{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:09:38Z","timestamp":1793722178440,"version":"4.6.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Discovery Today"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.drudis.2022.05.026","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T21:13:42Z","timestamp":1654031622000},"page":"1785-1788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Drug repurposing: An effective strategy to accelerate contemporary drug discovery"],"prefix":"10.1016","volume":"27","author":[{"given":"Peng","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.drudis.2022.05.026_b0005","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1021\/acs.jmedchem.9b00359","article-title":"Overview of Recent Strategic Advances in Medicinal Chemistry","volume":"62","author":"Wu","year":"2019","journal-title":"J Med Chem."},{"issue":"10","key":"10.1016\/j.drudis.2022.05.026_b0010","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.drudis.2019.06.014","article-title":"Drug repurposing: a promising tool to accelerate the drug discovery process","volume":"24","author":"Parvathaneni","year":"2019","journal-title":"Drug Discov Today."},{"issue":"1","key":"10.1016\/j.drudis.2022.05.026_b0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat Rev Drug Discov."},{"issue":"3","key":"10.1016\/j.drudis.2022.05.026_b0020","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.drudis.2018.11.022","article-title":"The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions","volume":"24","author":"Polamreddy","year":"2019","journal-title":"Drug Discov Today."},{"issue":"7673","key":"10.1016\/j.drudis.2022.05.026_b0025","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/549445a","article-title":"The drug-maker's guide to thegalaxy","volume":"549","author":"Mullard","year":"2017","journal-title":"Nature."},{"issue":"2","key":"10.1016\/j.drudis.2022.05.026_b0030","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.apsb.2021.08.027","article-title":"Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors","volume":"12","author":"Gao","year":"2022","journal-title":"Acta Pharm Sin B."},{"key":"10.1016\/j.drudis.2022.05.026_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.04.008","article-title":"Repurposing drugs targeting epidemic viruses","author":"Namasivayam","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.02.012","article-title":"Efficacy of repurposed antiviral drugs: Lessons from COVID-19","author":"Martinez","year":"2022","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.drudis.2022.05.026_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.02.004","article-title":"Drug repurposing against SARS-CoV-2 using computational approaches","author":"Kumar","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.04.001","article-title":"Repurposing drugs as COVID-19 therapies: A toxicity evaluation","author":"Ngan","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.02.013","article-title":"Nucleosides and emerging viruses: A new story","author":"Roy","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.02.016","article-title":"Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing","author":"Ruiz","year":"2022","journal-title":"Drug Discov Today."},{"issue":"22","key":"10.1016\/j.drudis.2022.05.026_b0065","article-title":"Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents","volume":"S1359\u20136446","author":"Han","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.05.006","article-title":"Drug repurposing to overcome microbial resistance","author":"Jampilek","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.03.021","article-title":"Targeting Clostridioides difficile: New uses for old drugs","author":"Chen","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.04.021","article-title":"Repurposing and optimization of drugs for discovery of novel antifungals","author":"Donlin","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.02.010","article-title":"Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics","author":"Liu","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.01.013","article-title":"Drug repositioning trends in rare and intractable diseases","author":"Sakate","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0095","article-title":"Repurposing drugs in autophagy for the treatment of cancer: From bench to bedside","author":"Bu","year":"2021","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.04.003","article-title":"Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases","author":"Liu","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.03.003","article-title":"Drug repurposing for stroke intervention","author":"Ghosh","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0110","doi-asserted-by":"crossref","unstructured":"Song Y, Yang X, Yu B. Repurposing antidepressants for anticancer drug discovery. Drug Discov Today. 2021 Oct 30:S1359-6446(21)00475-X. doi: 10.1016\/j.drudis.2021.10.019.","DOI":"10.1016\/j.drudis.2021.10.019"},{"key":"10.1016\/j.drudis.2022.05.026_b0115","article-title":"Deep learning in target prediction and drug repositioning: Recent advances and challenges","author":"Yu","year":"2021","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.05.013","article-title":"Artificial intelligence in virtual screening: Models versus experiments","author":"Arul Murugan","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.03.006","article-title":"Structure-based drug repurposing: Traditional and advanced AI\/ML-aided methods","author":"Choudhury","year":"2022","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.drudis.2022.05.026_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.02.007","article-title":"Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives","author":"Huang","year":"2022","journal-title":"Drug Discov Today."}],"container-title":["Drug Discovery Today"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644622002173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1359644622002173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:58:32Z","timestamp":1761224312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1359644622002173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1359644622002173"],"URL":"https:\/\/doi.org\/10.1016\/j.drudis.2022.05.026","relation":{},"ISSN":["1359-6446"],"issn-type":[{"value":"1359-6446","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug repurposing: An effective strategy to accelerate contemporary drug discovery","name":"articletitle","label":"Article Title"},{"value":"Drug Discovery Today","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.drudis.2022.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}