{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T13:08:03Z","timestamp":1761224883772,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001849","name":"Defence Research and Development Organization","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001849","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Government of India"},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.drudis.2020.02.004","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T11:57:05Z","timestamp":1581595025000},"page":"781-786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developing polyphenolic acetates as radiation countermeasure agents: current status and future perspectives"],"prefix":"10.1016","volume":"25","author":[{"given":"Kavya","family":"Venkateswaran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-2065","authenticated-orcid":false,"given":"Anju","family":"Shrivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok K.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virinder S.","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilikere S.","family":"Dwarakanath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.drudis.2020.02.004_bib0005","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1517\/17460441.2015.1023290","article-title":"Animal models for acute radiation syndrome drug discovery","volume":"10","author":"Singh","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"year":"2006","series-title":"Radiobiology for the Radiobiologist","author":"Hall","key":"10.1016\/j.drudis.2020.02.004_bib0010"},{"key":"10.1016\/j.drudis.2020.02.004_bib0015","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/09553002.2012.652726","article-title":"A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute","volume":"88","author":"Singh","year":"2012","journal-title":"Intl. J. Radiat. Biol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0020","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1080\/09553000902985144","article-title":"History and development of radiation-protective agents","volume":"85","author":"Weiss","year":"2009","journal-title":"Intl. J. Radiat. Biol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0025","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1517\/13543776.2014.964684","article-title":"Radiation countermeasure agents: an update (2011-2014)","volume":"24","author":"Singh","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.drudis.2020.02.004_bib0030","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0968-0896(02)00515-1","article-title":"Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 10: identification of inhibitors for the liver microsomal acetoxycoumarin: protein transacetylase","volume":"11","author":"Raj","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-5793(02)03445-2","article-title":"Establishment of the enzymatic protein acetylation independent of acetyl CoA: recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane bound transacetylase using 7, 8-diacetoxy-4-methyl coumarin as the acetyl donor","volume":"530","author":"Kohli","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.drudis.2020.02.004_bib0040","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bmc.2005.08.044","article-title":"Acetoxy drug: protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic peracetates","volume":"14","author":"Khurana","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0045","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1016\/j.bmc.2010.04.011","article-title":"Characterization of 4-methyl-2-oxo-1, 2-dihydroquinolin-6-yl acetate as an effective antiplatelet agent","volume":"18","author":"Priya","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0050","first-page":"1273","article-title":"Suicidal oxidative stress induced by certain antioxidants","volume":"41","author":"Koshy","year":"2003","journal-title":"Ind. J. Exp. Biol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0055","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.febslet.2007.04.052","article-title":"7, 8-Dihydroxy- 4-methylcoumarin induces apoptosis of human lung adenocarcinoma cells by ROS-independent mitochondrial pathway through partial inhibition of ERK\/MAPK signaling","volume":"581","author":"Goel","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.drudis.2020.02.004_bib0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cbi.2013.09.017","article-title":"Calreticulin transacetylase mediated upregulation of thioredoxin by 7, 8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells","volume":"206","author":"Joshi","year":"2013","journal-title":"Chemico-Biol. Interact."},{"key":"10.1016\/j.drudis.2020.02.004_bib0065","first-page":"13","article-title":"Targeting protein acetylation for improving cancer therapy","volume":"128","author":"Dwarakanath","year":"2008","journal-title":"Ind. J. Med. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0070","doi-asserted-by":"crossref","first-page":"403","DOI":"10.14429\/dsj.55.2003","article-title":"Chemical radioprotectors \u2013 a review","volume":"55","author":"Upadhaya","year":"2005","journal-title":"Defence Sci. J."},{"key":"10.1016\/j.drudis.2020.02.004_bib0075","first-page":"848","article-title":"Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression","volume":"86","author":"Park","year":"2010","journal-title":"Int. J. Radiation Biol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0080","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ars.2013.5635","article-title":"Hematopoietic stem cell Injury induced by ionizing radiation","volume":"20","author":"Shao","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.drudis.2020.02.004_bib0085","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/oxfordjournals.jncimonographs.a003433","article-title":"Protection against mucosal injury by growth factors and cytokines","volume":"29","author":"Booth","year":"2001","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"10.1016\/j.drudis.2020.02.004_bib0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<53::AID-IJC8>3.0.CO;2-Z","article-title":"Transforming growth factor-\u03b23 protects murine small intestinal crypt stem cells and animal survival after irradiation, possibly by reducing stem-cell cycling","volume":"86","author":"Booth","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.drudis.2020.02.004_bib0095","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2307\/3579609","article-title":"Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor","volume":"148","author":"Khan","year":"1997","journal-title":"Radiat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2011.12.012","article-title":"Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury","volume":"327","author":"Azzam","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.drudis.2020.02.004_bib0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/B:CANC.0000031769.14728.bc","article-title":"Metabolic oxidation\/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology","volume":"23","author":"Spitz","year":"2004","journal-title":"Cancer Metastasis Rev."