible rogue proteins and their solutions","volume":"324","author":"Williams","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.drudis.2018.10.012_bib0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"Blennow","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0045","doi-asserted-by":"crossref","DOI":"10.1038\/nrd2176","article-title":"Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics","volume":"6","author":"Shaw","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.drudis.2018.10.012_bib0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-013611","article-title":"Instruments measuring the disease-specific quality of life of family carers of people with neurodegenerative diseases: a systematic review","volume":"7","author":"Page","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.drudis.2018.10.012_bib0055","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/jnnp.69.3.308","article-title":"What contributes to quality of life in patients with Parkinson\u2019s disease?","volume":"69","author":"Schrag","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.drudis.2018.10.012_bib0060","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/cr.2013.96","article-title":"New hope for therapy in neurodegenerative diseases","volume":"23","author":"do Carmo Costa","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.drudis.2018.10.012_bib0065","doi-asserted-by":"crossref","first-page":"9470","DOI":"10.1021\/acsnano.5b05341","article-title":"Penetrating the blood\u2013brain barrier: promise of novel nanoplatforms and delivery vehicles","volume":"9","author":"Ali","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0070","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1083\/jcb.40.3.648","article-title":"Junctions between intimately apposed cell membranes in the vertebrate brain","volume":"40","author":"Brightman","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0075","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.progpolymsci.2007.05.014","article-title":"Nanomedicine in the diagnosis and therapy of neurodegenerative disorders","volume":"32","author":"Kabanov","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.drudis.2018.10.012_bib0080","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jalz.2009.06.003","article-title":"Alzheimer\u2019s disease drug development and the problem of the blood\u2013brain barrier","volume":"5","author":"Pardridge","year":"2009","journal-title":"Alzheimers Demen."},{"key":"10.1016\/j.drudis.2018.10.012_bib0085","doi-asserted-by":"crossref","DOI":"10.1038\/nrn1435","article-title":"Back to the future: the \u2018old-fashioned\u2019 way to new medications for neurodegeneration","volume":"10","author":"Lansbury","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2018.10.012_bib0090","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrn3505","article-title":"BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases","volume":"14","author":"Lu","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.drudis.2018.10.012_bib0095","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/nn203892h","article-title":"Cellular uptake of nanoparticles by membrane penetration: a study combining confocal microscopy with FTIR spectroelectrochemistry","volume":"6","author":"Wang","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1743-8977-7-3","article-title":"Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood\u2013brain barrier: perspectives on tracking and neuroimaging","volume":"7","author":"Bhaskar","year":"2010","journal-title":"Particle Fibre Toxicol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0105","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.281.5385.2013","article-title":"Semiconductor nanocrystals as fluorescent biological labels","volume":"281","author":"Bruchez","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.drudis.2018.10.012_bib0110","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1126\/science.281.5385.2016","article-title":"Quantum dot bioconjugates for ultrasensitive nonisotopic detection","volume":"281","author":"Chan","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.drudis.2018.10.012_bib0115","doi-asserted-by":"crossref","first-page":"9988","DOI":"10.1021\/nn503150w","article-title":"Ultrasensitive detection of DNA and RNA based on enzyme-free click chemical ligation chain reaction on dispersed gold nanoparticles","volume":"8","author":"Kato","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0120","doi-asserted-by":"crossref","first-page":"10530","DOI":"10.1021\/acs.chemrev.5b00321","article-title":"Nanoparticle probes for the detection of cancer biomarkers, cells, and tissues by fluorescence","volume":"15","author":"Chinen","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.drudis.2018.10.012_bib0125","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1021\/acsnano.5b07249","article-title":"Duality of iron oxide nanoparticles in cancer therapy: amplification of heating efficiency by magnetic hyperthermia and photothermal bimodal treatment","volume":"10","author":"Espinosa","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0130","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/1521-4095(20020618)14:12<882::AID-ADMA882>3.0.CO;2-Y","article-title":"Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks","volume":"14","author":"Parak","year":"2002","journal-title":"Adv. Mater."},{"key":"10.1016\/j.drudis.2018.10.012_bib0135","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1021\/acs.chemrev.5b00148","article-title":"Nanochemistry and nanomedicine for nanoparticle-based diagnostics and therapy","volume":"116","author":"Chen","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.drudis.2018.10.012_bib0140","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jconrel.2009.10.014","article-title":"Size and shape effects in the biodistribution of intravascularly injected particles","volume":"141","author":"Decuzzi","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.drudis.2018.10.012_bib0145","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1021\/nn5018523","article-title":"Imaging approach to mechanistic study of nanoparticle interactions with the blood-brain barrier","volume":"8","author":"Bramini","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0150","doi-asserted-by":"crossref","first-page":"22595","DOI":"10.1038\/srep22595","article-title":"An unexpected transient breakdown of the blood brain barrier triggers passage of