},{"issue":"Suppl","key":"10.1016\/j.drudis.2020.02.004_bib0110","first-page":"87","article-title":"Role of superoxide dismutase in modification of radiation injury","volume":"8","author":"Petkau","year":"1987","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.drudis.2020.02.004_bib0115","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1089\/ars.2013.5489","article-title":"Effects of ionizing radiation on biological molecules\u2013mechanisms of damage and emerging methods of detection","volume":"21","author":"Reisz","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.drudis.2020.02.004_bib0120","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/ar800077q","article-title":"Elementary lesions in DNA subunits: electron, hydrogen atom, proton, and hydride transfers","volume":"42","author":"Duncan Lyngdoh","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0125","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mrrev.2012.06.002","article-title":"Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography","volume":"751","author":"Thompson","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0130","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2174\/1568026614666141203122005","article-title":"Modifications of cell signalling and redox balance by targeting protein acetylation using natural and engineered molecules: implications in cancer therapy","volume":"14","author":"Venkateswaran","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0135","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jcp.22466","article-title":"Protein acetylation within the cellular response to radiation","volume":"226","author":"Averbeck","year":"2011","journal-title":"J. Cell Physiol"},{"key":"10.1016\/j.drudis.2020.02.004_bib0140","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrgentox.2013.08.009","article-title":"Sulforaphane mitigates genotoxicity induced by radiation and anticancer drugs in human lymphocytes","volume":"758","author":"Katoch","year":"2013","journal-title":"Mutat Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0145","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4161\/cbt.3.7.931","article-title":"Histone deacetylase inhibitors are potent radiation protectants","volume":"3","author":"Paoluzzi","year":"2004","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.drudis.2020.02.004_bib0150","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1667\/RR1245.1","article-title":"Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice","volume":"169","author":"Brown","year":"2008","journal-title":"Radia. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0155","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1615\/JEnvironPatholToxicolOncol.2013005833","article-title":"Mitigation of hematopoietic radiation injury by diallylsulphide","volume":"3","author":"Katoch","year":"2012","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0160","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1128\/MCB.01476-09","article-title":"MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair","volume":"30","author":"Sharma","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0165","doi-asserted-by":"crossref","first-page":"18271","DOI":"10.1074\/jbc.M113.473199","article-title":"Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover","volume":"288","author":"Yang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0170","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4161\/cc.29215","article-title":"Inhibition of histone deacetylases enhances DNA-damage repair in SCNT embryos","volume":"13","author":"Bohrer","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.drudis.2020.02.004_bib0175","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1172\/JCI70313","article-title":"Epigenetic reprogramming induces the expansion of cord blood stem cells","volume":"124","author":"Chaurasia","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.drudis.2020.02.004_bib0180","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10715769509145649","article-title":"The relative antioxidant activities of plant-derived polyphenolic flavonoids","volume":"22","author":"Rice-Evans","year":"1995","journal-title":"Free Radical Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0185","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutrit. Biochem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0190","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.drudis.2020.02.004_bib0195","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0891-5849(01)00812-7","article-title":"Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter","volume":"32","author":"Myhrstad","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.drudis.2020.02.004_bib0200","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1093\/carcin\/15.11.2669","article-title":"Radioprotective effect of antioxidative flavonoids in gamma-ray irradiated mice","volume":"15","author":"Shimoi","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.drudis.2020.02.004_bib0205","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0027-5107(95)00116-6","article-title":"Radioprotective effects of antioxidative plant flavonoids in mice","volume":"350","author":"Shimoi","year":"1996","journal-title":"Mutat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1383-5718(01)00176-0","article-title":"Acetoxy-4-methylcoumarins confer differential protection from aflatoxin B (1)-induced micronuclei and apoptosis in lung and bone marrow cells","volume":"494","author":"Raj","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0215","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0968-0896(98)00111-4","article-title":"Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin","volume":"6","author":"Raj","year":"1998","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.drudis.2020.02.004_bib0220","article-title":"Mitigation of radiation-induced hematopoietic injury by the polyphenolic acetate 7,8-diacetoxy-4-methylthiocoumarin in mice","volume":"6","author":"Venkateswaran","year":"2016","journal-title":"Nat. Sci. Rep."},{"key":"10.1016\/j.drudis.2020.02.004_bib0225","article-title":"Mitigation of radiation-induced gastro-intestinal injury by the polyphenolic acetate 7,8-diacetoxy-4-methylthiocoumarin in mice","volume":"9","author":"Venkateswaran","year":"2019","journal-title":"Nat. Sci. Rep."},{"key":"10.1016\/j.drudis.2020.02.004_bib0230","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0027-5107(77)90115-4","article-title":"The DNA content of micronuclei induced in mouse bone marrow by gamma irradiation: evidence that micronuclei arise from acentric chromosomal fragments","volume":"44","author":"Heddle","year":"1977","journal-title":"Mutat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0027-5107(80)90012-3","article-title":"A comparison of diameters of micronuclei induced by clastogens and by spindle poisons","volume":"71","author":"Yamamoto","year":"1980","journal-title":"Mutat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0240","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0027-5107(73)90035-3","article-title":"A rapid in vivo test for chromosomal damage","volume":"18","author":"Heddle","year":"1973","journal-title":"Mutat. Res."},{"key":"10.1016\/j.drudis.2020.02.004_bib0245","first-page":"381","article-title":"New approaches to radiation protection","volume":"4","author":"Rosen","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.drudis.2020.02.004_bib0250","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Science"}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644620300726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644620300726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:42:42Z","timestamp":1761223362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644620300726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1359644620300726"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2020.02.004","relation":{},"ISSN":["1359-6446"],"issn-type":[{"type":"print","value":"1359-6446"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developing polyphenolic acetates as radiation countermeasure agents: current status and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2020.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}