large intravenously administered nanoparticles","volume":"6","author":"Smith","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0155","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0160","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2217\/nnm.10.74","article-title":"Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide","volume":"5","author":"Guerrero","year":"2010","journal-title":"Nanomedicine"},{"key":"10.1016\/j.drudis.2018.10.012_bib0165","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1073\/pnas.0914140107","article-title":"Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles","volume":"107","author":"Choi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.drudis.2018.10.012_bib0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2011.08.001","article-title":"Rutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brain","volume":"207","author":"Zhang","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.drudis.2018.10.012_bib0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/17435390.2014.886740","article-title":"Particulate nature of inhaled zinc oxide nanoparticles determines systemic effects and mechanisms of pulmonary inflammation in mice","volume":"9","author":"Chen","year":"2015","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.drudis.2018.10.012_bib0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/cr068212n","article-title":"Dendrimers in oncology: an expanding horizon","volume":"109","author":"Tekade","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.drudis.2018.10.012_bib0185","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1021\/bm7008203","article-title":"Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells","volume":"8","author":"Stasko","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.drudis.2018.10.012_bib0190","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/bc400496u","article-title":"Surface-engineered dendrimers with a diaminododecane core achieve efficient gene transfection and low cytotoxicity","volume":"25","author":"Chang","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.drudis.2018.10.012_bib0195","first-page":"46","article-title":"Nanoparticulate carrier mediated intranasal delivery of insulin for the restoration of memory signaling in Alzheimer\u2019s disease","volume":"9","author":"Dwivedi","year":"2013","journal-title":"Curr. Nanosci."},{"key":"10.1016\/j.drudis.2018.10.012_bib0200","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jconrel.2014.09.001","article-title":"Nanocarrier mediated delivery of siRNA\/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances","volume":"194","author":"Gandhi","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.drudis.2018.10.012_bib0205","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/ar300028m","article-title":"Understanding the toxicity of carbon nanotubes","volume":"46","author":"Liu","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.drudis.2018.10.012_bib0210","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/nano5031351","article-title":"Role of physicochemical properties in nanoparticle toxicity","volume":"5","author":"Shin","year":"2015","journal-title":"Nanomaterials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0215","doi-asserted-by":"crossref","first-page":"17604","DOI":"10.1021\/ja0567081","article-title":"Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity","volume":"127","author":"Yu","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.drudis.2018.10.012_bib0220","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/17435390.2013.855828","article-title":"Carboxylated nanodiamonds are neither cytotoxic nor genotoxic on liver, kidney, intestine and lung human cell lines","volume":"8","author":"Paget","year":"2014","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.drudis.2018.10.012_bib0225","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00709-017-1146-4","article-title":"Detonation nanodiamonds are promising nontoxic delivery system for urothelial cells","volume":"255","author":"Zupan\u010di\u010d","year":"2018","journal-title":"Protoplasma"},{"key":"10.1016\/j.drudis.2018.10.012_bib0230","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3390\/ma10040352","article-title":"Haemocompatibility of modified nanodiamonds","volume":"10","author":"W\u0105sowicz","year":"2017","journal-title":"Materials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0235","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001713","article-title":"Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment","volume":"3","author":"Chow","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.drudis.2018.10.012_bib0240","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/srep02159","article-title":"Understanding ultrafine nanodiamond formation using nanostructured explosives","volume":"3","author":"Pichot","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0245","doi-asserted-by":"crossref","first-page":"235436","DOI":"10.1103\/PhysRevB.87.235436","article-title":"Spin relaxometry of single nitrogen-vacancy defects in diamond nanocrystals for magnetic noise sensing","volume":"87","author":"Tetienne","year":"2013","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.drudis.2018.10.012_bib0250","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1039\/C6CP07431F","article-title":"Shape and crystallographic orientation of nanodiamonds for quantum sensing","volume":"19","author":"Ong","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.drudis.2018.10.012_bib0255","doi-asserted-by":"crossref","first-page":"130","DOI":"10.15171\/ijb.1320","article-title":"Role of nanodiamonds in drug delivery and stem cell therapy","volume":"14","author":"Ansari","year":"2016","journal-title":"Iran. J. Biotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0260","article-title":"Anchored but not internalized: shape dependent endocytosis of nanodiamond","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0265","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1021\/nl2030213","article-title":"Receptor-mediated endocytosis of nanoparticles of various shapes","volume":"11","author":"V\u00e1cha","year":"2011","journal-title":"Nano Lett."},{"key":"10.1016\/j.drudis.2018.10.012_bib0270","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1039\/c2cs15309b","article-title":"Endocytosis at the nanoscale","volume":"41","author":"Canton","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.drudis.2018.10.012_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.drudis.2018.10.012_bib0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nnano.2011.209","article-title":"The properties and applications of nanodiamonds","volume":"7","author":"Mochalin","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0285","series-title":"On the History of the Discovery of Nanodiamond Synthesis","author":"Danilenko","year":"2004"},{"key":"10.1016\/j.drudis.2018.10.012_bib0290","doi-asserted-by":"crossref","DOI":"10.1038\/srep33966","article-title":"Direct synthesis of nanodiamonds by femtosecond laser irradiation of ethanol","volume":"6","author":"Nee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0295","doi-asserted-by":"crossref","first-page":"235602","DOI":"10.1088\/0957-4484\/20\/23\/235602","article-title":"High yield fabrication of fluorescent nanodiamonds","volume":"20","author":"Boudou","year":"2009","journal-title":"Nanotechnology"},{"key":"10.1016\/j.drudis.2018.10.012_bib0300","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1021\/cm047739i","article-title":"Synthesis of carbide-derived carbon by chlorination of Ti2AlC","volume":"17","author":"Hoffman","year":"2005","journal-title":"Chem. Mater."},{"key":"10.1016\/j.drudis.2018.10.012_bib0305","doi-asserted-by":"crossref","DOI":"10.1038\/srep35244","article-title":"On the thermodynamic path enabling a room-temperature, laser-assisted graphite to nanodiamond transformation","volume":"6","author":"Gorrini","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0310","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1039\/C8NR01688G","article-title":"Predicting the impact of structural diversity on the performance of nanodiamond drug carriers","volume":"10","author":"Barnard","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.drudis.2018.10.012_bib0315","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201703838","article-title":"Nanodiamonds for in vivo applications","volume":"14","author":"van der Laan","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.drudis.2018.10.012_bib0320","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature13381","article-title":"Nanotwinned diamond with unprecedented hardness and stability","volume":"510","author":"Huang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.drudis.2018.10.012_bib0325","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1369-7021(11)70087-6","article-title":"Medical applications of diamond particles & surfaces","volume":"14","author":"Narayan","year":"2011","journal-title":"Mater. Today"},{"key":"10.1016\/j.drudis.2018.10.012_bib0330","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3844\/ajbbsp.2017.34.41","article-title":"Nano-diamond hybrid materials for structural biomedical application","volume":"13","author":"Aversa","year":"2017","journal-title":"Am. J. Biochem. Biotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0335","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1039\/C7TB00723J","article-title":"Functionalization of bone implants with nanodiamond particles and angiopoietin-1 to improve vascularization and bone regeneration","volume":"5","author":"Wu","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.drudis.2018.10.012_bib0340","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1038\/srep04531","article-title":"Nitrogen-incorporated ultrananocrystalline diamond and multi-layer-graphene-like hybrid carbon films","volume":"4","author":"Tzeng","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0345","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1021\/nl1021909","article-title":"In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans","volume":"10","author":"Mohan","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.drudis.2018.10.012_bib0350","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1021\/acs.accounts.5b00484","article-title":"Fluorescent nanodiamond: a versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing","volume":"49","author":"Hsiao","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.drudis.2018.10.012_bib0355","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/adma.200901596","article-title":"Sub-20-nm fluorescent nanodiamonds as photostable biolabels and fluorescence resonance energy transfer donors","volume":"22","author":"Mohan","year":"2010","journal-title":"Adv. Mater."},{"key":"10.1016\/j.drudis.2018.10.012_bib0360","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1002\/adma.201102263","article-title":"Multimodal nanodiamond drug delivery carriers for selective targeting, imaging, and enhanced chemotherapeutic efficacy","volume":"23","author":"Zhang","year":"2011","journal-title":"Adv. Mater."},{"key":"10.1016\/j.drudis.2018.10.012_bib0365","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1021\/acs.jpcb.6b00790","article-title":"Investigating functional DNA grafted on nanodiamond surface using site-directed spin labeling and electron paramagnetic resonance spectroscopy","volume":"120","author":"Akiel","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.drudis.2018.10.012_bib0370","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41598-017-18601-6","article-title":"Functionalisation of detonation nanodiamond for monodispersed, soluble DNA-nanodiamond conjugates using mixed silane bead-assisted sonication disintegration","volume":"8","author":"Edgington","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0375","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500439","article-title":"Nanodiamonds: the intersection of nanotechnology, drug development, and personalized medicine","volume":"1","author":"Ho","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.drudis.2018.10.012_bib0380","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jcis.2016.01.062","article-title":"The adsorption of tetracycline and vancomycin onto nanodiamond with controlled release","volume":"468","author":"Giammarco","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.drudis.2018.10.012_bib0385","doi-asserted-by":"crossref","first-page":"23558","DOI":"10.1021\/acsami.6b08079","article-title":"Paclitaxel-nanodiamond nanocomplexes enhance aqueous dispersibility and drug retention in cells","volume":"8","author":"Lim","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.drudis.2018.10.012_bib0390","doi-asserted-by":"crossref","first-page":"11780","DOI":"10.1021\/acsami.6b15954","article-title":"Cancer-cell-specific mitochondria-targeted drug delivery by dual-ligand-functionalized nanodiamonds circumvent drug resistance","volume":"9","author":"Chan","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.drudis.2018.10.012_bib0395","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1039\/C8NR00641E","article-title":"Self-assembled nanodiamond supraparticles for anticancer chemotherapy","volume":"10","author":"Yu","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.drudis.2018.10.012_bib0400","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1021\/acs.jpclett.5b00820","article-title":"Probing interfacial water on nanodiamonds in colloidal dispersion","volume":"6","author":"Petit","year":"2015","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.drudis.2018.10.012_bib0405","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/nn405240g","article-title":"Nanostructuring of biosensing electrodes with nanodiamonds for antibody immobilization","volume":"8","author":"Zhang","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0410","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.nano.2016.12.013","article-title":"Nanodiamond-manganese dual mode MRI contrast agents for enhanced liver tumor detection","volume":"13","author":"Hou","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.drudis.2018.10.012_bib0415","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1021\/acs.nanolett.6b03378","article-title":"Nanodiamond-gadolinium (iii) aggregates for tracking cancer growth in vivo at high field","volume":"16","author":"Rammohan","year":"2016","journal-title":"Nano Lett."},{"key":"10.1016\/j.drudis.2018.10.012_bib0420","doi-asserted-by":"crossref","first-page":"12151","DOI":"10.1021\/nn503491e","article-title":"Epirubicin-adsorbed nanodiamonds kill chemoresistant hepatic cancer stem cells","volume":"8","author":"Wang","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0425","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/brain\/awf002","article-title":"Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy","volume":"125","author":"Sisodiya","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.drudis.2018.10.012_bib0430","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte\u2013endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.drudis.2018.10.012_bib0435","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1093\/brain\/aws147","article-title":"Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy","volume":"135","author":"Liu","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.drudis.2018.10.012_bib0440","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/bc800327f","article-title":"Novel system to achieve one-pot modification of cargo molecules with oligoarginine vectors for intracellular delivery","volume":"20","author":"Takayama","year":"2009","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.drudis.2018.10.012_bib0445","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.nano.2013.07.013","article-title":"Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment","volume":"10","author":"Xi","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.drudis.2018.10.012_bib0450","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ncb0304-189","article-title":"Transduction peptides: from technology to physiology","volume":"6","author":"Joliot","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0455","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0460","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/ana.410230616","article-title":"Possible neurotransmitter basis of behavioral changes in Alzheimer\u2019s disease","volume":"23","author":"Palmer","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0465","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0140-6736(76)93095-6","article-title":"Dopamine acetylcholine imbalance in Parkinson\u2019s disease: possible regenerative overgrowth of cholinergic axon terminals","volume":"307","author":"Spehlmann","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.drudis.2018.10.012_bib0470","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s13105-014-0358-8","article-title":"Alleviation of glutamate mediated neuronal insult by piroxicam in rodent model of focal cerebral ischemia: a possible mechanism of GABA agonism","volume":"70","author":"Bhattacharya","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.drudis.2018.10.012_bib0475","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12951-016-0176-y","article-title":"Neuroactivity of detonation nanodiamonds: dose-dependent changes in transporter-mediated uptake and ambient level of excitatory\/inhibitory neurotransmitters in brain nerve terminals","volume":"14","author":"Pozdnyakova","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0480","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2010.03.032","article-title":"Genetic heterogeneity in human disease","volume":"141","author":"McClellan","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.drudis.2018.10.012_bib0485","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrneurol.2012.156","article-title":"Gene expression profiling in human neurodegenerative disease","volume":"8","author":"Cooper-Knock","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0490","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","article-title":"Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.drudis.2018.10.012_bib0495","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrn3380","article-title":"Axonal transport deficits and neurodegenerative diseases","volume":"14","author":"Millecamps","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.drudis.2018.10.012_bib0500","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nnano.2016.260","article-title":"Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors","volume":"12","author":"Haziza","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0505","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1126\/science.1090349","article-title":"Looking backward to move forward: early detection of neurodegenerative disorders","volume":"302","author":"DeKosky","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.drudis.2018.10.012_bib0510","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/bmj.319.7213.807","article-title":"Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident","volume":"319","author":"Altmann","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.drudis.2018.10.012_bib0515","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1007\/s12035-016-9762-0","article-title":"Neuroprotective effect of nanodiamond in Alzheimer\u2019s disease rat model: a pivotal role for modulating NF-\u03baB and STAT3 signaling","volume":"54","author":"Alawdi","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0520","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fneur.2014.00167","article-title":"Aluminum-induced amyloidogenesis and impairment in the clearance of amyloid peptides from the central nervous system in Alzheimer\u2019s disease","volume":"5","author":"Zhao","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0525","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri2093","article-title":"SOCS proteins, cytokine signalling and immune regulation","volume":"7","author":"Yoshimura","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0530","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/cr.2008.18","article-title":"STAT3 as a target for inducing apoptosis in solid and hematological tumors","volume":"18","author":"Siddiquee","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.drudis.2018.10.012_bib0535","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm.1912","article-title":"Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer\u2019s disease","volume":"15","author":"Nagahara","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.drudis.2018.10.012_bib0540","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1038\/srep06919","article-title":"The effect of fluorescent nanodiamonds on neuronal survival and morphogenesis","volume":"4","author":"Huang","year":"2014","journal-title":"Sci. Rep"},{"key":"10.1016\/j.drudis.2018.10.012_bib0545","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/10\/5\/056022","article-title":"Patterned neuronal networks using nanodiamonds and the effect of varying nanodiamond properties on neuronal adhesion and outgrowth","volume":"10","author":"Edgington","year":"2013","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.drudis.2018.10.012_bib0550","doi-asserted-by":"crossref","first-page":"25461","DOI":"10.1021\/acsami.6b08311","article-title":"Salt-assisted ultrasonic deaggregation of nanodiamond","volume":"8","author":"Turcheniuk","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.drudis.2018.10.012_bib0555","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jab.2016.09.003","article-title":"Deagglomeration and characterization of detonation nanodiamonds for biomedical applications","volume":"15","author":"Pedroso-Santana","year":"2017","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.drudis.2018.10.012_bib0560","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3390\/ma11081285","article-title":"Effective method for obtaining the hydrosols of detonation nanodiamond with particle size <4nm","volume":"11","author":"Trofimuk","year":"2018","journal-title":"Materials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0565","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1038\/srep06612","article-title":"Direct laser writing of nanodiamond films from graphite under ambient conditions","volume":"4","author":"Nian","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0570","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1016\/j.biomaterials.2009.03.058","article-title":"The effect of ultra-nanocrystalline diamond films on the proliferation and differentiation of neural stem cells","volume":"30","author":"Chen","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0575","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1016\/j.biomaterials.2003.11.006","article-title":"Ordered growth of neurons on diamond","volume":"25","author":"Specht","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0580","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1016\/j.biomaterials.2008.08.017","article-title":"Micro-stamped surfaces for the patterned growth of neural stem cells","volume":"29","author":"Ruiz","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0585","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1021\/acsnano.7b04647","article-title":"Effect of surface chemistry on the fluorescence of detonation nanodiamonds","volume":"11","author":"Reineck","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.drudis.2018.10.012_bib0590","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41598-017-00797-2","article-title":"Nanodiamonds as multi-purpose labels for microscopy","volume":"7","author":"Hemelaar","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0595","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.biomaterials.2009.11.109","article-title":"The use of nanodiamond monolayer coatings to promote the formation of functional neuronal networks","volume":"31","author":"Thalhammer","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.drudis.2018.10.012_bib0600","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1038\/srep05004","article-title":"Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds","volume":"4","author":"Hsu","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.drudis.2018.10.012_bib0605","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12951-018-0385-7","article-title":"Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer\u2019s disease","volume":"16","author":"Morales-Zavala","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0610","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nnano.2008.99","article-title":"Mass production and dynamic imaging of fluorescent nanodiamonds","volume":"3","author":"Chang","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.drudis.2018.10.012_bib0615","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1073\/pnas.0605409104","article-title":"Characterization and application of single fluorescent nanodiamonds as cellular biomarkers","volume":"104","author":"Fu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644618303635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644618303635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:39:06Z","timestamp":1761223146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644618303635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":123,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S1359644618303635"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2018.10.012","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growing synergy of nanodiamonds in neurodegenerative interventions","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2018.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}